{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:01:56Z","timestamp":1789729316018,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"13-14","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.lfs.2007.12.027","type":"journal-article","created":{"date-parts":[[2008,2,7]],"date-time":"2008-02-07T12:22:34Z","timestamp":1202386954000},"page":"677-683","source":"Crossref","is-referenced-by-count":43,"title":["Predominant role of 25OHD in the negative regulation of PTH expression: Clinical relevance for hypovitaminosis D"],"prefix":"10.1016","volume":"82","author":[{"given":"Masayuki","family":"Kawahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nigawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tsugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihoro","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2007.12.027_bib1","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1210\/en.2003-1763","article-title":"Contrasting mammalian parathyroid hormone (PTH) promoters: nuclear factor-Y binds to a deoxyribonucleic acid element unique to the human PTH promoter and acts as a transcriptional enhancer","volume":"145","author":"Alimov","year":"2004","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.lfs.2007.12.027_bib2","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1210\/en.2005-0272","article-title":"Transactivation of the parathyroid hormone promoter by specificity proteins and the nuclear factor Y complex","volume":"146","author":"Alimov","year":"2005","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.lfs.2007.12.027_bib3","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1210\/en.138.5.1923","article-title":"Regulation of the rat proopiomelanocortin gene expression in AtT-20 cells. I: effects of the common secretagogues","volume":"138","author":"Aoki","year":"1997","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.lfs.2007.12.027_bib4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1532-5415.2007.01161.x","article-title":"Secondary hyperparathyroidism due to hypovitaminosis D affects bone mineral density response to alendronate in elderly women with osteoporosis: a randomized controlled trial","volume":"55","author":"Barone","year":"2007","journal-title":"Journal of American Geriatric Society"},{"issue":"3","key":"10.1016\/j.lfs.2007.12.027_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/ajcn\/80.3.752","article-title":"Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60\u00a0y","volume":"80","author":"Bischoff-Ferrari","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"issue":"16","key":"10.1016\/j.lfs.2007.12.027_bib6","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1001\/jama.291.16.1999","article-title":"Effect of vitamin D on falls: a meta-analysis","volume":"291","author":"Bischoff-Ferrari","year":"2004","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.lfs.2007.12.027_bib7","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.amjmed.2003.12.029","article-title":"Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults","volume":"116","author":"Bischoff-Ferrari","year":"2004","journal-title":"American Journal of Medicine"},{"issue":"6","key":"10.1016\/j.lfs.2007.12.027_bib34","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/art.21601","article-title":"Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis","volume":"53","author":"Bischoff-Ferrari","year":"2005","journal-title":"Arthritis & Rheumatism"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib8","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1210\/en.2005-1300","article-title":"Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism","volume":"147","author":"Christoffolete","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.lfs.2007.12.027_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/abbi.1996.0450","article-title":"Analysis of binding of the 1,25-dihydroxyvitamin D3 receptor to positive and negative vitamin D response elements","volume":"334","author":"Darwish","year":"1996","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"6 Suppl.","key":"10.1016\/j.lfs.2007.12.027_bib33","doi-asserted-by":"crossref","first-page":"1763S","DOI":"10.1093\/ajcn\/80.6.1763S","article-title":"Racial\/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women","volume":"80","author":"Dawson-Hughes","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"issue":"7","key":"10.1016\/j.lfs.2007.12.027_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Dawson-Hughes","year":"2005","journal-title":"Osteoporososis International"},{"issue":"2","key":"10.1016\/j.lfs.2007.12.027_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/jme.0.0290193","article-title":"The murine gene encoding parathyroid hormone: genomic organization, nucleotide sequence and transcriptional regulation","volume":"29","author":"He","year":"2002","journal-title":"Journal of Molecular Endocrinology"},{"issue":"3","key":"10.1016\/j.lfs.2007.12.027_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbrc.2005.01.033","article-title":"Negative regulation of human parathyroid hormone gene promoter by vitamin D3 through nuclear factor Y","volume":"328","author":"Jaaskelainen","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib14","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D","volume":"78","author":"Jones","year":"1998","journal-title":"Physiology Review"},{"issue":"1\u20135","key":"10.1016\/j.lfs.2007.12.027_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsbmb.2004.03.100","article-title":"Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex","volume":"89\u201390","author":"Kato","year":"2004","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MNH.0b013e3281c55f16","article-title":"Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D","volume":"16","author":"Kato","year":"2007","journal-title":"Current