{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:06:40Z","timestamp":1761718000320},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.lfs.2006.09.005","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T14:32:22Z","timestamp":1158676342000},"page":"212-218","source":"Crossref","is-referenced-by-count":11,"title":["Genotoxic potential of medroxyprogesterone acetate in cultured human peripheral blood lymphocytes"],"prefix":"10.1016","volume":"80","author":[{"given":"Yasir Hasan","family":"Siddique","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulshan","family":"Ara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanveer","family":"Beg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2006.09.005_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1383-5718(01)00164-4","article-title":"Evaluation of genotoxic potential of synthetic progestins\u2013norethindrone and norgestrel in human lymphocytes in vitro","volume":"494","author":"Ahmad","year":"2001","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0300-483X(02)00195-6","article-title":"Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens","volume":"177","author":"Bolton","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2006.09.005_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1383-5742(02)00047-9","article-title":"Are some progestins genotoxic liver carcinogens?","volume":"512","author":"Brambilla","year":"2002","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0027-5107(93)90087-V","article-title":"Cellular stress by light and Rose Bengal in human lymphocytes","volume":"288","author":"Carballo","year":"1993","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1021\/tx980083l","article-title":"The equine estrogen metabolite 4-hydroequilenin causes DNA single strand breaks and oxidation of DNA bases in vitro","volume":"11","author":"Chen","year":"1998","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.lfs.2006.09.005_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0070-2137(01)80005-4","article-title":"Superoxide dismutase, oxidative stress, and cell metabolism","volume":"36","author":"Culotta","year":"2000","journal-title":"Current Topics in Cellular Regulation"},{"key":"10.1016\/j.lfs.2006.09.005_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1218(94)90004-3","article-title":"In vitro and in vivo genotoxicity evaluation of hormonal drugs V, Mestranol","volume":"322","author":"Dhillon","year":"1994","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib8","series-title":"Therapeutic Drugs","author":"Dollery","year":"1991"},{"key":"10.1016\/j.lfs.2006.09.005_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0887-2333(98)80005-2","article-title":"DNA adduct formation of selected sex steroids in human liver slices in vitro","volume":"12","author":"Feser","year":"1998","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.lfs.2006.09.005_bib10","series-title":"Agricultural and Medical Research Workers","first-page":"138","article-title":"Statistical Table for Biological","author":"Fisher","year":"1963"},{"key":"10.1016\/j.lfs.2006.09.005_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/tx00022a001","article-title":"Oxidation of toxic and carcinogenic chemicals by human cytochrome P450 enzymes","volume":"4","author":"Guengerich","year":"1991","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.lfs.2006.09.005_bib12","first-page":"5515","article-title":"8-Hydroxylation of guanine bases in kidney and liver DNA of hamsters treated with estradiol: role of free radicals in estrogen induced carcinogenesis","volume":"54","author":"Han","year":"1994","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib13","first-page":"311","article-title":"Evaluation of the mutagenicity of medroxyprogesterone acetate in vitro and in vivo","volume":"45","author":"Herzog","year":"1995","journal-title":"Drug Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib14","unstructured":"IARC, 1987. Monographs on the Evaluation of the carcinogenic risks to humans vol. 1-42, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, IARC, Lyon France, 96\u201397 and 273\u2013310."},{"key":"10.1016\/j.lfs.2006.09.005_bib15","first-page":"399","article-title":"Monographs on the hormonal contraceptives, progestogens only (Group 2B)","volume":"vol. 72","author":"IARC","year":"1999"},{"key":"10.1016\/j.lfs.2006.09.005_bib16","series-title":"Guidelines for the Study of Genetic Effects in Human Population","first-page":"25","article-title":"International programme on chemical safety: environmental health criteria 46","author":"IPCS","year":"1985"},{"key":"10.1016\/j.lfs.2006.09.005_bib17","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1093\/carcin\/16.10.2309","article-title":"In vitro mutagenicity studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells","volume":"16","author":"Kasper","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2006.09.005_bib18","first-page":"3297","article-title":"Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate","volume":"6","author":"Kobayashi","year":"2000","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib19","first-page":"9","article-title":"Pharmacology of progestins. Basic aspects \u2014 progesterone derivatives","volume":"VI","author":"Kuhl","year":"2001","journal-title":"Menopause Review"},{"key":"10.1016\/j.lfs.2006.09.005_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3835(86)90027-3","article-title":"Induction of mammary adenocarcinomas by medroxyprogesterone in BALB\/c female mice","volume":"33","author":"Lanari","year":"1986","journal-title":"Cancer Letters"},{"key":"10.1016\/j.lfs.2006.09.005_bib21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/em.2850210311","article-title":"Studies for a genotoxic potential of some endogenous and exogenous steroids.I. Communication: examination for the induction of gene mutation using the Ames Salmonella\/Microsome Test and the HGPRT Test in V79 cells","volume":"21","author":"Lang","year":"1993","journal-title":"Environmental and Molecular Mutagenesis"},{"key":"10.1016\/j.lfs.2006.09.005_bib22","series-title":"Advances in Applied