{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:05:49Z","timestamp":1758413149041,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.lfs.2008.06.022","type":"journal-article","created":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T05:52:36Z","timestamp":1215150756000},"page":"301-304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese"],"prefix":"10.1016","volume":"83","author":[{"given":"Mitsushige","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohito","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chise","family":"Kodaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Yamade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuhiro","family":"Ikuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2008.06.022_bib1","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.3748\/wjg.v11.i18.2720","article-title":"Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection","volume":"11","author":"Babic","year":"2005","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.lfs.2008.06.022_bib2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1349-7006.2006.00241.x","article-title":"Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans","volume":"97","author":"Bae","year":"2006","journal-title":"Cancer Science"},{"key":"10.1016\/j.lfs.2008.06.022_bib3","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3748\/wjg.v7.i6.792","article-title":"Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province","volume":"7","author":"Cai","year":"2001","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.lfs.2008.06.022_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1067\/mcp.2001.114164","article-title":"Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects","volume":"69","author":"Cascorbi","year":"2001","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.lfs.2008.06.022_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2008.06.022_bib6","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"124","author":"El-Omar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2008.06.022_bib7","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1158\/0008-5472.CAN-06-3952","article-title":"P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines","volume":"67","author":"Fantappie","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2008.06.022_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.84.1.265","article-title":"Expression of a multidrug-resistance gene in human tumors and tissues","volume":"84","author":"Fojo","year":"1987","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.lfs.2008.06.022_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/14766650252962658","article-title":"Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese","volume":"11","author":"Gao","year":"2002","journal-title":"Cancer Epidemiology, Biomarkers Prevention"},{"key":"10.1016\/j.lfs.2008.06.022_bib10","first-page":"246","article-title":"Helicobacter pylori eradication as a preventive tool against gastric cancer","volume":"5","author":"Hamajima","year":"2004","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.1016\/j.lfs.2008.06.022_bib11","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.97.7.3473","article-title":"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo","volume":"97","author":"Hoffmeyer","year":"2000","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.lfs.2008.06.022_bib12","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1023\/A:1020433422259","article-title":"Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin","volume":"19","author":"Horinouchi","year":"2002","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.lfs.2008.06.022_bib13","first-page":"2735","article-title":"MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry","volume":"23","author":"Humeny","year":"2003","journal-title":"Anticancer Research"},{"key":"10.1016\/j.lfs.2008.06.022_bib14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1600-0609.2004.00228.x","article-title":"Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia","volume":"72","author":"Jamroziak","year":"2004","journal-title":"European Journal of Haematology"},{"key":"10.1016\/j.lfs.2008.06.022_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/carcin\/bgh018","article-title":"Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats","volume":"25","author":"Kankesan","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2008.06.022_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.1135308","article-title":"A \u201csilent\u201d polymorphism in the MDR1 gene changes substrate specificity","volume":"315","author":"Kimchi-Sarfaty","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.lfs.2008.06.022_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2133\/dmpk.21.126","article-title":"MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer","volume":"21","author":"Komoto","year":"2006","journal-title":"Drug Metabolism and Pharmacokinetics"},{"key":"10.1016\/j.lfs.2008.06.022_bib18","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1248\/bpb.29.1449","article-title":"MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese","volume":"29","author":"Koyama","year":"2006","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2008.06.022_bib19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00008571-200308000-00006","article-title":"Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene","volume":"13","author":"Kroetz","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.lfs.2008.06.022_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00228-005-0926-5","article-title":"Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients","volume":"61","author":"Kurzawski","year":"2005","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.lfs.2008.06.022_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification","volume":"64","author":"Lauren","year":"1965","journal-title":"Acta Pathologica et Microbioliogica Scandinavica"},{"key":"10.1016\/j.lfs.2008.06.022_bib22","first-page":"22","article-title":"Is C3435T polymorphism of MDR1 related to inflammatory bowel disease or colorectal cancer in Korean?","volume":"47","author":"Lee","year":"2006","journal-title":"Korean Journal of Gastroenterology"},{"key":"10.1016\/j.lfs.2008.06.022_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1067\/mcp.2002.122055","article-title":"Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects","volume":"71","author":"Nakamura","year":"2002","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.lfs.2008.06.022_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/path.1512","article-title":"Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H. pylori-related gastric carcinogenesis","volume":"202","author":"Nardone","year":"2004","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.lfs.2008.06.022_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00228-006-0225-9","article-title":"Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers","volume":"63","author":"Osswald","year":"2007","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.lfs.2008.06.022_bib26","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1046\/j.1440-1746.2003.03167.x","article-title":"Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans","volume":"18","author":"Park","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.lfs.2008.06.022_bib27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00210-001-0489-7","article-title":"Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein","volume":"364","author":"Pauli-Magnus","year":"2001","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"key":"10.1016\/j.lfs.2008.06.022_bib28","first-page":"92","article-title":"Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability","volume":"7","author":"Potocnik","year":"2002","journal-title":"Cellular and Molecular Biology Letters"},{"key":"10.1016\/j.lfs.2008.06.022_bib29","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/01.ASN.0000019412.87412.BC","article-title":"Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors","volume":"13","author":"Siegsmund","year":"2002","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.lfs.2008.06.022_bib30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1365-2036.2005.02678.x","article-title":"Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection","volume":"22","author":"Sugimoto","year":"2005","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.lfs.2008.06.022_bib31","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/j.1440-1746.2006.04613.x","article-title":"Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects","volume":"22","author":"Sugimoto","year":"2007","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.lfs.2008.06.022_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1440-1746.2006.04442.x","article-title":"Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer","volume":"22","author":"Sugimoto","year":"2007","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.lfs.2008.06.022_bib33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00535-003-1281-x","article-title":"Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer","volume":"39","author":"Suzuki","year":"2004","journal-title":"Journal of Gastroenterology"},{"key":"10.1016\/j.lfs.2008.06.022_bib34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1182\/blood-2001-12-0371","article-title":"MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia","volume":"100","author":"Tafuri","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2008.06.022_bib35","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1440-1746.2007.04848.x","article-title":"Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population","volume":"22","author":"Tahara","year":"2007","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.lfs.2008.06.022_bib36","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.1073\/pnas.84.21.7735","article-title":"Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues","volume":"84","author":"Thiebaut","year":"1987","journal-title":"Proceedings of the National Academy of Science of the United States of America"},{"key":"10.1016\/j.lfs.2008.06.022_bib37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ijc.10492","article-title":"Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma","volume":"100","author":"Tsukino","year":"2002","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.lfs.2008.06.022_bib38","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1349-7006.1998.tb00492.x","article-title":"Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach","volume":"89","author":"Yokose","year":"1998","journal-title":"Japanese Journal of Cancer Research"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320508002804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320508002804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:07:59Z","timestamp":1758398879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320508002804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":38,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0024320508002804"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2008.06.022","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2008.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}