{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:44Z","timestamp":1792009544718,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"17-18","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":660,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"State of S\u00e3o Paulo research support foundation\u2014FAPESP 05\/60284-6"},{"name":"FAEPEX\/UNICAMP"},{"name":"CNPq"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.lfs.2011.08.004","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T04:16:27Z","timestamp":1313640987000},"page":"631-637","source":"Crossref","is-referenced-by-count":35,"title":["Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology"],"prefix":"10.1016","volume":"89","author":[{"given":"Ana Paula","family":"Tanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vander Jos\u00e9 das","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleizu Teodoro","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Sousa","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Cristina Linarello","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Morini","family":"Calil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Guzzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilamar Menezes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Duarte","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cl\u00e1udia","family":"Irigoyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 Costa Sampaio","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Klein","family":"Marcondes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2011.08.004_bb0005","doi-asserted-by":"crossref","first-page":"R381","DOI":"10.1152\/ajpregu.00933.2007","article-title":"AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats","volume":"295","author":"Barauna","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199607043350101","article-title":"The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men","volume":"335","author":"Bhasin","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.lfs.2009.08.009","article-title":"Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine","volume":"85","author":"Castor","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2011.08.004_bb0020","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1161\/01.CIR.103.6.820","article-title":"Relations of stroke volume and cardiac output to body composition: the Strong Heart Study","volume":"103","author":"Collins","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2011.08.004_bb0025","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/01.HYP.0000174600.51515.e7","article-title":"Vascular sensitivity to phenylephrine in rats submitted to anaerobic training and nandrolone treatment","volume":"46","author":"Cunha","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2011.08.004_bb0030","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.lfs.2005.03.001","article-title":"Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content","volume":"77","author":"Cunha","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2011.08.004_bb0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-5273(02)00194-8","article-title":"Association between left ventricular structure and cardiac performance during effort in two morphological forms of athlete's heart","volume":"86","author":"D'Andrea","year":"2002","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0040","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1540-8175.2006.00186.x","article-title":"The usefulness of Doppler myocardial imaging in the study of the athlete's heart and in the differential diagnosis between physiological and pathological ventricular hypertrophy","volume":"23","author":"D'Andrea","year":"2006","journal-title":"Echocardiography"},{"key":"10.1016\/j.lfs.2011.08.004_bb0045","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-2007-1024703","article-title":"Anabolic steroid use in body builders: an echocardiographic study of left ventricle morphology and function","volume":"12","author":"De Piccoli","year":"1991","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0050","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings","volume":"57","author":"Devereux","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0055","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0002-8703(89)90267-6","article-title":"Altered sympathetic system and adrenoceptors during the development of cardiac hypertrophy","volume":"118","author":"Ganguly","year":"1989","journal-title":"Am Heart J"},{"key":"10.1016\/j.lfs.2011.08.004_bb0060","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1440-1681.2003.03873.x","article-title":"Cardiac hypertrophy: a matter of translation","volume":"30","author":"Hannan","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0065","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/s-2003-40705","article-title":"Prospective echocardiographic assessment of androgenic\u2013anabolic steroids effects on cardiac structure and function in strength athletes","volume":"24","author":"Hartgens","year":"2003","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0070","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2165\/00007256-200232130-00003","article-title":"Resistance training and cardiac hypertrophy: unravelling the training effect","volume":"32","author":"Haykowsky","year":"2002","journal-title":"Sports Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0075","doi-asserted-by":"crossref","first-page":"R2029","DOI":"10.1152\/ajpregu.2001.281.6.R2029","article-title":"Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat","volume":"281","author":"Iemitsu","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem J"},{"key":"10.1016\/j.lfs.2011.08.004_bb0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1748-1716.1988.tb08411.x","article-title":"Anabolic steroids alter the haemodynamic effects of endurance training and deconditioning in rats","volume":"133","author":"Karhunen","year":"1988","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.lfs.2011.08.004_bb0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-2999(80)90017-5","article-title":"Chronic heart failure in the guinea pig increases cardiac alpha 1- and beta-adrenoceptors","volume":"67","author":"Karliner","year":"1980","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0031-6997(24)01434-0","article-title":"Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases","volume":"52","author":"Kim","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.lfs.2011.08.004_bb0100","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1749-6632.1995.tb17426.x","article-title":"Markers of cardiac hypertrophy","volume":"752","author":"Klein","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.lfs.2011.08.004_bb0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1210\/rp.57.1.411","article-title":"Anabolic steroids","volume":"57","author":"Kuhn","year":"2002","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.lfs.2011.08.004_bb0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1210\/er.2003-0005","article-title":"Androgens and cardiovascular disease","volume":"24","author":"Liu","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.lfs.2011.08.004_bb0115","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.81.9.2626","article-title":"Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem","volume":"81","author":"Mahdavi","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lfs.2011.08.004_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.CIR.98.3.256","article-title":"Androgen receptors mediate hypertrophy in cardiac myocytes","volume":"98","author":"Marsh","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2011.08.004_bb0125","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1196\/annals.1330.024","article-title":"Anabolic androgenic steroids and aggression: studies using animal