{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:59:17Z","timestamp":1772852357986,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"15","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.lfs.2013.07.027","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T16:16:29Z","timestamp":1375978589000},"page":"516-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC\/Nga mice"],"prefix":"10.1016","volume":"93","author":[{"given":"Tae-Ho","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gun-Dong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Je","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Seek","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheung-Seog","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.lfs.2013.07.027_bb0005","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1096\/fj.02-1070com","article-title":"T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory\/effector Th1 cells","volume":"17","author":"Akdis","year":"2003","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.lfs.2013.07.027_bb0015","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1158\/0008-5472.CAN-08-3393","article-title":"Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis","volume":"69","author":"Du","year":"2009","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbrc.2010.05.065","article-title":"A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression","volume":"397","author":"Fang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"84","key":"10.1016\/j.lfs.2013.07.027_bb0025","first-page":"602","article-title":"Atopic dermatitis as an actual problem of modern allergology","volume":"14","author":"Fedenko","year":"2003","journal-title":"Pol Merkur Lekarski"},{"issue":"10","key":"10.1016\/j.lfs.2013.07.027_bb0030","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/carcin\/10.10.1953","article-title":"Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N\u2032-nitro-N-nitrosoguanidine","volume":"10","author":"Francis","year":"1989","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.lfs.2013.07.027_bb0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0891-5849(00)00481-0","article-title":"Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation","volume":"30","author":"Galati","year":"2001","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/1566524033361564","article-title":"Atopic dermatitis: molecular mechanisms, clinical aspects and new therapeutical approaches","volume":"3","author":"Galli","year":"2003","journal-title":"Curr Mol Med"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"issue":"1 Suppl. 1","key":"10.1016\/j.lfs.2013.07.027_bb0050","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jaad.2005.04.026","article-title":"Therapeutic options in the treatment of psoriasis and atopic dermatitis","volume":"53","author":"Gottlieb","year":"2005","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-0625.2011.01412.x","article-title":"IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion","volume":"21","author":"Gutowska-Owsiak","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.lfs.2013.07.027_bb9000","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.lfs.2004.07.022","article-title":"Scratching of their skin by NC\/Nga mice leads to development of dermatitis","volume":"76","author":"Hashimoto","year":"2004","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaci.2006.03.047","article-title":"Cytokines and chemokines orchestrate atopic skin inflammation","volume":"118","author":"Homey","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0065","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2332\/allergolint.09-OA-0118","article-title":"Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells","volume":"59","author":"Iwamura","year":"2010","journal-title":"Allergol Int"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"6","key":"10.1016\/j.lfs.2013.07.027_bb0080","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(01)00159-5","article-title":"Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival","volume":"14","author":"Kalesnikoff","year":"2001","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.lfs.2013.07.027_bb0085","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1600-0625.2008.00737.x","article-title":"Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC\/Nga mice","volume":"17","author":"Kang","year":"2008","journal-title":"Exp Dermatol"},{"issue":"3","key":"10.1016\/j.lfs.2013.07.027_bb0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jep.2008.12.029","article-title":"Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC\/Nga mice","volume":"122","author":"Kim","year":"2009","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.lfs.2013.07.027_bb0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-079X.2009.00718.x","article-title":"Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC\/Nga mice","volume":"47","author":"Kim","year":"2009","journal-title":"J Pineal Res"},{"issue":"12","key":"10.1016\/j.lfs.2013.07.027_bb0100","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/intimm\/dxl113","article-title":"IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells","volume":"18","author":"Kitawaki","year":"2006","journal-title":"Int Immunol"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1207\/S15327914NC381_16","article-title":"Flavonoids suppress androgen-independent human prostate tumor proliferation","volume":"38","author":"Knowles","year":"2000","journal-title":"Nutr Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2013.07.027_bb0115","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1006\/bbrc.2001.5001","article-title":"Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits","volume":"284","author":"Lee","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.lfs.2013.07.027_bb0110","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1365-2133.2006.07191.x","article-title":"Transepidermal