Toxicology","first-page":"51","article-title":"Experimental toxicity studies with contraceptives steroids and their relevance for human risk estimation","author":"Lehmann","year":"1989"},{"key":"10.1016\/j.lfs.2006.09.005_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0165-1218(79)90167-8","article-title":"Induction of sister chromatid exchange in Chinese Hamster ovary cells by thiol and hydrazine compounds","volume":"68","author":"MacRae","year":"1979","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1161(83)90010-9","article-title":"Revised methods for the salmonella mutagenicity test","volume":"113","author":"Maron","year":"1983","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1383-5718(03)00036-6","article-title":"Species, sex and interindividual differences in DNA repair induced by nine sex steroids in primary culture of rats and human hepatocytes","volume":"536","author":"Martelli","year":"2003","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrgentox.2004.07.006","article-title":"DNA fragmentation, DNA repair and apoptosis induced in primary rat hepatocytes by dienogest, dydrogesterone and 1,4,6-androstatriene-17-beta-ol-3-one acetate","volume":"564","author":"Mattioli","year":"2004","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1383-5718(96)00070-8","article-title":"Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B). The summary report of the 6th collaborative study of the Micronucleus Group Test. Mammalian mutaenicity study group","volume":"389","author":"Morita","year":"1997","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/251156a0","article-title":"New Giemsa method for differential staining of sister chromatids","volume":"251","author":"Perry","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2006.09.005_bib29","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.maturitas.2003.09.014","article-title":"Classification and pharmacology of progestins","volume":"46S1","author":"Schindler","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.lfs.2006.09.005_bib30","first-page":"9","article-title":"Induction of sister chromatid exchanges by androstenedione in human lymphocytes in vitro","volume":"1","author":"Siddique","year":"2003","journal-title":"Bulletin of Environmental Biology"},{"key":"10.1016\/j.lfs.2006.09.005_bib31","first-page":"1161","article-title":"Evaluation of genotoxic potential of synthetic progestin ethynodiol diacetate in human lymphocytes in vitro","volume":"86","author":"Siddique","year":"2004","journal-title":"Current Science"},{"key":"10.1016\/j.lfs.2006.09.005_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.toxlet.2004.03.026","article-title":"Evaluation of genotoxic potential of chlormadinone acetate","volume":"153","author":"Siddique","year":"2004","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.lfs.2006.09.005_bib33","first-page":"1078","article-title":"Induction of chromosomal aberrations and sister chromatid exchanges by chlormadinone acetate: a possible role of reactive oxygen species","volume":"42","author":"Siddique","year":"2004","journal-title":"Indian Journal of Experimental Biology"},{"key":"10.1016\/j.lfs.2006.09.005_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tiv.2004.06.008","article-title":"Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species","volume":"19","author":"Siddique","year":"2005","journal-title":"Toxicology in Vitro"},{"key":"10.1016\/j.lfs.2006.09.005_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cbi.2004.10.008","article-title":"Genotoxic potential of ethinylestradiol in cultured mammalian cells","volume":"151","author":"Siddique","year":"2005","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.lfs.2006.09.005_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1191\/0960327104ht508oa","article-title":"Antigenotoxic effects of ascorbic acid against megestrol acetate induced genotoxicity in mice","volume":"24","author":"Siddique","year":"2005","journal-title":"Human and Experimental Toxicology"},{"key":"10.1016\/j.lfs.2006.09.005_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0027-5107(94)90201-1","article-title":"In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone","volume":"308","author":"Singh","year":"1994","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-7992(84)90067-8","article-title":"Induction of chromosomal aberrations in cultured Chinese Hamster Cells Superoxide generation system","volume":"140","author":"Sofuni","year":"1984","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib39","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0891-5849(99)00183-5","article-title":"DNA damage induced by catechol estrogens in the presence of copper (II): generation of reactive oxygen species and enhancement by NADPH","volume":"27","author":"Thibodeau","year":"1999","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.lfs.2006.09.005_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1266\/jjg.56.1","article-title":"Chromosomal aberrations induced by hydrogen peroxide in cultured mammalian cells","volume":"56","author":"Tsuda","year":"1981","journal-title":"Japanese Journal of Genetics"},{"key":"10.1016\/j.lfs.2006.09.005_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1383-5718(97)00167-8","article-title":"Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes","volume":"395","author":"Werner","year":"1997","journal-title":"Mutation Research"},{"key":"10.1016\/j.lfs.2006.09.005_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/em.2850190603","article-title":"Salmonella mutagenicity tests, V. Results from testing 311 chemicals","volume":"19","author":"Zeiger","year":"1992","journal-title":"Environmental and Molecular Mutagenesis"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506006990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506006990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T05:54:02Z","timestamp":1547358842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506006990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0024320506006990"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.09.005","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}