{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:01:07Z","timestamp":1783472467592,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"24-26","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Instituto de Investiga\u00e7\u00e3o Interdisciplinar da Universidade de Coimbra","award":["III\/34\/2008"],"award-info":[{"award-number":["III\/34\/2008"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["PTDC\/AGR-ALI\/108326\/2008"],"award-info":[{"award-number":["PTDC\/AGR-ALI\/108326\/2008"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["PEst-C\/SAU\/LA0001\/2011"],"award-info":[{"award-number":["PEst-C\/SAU\/LA0001\/2011"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["SFRH\/BPD\/34711\/2007"],"award-info":[{"award-number":["SFRH\/BPD\/34711\/2007"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["SFRH\/BD\/76086\/2011"],"award-info":[{"award-number":["SFRH\/BD\/76086\/2011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.lfs.2013.04.016","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T19:00:25Z","timestamp":1368471625000},"page":"1157-1164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria"],"prefix":"10.1016","volume":"92","author":[{"given":"Teresa","family":"Cunha-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina R.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2013.04.016_bb0005","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1016039604958","article-title":"The quantitative measurement of H2O2 generation in isolated mitochondria","volume":"34","author":"Barja","year":"2002","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.lfs.2013.04.016_bb0010","series-title":"Disposition of toxic drugs & chemicals in man","author":"Baselt","year":"2000"},{"key":"10.1016\/j.lfs.2013.04.016_bb0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1196\/annals.1369.061","article-title":"Nitric oxide and oxidative stress in the brain of rats exposed in utero to cocaine","volume":"1074","author":"Bashkatova","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.lfs.2013.04.016_bb0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tice.2010.06.001","article-title":"Morphine sulphate induced histopathological and histochemical changes in the rat liver","volume":"42","author":"Bekheet","year":"2010","journal-title":"Tissue Cell"},{"issue":"5","key":"10.1016\/j.lfs.2013.04.016_bb0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0006-2952(00)00355-5","article-title":"Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species","volume":"60","author":"Boess","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.lfs.2013.04.016_bb0030","first-page":"65","article-title":"The respiratory chain and oxidative phosphorylation","volume":"17","author":"Chance","year":"1956","journal-title":"Adv Enzymol Relat Subj Biochem"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0035","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2006.03.061","article-title":"Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine","volume":"1089","author":"Cunha-Oliveira","year":"2006","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0050","first-page":"21","article-title":"Chronic effects of heroin and hydrogen peroxide in PC12 cells","volume":"2","author":"Cunha-Oliveira","year":"2006","journal-title":"Coimbra Med"},{"issue":"2","key":"10.1016\/j.lfs.2013.04.016_bb0040","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1471-4159.2006.04406.x","article-title":"Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons","volume":"101","author":"Cunha-Oliveira","year":"2007","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0055","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainresrev.2008.03.002","article-title":"Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs","volume":"58","author":"Cunha-Oliveira","year":"2008","journal-title":"Brain Res Rev"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2010.06.009","article-title":"Neurotoxicity of heroin\u2013cocaine combinations in rat cortical neurons","volume":"276","author":"Cunha-Oliveira","year":"2010","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/taap.1998.8510","article-title":"Tamoxifen inhibits induction of the mitochondrial permeability transition by Ca2+ and inorganic phosphate","volume":"152","author":"Custodio","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"issue":"11","key":"10.1016\/j.lfs.2013.04.016_bb0065","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0024-3205(97)00013-1","article-title":"Impairment of mitochondrial respiration and electron transport chain enzymes during cocaine-induced hepatic injury","volume":"60","author":"Devi","year":"1997","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2013.04.016_bb0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1196\/annals.1316.042","article-title":"Cocaine downregulates the expression of the mitochondrial genome in rat brain","volume":"1025","author":"Dietrich","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.lfs.2013.04.016_bb0070","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.neuropharm.2005.01.018","article-title":"Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures","volume":"48","author":"Dietrich","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2013.04.016_bb0080","series-title":"Membranes of mitochondria and chloroplasts","first-page":"172","author":"Estabrook","year":"1967"},{"key":"10.1016\/j.lfs.2013.04.016_bb0085","series-title":"Polydrug use: patterns and responses","author":"European Monitoring Center for Drugs and Drug Addiction","year":"2009"},{"key":"10.1016\/j.lfs.2013.04.016_bb0090","series-title":"The state of the drugs problem in Europe","article-title":"Annual report 2012","author":"European Monitoring Center for Drugs and Drug Addiction","year":"2012"},{"issue":"13\u201314","key":"10.1016\/j.lfs.2013.04.016_bb0095","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.lfs.2008.01.004","article-title":"Endomorphins and morphine limit anoxia\u2013reoxygenation-induced brain mitochondrial dysfunction in the mouse","volume":"82","author":"Feng","year":"2008","journal-title":"Life Sci"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2013.04.016_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-007-9645-9","article-title":"Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria","volume":"309","author":"Fernandes","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.lfs.2013.04.016_bb0105","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-007-1375-z","article-title":"Spectroscopic and electrochemical studies of cocaine-opioid interactions","author":"Garrido","year":"2007","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.lfs.2013.04.016_bb0110","series-title":"A laboratory manual on transport and bioenergetics","first-page":"62","article-title":"Membrane