{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:01:18Z","timestamp":1785330078447,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.lfs.2009.06.001","type":"journal-article","created":{"date-parts":[[2009,6,14]],"date-time":"2009-06-14T08:25:33Z","timestamp":1244967933000},"page":"281-290","source":"Crossref","is-referenced-by-count":8,"title":["Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers"],"prefix":"10.1016","volume":"85","author":[{"given":"Yong Kyun","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Won","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Il","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Kyu","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hyun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Kyung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Moo","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Shin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1086\/423488","article-title":"Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein","volume":"190","author":"Abdalla","year":"2004","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.lfs.2009.06.001_bib2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1100\/tsw.2007.193","article-title":"Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCl4 model of liver fibrosis in rats","volume":"7","author":"Abdel-Salam","year":"2007","journal-title":"Scientific World Journal"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib3","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jhep.2007.01.020","article-title":"Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats","volume":"46","author":"Abraldes","year":"2007","journal-title":"Journal of Hepatology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1665-2681(19)32178-7","article-title":"Pathophysiology, diagnosis and treatment of ascites in cirrhosis","volume":"1","author":"Arroyo","year":"2002","journal-title":"Annals of Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-8278(00)80422-5","article-title":"Complications of cirrhosis. I. Portal hypertension","volume":"32","author":"Bosch","year":"2000","journal-title":"Journal of Hepatology"},{"issue":"7","key":"10.1016\/j.lfs.2009.06.001_bib6","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1074\/jbc.275.7.5179","article-title":"Endothelial nitric-oxide synthase (Type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases","volume":"275","author":"Butt","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/j.lfs.2009.06.001_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(98)01705-0","article-title":"AMP-activated protein kinase phosphorylation of endothelial NO synthase","volume":"443","author":"Chen","year":"1999","journal-title":"FEBS Letters"},{"issue":"4","key":"10.1016\/j.lfs.2009.06.001_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/hep.510230415","article-title":"Inhibition of Kupffer cell function as an explanation for the hepatoprotective properties of silibinin","volume":"23","author":"Dehmlow","year":"1996","journal-title":"Hepatology"},{"issue":"6736","key":"10.1016\/j.lfs.2009.06.001_bib9","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/phrs.1999.0575","article-title":"Silymarin effects on intracellular calcuim and cytotoxicity: A study in perfused rat hepatocytes after oxidative stress injury","volume":"41","author":"Farghali","year":"2000","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.lfs.2009.06.001_bib11","series-title":"The Oxyhaemoglobin Assay in Methods in Nitric Oxide Research","first-page":"455","author":"Feelish","year":"1996"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.hepres.2005.03.015","article-title":"Relationships between NOS2 and HO-1 in liver of rats with chronic bile duct ligation","volume":"32","author":"Flores","year":"2005","journal-title":"Hepatology Research"},{"issue":"4","key":"10.1016\/j.lfs.2009.06.001_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3748\/wjg.v12.i4.588","article-title":"Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis","volume":"12","author":"Goh","year":"2006","journal-title":"World Journal of Gastroenterology"},{"issue":"4","key":"10.1016\/j.lfs.2009.06.001_bib14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hep.510280405","article-title":"Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats","volume":"28","author":"Gupta","year":"1998","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib15","first-page":"68","article-title":"Oral silymarin for chronic hepatitis C \u2014 a retrospective analysis comparing three dose regimens","volume":"10","author":"Huber","year":"2005","journal-title":"European Journal of Medical Research"},{"issue":"3","key":"10.1016\/j.lfs.2009.06.001_bib16","doi-asserted-by":"crossref","first-page":"S288","DOI":"10.1097\/MCG.0b013e3181468b4c","article-title":"The molecules: Mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension","volume":"41","author":"Iwakiri","year":"2007","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"5","key":"10.1016\/j.lfs.2009.06.001_bib17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2007.02.006","article-title":"Vascular endothelial dysfunction in cirrhosis","volume":"46","author":"Iwakiri","year":"2007","journal-title":"Journal of Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Analytical Biochemistry"},{"issue":"8","key":"10.1016\/j.lfs.2009.06.001_bib19","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3748\/wjg.v11.i8.1141","article-title":"Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis","volume":"11","author":"Jeong","year":"2005","journal-title":"World