{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:49:15Z","timestamp":1792601355235,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"17-18","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.lfs.2010.02.014","type":"journal-article","created":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T09:28:53Z","timestamp":1266744533000},"page":"646-653","source":"Crossref","is-referenced-by-count":84,"title":["A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss"],"prefix":"10.1016","volume":"86","author":[{"given":"Alysia N.","family":"Lozano-Ondoua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vardanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tally M.","family":"Largent-Milnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Jimenez-Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Mantyh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Vanderah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neulet.2005.11.038","article-title":"Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study","volume":"396","author":"Ashton","year":"2006","journal-title":"Neuroscience Letters"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/sj.bjp.0707593","article-title":"Cannabinoid receptors and the regulation of bone mass","volume":"153","author":"Bab","year":"2008","journal-title":"British Journal of Pharmacology"},{"issue":"6","key":"10.1016\/j.lfs.2010.02.014_bib4","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1111\/j.1460-9568.2006.04684.x","article-title":"CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms","volume":"23","author":"Beltramo","year":"2006","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.lfs.2010.02.014_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000071560","article-title":"Neutrophils and angiogenesis: potential initiators of the angiogenic cascade","volume":"83","author":"Benelli","year":"2003","journal-title":"Chemical Immunology and Allergy"},{"issue":"6053","key":"10.1016\/j.lfs.2010.02.014_bib6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/319516a0","article-title":"Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors","volume":"3119","author":"Bertolini","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2010.02.014_bib7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/sj.bjp.0707303","article-title":"Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers","volume":"151","author":"Bingham","year":"2007","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2010.02.014_bib8","first-page":"365","article-title":"Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters","volume":"25","author":"Bolat","year":"2006","journal-title":"Journal of Experimental and Clinical Cancer Research: CR"},{"issue":"6937","key":"10.1016\/j.lfs.2010.02.014_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"4223","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.lfs.2010.02.014_bib10","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/syn.20569","article-title":"Postsynaptic localization of CB2 receptors in the rat hippocampus","volume":"62","author":"Brusco","year":"2008","journal-title":"Synapse"},{"key":"10.1016\/j.lfs.2010.02.014_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.176.1.284","article-title":"Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression","volume":"176","author":"Bunt","year":"2006","journal-title":"Journal of Immunology"},{"issue":"5","key":"10.1016\/j.lfs.2010.02.014_bib12","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1210\/endo-121-5-1596","article-title":"Effects of tumor necrosis factor on bone formation in vitro","volume":"121","author":"Canalis","year":"1987","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1567-5769(01)00147-3","article-title":"Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation","volume":"2","author":"Carlisle","year":"2002","journal-title":"International Immunopharmacology"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"Journal of Neuroscience Methods"},{"issue":"20 Pt 2","key":"10.1016\/j.lfs.2010.02.014_bib16","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.lfs.2010.02.014_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","article-title":"Macrophages: obligate partners for tumor cell migration, invasion, and metastasis","volume":"124","author":"Condeelis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2010.02.014_bib18","doi-asserted-by":"crossref","unstructured":"Coussens LM, Werb Z. Inflammation and cancer. Nature 420 (6917), 860\u20137, 2002.","DOI":"10.1038\/nature01322"},{"key":"10.1016\/j.lfs.2010.02.014_bib87","doi-asserted-by":"crossref","unstructured":"Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey GH, Hanahan D. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes and Development 13, 1382\u201397, 1999.","DOI":"10.1101\/gad.13.11.1382"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/neu.20080","article-title":"The endogenous cannabinoid system and its role in nociceptive behavior","volume":"61","author":"Cravatt","year":"2004","journal-title":"Journal of Neurobiology"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-5793(95)00746-V","article-title":"Cannabinoids enhance human B-cell growth at low nanomolar concentrations","volume":"369","author":"Derocq","year":"1995","journal-title":"Federation of European Biochemical Societies"},{"issue":"4","key":"10.1016\/j.lfs.2010.02.014_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/bcr1746","article-title":"Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression","volume":"9","author":"DeNardo","year":"2007","journal-title":"Breast Cancer Research"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10555-007-9100-0","article-title":"Immune cells as mediators of solid tumor metastasis","volume":"27","author":"DeNardo","year":"2008","journal-title":"Cancer