biochemistry","author":"Gazzotti","year":"1979"},{"issue":"2","key":"10.1016\/j.lfs.2013.04.016_bb0115","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0120","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1046\/j.1471-4159.2001.t01-1-00227.x","article-title":"Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss","volume":"77","author":"Grunblatt","year":"2001","journal-title":"J Neurochem"},{"issue":"4","key":"10.1016\/j.lfs.2013.04.016_bb0125","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11064-006-9053-7","article-title":"Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain","volume":"31","author":"Guzman","year":"2006","journal-title":"Neurochem Res"},{"issue":"9","key":"10.1016\/j.lfs.2013.04.016_bb0130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/1874143600802010070","article-title":"Mechanisms of acute cocaine toxicity","volume":"2","author":"Heard","year":"2008","journal-title":"Open Pharmacol J"},{"issue":"3","key":"10.1016\/j.lfs.2013.04.016_bb0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0740-5472(02)00250-7","article-title":"Adolescent heroin use: a review of the descriptive and treatment literature","volume":"23","author":"Hopfer","year":"2002","journal-title":"J Subst Abuse Treat"},{"issue":"5","key":"10.1016\/j.lfs.2013.04.016_bb0140","first-page":"175","article-title":"Effect of N-stearoylethanolamine on the lipid peroxidation process and lipid composition of the rat liver in acute morphine intoxication","volume":"79","author":"Horid'ko","year":"2007","journal-title":"Ukr Biokhim Zh"},{"issue":"2","key":"10.1016\/j.lfs.2013.04.016_bb0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01868720","article-title":"Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state","volume":"49","author":"Kamo","year":"1979","journal-title":"J Membr Biol"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.tpj.6500146","article-title":"Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse","volume":"3","author":"Lehrmann","year":"2003","journal-title":"Pharmacogenomics J"},{"issue":"3","key":"10.1016\/j.lfs.2013.04.016_bb0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0024-3205(92)90274-S","article-title":"Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice","volume":"50","author":"Leon-Velarde","year":"1992","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1046\/j.1360-0443.2003.00236.x","article-title":"Understanding polydrug use: review of heroin and cocaine co-use","volume":"98","author":"Leri","year":"2003","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.lfs.2013.04.016_bb0165","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0006-291X(75)90128-X","article-title":"A rapid and ultrasensitive method to measure Ca++ movements across biological membranes","volume":"64","author":"Madeira","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.lfs.2013.04.016_bb0170","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0006-291X(74)80228-7","article-title":"Activation energies of the ATPase activity of sarcoplasmic reticulum","volume":"58","author":"Madeira","year":"1974","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.lfs.2013.04.016_bb0175","first-page":"190","article-title":"Effect of chronic morphine treatment on free radical state","volume":"53","author":"Miskevich","year":"2007","journal-title":"Biomed Khim"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-2952(03)00246-6","article-title":"Cocaine-protein targets in mouse liver","volume":"66","author":"Ndikum-Moffor","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"9566","key":"10.1016\/j.lfs.2013.04.016_bb0185","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0140-6736(07)60464-4","article-title":"Development of a rational scale to assess the harm of drugs of potential misuse","volume":"369","author":"Nutt","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.lfs.2013.04.016_bb0190","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/dmrr.200","article-title":"Brain and liver mitochondria isolated from diabetic Goto\u2013Kakizaki rats show different susceptibility to induced oxidative stress","volume":"17","author":"Santos","year":"2001","journal-title":"Diabetes Metab Res Rev"},{"issue":"6","key":"10.1016\/j.lfs.2013.04.016_bb0195","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0896-6273(90)90339-H","article-title":"Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action","volume":"5","author":"Sulzer","year":"1990","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.lfs.2013.04.016_bb0200","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1038\/npp.2011.143","article-title":"Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity","volume":"36","author":"Uys","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lfs.2013.04.016_bb0205","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4899-1648-8_16","article-title":"Hepatotoxicity associated with cocaine abuse","volume":"10","author":"Van Thiel","year":"1992","journal-title":"Recent Dev Alcohol"},{"issue":"5","key":"10.1016\/j.lfs.2013.04.016_bb0210","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.freeradbiomed.2010.05.024","article-title":"Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction: prevention by the targeted antioxidant MitoQ","volume":"49","author":"Vergeade","year":"2010","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10.1016\/j.lfs.2013.04.016_bb0215","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1523\/JNEUROSCI.1371-12.2013","article-title":"Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence","volume":"33","author":"Wong","year":"2013","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.lfs.2013.04.016_bb0220","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1081\/DCT-100100119","article-title":"Effect of cocaine on mitochondrial electron transport chain evaluated in primary cultures of neonatal rat myocardial cells and in isolated mitochondrial preparations","volume":"23","author":"Yuan","year":"2000","journal-title":"Drug Chem Toxicol"},{"issue":"1","key":"10.1016\/j.lfs.2013.04.016_bb9000","first-page":"8","article-title":"Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway","volume":"292","author":"Xiao","year":"2000","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432051300266X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432051300266X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T22:57:31Z","timestamp":1645052251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432051300266X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":45,"journal-issue":{"issue":"24-26","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S002432051300266X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2013.04.016","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2013.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}