Journal of Gastroenterology"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/bbrc.2000.3474","article-title":"Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin: Inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells","volume":"276","author":"Jiang","year":"2000","journal-title":"Biochemical and Biophysical Research Communication"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1165\/rcmb.2007-0323OC","article-title":"Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1","volume":"39","author":"Jin","year":"2008","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"11","key":"10.1016\/j.lfs.2009.06.001_bib22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1055\/s-2002-35663","article-title":"Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB\/c mice: II. Alterations in thymic differentiation correlate with changes in c-myc gene expression","volume":"68","author":"Johnson","year":"2002","journal-title":"Planta Medica"},{"issue":"10","key":"10.1016\/j.lfs.2009.06.001_bib23","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1096\/fj.03-1391com","article-title":"Caveolae compartmentalization of heme oxygenase-1 in endothelial cells","volume":"18","author":"Kim","year":"2004","journal-title":"The FASEB Journal"},{"issue":"7","key":"10.1016\/j.lfs.2009.06.001_bib24","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1096\/fj.07-103366","article-title":"Resveratrol stimulates nitric oxide production by increasing estrogen receptor {alpha}-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells","volume":"22","author":"Klinge","year":"2008","journal-title":"The FASEB Journal"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1478-3231.2005.01163.x","article-title":"Portal hypertension: From pathophysiology to clinical practice","volume":"25","author":"Laleman","year":"2005","journal-title":"Liver International"},{"issue":"2A","key":"10.1016\/j.lfs.2009.06.001_bib26","first-page":"1029","article-title":"Diagnostic evaluation of carbon tetrachloride-induced rat hepatic cirrhosis model","volume":"25","author":"Lee","year":"2008","journal-title":"Anticancer Research"},{"issue":"9","key":"10.1016\/j.lfs.2009.06.001_bib27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1289","article-title":"A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension","volume":"11","author":"Liu","year":"2005","journal-title":"Nature Medicine"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib28","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2003.09.018","article-title":"A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats","volume":"39","author":"Loureiro-Silva","year":"2003","journal-title":"Journal of Hepatology"},{"issue":"12","key":"10.1016\/j.lfs.2009.06.001_bib29","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1111\/j.1440-1746.2006.04608.x","article-title":"Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats","volume":"22","author":"Malyshev","year":"2007","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.21228","article-title":"The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis","volume":"44","author":"Matei","year":"2006","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.lfs.2009.06.001_bib31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/147323000203000309","article-title":"Increased heme oxygenase-1 gene expression in the livers of patients with portal hypertension due to severe hepatic cirrhosis","volume":"30","author":"Matsumi","year":"2002","journal-title":"The Journal of International Medical Research"},{"issue":"4","key":"10.1016\/j.lfs.2009.06.001_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1534735405282475","article-title":"Multifocal angiostatic therapy: An update","volume":"4","author":"McCarty","year":"2005","journal-title":"Integrative Cancer Therapies"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0016-5085(03)00909-0","article-title":"Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats","volume":"125","author":"Morales-ruiz","year":"2003","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.lfs.2009.06.001_bib34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1742-7843.2005.pto_06.x","article-title":"Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: Effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid","volume":"96","author":"Muriel","year":"2005","journal-title":"Basic and Clinical Pharmacology and Toxicology"},{"issue":"5","key":"10.1016\/j.lfs.2009.06.001_bib35","first-page":"491","article-title":"Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine","volume":"124","author":"Pradhan","year":"2006","journal-title":"The Indian Journal of Medical Research"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib36","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0016-5085(82)80126-1","article-title":"High yield micronodular cirrhosis in the rat","volume":"83","author":"Proctor","year":"1982","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0016-5085(98)70487-1","article-title":"Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension","volume":"114","author":"Rockey","year":"1998","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib38","first-page":"554","article-title":"Nitric oxide production in arterial vessels of cirrhotic rats","volume":"21","author":"Ros","year":"1995","journal-title":"Hepatology"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2009.06.001_bib39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0014-5793(98)01409-4","article-title":"Selective