{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:20:41Z","timestamp":1758637241946,"version":"3.32.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.lfs.2006.11.053","type":"journal-article","created":{"date-parts":[[2006,12,23]],"date-time":"2006-12-23T12:13:56Z","timestamp":1166876036000},"page":"1115-1122","source":"Crossref","is-referenced-by-count":7,"title":["Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits"],"prefix":"10.1016","volume":"80","author":[{"given":"Takashi","family":"Konno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Uchibori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimichi","family":"Nakahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0021-5155(00)00163-5","article-title":"In vivo measurement of ocular circulation with the laser speckle method-development of apparatus and application in ophthalmological research","volume":"44","author":"Araie","year":"2000","journal-title":"Japanese Journal of Ophthalmology"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/jop.1988.4.61","article-title":"The potential role of adenosine in regulating blood flow in the eye","volume":"4","author":"Braunagel","year":"1988","journal-title":"Journal of Ocular Pharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/archopht.1989.01070010422038","article-title":"Adenosine and its agonists cause retinal vasodilation and hemorrhages. Implications for ischemic retinopathies","volume":"107","author":"Campochiaro","year":"1989","journal-title":"Archives of Ophthalmology"},{"issue":"9","key":"10.1016\/j.lfs.2006.11.053_bib4","first-page":"1833","article-title":"Characterization of ocular hypertension induced by adenosine agonists","volume":"37","author":"Crosson","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"9","key":"10.1016\/j.lfs.2006.11.053_bib5","first-page":"2054","article-title":"Contributions of adenosine receptor activation to the ocular actions of epinephrine","volume":"40","author":"Crosson","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s004170050203","article-title":"Risk factors for visual field damage progression in normal-tension glaucoma eyes","volume":"237","author":"Daugeliene","year":"1999","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/112067219400400105","article-title":"Influence of nifedipine on the visual fields of patients with optic-nerve-head diseases","volume":"4","author":"Gaspar","year":"1994","journal-title":"European Journal of Ophthalmology"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1203\/00006450-199306000-00018","article-title":"Microcirculatory responses to adenosine in the newborn pig retina","volume":"33","author":"Gidday","year":"1993","journal-title":"Pediatric Research"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0161-6420(89)33070-3","article-title":"Visual field change in low-tension glaucoma over a five-year follow-up","volume":"96","author":"Gliklich","year":"1989","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.icu.0000156134.38495.0b","article-title":"Blood flow in glaucoma","volume":"16","author":"Grieshaber","year":"2005","journal-title":"Current Opinion in Ophthalmology"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib11","first-page":"124","article-title":"Autoregulation of the retinal circulation in response to decrease of intraocular pressure below normal","volume":"23","author":"Grunwald","year":"1982","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0002-9394(14)70821-9","article-title":"Hemodynamic and visual function effects of oral nifedipine in patients with normal-tension glaucoma","volume":"124","author":"Harris","year":"1997","journal-title":"American Journal of Ophthalmology"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib13","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1167\/iovs.04-1438","article-title":"Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine","volume":"46","author":"Hein","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.exer.2004.08.008","article-title":"Effects of adenosine on optic nerve head circulation in rabbits","volume":"79","author":"Hirao","year":"2004","journal-title":"Experimental Eye Research"},{"issue":"4","key":"10.1016\/j.lfs.2006.11.053_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00417552","article-title":"Visual field decay in normal subjects and in cases of chronic glaucoma","volume":"213","author":"Holmin","year":"1980","journal-title":"Albrecht von Graefes Archiv f\u00fcr Klinische und Experimentelle Ophthalmologie"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0002-9394(00)00441-4","article-title":"Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma","volume":"129","author":"Ishida","year":"2000","journal-title":"American Journal of