{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:35:14Z","timestamp":1790678114842,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.lfs.2006.01.002","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T13:24:53Z","timestamp":1139405093000},"page":"281-286","source":"Crossref","is-referenced-by-count":184,"title":["Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania"],"prefix":"10.1016","volume":"79","author":[{"given":"Ben\u00edcio N.","family":"Frey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Andreazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keila M.M.","family":"Ceres\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio R.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira S.","family":"Valvassori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Z.","family":"R\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2006.01.002_bib1","article-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"issue":"7","key":"10.1016\/j.lfs.2006.01.002_bib2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1176\/appi.ajp.157.7.1108","article-title":"Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients","volume":"157","author":"Anand","year":"2000","journal-title":"American Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF00217062","article-title":"Hyperactivity induced by dexamphetamine\/chlordiazepoxide mixtures in rats and its attenuation by lithium pretreatment: a role for dopamine?","volume":"91","author":"Aylmer","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"issue":"14","key":"10.1016\/j.lfs.2006.01.002_bib4","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.0307921101","article-title":"Lithium antagonizes dopamine-dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade","volume":"101","author":"Beaulieu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.002_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpsyc.57.1.95","article-title":"A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania","volume":"57","author":"Bebchuk","year":"2000","journal-title":"Archives of General Psychiatry"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hup.665","article-title":"Lithium and valproate attenuate dextroamphetamine-induced changes in brain activation","volume":"20","author":"Bell","year":"2005","journal-title":"Human Psychopharmacology"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.002_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMra035354","article-title":"Bipolar disorder","volume":"351","author":"Belmaker","year":"2004","journal-title":"The New England Journal of Medicine"},{"issue":"10","key":"10.1016\/j.lfs.2006.01.002_bib7","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0006-3223(02)01911-X","article-title":"Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging","volume":"53","author":"Bertolino","year":"2003","journal-title":"Biological Psychiatry"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/070674370204700203","article-title":"The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression","volume":"47","author":"Bezchlibnyk","year":"2002","journal-title":"Canadian Journal of Psychiatry"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1034\/j.1399-5618.2002.01179.x","article-title":"Neuroprotective effects of lithium in cultured cells and animal models of diseases","volume":"4","author":"Chuang","year":"2002","journal-title":"Bipolar Disorders"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0896-6273(03)00195-8","article-title":"Finding the intracellular signaling pathways affected by mood disorder treatments","volume":"38","author":"Coyle","year":"2003","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.002_bib11","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1176\/appi.ajp.160.5.873","article-title":"Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder","volume":"160","author":"Deicken","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.lfs.2006.01.002_bib12","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.mp.4001016","article-title":"Synaptic plasticity and mood disorders","volume":"7","author":"Duman","year":"2002","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.lfs.2006.01.002_bib13","series-title":"Contemporary Issues in Modeling Psychopathology","first-page":"165","article-title":"Animal models of bipolar disorder: from a single episode to progressive cycling models","author":"Einat","year":"2000"},{"issue":"19","key":"10.1016\/j.lfs.2006.01.002_bib14","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1523\/JNEUROSCI.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood regulation","volume":"23","author":"Einat","year":"2003","journal-title":"Journal of Neuroscience"},{"issue":"6","key":"10.1016\/j.lfs.2006.01.002_bib15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00008877-199000160-00001","article-title":"Animal models with construct validity for schizophrenia","volume":"1","author":"Ellenbroek","year":"1990","journal-title":"Behavioural Pharmacology"},{"key":"10.1016\/j.lfs.2006.01.002_bib16","unstructured":"Frey, B.N., Martins, M.R., Petronilho, F.C., Dal-Pizzol, F., Quevedo, J., Kapczinski, F. Increased oxidative stress after repeated amphetamine exposure: possible relevance as an animal model of acute mania. Bipolar Disorders (in press)."},{"issue":"1","key":"10.1016\/j.lfs.2006.01.002_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s002130100871","article-title":"Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain","volume":"158","author":"Fukumoto","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.002_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/107385802237176","article-title":"The Wnt signaling pathway in bipolar disorder","volume":"8","author":"Gould","year":"2002","journal-title":"Neuroscientist"},{"issue":"6833","key":"10.1016\/j.lfs.2006.01.002_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35075076","article-title":"BDNF controls dopamine D3 receptor expression and triggers behavioral sensitization","volume":"411","author":"Guillin","year":"2001","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.lfs.2006.01.002_bib20","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0028-3908(02)00217-4","article-title":"Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity","volume":"43","author":"Hashimoto","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2006.01.002_bib21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainresrev.2004.02.003","article-title":"Critical