{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:40:31Z","timestamp":1791765631808,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.lfs.2009.05.008","type":"journal-article","created":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T08:07:20Z","timestamp":1243238840000},"page":"196-205","source":"Crossref","is-referenced-by-count":35,"title":["Chemopreventive effect of farnesol on DMBA\/TPA-induced skin tumorigenesis: Involvement of inflammation, Ras-ERK pathway and apoptosis"],"prefix":"10.1016","volume":"85","author":[{"given":"Sandeep Chand","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sarwar","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Saeed","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Athar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2009.05.008_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ijc.20587","article-title":"Anthocyanin and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-\u03baB pathways and inhibits skin tumorigenesis in CD-1 mice","volume":"113","author":"Afaq","year":"2005","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.lfs.2009.05.008_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/360355a0","article-title":"Ornithine decarboxylase activity is critical for cell transformation","volume":"360","author":"Auvinen","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2009.05.008_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","article-title":"Cancer: An inflammatory link","volume":"431","author":"Balkwill","year":"2004","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2009.05.008_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/abbi.1998.0611","article-title":"Phosphorylation of farnesol in rat liver microsomes: Properties of farnesol kinase and farnesyl phosphate kinase","volume":"353","author":"Bentinger","year":"1998","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.lfs.2009.05.008_bib5","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1038\/sj.jid.5700340","article-title":"Oxidative stress in the pathogenesis of skin disease","volume":"126","author":"Bicker","year":"2006","journal-title":"The Journal of Investigative Dermatology"},{"key":"10.1016\/j.lfs.2009.05.008_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.lfs.2009.05.008_bib7","first-page":"3127","article-title":"Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention","volume":"22","author":"Burke","year":"2002","journal-title":"Anticancer Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cellsig.2004.07.008","article-title":"Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-\u03baB, but not p38 MAPK pathways","volume":"17","author":"Chang","year":"2005","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.lfs.2009.05.008_bib9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/carcin\/bgh076","article-title":"Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin","volume":"25","author":"Chun","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2009.05.008_bib10","series-title":"Handbook of Methods for Oxygen Radical Research","first-page":"283","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"key":"10.1016\/j.lfs.2009.05.008_bib11","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1038\/sj.onc.1207102","article-title":"The Bcl-2 family: Roles in cell survival and oncogenesis","volume":"22","author":"Cory","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2009.05.008_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000419252","article-title":"Modification of multistage skin carcinogenesis in mice","volume":"33","author":"DiGiovanni","year":"1991","journal-title":"Progress in Experimental Tumor Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib13","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1074\/jbc.M610575200","article-title":"A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway","volume":"282","author":"Fairn","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.05.008_bib14","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1006\/bbrc.1995.1555","article-title":"Evidence that in situ generated ROS act as potent stage-I tumor promoter in mouse skin","volume":"209","author":"Giri","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.lfs.2009.05.008_bib15","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S transferase: The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2009.05.008_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbi.2005.02.006","article-title":"Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol","volume":"152","author":"Horn","year":"2005","journal-title":"Chemico-biological Interaction"},{"key":"10.1016\/j.lfs.2009.05.008_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"24","key":"10.1016\/j.lfs.2009.05.008_bib18","doi-asserted-by":"crossref","first-page":"16,391","DOI":"10.1074\/jbc.M800945200","article-title":"NF-\u03baB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65\/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway","volume":"283","author":"Joo","year":"2008","journal-title":"Journal of Biological Chemistry"},{"issue":"16","key":"10.1016\/j.lfs.2009.05.008_bib19","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1158\/0008-5472.CAN-07-0931","article-title":"Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response","volume":"67","author":"Joo","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib20","first-page":"7777","article-title":"Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 Cells: Role of myeloperoxidase","volume":"61","author":"Kagan","year":"2001","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2007.08.012","article-title":"Regulation of p53, nuclear factor \u03baB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin","volume":"226","author":"Kalra","year":"2008","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"2","key":"10.1016\/j.lfs.2009.05.008_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1043-6618(02)00285-2","article-title":"Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot","volume":"47","author":"Kapadia","year":"2003","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3835(02)00711-5","article-title":"Palm oil alleviates 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion response in murine skin","volume":"192","author":"Kausar","year":"2003","journal-title":"Cancer Letters"},{"issue":"7","key":"10.1016\/j.lfs.2009.05.008_bib24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1093\/carcin\/bgi349","article-title":"Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kB in mouse skin by blocking IkB kinase activity","volume":"27","author":"Kundu","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2009.05.008_bib25","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.22.13.4851-4862.2002","article-title":"Caspase processing and nuclear export of CTP: Phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis","volume":"22","author":"Lagace","year":"2002","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.lfs.2009.05.008_bib26","first-page":"35","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications","volume":"5","author":"Lastra","year":"2007","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.lfs.2009.05.008_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0923-1811(03)00094-X","article-title":"Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice","volume":"32","author":"Lee","year":"2003","journal-title":"Journal