{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:06:29Z","timestamp":1736399189974,"version":"3.32.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.lfs.2006.02.034","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T12:10:13Z","timestamp":1143547813000},"page":"854-860","source":"Crossref","is-referenced-by-count":4,"title":["l-NAME pre-treatment partially inhibits the agmatine-evoked depression of the electrically induced twitch contraction of isolated rat vas deferens"],"prefix":"10.1016","volume":"79","author":[{"given":"L\u00facia","family":"Garcez-do-Carmo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2006.02.034_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0006-8993(00)02517-8","article-title":"Agmatine suppresses nitric oxide production in microglia","volume":"872","author":"Abe","year":"2000","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.02.034_bib2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1476-5381.1994.tb16206.x","article-title":"Effects of 7-nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase","volume":"113","author":"Allawi","year":"1994","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jjp.69.285","article-title":"Selective inhibition of inducible nitric oxide synthase by agmatine","volume":"69","author":"Auguet","year":"1995","journal-title":"Japanese Journal of Pharmacology"},{"issue":"7","key":"10.1016\/j.lfs.2006.02.034_bib4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0306-3623(96)00038-9","article-title":"Are there imidazoline receptors in sympathetic neurotransmission in rat vas deferens?","volume":"27","author":"Avellar","year":"1996","journal-title":"General Pharmacology"},{"issue":"part 2","key":"10.1016\/j.lfs.2006.02.034_bib5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.HYP.34.4.744","article-title":"Rostral ventrolateral medulla. A source of sympathetic activation in rats subjected to long-term treatment with l-NAME","volume":"34","author":"Bergamaschi","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2006.02.034_bib6","first-page":"1235","article-title":"Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats","volume":"278","author":"Bockman","year":"1996","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.lfs.2006.02.034_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod52.1.1","article-title":"Localisation of nitric oxide synthase in the reproductive organs of the male rat","volume":"52","author":"Burnett","year":"1995","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.lfs.2006.02.034_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1749-6632.1995.tb32433.x","article-title":"Role of the epithelium in the release of contractile agents from the rat vas deferens by clonidine","volume":"763","author":"Caricati-Neto","year":"1995","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.lfs.2006.02.034_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-8993(94)91483-4","article-title":"Immunohistochemical demonstration of nitric oxide synthase in the peripheral autonomic nervous system","volume":"656","author":"Ceccatelli","year":"1994","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.02.034_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1748-1716.1994.tb09661.x","article-title":"Modulation of neuroeffector transmission in guinea-pig pulmonary artery and vas deferens by exogenous oxide nitric","volume":"150","author":"Cederqvist","year":"1994","journal-title":"Acta Physiologica Scandinavica"},{"key":"10.1016\/j.lfs.2006.02.034_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/mol.59.1.24","article-title":"Agmatine enhances the NADPH oxidase activity of neuronal NO-synthase and leads to oxidative inactivation of the enzyme","volume":"59","author":"Demady","year":"2001","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.02.034_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bj3160247","article-title":"Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine","volume":"316","author":"Galea","year":"1996","journal-title":"Biochemical Journal"},{"issue":"8","key":"10.1016\/j.lfs.2006.02.034_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0024-3205(95)02011-7","article-title":"Agmatine: a novel endogenous vasodilator substance","volume":"57","author":"Gao","year":"1995","journal-title":"Life Sciences"},{"key":"10.1016\/j.lfs.2006.02.034_bib15","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.lfs.2006.02.034_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/bbrc.1995.2268","article-title":"N\u03c9-Hydroxyagmatine: a novel substance causing endothelium-dependent vasorelaxation","volume":"214","author":"Ishikawa","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.lfs.2006.02.034_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.lfs.2006.02.034_bib18","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.7906055","article-title":"Agmatine: an endogenous clonidine-displacing substance in the brain","volume":"263","author":"Li","year":"1994","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.lfs.2006.02.034_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0031-6997(24)01319-X","article-title":"XIV International Union of Pharmacology Nomenclature in Nitric Oxide Research","volume":"49","author":"Moncada","year":"1997","journal-title":"Pharmacological Reviews"},{"issue":"1","key":"10.1016\/j.lfs.2006.02.034_bib20","first-page":"51","article-title":"Agmatine activation of nitric oxide synthase in endothelial cells","volume":"109","author":"Morrissey","year":"1997","journal-title":"Proceedings of Associate American Physiology"},{"issue":"24","key":"10.1016\/j.lfs.2006.02.034_bib21","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1016\/S0024-3205(02)01545-X","article-title":"Contractile responses of the rat vas deferens after epithelium removal","volume":"70","author":"Okpalaugo","year":"2002","journal-title":"Life Sciences"},{"key":"10.1016\/j.lfs.2006.02.034_bib22","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.02.034_bib23","first-page":"354","article-title":"Synergyst effect of 5-hydroxytriptamine on the response of rat seminal vesicle to adrenaline and