{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:58:43Z","timestamp":1787317123558,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.lfs.2006.01.023","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:25:10Z","timestamp":1140593110000},"page":"365-373","source":"Crossref","is-referenced-by-count":125,"title":["Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters"],"prefix":"10.1016","volume":"79","author":[{"given":"Rachel W.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre G.","family":"Theriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa D.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Casaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta M.","family":"Kurowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinee","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2006.01.023_bib1","first-page":"RA55","article-title":"Adiponectin and resistin\u2014new hormones of white adipose tissue","volume":"9","author":"Beltowski","year":"2003","journal-title":"Medical Science Monitor"},{"key":"10.1016\/j.lfs.2006.01.023_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.metabol.2004.09.016","article-title":"Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters","volume":"54","author":"Casaschi","year":"2005","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: the link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"TRENDS in Immunology"},{"issue":"17","key":"10.1016\/j.lfs.2006.01.023_bib4","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1097\/00001756-200112040-00053","article-title":"Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease","volume":"12","author":"Datla","year":"2001","journal-title":"Neuroreport"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2006.01.023_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-5793(04)00096-1","article-title":"Interleukin-6 is a positive regulator of tumor necrosis factor [alpha]-induced adipose-related protein in 3T3-L1 adipocytes","volume":"560","author":"Fasshauer","year":"2004","journal-title":"FEBS Letters"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1051\/jbio\/1999193010067","article-title":"Molecular mechanism of action of the fibrates","volume":"193","author":"Fruchart","year":"1999","journal-title":"Journal of Society Biology"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1210\/en.134.1.264","article-title":"Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance","volume":"134","author":"Hofmann","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2006.01.023_bib8","series-title":"Citrus Science and Technology","first-page":"397","article-title":"Flavonoid constituents of citrus","author":"Horowitz","year":"1977"},{"key":"10.1016\/j.lfs.2006.01.023_bib9","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/sj.ijo.0802502","article-title":"Inflammatory pathways and insulin action","volume":"27","author":"Hotamisligil","year":"2003","journal-title":"International Journal of Obesity"},{"issue":"11","key":"10.1016\/j.lfs.2006.01.023_bib10","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1073\/pnas.91.11.4854","article-title":"Tumor necrosis factor {alpha} inhibits signaling from the insulin receptor","volume":"91","author":"Hotamisligil","year":"1994","journal-title":"PNAS"},{"issue":"5091","key":"10.1016\/j.lfs.2006.01.023_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-\u03b1: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.lfs.2006.01.023_bib12","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients","volume":"20","author":"Hotta","year":"2000","journal-title":"Arteriosclerosis, Thrombosis and Vascular Biology"},{"issue":"6662","key":"10.1016\/j.lfs.2006.01.023_bib13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/34184","article-title":"PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.023_bib14","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/hep.510270515","article-title":"Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes","volume":"27","author":"Kanemaki","year":"1998","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/01.ATV.0000048856.22331.50","article-title":"Association of hypoadiponectinemia with coronary artery disease in men","volume":"23","author":"Kumada","year":"2003","journal-title":"Arteriosclerosis, Thrombosis and Vascular Biology"},{"key":"10.1016\/j.lfs.2006.01.023_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-4757-5235-9_16","article-title":"Regulation of lipoprotein metabolism in HepG2 cells by citrus flavonoids","volume":"505","author":"Kurowska","year":"2002","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"10","key":"10.1016\/j.lfs.2006.01.023_bib17","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1021\/jf035354z","article-title":"Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia","volume":"52","author":"Kurowska","year":"2004","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.lfs.2006.01.023_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11745-004-1212-8","article-title":"Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin","volume":"39","author":"Kurowska","year":"2004","journal-title":"Lipids"},{"issue":"12","key":"10.1016\/j.lfs.2006.01.023_bib19","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/S0006-2952(03)00203-X","article-title":"Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages","volume":"65","author":"Lin","year":"2003","journal-title":"Biochemical Pharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2006.01.023_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1021\/np980431j","article-title":"Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes","volume":"62","author":"Manthey","year":"1999","journal-title":"Journal of Natural Products"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2006.01.023_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1011927113563","article-title":"Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob\/ob mouse model of non-insulin dependent diabetes mellitus","volume":"224","author":"Rahimian","year":"2001","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"45","key":"10.1016\/j.lfs.2006.01.023_bib22","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"10.1016\/j.lfs.2006.01.023_bib23","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1053\/meta.2000.8604","article-title":"Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia","volume":"49","author":"Scribner","year":"2000","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/scdb.1998.0273","article-title":"The role of TNF alpha in adipocyte metabolism","volume":"10","author":"Sethi","year":"1999","journal-title":"Seminars in Cellular and Developmental Biology"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1440-6047.2002.00271.x","article-title":"Anticancer and health protective properties of citrus fruit components","volume":"11","author":"Silalahi","year":"2002","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"issue":"12","key":"10.1016\/j.lfs.2006.01.023_bib26","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.1074\/jbc.275.12.8416","volume":"275","author":"Taghibiglou","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2006.01.023_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1254\/jphs.FMJ04008X2","article-title":"Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by proxisome proliferator-activated receptor Y, CREB-binding protein, and adiponectin","volume":"97","author":"Tsuchida","year":"2005","journal-title":"Journal of Pharmacological Sciences"},{"issue":"5","key":"10.1016\/j.lfs.2006.01.023_bib28","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jc.86.5.1930","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.lfs.2006.01.023_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.atherosclerosis.2004.07.034","article-title":"Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages","volume":"178","author":"Whitman","year":"2005","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.lfs.2006.01.023_bib30","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1210\/jc.2003-031826","article-title":"Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction","volume":"89","author":"Xydakis","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"10.1016\/j.lfs.2006.01.023_bib31","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/sj.ijo.0802496","article-title":"Adipose tissue, insulin action and vascular disease: inflammatory signals","volume":"27","author":"Yudkin","year":"2003","journal-title":"International Journal of Obesity and Related Metabolic Disorders"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506000762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506000762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T21:48:11Z","timestamp":1555451291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506000762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0024320506000762"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.01.023","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}