role of brain-derived neurotrophic factor in mood disorders","volume":"45","author":"Hashimoto","year":"2004","journal-title":"Brain Research Reviews"},{"issue":"4","key":"10.1016\/j.lfs.2006.01.002_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-0327(94)00094-P","article-title":"Urinary catecholamines and plasma hormones predict mood state in rapid cycling bipolar affective disorder","volume":"33","author":"Joyce","year":"1995","journal-title":"Journal of Affective Disorders"},{"issue":"20","key":"10.1016\/j.lfs.2006.01.002_bib23","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1001\/jama.293.20.2528","article-title":"The increasing medical burden in bipolar disorder","volume":"293","author":"Kupfer","year":"2005","journal-title":"Journal of American Medical Association"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.002_bib24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/ebeh.2001.0254","article-title":"Effect of the new antiepileptic drug levetiracetam in an animal model of mania","volume":"2","author":"Lamberty","year":"2001","journal-title":"Epilepsy and Behavior"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2006.01.002_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0327(00)00361-X","article-title":"Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?","volume":"69","author":"Li","year":"2002","journal-title":"Journal of Affective Disorders"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2003.10.015","article-title":"Perspectives for the development of animal models of bipolar disorder","volume":"28","author":"Machado-Vieira","year":"2004","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.002_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1471-4159.2002.00939.x","article-title":"BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents","volume":"82","author":"Mai","year":"2002","journal-title":"Journal of Neurochemistry"},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2006.01.002_bib29","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1038\/sj.mp.4001018","article-title":"PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers","volume":"7","author":"Manji","year":"2002","journal-title":"Molecular Psychiatry"},{"issue":"6","key":"10.1016\/j.lfs.2006.01.002_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0006-3223(00)00929-X","article-title":"Signaling: cellular insights into the pathophysiology of bipolar disorder","volume":"48","author":"Manji","year":"2000","journal-title":"Biological Psychiatry"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.002_bib30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/87865","article-title":"The cellular neurobiology of depression","volume":"7","author":"Manji","year":"2001","journal-title":"Nature Medicine"},{"issue":"3","key":"10.1016\/j.lfs.2006.01.002_bib31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0306-4522(03)00099-X","article-title":"Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine","volume":"119","author":"Narita","year":"2003","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.lfs.2006.01.002_bib32","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0091-3057(90)90377-T","article-title":"Inhibition by antimanic drugs of hyperactivity induced by methamphetamine\u2013chlordiazepoxide mixture in mice","volume":"35","author":"Okada","year":"1990","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0893-133X(01)00327-X","article-title":"Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients","volume":"26","author":"Pandey","year":"2002","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2006.01.002_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/syn.20076","article-title":"Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics","volume":"54","author":"Pantazopoulos","year":"2004","journal-title":"Synapse"},{"issue":"4","key":"10.1016\/j.lfs.2006.01.002_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0091-3057(81)90299-9","article-title":"Central and peripheral effects of lithium on amphetamine-induced hyperactivity in rats","volume":"14","author":"Smith","year":"1981","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.lfs.2006.01.002_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-1781(00)00175-X","article-title":"Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study","volume":"95","author":"Soares","year":"2000","journal-title":"Psychiatry Research"},{"issue":"11","key":"10.1016\/j.lfs.2006.01.002_bib37","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0006-3223(97)00454-X","article-title":"Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans","volume":"44","author":"Strakowski","year":"1998","journal-title":"Biological Psychiatry"},{"issue":"4","key":"10.1016\/j.lfs.2006.01.002_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000080958","article-title":"Decreased levels of dopamine D3 receptor mRNA in schizophrenic and bipolar patients","volume":"50","author":"Vogel","year":"2004","journal-title":"Neuropsychobiology"},{"issue":"7","key":"10.1016\/j.lfs.2006.01.002_bib39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/0006-3223(95)00611-7","article-title":"Enhanced protein kinase C activity and translocation in bipolar affective disorder brains","volume":"40","author":"Wang","year":"1996","journal-title":"Biological Psychiatry"},{"issue":"Suppl 3","key":"10.1016\/j.lfs.2006.01.002_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1399-5618.2005.00219.x","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies","volume":"7","author":"Yatham","year":"2005","journal-title":"Bipolar Disorders"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506000300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506000300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T17:00:17Z","timestamp":1555434017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506000300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0024320506000300"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.01.002","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}