of Dermatological Science"},{"key":"10.1016\/j.lfs.2009.05.008_bib28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0014-5793(99)01506-9","article-title":"Farnesol-induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F0F1-ATPase in yeast","volume":"462","author":"Machida","year":"1999","journal-title":"FEBS Letters"},{"key":"10.1016\/j.lfs.2009.05.008_bib29","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1096\/fasebj.4.15.2123808","article-title":"Posttranslational modifications of proteins by isoprenoids in mammalian cells","volume":"4","author":"Maltease","year":"1990","journal-title":"FASEB Journal"},{"key":"10.1016\/j.lfs.2009.05.008_bib30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1006\/bbrc.1996.1265","article-title":"Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells","volume":"225","author":"Miquel","year":"1996","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.lfs.2009.05.008_bib31","first-page":"5086","article-title":"Differential distribution of glutathione and glutathione related enzymes in rabbit kidney: Possible interactions in analgesic neuropathy","volume":"44","author":"Mohandas","year":"1984","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/1381612013398185","article-title":"The nuclear receptors FXR and LXR alpha: Potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases","volume":"7","author":"Niesor","year":"2001","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.lfs.2009.05.008_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ijc.20785","article-title":"Anti-proliferative and proapoptotic effects of (\u2212)-epigallocatechin-3-gallate on human melanoma: Possible implications for the chemoprevention of melanoma","volume":"114","author":"Nihal","year":"2005","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.lfs.2009.05.008_bib34","first-page":"2630","article-title":"Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin","volume":"57","author":"O'Brien","year":"1997","journal-title":"Cancer Research"},{"issue":"6","key":"10.1016\/j.lfs.2009.05.008_bib35","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/carcin\/bgi291","article-title":"Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMG CoA reductase","volume":"27","author":"Ong","year":"2006","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.lfs.2009.05.008_bib36","doi-asserted-by":"crossref","first-page":"2371s","DOI":"10.1158\/1078-0432.CCR-05-2539","article-title":"Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma","volume":"12","author":"Panka","year":"2006","journal-title":"Clinical Cancer Research"},{"issue":"2","key":"10.1016\/j.lfs.2009.05.008_bib37","first-page":"M 69","article-title":"Cyclooxygenase-2 and carcinogenesis","volume":"1470","author":"Prescott","year":"2000","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.lfs.2009.05.008_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-291X(02)00178-X","article-title":"Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes","volume":"293","author":"Raner","year":"2002","journal-title":"Biochemical and Biophysical Research Communication"},{"key":"10.1016\/j.lfs.2009.05.008_bib39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0361-090X(02)00119-8","article-title":"Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis","volume":"26","author":"Rao","year":"2002","journal-title":"Cancer Detection and Prevention"},{"key":"10.1016\/j.lfs.2009.05.008_bib40","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/carcin\/11.6.957","article-title":"Modulation of catalase activities in murine epidermal cells as a function of differentiation and exposure to 12-O-tetradecanoyl phorbol-13-acetate","volume":"11","author":"Reiners","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2009.05.008_bib41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0014-5793(00)01168-6","article-title":"Preferential induction of apoptosis of leukaemic cells by farnesol","volume":"467","author":"Rioja","year":"2000","journal-title":"FEBS Letter"},{"key":"10.1016\/j.lfs.2009.05.008_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/embo-reports\/kve020","article-title":"p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes","volume":"2","author":"Roper","year":"2001","journal-title":"EMBO Report"},{"key":"10.1016\/j.lfs.2009.05.008_bib43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jn\/130.2.465S","article-title":"Diet, natural products and cancer chemoprevention","volume":"130","author":"Singletery","year":"2000","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.lfs.2009.05.008_bib44","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/carcin\/7.11.1865","article-title":"sn-1,2-Diacyl-glycerol mimics the effects of TPA in-vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis","volume":"7","author":"Smart","year":"1986","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2009.05.008_bib45","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1111\/j.1742-4658.2005.04914.x","article-title":"Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction","volume":"272","author":"Taylor","year":"2005","journal-title":"FEBS Journal"},{"key":"10.1016\/j.lfs.2009.05.008_bib46","first-page":"419","article-title":"Correlation of the inhibition by retinoid of tumor promoter induced mouse epidermal ornithine decarboxylase activity and skin tumor promotion","volume":"39","author":"Verma","year":"1979","journal-title":"Cancer Research"},{"key":"10.1016\/j.lfs.2009.05.008_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2007.10.005","article-title":"Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species\/c-Jun N-terminal kinase pathways in human melanoma A375\u00a0S2 cells","volume":"259","author":"Wang","year":"2008","journal-title":"Cancer Letters"},{"issue":"3","key":"10.1016\/j.lfs.2009.05.008_bib48","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1124\/jpet.106.111666","article-title":"Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21Cip1 and p27Kip1 in human pancreatic adenocarcinoma cells","volume":"320","author":"Wiseman","year":"2007","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.lfs.2009.05.008_bib49","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0003-9861(81)90095-3","article-title":"Cytosolic factors which affect microsomal lipid peroxidation in lung and liver","volume":"206","author":"Wright","year":"1981","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"3","key":"10.1016\/j.lfs.2009.05.008_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1165\/rcmb.2002-0156OC","article-title":"Reactive oxygen species and extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium","volume":"28","author":"Zhang","year":"2003","journal-title":"American Journal of Respiratory Cell and Molecular Biology"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509002264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509002264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T05:03:20Z","timestamp":1633496600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320509002264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":50,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0024320509002264"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2009.05.008","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}