Ophthalmology"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/0022-3859.917","article-title":"Neuroprotection in glaucoma","volume":"49","author":"Kaushik","year":"2003","journal-title":"Journal of Postgraduate Medicine"},{"issue":"8","key":"10.1016\/j.lfs.2006.11.053_bib18","first-page":"2399","article-title":"Autoregulation of choroidal blood flow in the rabbit","volume":"33","author":"Kiel","year":"1992","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/BF02172889","article-title":"The effect of Ca2+-antagonist on visual field in low-tension glaucoma","volume":"227","author":"Kitazawa","year":"1989","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1254\/jjp.57.153","article-title":"Pharmacological profile of the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146) in the cardiovascular system","volume":"57","author":"Kogi","year":"1991","journal-title":"Japanese Journal of Pharmacology"},{"issue":"4","key":"10.1016\/j.lfs.2006.11.053_bib21","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0002-9394(00)00521-3","article-title":"Retrobulbar hemodynamics in normal-tension glaucoma with asymmetric visual field change and asymmetric ocular perfusion pressure","volume":"130","author":"Kondo","year":"2000","journal-title":"American Journal of Ophthalmology"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejphar.2003.12.034","article-title":"The effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits","volume":"486","author":"Konno","year":"2004","journal-title":"European Journal of Pharmacology"},{"issue":"4","key":"10.1016\/j.lfs.2006.11.053_bib23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1254\/jphs.FP0040730","article-title":"Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine","volume":"97","author":"Konno","year":"2005","journal-title":"Journal of Pharmacological Sciences"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejphar.2003.12.034","article-title":"2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits","volume":"486","author":"Konno","year":"2005","journal-title":"European Journal of Pharmacology"},{"issue":"7","key":"10.1016\/j.lfs.2006.11.053_bib25","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/bjo.2006.091496","article-title":"Adenosine A2A receptor-mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischemia\/reperfusion damage in rats","volume":"90","author":"Konno","year":"2006","journal-title":"British Journal of Ophthalmology"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1006\/exer.1996.0352","article-title":"Localization of adenosine receptor messenger RNAs in the rat eye","volume":"65","author":"Kvanta","year":"1997","journal-title":"Experimental Eye Research"},{"issue":"13","key":"10.1016\/j.lfs.2006.11.053_bib27","first-page":"2695","article-title":"Adenosine-induced relaxation of cultured bovine retinal pericytes","volume":"38","author":"Matsugi","year":"1997","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0002-9394(14)71458-8","article-title":"Calcium channel blockers in the management of low-tension and open-angle glaucoma","volume":"115","author":"Netland","year":"1993","journal-title":"American Journal of Ophthalmology"},{"issue":"7","key":"10.1016\/j.lfs.2006.11.053_bib29","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1167\/iovs.02-1133","article-title":"Effects of adenosine on intraocular pressure, optic nerve head blood flow, and choroidal blood flow in healthy humans","volume":"44","author":"Polska","year":"2003","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib30","first-page":"295","article-title":"Trends in neuroprotection","volume":"77","author":"Pop","year":"2002","journal-title":"Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacological Reviews"},{"issue":"4","key":"10.1016\/j.lfs.2006.11.053_bib32","first-page":"597","article-title":"Complementary therapy for the treatment of glaucoma: a perspective","volume":"18","author":"Ritch","year":"2005","journal-title":"Ophthalmology Clinics of North America"},{"issue":"12","key":"10.1016\/j.lfs.2006.11.053_bib33","first-page":"1706","article-title":"Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry","volume":"27","author":"Riva","year":"1986","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib34","first-page":"722","article-title":"Retinal blood flow autoregulation in response to an acute increase in blood pressure","volume":"27","author":"Robinson","year":"1986","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3171\/jns.1987.66.3.0396","article-title":"Intraoperative measurement of cortical blood flow adjacent to cerebral AVM using laser Doppler velocimetry","volume":"66","author":"Rosenblum","year":"1987","journal-title":"Journal of Neurosurgery"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0161-6420(96)30703-3","article-title":"Prevention