models","volume":"1036","author":"McGinnis","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.lfs.2011.08.004_bb0130","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1249\/00005768-199509000-00004","article-title":"Cardiovascular effects of androgenic\u2013anabolic steroids","volume":"27","author":"Melchert","year":"1995","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.lfs.2011.08.004_bb0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1249\/00005768-199202000-00008","article-title":"The effect of anabolic\u2013androgenic steroids on primary myocardial cell cultures","volume":"24","author":"Melchert","year":"1992","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.lfs.2011.08.004_bb0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cbir.1996.0004","article-title":"Structural biology of the fibres of the collagenous and elastic systems","volume":"20","author":"Montes","year":"1996","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.lfs.2011.08.004_bb0145","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/oxfordjournals.eurheartj.a014724","article-title":"Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters","volume":"17","author":"Nieminen","year":"1996","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lfs.2011.08.004_bb0150","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s004210050048","article-title":"Attenuated beta-adrenoceptor-mediated cardiac contractile responses following androgenic steroid administration to sedentary rats","volume":"81","author":"Norton","year":"2000","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0155","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.amjcard.2005.10.026","article-title":"Cardiovascular effects of androgenic anabolic steroids in male bodybuilders determined by tissue Doppler imaging","volume":"97","author":"Nottin","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2005.07.026","article-title":"Chronic beta-adrenoceptor stimulation and cardiac hypertrophy with no induction of circulating renin","volume":"520","author":"Oliveira","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0165","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/j.1552-4604.1996.tb04167.x","article-title":"Cardiovascular effects of anabolic steroids in weight-trained subjects","volume":"36","author":"Palatini","year":"1996","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0170","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1249\/01.mss.0000210194.56834.5d","article-title":"Anabolic androgenic steroids: a survey of 500 users","volume":"38","author":"Parkinson","year":"2006","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.lfs.2011.08.004_bb0175","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/s-2000-3834","article-title":"The effect of supraphysiological doses of anabolic androgenic steroids on collagen metabolism","volume":"21","author":"P\u00e4rssinen","year":"2000","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-2000-304","article-title":"Increased premature mortality of competitive powerlifters suspected to have used anabolic agents","volume":"21","author":"P\u00e4rssinen","year":"2000","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.lfs.2011.08.004_bb0185","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1161\/01.CIR.101.3.336","article-title":"The athlete's heart. A meta-analysis of cardiac structure and function","volume":"101","author":"Pluim","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2011.08.004_bb0190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1176\/ajp.145.4.487","article-title":"Affective and psychotic symptoms associated with anabolic steroid use","volume":"145","author":"Pope","year":"1988","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.lfs.2011.08.004_bb0195","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/138920111794295792","article-title":"Anabolic steroid- and exercise-induced cardio-depressant cytokines and myocardial \u03b21 receptor expression in CD1 mice","volume":"12","author":"Riezzo","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2174\/138955711795445862","article-title":"Heart disease induced by AAS abuse, using experimental mice\/rats models and the role of exercise-induced cardiotoxicity","volume":"11","author":"Riezzo","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.lfs.2011.08.004_bb0205","doi-asserted-by":"crossref","first-page":"H3575","DOI":"10.1152\/ajpheart.01251.2006","article-title":"Anabolic steroids induce cardiac renin\u2013angiotensin system and impair the beneficial effects of aerobic training in rats","volume":"293","author":"Rocha","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0210","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.HYP.0000215289.51180.5c","article-title":"Impairment of in vitro and in vivo heart function in angiotensin-(1\u20137) receptor MAS knockout mice","volume":"47","author":"Santos","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2011.08.004_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1096-6374(02)00137-5","article-title":"Short-and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression","volume":"13","author":"Scheinowitz","year":"2003","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.lfs.2011.08.004_bb0220","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1152\/japplphysiol.00921.2006","article-title":"Dependence of changes in beta-adrenoceptor signal transduction on type and stage of cardiac hypertrophy","volume":"102","author":"Sethi","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0225","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physiolgenomics.00145.2010","article-title":"MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats","volume":"43","author":"Soci","year":"2011","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.lfs.2011.08.004_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0033-0620(98)80019-4","article-title":"The cardiac toxicity of anabolic steroids","volume":"41","author":"Sullivan","year":"1998","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.lfs.2011.08.004_bb0235","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/jappl.2000.88.2.534","article-title":"Enhanced inotropic response to dobutamine in strength-trained subjects with left ventricular hypertrophy","volume":"88","author":"Suman","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0240","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1152\/jappl.2000.89.4.1462","article-title":"Collagen gene expression in rat left ventricle: interactive effect of age and exercise training","volume":"89","author":"Thomas","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0245","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0735-1097(92)90478-6","article-title":"Left ventricular function is not impaired in weight-lifters who use anabolic steroids","volume":"19","author":"Thompson","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0250","first-page":"H1096","article-title":"An androgenic steroid decreases left ventricular compliance in rats","volume":"268","author":"Trifunovic","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2011.08.004_bb0255","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF00418510","article-title":"One- and two-dimensional echocardiography in bodybuilders using anabolic steroids","volume":"58","author":"Urhausen","year":"1989","journal-title":"Eur J Appl Physiol Occup Physiol"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320511004012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320511004012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T17:26:46Z","timestamp":1741454806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320511004012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":51,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0024320511004012"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2011.08.004","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}