{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:51:45Z","timestamp":1784029905444,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.lfs.2007.07.022","type":"journal-article","created":{"date-parts":[[2007,8,4]],"date-time":"2007-08-04T07:11:35Z","timestamp":1186211495000},"page":"916-923","source":"Crossref","is-referenced-by-count":57,"title":["Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991"],"prefix":"10.1016","volume":"81","author":[{"given":"Anderson J.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thauana L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina M.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvair P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo V.","family":"Caliari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisandra","family":"Gava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Kitten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson A.S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2007.07.022_bib1","first-page":"H684","article-title":"Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with l-NAME","volume":"290","author":"Benter","year":"2006","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/eurheartj\/ehi114","article-title":"Myocardial infarction increases ACE2 expression in rat and humans","volume":"26","author":"Burrell","year":"2005","journal-title":"European Heart Journal"},{"key":"10.1016\/j.lfs.2007.07.022_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1590\/S0036-46652002000500008","article-title":"Quantitative analysis of cardiac lesions in chronic canine chagasic cardiomyopathy","volume":"44","author":"Caliari","year":"2002","journal-title":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"},{"key":"10.1016\/j.lfs.2007.07.022_bib4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.lfs.2006.09.007","article-title":"Effects of genetic deletion of angiotensin-(1-7) receptor Mas on cardiac function during ischemia\/reperfusion in the isolated perfused mouse heart","volume":"80","author":"Castro","year":"2006","journal-title":"Life Sciences"},{"key":"10.1016\/j.lfs.2007.07.022_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1152\/physiolgenomics.00312.2005","article-title":"ACE2 gene transfer attenuated hypertension-linked pathophysiological changes in the SHR","volume":"27","author":"Diez-Freire","year":"2006","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.lfs.2007.07.022_bib6","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circulation Research"},{"key":"10.1016\/j.lfs.2007.07.022_bib7","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.HYP.0000174594.17052.33","article-title":"Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats","volume":"46","author":"Faria-Silva","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/01.HYP.0000196268.08909.fb","article-title":"Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation","volume":"47","author":"Ferrario","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib9","first-page":"H1113","article-title":"The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE 0991 attenuates heart failure induced by myocardial infarction","volume":"292","author":"Ferreira","year":"2007","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.HYP.38.3.665","article-title":"Angiotensin-(1-7): cardioprotective effect in myocardial ischemia\/reperfusion","volume":"38","author":"Ferreira","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1590\/S0100-879X2002000900009","article-title":"Angiotensin-(1-7) improves the post-ischemic function in isolated perfused rat hearts","volume":"35","author":"Ferreira","year":"2002","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.lfs.2007.07.022_bib12","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1161\/01.CIR.0000164237.58200.5A","article-title":"Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo","volume":"111","author":"Freund","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2007.07.022_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1741-7015-2-19","article-title":"ACE2 gene expression is up-regulated in the human failing heart","volume":"2","author":"Goulter","year":"2004","journal-title":"BMC Medicine"},{"key":"10.1016\/j.lfs.2007.07.022_bib14","first-page":"H2417","article-title":"Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension","volume":"290","author":"Grobe","year":"2006","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib15","first-page":"H736","article-title":"Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)","volume":"292","author":"Grobe","year":"2007","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/expphysiol.2005.031096","article-title":"Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats","volume":"90","author":"Huentelman","year":"2005","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib17","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.HYP.0000124667.34652.1a","article-title":"Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors","volume":"43","author":"Ishiyama","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib18","first-page":"H2356","article-title":"Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate anti-fibrotic and anti-trophic effects","volume":"289","author":"Iwata","year":"2005","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/01.fjc.0000175237.41573.63","article-title":"The endothelium-dependent vasodilator effect of the nonpeptide Ang-(1-7) mimic AVE 0991 is abolished in the aorta of Mas-knockout mice","volume":"46","author":"Lemos","year":"2005","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.lfs.2007.07.022_bib20","first-page":"R274","article-title":"Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion","volume":"280","author":"Leon-Velarde","year":"2001","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib21","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/01.CIR.0000013847.07035.B9","article-title":"Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats","volume":"105","author":"Loot","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2007.07.022_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.regpep.2004.07.023","article-title":"Chronic infusion of angiotensin-(1-7) reduces heart angiotensin II levels in rats","volume":"125","author":"Mendes","year":"2005","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.lfs.2007.07.022_bib23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.HYP.0000141438.64887.42","article-title":"Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney","volume":"44","author":"Pinheiro","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib24","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.lfs.2007.07.022_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1152\/physiolgenomics.00227.2003","article-title":"Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats","volume":"17","author":"Santos","year":"2004","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.lfs.2007.07.022_bib26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1517\/13543784.14.8.1019","article-title":"Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs","volume":"14","author":"Santos","year":"2005","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"10.1016\/j.lfs.2007.07.022_bib27","first-page":"H1560","article-title":"Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor","volume":"289","author":"Tallant","year":"2005","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2007.07.022_bib28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.HYP.0000215289.51180.5c","article-title":"Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice","volume":"47","author":"Santos","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib29","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2007.07.022_bib30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/01.HYP.0000037979.53963.8F","article-title":"AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium","volume":"40","author":"Wiemer","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2007.07.022_bib31","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.0000094734.67990.99","article-title":"Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for up regulation of the angiotensin-converting enzyme homologue ACE2","volume":"108","author":"Zisman","year":"2003","journal-title":"Circulation"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320507005358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320507005358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T07:20:15Z","timestamp":1546672815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320507005358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0024320507005358"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2007.07.022","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}