of visual field defect progression with brovincamine in eyes with normal-tension glaucoma","volume":"103","author":"Sawada","year":"1996","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00055735-200404000-00011","article-title":"Current management of glaucoma","volume":"15","author":"Schwartz","year":"2004","journal-title":"Current Opinion in Ophthalmology"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib38","first-page":"133","article-title":"Epidemiology of glaucoma in Japan\u2014a nationwide glaucoma survey","volume":"35","author":"Shiose","year":"1991","journal-title":"Japanese Journal of Ophthalmology"},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2006.11.053_bib39","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1016\/S0039-6257(99)00014-4","article-title":"Periocular accumulation of timolol and betaxolol in glaucoma patients under long-term therapy","volume":"43","author":"Sponsel","year":"1999","journal-title":"Survey of Ophthalmology"},{"issue":"3","key":"10.1016\/j.lfs.2006.11.053_bib40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00061198-199201030-00005","article-title":"The effects of phenylephrine on the ciliary body and optic nerve head microvasculature in rabbits","volume":"1","author":"Sugiyama","year":"1992","journal-title":"Journal of Glaucoma"},{"issue":"18","key":"10.1016\/j.lfs.2006.11.053_bib41","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1021\/jm9608725","article-title":"New approaches to antiglaucoma therapy","volume":"40","author":"Sugrue","year":"1997","journal-title":"Journal of Medicinal Chemistry"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/archopht.1992.01080180134041","article-title":"Protective effects of flunarizine on ischemic injury in the rat retina","volume":"110","author":"Takahashi","year":"1992","journal-title":"Archives of Ophthalmology"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2006.11.053_bib43","first-page":"115","article-title":"Ophthalmoscopic examination of ocular fundus in rats, mice and rabbits","volume":"14","author":"Takekawa","year":"1995","journal-title":"Animal Eye Research"},{"issue":"2","key":"10.1016\/j.lfs.2006.11.053_bib44","first-page":"220","article-title":"Effects of local hypothermia on ischemic eyes in vitrectomy","volume":"40","author":"Tamai","year":"1996","journal-title":"Japanese Journal of Ophthalmology"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib45","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/exer.1997.0386","article-title":"Protective effects of local hypothermia in vitrectomy under fluctuating intraocular pressure","volume":"65","author":"Tamai","year":"1997","journal-title":"Experimental Eye Research"},{"issue":"5","key":"10.1016\/j.lfs.2006.11.053_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0021-5155(97)00054-3","article-title":"Effect of topical timolol on tissue circulation in optic nerve head","volume":"41","author":"Tamaki","year":"1997","journal-title":"Japanese Journal of Ophthalmology"},{"issue":"6","key":"10.1016\/j.lfs.2006.11.053_bib47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1006\/exer.1997.0296","article-title":"Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys","volume":"64","author":"Tian","year":"1997","journal-title":"Experimental Eye Research"},{"issue":"4","key":"10.1016\/j.lfs.2006.11.053_bib48","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/exer.1999.0809","article-title":"Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia\/reperfusion damage in rat retina","volume":"70","author":"Toriu","year":"2000","journal-title":"Experimental Eye Research"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0021-5155(00)00302-6","article-title":"Effect of topically applied iganidipine dihydrochloride, a novel calcium antagonist, on optic nerve head circulation in rabbits","volume":"45","author":"Waki","year":"2001","journal-title":"Japanese Journal of Ophthalmology"},{"issue":"1","key":"10.1016\/j.lfs.2006.11.053_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1350-9462(97)00009-8","article-title":"Vascular pathogenesis of normal-tension glaucoma: a possible pathogenetic factor, other than intraocular pressure, of glaucomatous optic neuropathy","volume":"17","author":"Yamamoto","year":"1998","journal-title":"Progress in Retinal and Eye Research"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506009441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506009441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T18:25:37Z","timestamp":1736706337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506009441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0024320506009441"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.11.053","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}