{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:15:11Z","timestamp":1790223311081,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.lfs.2009.04.010","type":"journal-article","created":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T08:46:04Z","timestamp":1241513164000},"page":"46-53","source":"Crossref","is-referenced-by-count":24,"title":["The 15-Deoxy-\u039412,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-\u03baB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1"],"prefix":"10.1016","volume":"85","author":[{"given":"Won-Kyo","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Su","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Su","family":"Yea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangtaek","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae-Gwang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Whan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2009.04.010_bib1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1902\/jop.2005.76.7.1148","article-title":"Expression of activated transcription factor nuclear factor-kappaB in periodontally diseased tissues","volume":"76","author":"Ambili","year":"2005","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.lfs.2009.04.010_bib2","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1046\/j.1523-1755.2000.00004.x","article-title":"Role of interleukin-6 in beta2-microglobulin-induced bone mineral dissolution","volume":"57","author":"Balint","year":"2000","journal-title":"Kidney International"},{"key":"10.1016\/j.lfs.2009.04.010_bib3","first-page":"299","article-title":"Tissue destruction in periodontitis: bacteria or cytokines fault?","volume":"36","author":"Bascones","year":"2005","journal-title":"Quintessence International"},{"key":"10.1016\/j.lfs.2009.04.010_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.hepres.2005.09.027","article-title":"Thiazolidinediones: pleiotropic drugs with potent anti-inflammatory properties for tissue protection","volume":"33","author":"Buckingham","year":"2005","journal-title":"Hepatology Research"},{"key":"10.1016\/j.lfs.2009.04.010_bib5","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1194\/jlr.M200224-JLR200","article-title":"15-Deoxy-12,14-prostaglandin J2-induced apoptosis does not require PPAR in breast cancer cells","volume":"43","author":"Clay","year":"2002","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.lfs.2009.04.010_bib6","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.4049\/jimmunol.171.10.5547","article-title":"Direct inhibition of NF-kB blocks bone erosion associated with inflammatory arthritis","volume":"171","author":"Clohisy","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib7","doi-asserted-by":"crossref","first-page":"978","DOI":"10.4049\/jimmunol.161.2.978","article-title":"Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1","volume":"161","author":"Colville-Nash","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4049\/jimmunol.178.2.720","article-title":"Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells","volume":"178","author":"D'Alimonte","year":"2007","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0165-5728(01)00267-3","article-title":"The cyclopentone, prostaglandin 15-deoxy-\u039412,14 prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells","volume":"115","author":"Drew","year":"2001","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib10","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1210\/en.2007-1719","article-title":"Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3","volume":"149","author":"Duplomb","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2009.04.010_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1600-051X.1988.tb01590.x","article-title":"The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease","volume":"15","author":"Dzink","year":"1988","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.lfs.2009.04.010_bib12","doi-asserted-by":"crossref","first-page":"48868","DOI":"10.1074\/jbc.M208494200","article-title":"Parathyroid hormone stimulates receptor activator of NF kappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP response element-binding protein","volume":"277","author":"Fu","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"issue":"Suppl 2","key":"10.1016\/j.lfs.2009.04.010_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"8","author":"Gabay","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.lfs.2009.04.010_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0757.1997.tb00194.x","article-title":"Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease","volume":"14","author":"Gemmell","year":"1997","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.lfs.2009.04.010_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.lfs.2009.04.010_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"Haffajee","year":"1994","journal-title":"Periodontology"},{"key":"10.1016\/j.lfs.2009.04.010_bib17","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1006\/cyto.2000.0747","article-title":"gp130 Cytokine family and bone cells","volume":"12","author":"Heymann","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.lfs.2009.04.010_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0757.1999.tb00162.x","article-title":"Virulence factors of Porphyromonas gingivalis","volume":"20","author":"Holt","year":"1999","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.lfs.2009.04.010_bib19","doi-asserted-by":"crossref","first-page":"28028","DOI":"10.1074\/jbc.M001387200","article-title":"Feedback control of cyclooxygenase-2 expression through PPARgamma","volume":"275","author":"Inoue","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.04.010_bib20","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.4049\/jimmunol.166.5.3574","article-title":"Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors","volume":"166","author":"Kikuchi","year":"2001","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/jpet.106.112466","article-title":"p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss","volume":"320","author":"Kirkwood","year":"2007","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"Suppl 2","key":"10.1016\/j.lfs.2009.04.010_bib22","article-title":"Interleukin-6: discovery of a pleiotropic cytokine","volume":"8","author":"Kishimoto","year":"2006","journal-title":"Arthritis Rresearch & Therapy"},{"key":"10.1016\/j.lfs.2009.04.010_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60618-5","article-title":"NF-kappa B and rel proteins in innate immunity","volume":"58","author":"Kopp","year":"1995","journal-title":"Advances in Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.joen.2008.01.015","article-title":"Terrein reduces pulpal inflammation in human dental pulp cells","volume":"34","author":"Lee","year":"2008","journal-title":"Journal of Endodontics"},{"key":"10.1016\/j.lfs.2009.04.010_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S8756-3282(01)00657-3","article-title":"The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation","volume":"30","author":"Lee","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.lfs.2009.04.010_bib26","doi-asserted-by":"crossref","first-page":"38152","DOI":"10.1074\/jbc.M101980200","article-title":"15-Deoxy-12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts: a pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors","volume":"276","author":"Li","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.04.010_bib27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcp.20992","article-title":"Interleukin-1beta induces MMP-9 expression via p42\/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells","volume":"211","author":"Liang","year":"2007","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.lfs.2009.04.010_bib28","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.4049\/jimmunol.180.6.4218","article-title":"Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes\/macrophages","volume":"180","author":"Luyendyk","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib29","doi-asserted-by":"crossref","first-page":"18934","DOI":"10.1074\/jbc.M101103200","article-title":"Akt stimulates the transactivation potential of the RelA\/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38","volume":"276","author":"Madrid","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.04.010_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1357-4310(00)01814-1","article-title":"NF-kappaB as a therapeutic target in chronic inflammation: recent advances","volume":"6","author":"Makarov","year":"2000","journal-title":"Molecular Medicine Today"},{"key":"10.1016\/j.lfs.2009.04.010_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2249.2007.03342.x","article-title":"Differential activation of NF-kB and gene expression in oral epithelial cells by periodontal pathogens","volume":"148","author":"Milward","year":"2007","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib32","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.intimp.2006.12.006","article-title":"Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia","volume":"7","author":"Moon","year":"2007","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.lfs.2009.04.010_bib33","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1359\/jbmr.2001.16.7.1220","article-title":"Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists","volume":"16","author":"Nagy","year":"2001","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.lfs.2009.04.010_bib34","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: mechanisms and misconceptions","volume":"64","author":"Nair","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.lfs.2009.04.010_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Critical Reviews in Oral Biology and Medicine"},{"key":"10.1016\/j.lfs.2009.04.010_bib36","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jlb.66.5.733","article-title":"The peroxisome proliferator-activated receptor (PPAR\u03b3) as a regulator of monocyte\/macrophage function","volume":"66","author":"Ricote","year":"1999","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.lfs.2009.04.010_bib37","doi-asserted-by":"crossref","first-page":"37731","DOI":"10.1074\/jbc.R100034200","article-title":"PPAR\u03b3: a nuclear regulator of metabolism, differentiation, and cell growth","volume":"276","author":"Rosen","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.04.010_bib38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00223-007-9060-y","article-title":"Adenosine inhibition of lipopolysaccharide-induced interleukin-6 secretion by the osteoblastic cell line MG-63","volume":"81","author":"Russell","year":"2007","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.lfs.2009.04.010_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","article-title":"Structure, regulation and function of NF-kB","volume":"10","author":"Siebelist","year":"1994","journal-title":"Annual Review of Cell Biology"},{"key":"10.1016\/j.lfs.2009.04.010_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/med.1006","article-title":"Cyclopentenone prostaglandins: new insights on biological activities and cellular targets","volume":"21","author":"Straus","year":"2001","journal-title":"Medicinal Research Reviews"},{"key":"10.1016\/j.lfs.2009.04.010_bib41","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1073\/pnas.97.9.4844","article-title":"15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway","volume":"97","author":"Straus","year":"2000","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.lfs.2009.04.010_bib42","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4049\/jimmunol.164.2.1046","article-title":"Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo","volume":"164","author":"Thieringer","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2009.04.010_bib43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0140-6736(98)10364-1","article-title":"Medical significance of peroxisome proliferator-activated receptors","volume":"354","author":"Vamecq","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2009.04.010_bib44","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1359\/JBMR.040919","article-title":"Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity","volume":"19","author":"Yip","year":"2004","journal-title":"Journal of Bone and Mineral Research"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509001799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509001799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T01:06:01Z","timestamp":1684976761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320509001799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0024320509001799"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2009.04.010","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}