Opinion in Nephrology and Hypertension"},{"issue":"2","key":"10.1016\/j.lfs.2007.12.027_bib17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1210\/me.2006-0231","article-title":"1\u03b1,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter","volume":"21","author":"Kim","year":"2007","journal-title":"Molecular Endocrinology"},{"issue":"41","key":"10.1016\/j.lfs.2007.12.027_bib18","doi-asserted-by":"crossref","first-page":"42431","DOI":"10.1074\/jbc.M407742200","article-title":"Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element","volume":"279","author":"Koszewski","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.lfs.2007.12.027_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1172\/JCI109430","article-title":"Inhibition of intrapituitary thyroxine to 3.5.3\u2032-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats","volume":"64","author":"Larsen","year":"1979","journal-title":"Journal of Clinical Investigation"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/er.22.4.477","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"Lips","year":"2001","journal-title":"Endocrine Review"},{"issue":"3","key":"10.1016\/j.lfs.2007.12.027_bib21","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/jc.86.3.1212","article-title":"A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial","volume":"86","author":"Lips","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.lfs.2007.12.027_bib22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1210\/me.10.2.206","article-title":"Characterization of a response element in the 5\u2032-flanking region of the avian (chicken) PTH gene that mediates negative regulation of gene transcription by 1,25-dihydroxyvitamin D3 and binds the vitamin D3 receptor","volume":"10","author":"Liu","year":"1996","journal-title":"Molecular Endocrinology"},{"issue":"3","key":"10.1016\/j.lfs.2007.12.027_bib23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1210\/me.10.3.298","article-title":"Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor","volume":"10","author":"Mackey","year":"1996","journal-title":"Molecular Endocrinology"},{"issue":"4","key":"10.1016\/j.lfs.2007.12.027_bib24","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/me.2006-0208","article-title":"Essential role of GATA2 in the negative regulation of thyrotropin beta gene by thyroid hormone and its receptors","volume":"21","author":"Matsushita","year":"2007","journal-title":"Molecular Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2007.12.027_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mce.2005.11.040","article-title":"Why is 11\u03b2-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11\u03b2-HSD1","volume":"248","author":"Odermatt","year":"2006","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"5","key":"10.1016\/j.lfs.2007.12.027_bib26","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/S0021-9258(18)69191-4","article-title":"5\u2032-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3","volume":"263","author":"Okazaki","year":"1988","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2007.12.027_bib27","series-title":"Metabolic Bone Diseased and Clinically Related Disorders","first-page":"327","article-title":"Osteomalacia and related disorders","author":"Parfitt","year":"1998"},{"issue":"11","key":"10.1016\/j.lfs.2007.12.027_bib28","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1359\/jbmr.1999.14.11.1828","article-title":"Vitamin D receptor interactions with the rat parathyroid hormone gene: synergistic effects between two negative vitamin D response elements","volume":"14","author":"Russell","year":"1999","journal-title":"Journal of Bone and Mineral Research"},{"issue":"10","key":"10.1016\/j.lfs.2007.12.027_bib29","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1073\/pnas.84.10.3269","article-title":"Functional epithelial cell line cloned from rat parathyroid glands","volume":"84","author":"Sakaguchi","year":"1987","journal-title":"Proceedings of the National Academy of Science U.S.A."},{"issue":"8","key":"10.1016\/j.lfs.2007.12.027_bib30","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1359\/JBMR.050402","article-title":"Amelioration of osteoporosis and hypovitaminosis D by sunlight exposure in hospitalized, elderly women with Alzheimer's disease: a randomized controlled trial","volume":"20","author":"Sato","year":"2005","journal-title":"Journal of Bone Mineral Research"},{"issue":"6","key":"10.1016\/j.lfs.2007.12.027_bib31","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1210\/jc.87.6.2967","article-title":"25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands","volume":"87","author":"Segersten","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"12","key":"10.1016\/j.lfs.2007.12.027_bib32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJM199803193381201","article-title":"Hypovitaminosis D in medical inpatients","volume":"338","author":"Thomas","year":"1998","journal-title":"New England Journal of Medicine"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320508000118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320508000118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:29Z","timestamp":1630713629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320508000118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":34,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0024320508000118"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2007.12.027","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}