{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:06Z","timestamp":1788872346397,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":360,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"FAPESP (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["03\/13502-2"],"award-info":[{"award-number":["03\/13502-2"]}]},{"name":"CNPq (INCTTox)"},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.lfs.2012.06.029","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T02:28:32Z","timestamp":1341455312000},"page":"230-236","source":"Crossref","is-referenced-by-count":13,"title":["Effects of a toxin isolated from Tityus bahiensis scorpion venom on the hippocampus of rats"],"prefix":"10.1016","volume":"91","author":[{"given":"Luciene ToshieTakeishi","family":"Ossanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geane Antiques","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Leonor A.","family":"Nencioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Lebrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Yamanouye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valquiria Abr\u00e3o Coronado","family":"Dorce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2012.06.029_bb0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2004.05.009","article-title":"Lung compliance, plasma electrolyte levels and acid\u2013base balance are affected by scorpion envenomation in anesthetized rats under mechanical ventilation","volume":"138","author":"Andrade","year":"2004","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0010","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0041-0101(89)90102-5","article-title":"A simplified procedure for the fraction of Tityus serrulatus venom: isolation and partial characterization of TsTx-IV, a new neurotoxin","volume":"27","author":"Arantes","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1590\/S1678-91992008000200010","article-title":"Embryotoxic effects of maternal exposure to Tityu serrulatus scorpion venom","volume":"14","author":"Bar\u00e3o","year":"2008","journal-title":"J Venomous Anim Toxins Incl Trop Dis"},{"key":"10.1016\/j.lfs.2012.06.029_bb0020","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/bj3130753","article-title":"Toxic peptides and genes encoding toxin \u03b3 of the Brazilian scorpions Tityus bahiensis and Tityus serrulatus","volume":"313","author":"Becerril","year":"1996","journal-title":"Biochem J"},{"key":"10.1016\/j.lfs.2012.06.029_bb0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0041-0101(96)00198-5","article-title":"Toxins and genes isolated from scorpions of the genus Tityus","volume":"35","author":"Becerril","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0030","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0041-0101(02)00391-4","article-title":"Effect of Tityus serrulatus scorpion venom and its major toxin, TsTX-I, on the complement system in vivo","volume":"41","author":"Bertazzi","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0091-3057(97)00407-3","article-title":"Behavioral, electroencephalographic, and histopathologic effects of a neuropeptide isolated from Tityus serrulatus scorpion venom in rats","volume":"60","author":"Carvalho","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.lfs.2012.06.029_bb0040","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1590\/S0104-79302000000200008","article-title":"Convulsive effects of some isolated fractions of Tityus serrulatus scorpion venom: behavioral, electroencephalographic and neuropathological aspects","volume":"6","author":"Carvalho","year":"2000","journal-title":"J Venomous Anim Toxins"},{"key":"10.1016\/j.lfs.2012.06.029_bb0045","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.lfs.2012.06.029_bb0050","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","article-title":"Glutamate neurotoxicity and disease of the nervous system","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2012.06.029_bb0055","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2174\/092986609788923329","article-title":"Tityus serrulatus scorpion venom and toxins: an overview","volume":"16","author":"Cologna","year":"2009","journal-title":"Protein Pept Lett"},{"key":"10.1016\/j.lfs.2012.06.029_bb0060","first-page":"519","article-title":"Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus","volume":"144","author":"Concei\u00e7\u00e3o","year":"2005","journal-title":"J Pharmacol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0065","series-title":"Handbook of natural toxins: insect poisons, allergens and other invertebrate venoms","first-page":"659","article-title":"Mechanism of action of scorpion toxins","author":"Couraud","year":"1984"},{"key":"10.1016\/j.lfs.2012.06.029_bb0070","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1471-4159.1980.tb03691.x","article-title":"The effects of scorpion venom toxin on the release of amino acid neurotransmitters from cerebral cortex in vivo and in vitro","volume":"35","author":"Coutinho-Netto","year":"1980","journal-title":"J Neurochem"},{"key":"10.1016\/j.lfs.2012.06.029_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2008.04.011","article-title":"Reproductive toxic effects of Tityus serrulatus scorpion venom in rats","volume":"25","author":"Cruttenden","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0024-3205(94)00583-4","article-title":"Amino acid receptors: a gallery of new targets for pharmacological intervention","volume":"54","author":"Cunningham","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2012.06.029_bb0085","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/0041-0101(94)90322-0","article-title":"Effects of Tityus serrulatus crude venom on the GABAergic and dopaminergic systems of the rat brain","volume":"32","author":"Dorce","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0090","series-title":"Neurotransmitters and epilepsy","first-page":"131","article-title":"Glutamate and