{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:38:22Z","timestamp":1790199502567,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.lfs.2006.12.013","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T14:28:20Z","timestamp":1168439300000},"page":"1221-1227","source":"Crossref","is-referenced-by-count":40,"title":["Effect of testosterone on oxidative stress and cell damage induced by 3-nitropropionic acid in striatum of ovariectomized rats"],"prefix":"10.1016","volume":"80","author":[{"given":"Isaac","family":"T\u00fanez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Feij\u00f3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Collado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del C.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Jimena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Muntan\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Montilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2006.12.013_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.lfs.2006.12.013_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0006-8993(00)03155-3","article-title":"Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism","volume":"892","author":"Ahlbom","year":"2001","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11920-996-0030-2","article-title":"An overview of psychiatric symptoms in Huntington's disease","volume":"3","author":"Anderson","year":"2001","journal-title":"Current Psychiatry Reports"},{"key":"10.1016\/j.lfs.2006.12.013_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/neu.1038","article-title":"Brain aromatase is neuroprotective","volume":"47","author":"Azcoitia","year":"2001","journal-title":"Journal of Neurobiology"},{"key":"10.1016\/j.lfs.2006.12.013_bib5","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1523\/JNEUROSCI.23-12-05020.2003","article-title":"Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease","volume":"23","author":"Bizat","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2006.12.013_bib6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1517\/14656566.5.4.767","article-title":"A review of the treatment options for Huntington's disease","volume":"5","author":"Bonelli","year":"2004","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"10.1016\/j.lfs.2006.12.013_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0006-8993(95)00901-2","article-title":"Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease","volume":"697","author":"Borlongan","year":"1995","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0168-0102(97)00045-X","article-title":"Systemic, but not intraparenchymal, administration of 3-nitropropionic acid mimics the neuropathology of Huntington's disease","volume":"28","author":"Borlongan","year":"1997","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib9","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1073\/pnas.92.15.7105","article-title":"Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates","volume":"92","author":"Brouillet","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United State of America"},{"key":"10.1016\/j.lfs.2006.12.013_bib10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jsbmb.2004.11.006","article-title":"Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain","volume":"94","author":"Calder\u00f3n Guzm\u00e1n","year":"2005","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10.1016\/j.lfs.2006.12.013_bib11","first-page":"63","article-title":"Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-l-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell","volume":"144","author":"Chisu","year":"2006","journal-title":"Archives Intaliennes de Biologie"},{"key":"10.1016\/j.lfs.2006.12.013_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.lfs.2006.12.013_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0301-0082(94)90042-6","article-title":"Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms","volume":"4","author":"Garc\u00eda-Segura","year":"1994","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.lfs.2006.12.013_bib14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1046\/j.1471-4159.2001.00345.x","article-title":"Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons","volume":"77","author":"Hammond","year":"2001","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.lfs.2006.12.013_bib15","first-page":"61","article-title":"Aromatase enzyme and Alzheimer's disease","volume":"31","author":"Hiltunen","year":"2006","journal-title":"Minerva Endocrinologica"},{"key":"10.1016\/j.lfs.2006.12.013_bib16","first-page":"163","article-title":"Serum total testosterone is lower in men with Alzheimer's disease","volume":"22","author":"Hogervost","year":"2001","journal-title":"Neuroendocrinology Letters"},{"key":"10.1016\/j.lfs.2006.12.013_bib17","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.5279-04.2005","article-title":"Gonadal steroid attenuation of developing hamster facial motoneurons loss by axotomy: equal effect of testosterone, dihydrotestosterone, and 17-\u03b2 estradiol","volume":"25","author":"Huppenbauer","year":"2005","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2006.12.013_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0014-4886(89)90174-X","article-title":"Testosterone-induced acceleration of recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters","volume":"105","author":"Kujawa","year":"1989","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.lfs.2006.12.013_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(96)00744-5","article-title":"Enhanced oxidative stress in female rat brain after gonadectomy","volume":"738","author":"Kume-Kick","year":"1996","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0006-8993(00)01948-X","article-title":"3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease","volume":"858","author":"La Fontaine","year":"2000","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib21","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1046\/j.1471-4159.2000.0751709.x","article-title":"Effect of exogenous and endogenous antioxidants on 3-nitropropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease","volume":"75","author":"La Fontaine","year":"2000","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.lfs.2006.12.013_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/A:1019852720521","article-title":"3-Nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease","volume":"27","author":"La Fontaine","year":"2002","journal-title":"Neurochemistry Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib23","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1523\/JNEUROSCI.23-05-01588.2003","article-title":"Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats","volume":"23","author":"Leranth","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2006.12.013_bib50","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.lfs.2006.12.013_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-3806(95)00052-F","article-title":"Estrogen-induction of dendritic spines in ventromedial hypothalamus and hippocampus: effect of neonatal blockade and adult