{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:40:57Z","timestamp":1762144857127,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"25-26","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.lfs.2012.05.001","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T16:57:50Z","timestamp":1337878670000},"page":"988-994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hydroxyxanthone as an inhibitor of cAMP-activated apical chloride channel in human intestinal epithelial cell"],"prefix":"10.1016","volume":"90","author":[{"given":"Wachiraporn","family":"Luerang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thongchai","family":"Khammee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watinee","family":"Kumpum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunit","family":"Suksamrarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varanuj","family":"Chatsudthipong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchai","family":"Muanprasat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2012.05.001_bb0005","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.physiol.62.1.535","article-title":"Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects","volume":"62","author":"Barrett","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0010","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/jb.100.2.1142-1143.1969","article-title":"Reaction of Vibrio cholerae and choleragenic toxin in ileal loop of laboratory animals","volume":"100","author":"Basu","year":"1969","journal-title":"J Bacteriol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1055\/s-0028-1088388","article-title":"Vasodilator and antioxidant effect of xanthones isolated from Brazilian medicinal plants","volume":"75","author":"Capettini","year":"2009","journal-title":"Planta Med"},{"key":"10.1016\/j.lfs.2012.05.001_bb0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1586\/14760584.7.4.403","article-title":"What about cholera vaccines?","volume":"7","author":"Chaignat","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.lfs.2012.05.001_bb0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00006454-199005000-00008","article-title":"Global progress in the control of diarrheal diseases","volume":"9","author":"Claeson","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.lfs.2012.05.001_bb0030","doi-asserted-by":"crossref","first-page":"854","DOI":"10.2174\/092986710790712147","article-title":"Recent insights into the biosynthesis and biological activities of natural xanthones","volume":"17","author":"El-Seedi","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.lfs.2012.05.001_bb0035","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1172\/JCI200318326","article-title":"Intestinal ion transport and the pathophysiology of diarrhea","volume":"111","author":"Field","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lfs.2012.05.001_bb0130","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1172\/JCI106874","article-title":"Effect of cholera enterotoxin on ion transport across isolated ileal mucosa","volume":"51","author":"Field","year":"1972","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lfs.2012.05.001_bb0045","doi-asserted-by":"crossref","first-page":"C1734","DOI":"10.1152\/ajpcell.2001.281.5.C1734","article-title":"Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists","volume":"281","author":"Galietta","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0050","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4269\/ajtmh.2006.75.973","article-title":"Review of reported cholera outbreaks worldwide, 1995\u20132005","volume":"75","author":"Griffith","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.lfs.2012.05.001_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1085\/jgp.200910339","article-title":"Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion","volume":"135","author":"Hoque","year":"2010","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-5793(97)00405-5","article-title":"Xanthones as antimalarial agents; studies of a possible mode of action","volume":"409","author":"Ignatushchenko","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.lfs.2012.05.001_bb0065","doi-asserted-by":"crossref","first-page":"C1838","DOI":"10.1152\/ajpcell.2000.279.6.C1838","article-title":"Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin","volume":"279","author":"Illek","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0070","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1016\/j.bmc.2006.04.014","article-title":"Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors","volume":"14","author":"Liu","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.lfs.2012.05.001_bb0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1254\/jphs.11153FP","article-title":"Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease","volume":"118","author":"Muanprasat","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.lfs.2012.05.001_bb0080","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1211\/jpp.61.06.0002","article-title":"Recent cancer drug development with xanthone structures","volume":"61","author":"Na","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0085","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ptr.2730","article-title":"Garcinia mangostana L.: a phytochemical and pharmacological review","volume":"23","author":"Obolskiy","year":"2009","journal-title":"Phytother Res"},{"key":"10.1016\/j.lfs.2012.05.001_bb0090","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.fct.2008.07.024","article-title":"Medicinal properties of mangosteen (Garcinia mangostana)","volume":"46","author":"Pedraza-Chaverri","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0140-6736(03)15328-7","article-title":"Cholera","volume":"363","author":"Sack","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2012.05.001_bb0100","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1093\/jn\/135.10.2320","article-title":"Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia","volume":"135","author":"Schuier","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.lfs.2012.05.001_bb0105","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.coph.2003.06.012","article-title":"CFTR pharmacology and its role in intestinal fluid secretion","volume":"3","author":"Thiagarajah","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.lfs.2012.05.001_bb0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2005.02.003","article-title":"New drug targets for cholera therapy","volume":"26","author":"Thiagarajah","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.lfs.2012.05.001_bb0115","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/10408391003698677","article-title":"Polyphenols and human health: a prospectus","volume":"51","author":"Visioli","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.lfs.2012.05.001_bb0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lfs.2007.10.014","article-title":"Mechanisms of the vasorelaxant effect of 1,5-dihydroxy-2,3-dimethoxy-xanthone, an active metabolite of 1-hydroxy-2,3,5-trimethoxy-xanthone isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery","volume":"82","author":"Wang","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2012.05.001_bb0125","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11095-009-0040-y","article-title":"A plant-derived hydrolysable tannin inhibits CFTR chloride channel: a potential treatment of diarrhea","volume":"27","author":"Wongsamitkul","year":"2010","journal-title":"Pharm Res"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320512002585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320512002585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:10:10Z","timestamp":1758399010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320512002585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":25,"journal-issue":{"issue":"25-26","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0024320512002585"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2012.05.001","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxyxanthone as an inhibitor of cAMP-activated apical chloride channel in human intestinal epithelial cell","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2012.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}