{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:04:52Z","timestamp":1761581092026,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"24-26","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23592319","23\u00b701705"],"award-info":[{"award-number":["23592319","23\u00b701705"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.lfs.2013.05.004","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T07:49:26Z","timestamp":1368863366000},"page":"1202-1207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats"],"prefix":"10.1016","volume":"92","author":[{"given":"Hiromi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsunori","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Sugimachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2013.05.004_bb0005","doi-asserted-by":"crossref","first-page":"R161","DOI":"10.1152\/ajpregu.00609.2003","article-title":"Effects of Ca2+ channel antagonists on acetylcholine and catecholamine releases in the in vivo rat adrenal medulla","volume":"287","author":"Akiyama","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0010","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0022-3565(24)36515-2","article-title":"Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons","volume":"280","author":"Fujii","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.lfs.2013.05.004_bb0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3565(24)35127-4","article-title":"Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes","volume":"291","author":"Furukawa","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"year":"2002","series-title":"Primer of biostatistics","author":"Glantz","key":"10.1016\/j.lfs.2013.05.004_bb0020"},{"key":"10.1016\/j.lfs.2013.05.004_bb0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1113\/jphysiol.2005.086512","article-title":"Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits","volume":"566","author":"Kamiya","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0030","doi-asserted-by":"crossref","first-page":"H2187","DOI":"10.1152\/ajpheart.00175.2006","article-title":"Effects of Ca2+ channel antagonists on nerve stimulation-induced and ischemia-induced myocardial interstitial acetylcholine release in cats","volume":"291","author":"Kawada","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12576-009-0055-5","article-title":"High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats","volume":"59","author":"Kawada","year":"2009","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.lfs.2013.05.004_bb0040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12576-010-0096-9","article-title":"Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction","volume":"60","author":"Kawada","year":"2010","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.lfs.2013.05.004_bb0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000169528","article-title":"A mathematical model to assess changes in the baroreceptor reflex","volume":"57","author":"Kent","year":"1972","journal-title":"Cardiology"},{"key":"10.1016\/j.lfs.2013.05.004_bb0050","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1248\/bpb.32.1695","article-title":"Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker","volume":"32","author":"Koganei","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.lfs.2013.05.004_bb0055","doi-asserted-by":"crossref","first-page":"97S","DOI":"10.1016\/0895-7061(96)87762-4","article-title":"Clinical relevance of 24h blood pressure control by 1,4-dihydropyridines","volume":"9","author":"Leenen","year":"1996","journal-title":"Am J Hypertens"},{"year":"2006","series-title":"Cardiovascular physiology, 6th ed","author":"Mohrman","key":"10.1016\/j.lfs.2013.05.004_bb0060"},{"key":"10.1016\/j.lfs.2013.05.004_bb0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0895-7061(95)00350-9","article-title":"Relevance of 24h blood pressure profile and sympathetic activity for outcome on short- versus long-acting 1,4-dihydropyridines","volume":"9","author":"Ruzicka","year":"1996","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.lfs.2013.05.004_bb0070","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0006-2952(03)00002-9","article-title":"Multidisciplinary utilization of dimethyl sulfoxide:pharmacological, cellular, and molecular aspects","volume":"65","author":"Santos","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0075","first-page":"H2251","article-title":"New analytic framework for understanding sympathetic baroreflex control of arterial pressure","volume":"276","author":"Sato","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0080","first-page":"H326","article-title":"New simple methods for isolating baroreceptor regions of carotid sinus and aortic depressor nerves in rats","volume":"276","author":"Sato","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0085","first-page":"H300","article-title":"New technique to completely isolate carotid sinus baroreceptor regions in rats","volume":"260","author":"Shoukas","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000123167","article-title":"The circumventricular organs and the central actions of angiotensin","volume":"32","author":"Simpson","year":"1981","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.lfs.2013.05.004_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-2999(01)01521-7","article-title":"Antisympathetic and hemodynamic property of a dual L\/N-type Ca2+ channel blocker cilnidipine in rats","volume":"434","author":"Takahara","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0100","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1291\/hypres.26.743","article-title":"Neuronal Ca2+ channel blocking action of an antihypertensive drug, cilnidipine, in IMR-32 human neuroblastoma cells","volume":"26","author":"Takahara","year":"2003","journal-title":"Hypertens Res"},{"key":"10.1016\/j.lfs.2013.05.004_bb0105","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1248\/bpb.27.1388","article-title":"Neuroprotective effects of a dual L\/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model","volume":"27","author":"Takahara","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.lfs.2013.05.004_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.bjp.0701342","article-title":"Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones","volume":"122","author":"Uneyama","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(99)00237-X","article-title":"Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels","volume":"373","author":"Uneyama","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0120","doi-asserted-by":"crossref","first-page":"H1382","DOI":"10.1152\/ajpheart.00801.2003","article-title":"Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc","volume":"286","author":"Yamamoto","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.lfs.2013.05.004_bb0125","first-page":"H1182","article-title":"A new, concise dialysis approach to assessment of cardiac sympathetic nerve terminal abnormalities","volume":"272","author":"Yamazaki","year":"1997","journal-title":"Am J Physiol"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513002695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513002695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:11:33Z","timestamp":1758399093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320513002695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":25,"journal-issue":{"issue":"24-26","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0024320513002695"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2013.05.004","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2013.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}