water loss, serum IgE and beta-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis","volume":"154","author":"Lee","year":"2006","journal-title":"Br J Dermatol"},{"issue":"8","key":"10.1016\/j.lfs.2013.07.027_bb0120","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1248\/bpb.30.1468","article-title":"Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC\/Nga mice","volume":"30","author":"Lee","year":"2007","journal-title":"Biol Pharm Bull"},{"issue":"5","key":"10.1016\/j.lfs.2013.07.027_bb0125","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1067\/mai.2000.106484","article-title":"Atopic dermatitis: new insights and opportunities for therapeutic intervention","volume":"105","author":"Leung","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1398-9995.2003.23790.x","article-title":"A mouse model of the atopic eczema\/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae","volume":"58","author":"Matsuoka","year":"2003","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2133.2004.06036.x","article-title":"Vital role of the itch-scratch response in development of spontaneous dermatitis in NC\/Nga mice","volume":"151","author":"Mihara","year":"2004","journal-title":"Br J Dermatol"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2013.07.027_bb0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2011.09.163","article-title":"Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells","volume":"671","author":"Moon","year":"2011","journal-title":"Eur J Pharmacol"},{"issue":"6 Suppl.","key":"10.1016\/j.lfs.2013.07.027_bb0145","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1016\/j.jaci.2003.09.032","article-title":"Immune mechanisms leading to atopic dermatitis","volume":"112","author":"Novak","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.lfs.2013.07.027_bb0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-2776(09)01203-6","article-title":"Cellular and molecular mechanisms in atopic dermatitis","volume":"102","author":"Oyoshi","year":"2009","journal-title":"Adv Immunol"},{"issue":"4","key":"10.1016\/j.lfs.2013.07.027_bb0155","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jaci.2012.12.1566","article-title":"Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin","volume":"131","author":"Pellerin","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.lfs.2013.07.027_bb0160","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0952-7915(01)00282-5","article-title":"Why are allergies increasing?","volume":"13","author":"Ring","year":"2001","journal-title":"Curr Opin Immunol"},{"issue":"9","key":"10.1016\/j.lfs.2013.07.027_bb0165","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1139\/Y09-065","article-title":"Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-kappaB activity in a murine model of asthma","volume":"87","author":"Shi","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"10.1016\/j.lfs.2013.07.027_bb0170","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.rvsc.2009.11.011","article-title":"Augmentation of CCL17 and CCL28 gene expression by TNF-alpha, IL-1beta, or IFN-gamma in cultured canine keratinocytes","volume":"88","author":"Shibata","year":"2010","journal-title":"Res Vet Sci"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2004.02.013","article-title":"Animal models for atopic dermatitis: are they relevant to human disease?","volume":"36","author":"Shiohara","year":"2004","journal-title":"J Dermatol Sci"},{"issue":"2","key":"10.1016\/j.lfs.2013.07.027_bb0180","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(96)04557-0","article-title":"Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen","volume":"112","author":"So","year":"1997","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.lfs.2013.07.027_bb0185","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1172\/JCI5669","article-title":"Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis","volume":"103","author":"Spergel","year":"1999","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.lfs.2013.07.027_bb0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.phymed.2005.01.016","article-title":"Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: comparison between subclasses of flavonoids","volume":"13","author":"Takano-Ishikawa","year":"2006","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.lfs.2013.07.027_bb0195","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1001\/archderm.1994.01690110059007","article-title":"IgE-mediated hypersensitivity and contact sensitivity to multiple environmental allergens in atopic dermatitis","volume":"130","author":"Tanaka","year":"1994","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0022-202X.2004.23516.x","article-title":"Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC\/Nga mice in specific-pathogen-free condition","volume":"124","author":"Tomimori","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.lfs.2013.07.027_bb0205","first-page":"8","article-title":"TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery","volume":"62","author":"Yun","year":"2011","journal-title":"J Dermatol Sci"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513004426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513004426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T02:57:39Z","timestamp":1539485859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320513004426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":42,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0024320513004426"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2013.07.027","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC\/Nga mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2013.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}