Metastasis Reviews"},{"key":"10.1016\/j.lfs.2010.02.014_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","article-title":"Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors","volume":"8","author":"DePalma","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lfs.2010.02.014_bib24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib25","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/jcp.21263","article-title":"Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells","volume":"214","author":"George","year":"2008","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"Galiegue","year":"1995","journal-title":"European Journal of Biochemistry"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","article-title":"Cannabinoid CB2 receptors: immunohistochemical localization in rat brain","volume":"1071","author":"Gong","year":"2006","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-2999(99)00402-1","article-title":"Evaluation of the cannabinoid CB2 receptor-selective antagonist. SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system","volume":"377","author":"Griffin","year":"1999","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.bjp.0707531","article-title":"Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain","volume":"153","author":"Guindon","year":"2008","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2010.02.014_bib85","doi-asserted-by":"crossref","unstructured":"Honore P, Luger NM, Sabino MA, Schwei MJ, Rogers SD, Mach DB, O'keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nature Medicine 6 (5), 521\u20138, 2000.","DOI":"10.1038\/74999"},{"key":"10.1016\/j.lfs.2010.02.014_bib30","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1073\/pnas.1834309100","article-title":"Activation of CB2 receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS","volume":"100","author":"Ibrahim","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/j.lfs.2010.02.014_bib31","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1073\/pnas.0409888102","article-title":"CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids","volume":"102","author":"Ibrahim","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2010.02.014_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pain.2005.12.018","article-title":"CB2 cannabinoid receptor mediation of antinociception","volume":"122","author":"Ibrahim","year":"2006","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.lfs.2010.02.014_bib33","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm1255","article-title":"Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors","volume":"11","author":"Idris","year":"2005","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib34","first-page":"1","article-title":"Bone cancer pain","volume":"17","author":"Jimenez-Andrade","year":"2009","journal-title":"Pain Clinical Updates"},{"key":"10.1016\/j.lfs.2010.02.014_bib35","doi-asserted-by":"crossref","unstructured":"Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A. Cannabinoid receptor type 2 gene is associated with human osteoporosis. Human Molecular Genetics 14 (22), 3389\u201396, 2005.","DOI":"10.1093\/hmg\/ddi370"},{"key":"10.1016\/j.lfs.2010.02.014_bib86","doi-asserted-by":"crossref","unstructured":"Kawasaki Y, Zhang L, Cheng KK, Ji RR. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. Journal of Neuroscience 28 (20), 5189\u201394, 2008.","DOI":"10.1523\/JNEUROSCI.3338-07.2008"},{"issue":"6","key":"10.1016\/j.lfs.2010.02.014_bib36","first-page":"1477","article-title":"Potential role of HER-2; in primary breast tumor with bone metastasis","volume":"15","author":"Kim","year":"2006","journal-title":"Oncology Reports"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.yexcr.2007.09.021","article-title":"Metastatic breast cancer induces and osteoblast inflammatory response","volume":"314","author":"Kinder","year":"2007","journal-title":"Experimental Cell Research"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2010.02.014_bib38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pain.2007.06.026","article-title":"Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer","volume":"132","author":"King","year":"2007","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.lfs.2010.02.014_bib39","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1189\/jlb.0303101","article-title":"The cannabinoid system and immune modulation","volume":"74","author":"Klein","year":"2003","journal-title":"Journal of Leukocyte Biology"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2010.02.014_bib40","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejphar.2005.10.020","article-title":"Cannabinoid CB2 receptor activity in the hindpaw incision model of postoperative pain","volume":"527","author":"LaBuda","year":"2005","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2010.02.014_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1020304003704","article-title":"Tumor-associated macrophages in breast cancer","volume":"7","author":"Leek","year":"2002","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib42","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.148.3.788","article-title":"Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL1, down-regulate the osteocalcin gene","volume":"148","author":"Li","year":"1992","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.lfs.2010.02.014_bib43","unstructured":"Lin EY, Pollard J. Macrophages: modulators of breast cancer progression. Novartis Foundation Symposium 256:158\u2013168 discussion 68\u201372, 259\u2013269, 2004."