{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:19:04Z","timestamp":1761707944447},"reference-count":55,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.lfs.2006.07.028","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T21:43:06Z","timestamp":1154554986000},"page":"2269-2274","source":"Crossref","is-referenced-by-count":16,"title":["Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels"],"prefix":"10.1016","volume":"79","author":[{"given":"A.","family":"Dairam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.S.","family":"Saravanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Daya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2006.07.028_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.lfs.2006.07.028_bib2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/bj1500511","article-title":"The regulation of rat liver tryptophan pyrrolase by its cofactor haem. Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms","volume":"150","author":"Badawy","year":"1975","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.lfs.2006.07.028_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1471-4159.1974.tb06923.x","article-title":"Radiometric assay of total tryptophan hydroxylation by intact cultured pineal glands","volume":"23","author":"Bensinger","year":"1974","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.lfs.2006.07.028_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(01)03394-7","article-title":"Long-term effects of St. John's wort and hypericin on monoaminelevels in rat hypothalamus and hippocampus","volume":"930","author":"Butterweck","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0090-6980(79)90025-X","article-title":"Release and specific binding of prostaglandins in bovine pineal glands","volume":"18","author":"Cardinali","year":"1979","journal-title":"Prostaglandins"},{"key":"10.1016\/j.lfs.2006.07.028_bib6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1210\/endo-111-2-530","article-title":"Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro","volume":"111","author":"Cardinali","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2006.07.028_bib7","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1046\/j.1471-4159.1998.70041584.x","article-title":"Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system","volume":"70","author":"Castano","year":"1998","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.lfs.2006.07.028_bib8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1460-9568.2002.01938.x","article-title":"Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging","volume":"15","author":"Cicchetti","year":"2002","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2006.07.028_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-079X.1995.tb00180.x","article-title":"Permeability of pure lipid bilayers to melatonin","volume":"19","author":"Costa","year":"1995","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib10","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1192\/bjp.115.529.1367","article-title":"Tryptophan pyrrolase\u2014a biochemical factor in depressive illness?","volume":"115","author":"Curzon","year":"1969","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.lfs.2006.07.028_bib11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/jnnp.33.5.698","article-title":"Tryptophan metabolism in depression","volume":"33","author":"Curzon","year":"1970","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.lfs.2006.07.028_bib12","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jnr.490230309","article-title":"Heme precursor 5-aminolevulinic acid alters brain tryptophan and serotonin levels without changing pineal serotonin and melatonin concentrations","volume":"23","author":"Daya","year":"1989","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib13","first-page":"770","article-title":"Effect of chlorophenylalanine or hydroxylation of tryptophan in pineal and brain of rats","volume":"8","author":"Deguchi","year":"1972","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.lfs.2006.07.028_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/240410a0","article-title":"Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)","volume":"240","author":"Flower","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.07.028_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0896-6273(00)80798-9","article-title":"Beyond the dopamine receptor: the DARPP-32\/protein phosphase-1 cascade","volume":"23","author":"Greengard","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2006.07.028_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s004840050053","article-title":"New actions of melatonin and their relevance to biometeorology","volume":"41","author":"Hardeland","year":"1997","journal-title":"International Journal of Biometeorology"},{"issue":"154","key":"10.1016\/j.lfs.2006.07.028_bib55","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/219619a0","article-title":"Circadian oscillation in rat liver tryptophan pyrrolase and its analysis by substrate and hormone induction","volume":"219","author":"Hardeland","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.07.028_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-079X.1995.tb00147.x","article-title":"On the primary functioning of melatonin in evolution: mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals","volume":"186","author":"Hardeland","year":"1995","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib19","series-title":"Biochemical and Medical Aspects of Tryptophan Metabolism","first-page":"15","author":"Hayaishi","year":"1980"},{"key":"10.1016\/j.lfs.2006.07.028_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0165-0173(91)90007-U","article-title":"Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity","volume":"16","author":"Kalivas","year":"1991","journal-title":"Brain Research Reviews"},{"key":"10.1016\/j.lfs.2006.07.028_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-4347(00)00341-8","article-title":"Clinical chemistry of serotonin and metabolites","volume":"74","author":"Kema","year":"2000","journal-title":"Journal of Chromatography. B, Biomedical Sciences and Applications"},{"key":"10.1016\/j.lfs.2006.07.028_bib22","first-page":"307","article-title":"The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland","volume":"52","author":"Klein","year":"1997","journal-title":"Recent Progress in Hormone Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/026988119701100205","article-title":"Dopamine, the prefrontal cortex and schizophrenia","volume":"11","author":"Knable","year":"1997","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-6147(92)90060-J","article-title":"Drugs of abuse: anatomy, pharmacology and function of reward pathways","volume":"13","author":"Koob","year":"1992","journal-title":"Trends in Pharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.278.5335.52","article-title":"Drug abuse: hedonic homeostatic dysregulation","volume":"278","author":"Koob","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.lfs.2006.07.028_bib26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/1531-8249(199910)46:4<598::AID-ANA7>3.0.CO;2-F","article-title":"Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine exposure","volume":"46","author":"Langston","year":"1999","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.lfs.2006.07.028_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1054-3589(08)61153-9","article-title":"Tryptophan