inhibition of NF-kB activation by the flavonoid hepatoprotector silymarin in HepG2","volume":"440","author":"Saliou","year":"1998","journal-title":"FEBS Letters"},{"issue":"14","key":"10.1016\/j.lfs.2009.06.001_bib40","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2165\/00003495-200161140-00003","article-title":"The use of silymarin in the treatment of liver diseases","volume":"61","author":"Saller","year":"2001","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000113648","article-title":"An updated systematic review with meta-analysis for the clinical evidence of silymarin","volume":"15","author":"Saller","year":"2008","journal-title":"Forschende Komplementarmedizin"},{"key":"10.1016\/j.lfs.2009.06.001_bib42","first-page":"61","article-title":"Assay of NOS activity by the measurement of conversion of oxyhemoglobin to methemoglobin by NO","volume":"100","author":"Salter","year":"1998","journal-title":"Methods in Molecular Biology"},{"issue":"5","key":"10.1016\/j.lfs.2009.06.001_bib43","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.44.5.749","article-title":"Hepatic and splanchnic nitric oxide activity in patients with cirrhosis","volume":"44","author":"Sarela","year":"1999","journal-title":"Gut"},{"issue":"9615","key":"10.1016\/j.lfs.2009.06.001_bib44","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.lfs.2009.06.001_bib45","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0016-5085(99)70408-7","article-title":"Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat","volume":"117","author":"Shah","year":"1999","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib46","doi-asserted-by":"crossref","first-page":"G1209","DOI":"10.1152\/ajpgi.2001.280.6.G1209","article-title":"Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats","volume":"280","author":"Shah","year":"2001","journal-title":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},{"issue":"6","key":"10.1016\/j.lfs.2009.06.001_bib47","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1152\/japplphysiol.00138.2006","article-title":"Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness","volume":"101","author":"Soucy","year":"2006","journal-title":"Journal of Applied Physiology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib48","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1006\/bbrc.1994.2811","article-title":"Carbon monoxide as an endogenous modulator of hepatic vascular perfusion","volume":"205","author":"Suematsu","year":"1994","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7","key":"10.1016\/j.lfs.2009.06.001_bib49","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2893.2008.00971.x","article-title":"Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats","volume":"15","author":"Tsai","year":"2008","journal-title":"Journal of Viral Hepatitis"},{"issue":"3","key":"10.1016\/j.lfs.2009.06.001_bib50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/path.1284","article-title":"Expression of haem oxygenase in cirrhotic rat liver","volume":"199","author":"Wei","year":"2003","journal-title":"The Journal of Pathology"},{"issue":"7","key":"10.1016\/j.lfs.2009.06.001_bib51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2165\/00063030-200115070-00005","article-title":"Silymarin: A review of its clinical properties in the management of hepatic disorders","volume":"15","author":"Wellington","year":"2001","journal-title":"BioDrugs"},{"issue":"1","key":"10.1016\/j.lfs.2009.06.001_bib52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-2999(03)01301-3","article-title":"The action of nitric oxide on hepatic haemodynamics during secondary biliary cirrhosis in the rat","volume":"461","author":"Yang","year":"2003","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.lfs.2009.06.001_bib53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-0676.2002.01588.x","article-title":"Enhanced expression of endothelial nitric oxide synthase and caveolin-1 in human cirrhosis","volume":"22","author":"Yokomori","year":"2002","journal-title":"Liver"},{"issue":"9","key":"10.1016\/j.lfs.2009.06.001_bib54","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s00535-003-1161-4","article-title":"Elevated expression of caveolin-1 at protein and mRNA level in human cirrhotic liver: Relation with nitric oxide","volume":"38","author":"Yokomori","year":"2003","journal-title":"Journal of Gastroenterology"},{"issue":"24","key":"10.1016\/j.lfs.2009.06.001_bib55","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.3748\/wjg.v11.i24.3710","article-title":"High expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis","volume":"11","author":"Yokomori","year":"2005","journal-title":"World Journal of Gastroenterology"},{"issue":"26","key":"10.1016\/j.lfs.2009.06.001_bib56","doi-asserted-by":"crossref","first-page":"14848","DOI":"10.1073\/pnas.94.26.14848","article-title":"Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide","volume":"94","author":"Zakhary","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509002598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320509002598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T18:16:53Z","timestamp":1589912213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320509002598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":56,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0024320509002598"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2009.06.001","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}