},{"key":"10.1016\/j.lfs.2010.02.014_bib44","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1158\/0008-5472.CAN-07-0912","article-title":"Tumor-associated macrophages press the angiogenic switch in breast cancer","volume":"67","author":"Lin","year":"2007","journal-title":"Cancer Research"},{"issue":"10","key":"10.1016\/j.lfs.2010.02.014_bib45","first-page":"4038","article-title":"Osteoprotegerin diminishes advanced bone cancer pain","volume":"61","author":"Luger","year":"2001","journal-title":"Cancer Research"},{"issue":"5 suppl","key":"10.1016\/j.lfs.2010.02.014_bib46","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jpainsymman.2005.01.008","article-title":"Bone cancer pain: from model to mechanism to therapy","volume":"29","author":"Luger","year":"2005","journal-title":"Journal of Pain and Symptom Management"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(01)00321-9","article-title":"CB2 cannabinoid receptor-mediated peripheral antinociception","volume":"93","author":"Malan","year":"2001","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1471-4892(02)00004-8","article-title":"CB2 cannabinoid receptor agonists. Pain relief without psychoactive effects?","volume":"3","author":"Malan","year":"2003","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.lfs.2010.02.014_bib49","doi-asserted-by":"crossref","unstructured":"Marcini I, Brusa R, Quadrato G, Foglia C, Scandroglio P, Silverman LS, Tulshian D, Reggiani A, Beltramo M. Constituitive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+) AM1241 and L768242. British Journal of Pharmacology 158, 382\u2013391, 2009.","DOI":"10.1111\/j.1476-5381.2009.00154.x"},{"key":"10.1016\/j.lfs.2010.02.014_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc747","article-title":"Molecular mechanisms of cancer pain","volume":"2","author":"Mantyh","year":"2002","journal-title":"Nature Reviews. Cancer"},{"issue":"24","key":"10.1016\/j.lfs.2010.02.014_bib51","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.2174\/138161206777947425","article-title":"Cannabinoids, immune system and cytokine network","volume":"12","author":"Massi","year":"2006","journal-title":"Current Pharmaceutical Design"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2010.02.014_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain: pathophysiology and treatment","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.lfs.2010.02.014_bib53","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/CCO.0b013e3281214400","article-title":"Management of painful bone metastases","volume":"19","author":"Mercadante","year":"2007","journal-title":"Current Opinion in Oncology"},{"key":"10.1016\/j.lfs.2010.02.014_bib54","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1358\/dot.2008.44.9.1251573","article-title":"Celecoxib, NSAIDs and the skeleton","volume":"9","author":"O'Connor","year":"2008","journal-title":"Drugs Today"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib55","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1073\/pnas.0504187103","article-title":"Peripheral cannabinoid receptor, CB2, regulates bone mass","volume":"103","author":"Ofek","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.lfs.2010.02.014_bib56","first-page":"3335","article-title":"Correlation of histological localization of tumorassociated macrophages with clinicopathological features in endometrial cancer","volume":"24","author":"Ohno","year":"2004","journal-title":"Anticancer Research"},{"key":"10.1016\/j.lfs.2010.02.014_bib57","first-page":"291","article-title":"Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression","volume":"123","author":"Onaivi","year":"2006","journal-title":"Methods in Molecular Medicine"},{"key":"10.1016\/j.lfs.2010.02.014_bib58","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.1711720302","article-title":"Tumour-associated leucocytes: friends or foes in breast carcinoma","volume":"172","author":"O'Sullivan","year":"1994","journal-title":"Journal of Pathology"},{"issue":"5","key":"10.1016\/j.lfs.2010.02.014_bib59","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0301-0082(00)00031-9","article-title":"Cannabinoid receptors and pain","volume":"63","author":"Pertwee","year":"2001","journal-title":"Progress in Neurobiology"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ptr.2030","article-title":"Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health","volume":"21","author":"Putnam","year":"2007","journal-title":"Phytotherapy Research: PTR"},{"issue":"4","key":"10.1016\/j.lfs.2010.02.014_bib61","doi-asserted-by":"crossref","first-page":"H2210","DOI":"10.1152\/ajpheart.00688.2007","article-title":"CB2 receptor stimulation attenuates TNF-alpha-induced human epithelial cell activation, transendothelial migration of monocytes, and monocyte\u2013endothelial adhesion","volume":"293","author":"Rajesh","year":"2007","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"10.1016\/j.lfs.2010.02.014_bib62","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1046\/j.1365-2141.2001.03202.x","article-title":"The role of mast cells in tumour angiogenesis","volume":"115","author":"Ribatti","year":"2001","journal-title":"British Journal Haematology"},{"key":"10.1016\/j.lfs.2010.02.014_bib63","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/j.1365-2222.2004.02104.x","article-title":"Mast cell contribution to angiogenesis related to tumour progression","volume":"34","author":"Ribatti","year":"2004","journal-title":"Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology"},{"issue":"4","key":"10.1016\/j.lfs.2010.02.014_bib64","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/ALN.0b013e318167af74","article-title":"Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury","volume":"108","author":"Romero-Sandoval","year":"2008","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib65","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0959-8049(97)10128-9","article-title":"Bone metastases \u2014 the clinical