noradrenaline","volume":"138","author":"Picarelli","year":"1962","journal-title":"Archives International of Pharmacodynamics"},{"key":"10.1016\/j.lfs.2006.02.034_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2680.1998.1810021.x","article-title":"Nitric oxide as a neuromodulator of sympathetic transmission in rat vas deferens","volume":"18","author":"Postorino","year":"1998","journal-title":"Journal of Autonomic Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.bjp.0704153","article-title":"Biological significance of agmatine, an endogenous ligand at imidazoline binding sites","volume":"133","author":"Raasch","year":"2001","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib26","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.86.9.3375","article-title":"Role of endothelium-derived nitric oxide in the regulation of blood pressure","volume":"86","author":"Rees","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.lfs.2006.02.034_bib27","first-page":"1272","article-title":"Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation","volume":"276","author":"Regunathan","year":"1996","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.lfs.2006.02.034_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0165-6147(00)01460-7","article-title":"Is agmatine a novel neurotransmitter in brain?","volume":"21","author":"Reis","year":"2000","journal-title":"Trends in Pharmacological Sciences"},{"issue":"3","key":"10.1016\/j.lfs.2006.02.034_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.20.3.298","article-title":"Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension","volume":"20","author":"Ribeiro","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2006.02.034_bib30","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1124\/jpet.105.086173","article-title":"Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in mouse","volume":"314","author":"Roberts","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.lfs.2006.02.034_bib31","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/sj.bjp.0704556","article-title":"Effect of agmatine on locus coerulus neuron activity: possible involvement of nitric oxide","volume":"135","author":"Ruiz-Dur\u00e1ntez","year":"2002","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(01)00897-4","article-title":"Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors","volume":"417","author":"Santos","year":"2001","journal-title":"European Journal of Pharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2006.02.034_bib33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1211\/002235702720","article-title":"Dual effect of agmatine in the bisected rat vas deferens","volume":"55","author":"Santos","year":"2003","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"5 pt 2","key":"10.1016\/j.lfs.2006.02.034_bib35","first-page":"f97","article-title":"Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanism","volume":"272","author":"Schwartz","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2006.02.034_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.pp.36.060185.001001","article-title":"Polyamines","volume":"36","author":"Smith","year":"1985","journal-title":"Annual Review of Plant Physiology"},{"issue":"3","key":"10.1016\/j.lfs.2006.02.034_bib37","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1152\/physrev.1989.69.3.864","article-title":"Modulation of neurotransmitter release by presynaptic autoreceptors","volume":"69","author":"Starke","year":"1989","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.lfs.2006.02.034_bib39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.bi.53.070184.003533","article-title":"Polyamines","volume":"53","author":"Tabor","year":"1984","journal-title":"Annual Review of Biochemistry"},{"issue":"Suppl. 3C","key":"10.1016\/j.lfs.2006.02.034_bib40","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1016\/0002-9343(89)90496-8","article-title":"Alpha2-adrenoceptors and endothelium-derived relaxing factor","volume":"87","author":"Vanhoutte","year":"1989","journal-title":"American Journal of Medicine"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2006.02.034_bib41","first-page":"299","article-title":"Cumulative dose\u2013response curves: ii. Technique for the making of dose\u2013response curves in isolated organs and evaluations of drug parameters","volume":"143","author":"Van Rossum","year":"1963","journal-title":"Archives International of Pharmacodynamics"},{"key":"10.1016\/j.lfs.2006.02.034_bib42","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1440-1681.1998.tb02169.x","article-title":"Autoinhibition, sympathetic cotransmission and biphasic contractile responses to trains of nerve stimulation in the rodent vas deferens","volume":"25","author":"Ventura","year":"1998","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.lfs.2006.02.034_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-2999(97)01172-2","article-title":"Evidence against nitrergic neuromodulation in the rat vas deferens","volume":"334","author":"Ventura","year":"1997","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.02.034_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.2042-7158.1998.tb06177.x","article-title":"Sodium nitroprusside enhances contractions of the guinea-pig isolated vas deferens","volume":"50","author":"Ventura","year":"1998","journal-title":"Journal of Pharmacy and Pharmacology"},{"issue":"14","key":"10.1016\/j.lfs.2006.02.034_bib45","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0024-3205(94)00240-1","article-title":"Evidence for participation of nitric oxide in excitatory neurotransmission in rat vas deferens","volume":"55","author":"Vladimirova","year":"1994","journal-title":"Life Sciences"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506002128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506002128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:44:37Z","timestamp":1736311477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506002128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0024320506002128"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.02.034","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}