GDX","volume":"87","author":"Lewis","year":"1995","journal-title":"Developmental Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.20428","article-title":"Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia","volume":"57","author":"Markianos","year":"2005","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.lfs.2006.12.013_bib26","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM198611133152006","article-title":"Huntington's disease: pathogenesis and management","volume":"315","author":"Mart\u00edn","year":"1986","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.lfs.2006.12.013_bib27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-510X(01)00688-8","article-title":"The serum level of free testosterone is reduced in amyotrophic lateral sclerosis","volume":"195","author":"Militello","year":"2002","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1016\/j.lfs.2006.12.013_bib28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0006-8993(02)03488-1","article-title":"Estrogen blocks 3-nitropropionic acid-induced [Ca2+]i increase and cell damage in cultured rat cerebral endothelial cells","volume":"956","author":"Mogami","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2004.02.004","article-title":"Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes","volume":"488","author":"Montilla","year":"2004","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.12.013_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0168-0102(98)00010-8","article-title":"Estrogen protects against while testosterone exacerbates vulnerability of the lateral striatal artery to chemical hypoxia by 3-nitropropionic acid","volume":"30","author":"Nishino","year":"1998","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/neu.2000.17.251","article-title":"The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability","volume":"17","author":"Nishino","year":"2000","journal-title":"Journal of Neurotrauma"},{"key":"10.1016\/j.lfs.2006.12.013_bib32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.4023706","article-title":"Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus","volume":"229","author":"Nordeen","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.lfs.2006.12.013_bib33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archneur.59.5.807","article-title":"Refractory nonmotor symptoms in male patients with Parkinson's disease due to testosterone deficiency: a common unrecognized comorbidity","volume":"59","author":"Okun","year":"2002","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.lfs.2006.12.013_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1212\/01.WNL.0000106840.72938.84","article-title":"Plasma testosterone levels in Alzheimer and Parkinson's diseases","volume":"62","author":"Okun","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.lfs.2006.12.013_bib35","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jnen\/62.6.633","article-title":"Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology","volume":"62","author":"Pang","year":"2003","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"10.1016\/j.lfs.2006.12.013_bib36","series-title":"Techniques biologiques en endocrinologie experimentale chez rat","author":"Poumeau-Delille","year":"1953"},{"key":"10.1016\/j.lfs.2006.12.013_bib37","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1523\/JNEUROSCI.22-12-05204.2002","article-title":"Androgens protect against apolipoprotein E4-induced cognitive deficits","volume":"22","author":"Raber","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2006.12.013_bib38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2003.08.048","article-title":"Androgens modulate neuronal vulnerability to kainate lesion","volume":"122","author":"Ramsden","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2006.12.013_bib39","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1176\/ajp.153.8.974","article-title":"Androgens, brain, and behaviour","volume":"153","author":"Rubinow","year":"1996","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.lfs.2006.12.013_bib40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1385-299X(97)00045-7","article-title":"A rapid and sensitive assay for measuring mitochondrial metabolic activity in isolated neural tissue","volume":"2","author":"Springer","year":"1997","journal-title":"Brain Research Protocols"},{"key":"10.1016\/j.lfs.2006.12.013_bib41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/abio.2001.5148","article-title":"Individual mitochondrion characterization: a comparison of classical assays to capillary electrophoresis with laser-induced fluorescence detection","volume":"294","author":"Strack","year":"2001","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.lfs.2006.12.013_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ajmg.c.20008","article-title":"Type I glutaric aciduria, Part 2: a model of acute striatal necrosis","volume":"121C","author":"Strauss","year":"2003","journal-title":"American Journal of Medical Genetics Part C"},{"key":"10.1016\/j.lfs.2006.12.013_bib43","series-title":"Current Protocols in Immunology","first-page":"1","article-title":"In vitro assays for mouse B and T lymphocyte function","author":"Taffs","year":"1991"},{"key":"10.1016\/j.lfs.2006.12.013_bib44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2004.09.061","article-title":"Effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes","volume":"504","author":"T\u00fanez","year":"2004","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2006.12.013_bib45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-079X.2004.00163.x","article-title":"Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease","volume":"3","author":"T\u00fanez","year":"2004","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.lfs.2006.12.013_bib46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000084169","article-title":"Treatment with dehydroepiandrosterone prevents oxidative stress induced by 3-nitropropionic acid in synaptosomes","volume":"74","author":"T\u00fanez","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.lfs.2006.12.013_bib47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuint.2005.11.011","article-title":"17 \u03b2-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats","volume":"48","author":"T\u00fanez","year":"2006","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.lfs.2006.12.013_bib48","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/neu.10249","article-title":"Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by enzyme aromatase","volume":"56","author":"Veiga","year":"2003","journal-title":"Journal of Neurobiology"},{"key":"10.1016\/j.lfs.2006.12.013_bib49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0304-3940(02)00581-5","article-title":"3-Nitropropionic acid induces cell death and mitochondrial dysfunction in rat corticostriatal slice cultures","volume":"329","author":"Vis","year":"2002","journal-title":"Neuroscience Letters"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506009660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320506009660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T16:47:14Z","timestamp":1556038034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320506009660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":50,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0024320506009660"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2006.12.013","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}