hydroxylation in mammalian systems","volume":"6","author":"Lovenberg","year":"1968","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2006.07.028_bib29","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.lfs.2006.07.028_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00001756-199512290-00057","article-title":"Single neonatal administration of serotonin antiserum inhibits serotonin metabolism and function in adult rats","volume":"7","author":"Mohanakumar","year":"1995","journal-title":"NeuroReport"},{"key":"10.1016\/j.lfs.2006.07.028_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(00)02189-2","article-title":"Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity","volume":"864","author":"Mohanakumar","year":"2000","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib32","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1096\/fasebj.12.10.905","article-title":"Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice","volume":"12","author":"Muralikrishnan","year":"1998","journal-title":"FASEB"},{"key":"10.1016\/j.lfs.2006.07.028_bib33","first-page":"133","article-title":"Nonsteroidal anti-inflammatory drugs alters body temperature and suppress melatonin in humans","volume":"69","author":"Murphy","year":"1986","journal-title":"Physiology and Behavior"},{"key":"10.1016\/j.lfs.2006.07.028_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-2423(08)60373-X","article-title":"Aspects of disorders of the kynurenine pathway of tryptophan metabolism in man","volume":"7","author":"Musajo","year":"1964","journal-title":"Advances in Clinical Chemistry"},{"key":"10.1016\/j.lfs.2006.07.028_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.278.5335.58","article-title":"Molecular and cellular basis of addiction","volume":"278","author":"Nestler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.lfs.2006.07.028_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-1-4831-6750-3.50009-3","article-title":"Testing the functional capacity of the tryptophan\u2013niacin pathway in man by analysis of urinary metabolites","volume":"2","author":"Price","year":"1965","journal-title":"Advances in Metabolic Disorders"},{"key":"10.1016\/j.lfs.2006.07.028_bib37","first-page":"223","article-title":"Melatonin: that ubiquitously acting pineal hormone","volume":"6","author":"Reiter","year":"1991","journal-title":"News in Physiological Sciences"},{"key":"10.1016\/j.lfs.2006.07.028_bib56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0197-0186(95)80002-3","article-title":"The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage","volume":"27","author":"Reiter","year":"1995","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.lfs.2006.07.028_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0301-0082(98)00052-5","article-title":"Oxidative damage in the central nervous system: protection by melatonin","volume":"56","author":"Reiter","year":"1998","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.lfs.2006.07.028_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.1995.tb00133.x","article-title":"A review of the evidence supporting melatonin's role as an antioxidant","volume":"18","author":"Reiter","year":"1995","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib40","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.1997.tb48415.x","article-title":"Prophylactic actions of melatonin in oxidative neurotoxicity","volume":"825","author":"Reiter","year":"1997","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.lfs.2006.07.028_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-8993(02)04174-4","article-title":"Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats","volume":"966","author":"Sairam","year":"2003","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib42","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-079X.1994.tb00102.x","article-title":"High melatonin solubility in aqueous medium","volume":"16","author":"Shida","year":"1994","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.lfs.2006.07.028_bib43","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.2042-7158.1987.tb05129.x","article-title":"Effect of ibuprofen and indomethacin on human plasma melatonin","volume":"39","author":"Surrall","year":"1987","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib44","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S1471-4892(02)00173-X","article-title":"Immunomodulatory effect of antidepressants","volume":"2","author":"Szelenyi","year":"2002","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.lfs.2006.07.028_bib45","first-page":"57","article-title":"Melatonin: a potent, endogenous hydroxyl radical scavenger","volume":"1","author":"Tan","year":"1993","journal-title":"Endocrine Journal"},{"key":"10.1016\/j.lfs.2006.07.028_bib46","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0165-0327(82)90025-8","article-title":"Depression, suicide and the metabolism of serotonin in the brain","volume":"4","author":"van Praag","year":"1982","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.lfs.2006.07.028_bib47","first-page":"231","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"234","author":"Vane","year":"1971","journal-title":"Nature. New Biology"},{"key":"10.1016\/j.lfs.2006.07.028_bib48","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1471-4159.1993.tb03199.x","article-title":"Prostaglandins stimulate serotonin acetylation in chick pineal cells: involvement of cyclic AMP-dependent and calcium\/calmodulin-dependent mechanisms","volume":"60","author":"Voisin","year":"1993","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.lfs.2006.07.028_bib49","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/S0024-3205(98)00223-9","article-title":"Influence of the antidepressants desipramine and fluoxetine on tryptophan-2,3-dioxygenase in the presence of exogenous melatonin","volume":"62","author":"Walsh","year":"1998","journal-title":"Life Sciences"},{"key":"10.1016\/j.lfs.2006.07.028_bib50","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/376572a0","article-title":"Modulation of memory fields by D1 receptors in prefrontal cortex","volume":"376","author":"Williams","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.07.028_bib51","first-page":"1","article-title":"Studies on tryptophan metabolism in man","volume":"136","author":"Wolf","year":"1974","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation. Supplement"},{"key":"10.1016\/j.lfs.2006.07.028_bib52","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1080\/10826079808005877","volume":"21","author":"Xie","year":"1998","journal-title":"Journal of Liquid Chromatography and Related Technologies"},{"key":"10.1016\/j.lfs.2006.07.028_bib53","series-title":"Biostatistical Analysis","first-page":"151","author":"Zar","year":"1974"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506005935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506005935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T02:12:59Z","timestamp":1627697579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506005935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":55,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0024320506005935"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.07.028","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}