problem","volume":"34","author":"Rubens","year":"1998","journal-title":"European Journal of Cancer"},{"issue":"2","key":"10.1016\/j.lfs.2010.02.014_bib66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1460-9568.2005.04206.x","article-title":"Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats","volume":"22","author":"Sagar","year":"2005","journal-title":"European Journal of Neuroscience"},{"issue":"24","key":"10.1016\/j.lfs.2010.02.014_bib67","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1523\/JNEUROSCI.19-24-10886.1999","article-title":"Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain","volume":"19","author":"Schwei","year":"1999","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib68","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00223-006-0171-7","article-title":"Cannabinoids stimulate fibrolastic colony formation by bone marrow cells indirectly via CB2 receptors","volume":"80","author":"Scutt","year":"2007","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.lfs.2010.02.014_bib69","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1158\/0008-5472.CAN-06-4174","article-title":"Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells","volume":"67","author":"Sinha","year":"2007","journal-title":"Cancer Research"},{"issue":"3","key":"10.1016\/j.lfs.2010.02.014_bib70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1006308619659","article-title":"Metastatic breast cancer: clinical course, prognosis, and therapy related to the first site of metastasis","volume":"59","author":"Solomayer","year":"2000","journal-title":"Breast Cancer Research and Treatment"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2010.02.014_bib71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0009-3084(00)00189-4","article-title":"2-Arachidonoylglycerol and the cannabinoid receptors","volume":"108","author":"Sugiura","year":"2000","journal-title":"Chemistry and Physics of Lipids"},{"issue":"6","key":"10.1016\/j.lfs.2010.02.014_bib72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jbmr.5650020612","article-title":"Interleukin 1 beta is a potential inhibitor of bone formation in vitro","volume":"2","author":"Stashenko","year":"1987","journal-title":"Journal of Bone and Mineral Research: the Official Journal of The American Society for Bone and Mineral Research"},{"key":"10.1016\/j.lfs.2010.02.014_bib73","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.it.2004.02.013","article-title":"Mast cells: the Jekyll and Hyde of tumor growth","volume":"25","author":"Theoharides","year":"2004","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.lfs.2010.02.014_bib74","first-page":"425","article-title":"Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density","volume":"14","author":"Tsutsui","year":"2005","journal-title":"Oncology Reports"},{"issue":"18","key":"10.1016\/j.lfs.2010.02.014_bib75","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1523\/JNEUROSCI.20-18-07074.2000","article-title":"Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance","volume":"20","author":"Vanderah","year":"2000","journal-title":"Journal of Neuroscience"},{"issue":"5746","key":"10.1016\/j.lfs.2010.02.014_bib77","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1115740","article-title":"Identification and functional characterization of brainstem cannabinoid CB2 receptors","volume":"310","author":"Van Sickle","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib78","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacology and Therapeutics"},{"issue":"8","key":"10.1016\/j.lfs.2010.02.014_bib79","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2174\/092986707780363023","article-title":"The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists","volume":"14","author":"Whiteside","year":"2007","journal-title":"Current Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib80","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2005.06.009","article-title":"Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons","volume":"135","author":"Wotherspoon","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2010.02.014_bib81","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/sj.bjp.0706838","article-title":"In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 recepor?","volume":"149","author":"Yao","year":"2006","journal-title":"British Journal of Pharmacology"},{"issue":"1","key":"10.1016\/j.lfs.2010.02.014_bib82","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2008.01.010","article-title":"Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain","volume":"583","author":"Yamamoto","year":"2008","journal-title":"European Journal of Pharmacology"},{"issue":"12","key":"10.1016\/j.lfs.2010.02.014_bib83","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1046\/j.1460-9568.2003.02704.x","article-title":"Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models","volume":"17","author":"Zhang","year":"2003","journal-title":"European Journal of Neuroscience"},{"issue":"6","key":"10.1016\/j.lfs.2010.02.014_bib84","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ctrv.2008.03.012","article-title":"Molecular treatment strategies and surgical reconstruction for metastatic bone diseases","volume":"34","author":"Zou","year":"2008","journal-title":"Cancer Treatment Reviews"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320510000755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320510000755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:51:12Z","timestamp":1685447472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320510000755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":84,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0024320510000755"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2010.02.014","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}