epilepsy","author":"Fisher","year":"1991"},{"key":"10.1016\/j.lfs.2012.06.029_bb0095","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0041-0101(96)00093-1","article-title":"Action of new world scorpion venom and its neurotoxins in secretion","volume":"34","author":"Fletcher","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0100","series-title":"Natural toxins \u2014 characterization, pharmacology and therapeutics","first-page":"139","article-title":"Pathophysiology and treatment of scorpion poisoning","author":"Freire-Maia","year":"1989"},{"key":"10.1016\/j.lfs.2012.06.029_bb0105","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.taap.2003.12.026","article-title":"The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting","volume":"196","author":"Fukuhara","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejphar.2006.06.022","article-title":"New targets for pharmacological intervention in the glutamatergic synapse","volume":"545","author":"Gardoni","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0306-4522(95)00130-B","article-title":"Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro","volume":"67","author":"Gerfin-Moser","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2012.06.029_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0041-0101(01)00202-1","article-title":"Neurotoxic effects of fractions isolated from Tityus bahiensis scorpion venom (Perty, 1984)","volume":"40","author":"Louren\u00e7o","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0125","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0028-3908(98)00025-2","article-title":"Alpha- and beta-scorpion toxins evoke glutamate release from rat cortical synaptosomes with different effects on [Na+]i and [Ca2+]i","volume":"37","author":"Massensini","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2012.06.029_bb0130","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1034\/j.1600-0773.2000.d01-28.x","article-title":"Neurotoxic effects of three fractions isolated from Tityus serrulatus scorpion venom","volume":"86","author":"Nencioni","year":"2000","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0091-3057(02)01025-0","article-title":"A microdialysis study of glutamate concentration in the hippocampus of rats after TsTX toxin injection and blockade of toxin effects by glutamate receptor antagonists","volume":"74","author":"Nencioni","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.lfs.2012.06.029_bb0140","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neulet.2009.08.006","article-title":"Central effects of Tityus serrulatus and Tityus bahiensis scorpion venoms after intraperitoneal injection in rats","volume":"463","author":"Nencioni","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.lfs.2012.06.029_bb0145","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0041-0101(94)90377-8","article-title":"Antigenic cross-reactivity among the venoms from several species of Brazilian scorpions","volume":"32","author":"Nishikawa","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0150","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.lfs.2012.06.029_bb0155","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0041-0101(00)00240-3","article-title":"Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae)","volume":"39","author":"Pimenta","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0160","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/S0021-9258(18)49971-1","article-title":"Discharge effects on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom","volume":"266","author":"Possani","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.lfs.2012.06.029_bb0165","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0041-0101(96)00074-8","article-title":"Body distribution of Tityus serrulatus scorpion venom in mice and effects of scorpion antivenom","volume":"34","author":"Revelo","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0170","first-page":"1255","article-title":"TsTX-VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from brain synaptosomes not blocked by tetrodotoxin","volume":"41","author":"Sampaio","year":"1997","journal-title":"Biochem Mol Biol Int"},{"key":"10.1016\/j.lfs.2012.06.029_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10753-008-9102-2","article-title":"Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms","volume":"32","author":"Severino","year":"2009","journal-title":"Inflammation"},{"key":"10.1016\/j.lfs.2012.06.029_bb0180","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.toxicon.2007.11.010","article-title":"Positively selected sites of scorpion depressant toxins: possible roles in toxin functional divergence","volume":"51","author":"Tian","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2012.06.029_bb0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0300-9629(95)00096-P","article-title":"Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons","volume":"112","author":"Trequattrini","year":"1995","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.lfs.2012.06.029_bb0190","first-page":"311","article-title":"The influence of hyperactivity of the hypothalamic pituitary\u2013adrenal axis and hyperglycemia on the 5HT2A receptor-mediated wet dog shake responses in rats","volume":"61","author":"Umeda","year":"2007","journal-title":"Acta Med Okayama"},{"key":"10.1016\/j.lfs.2012.06.029_bb0195","series-title":"Neurotransmitters and epilepsy","first-page":"17","article-title":"Mechanisms of neurotransmitter receptor actions","author":"Vornov","year":"1991"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320512003372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320512003372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:49:32Z","timestamp":1642639772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320512003372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":39,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0024320512003372"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2012.06.029","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}