{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:33Z","timestamp":1790717073525,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.lfs.2013.12.030","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T15:45:56Z","timestamp":1388850356000},"page":"145-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart"],"prefix":"10.1016","volume":"97","author":[{"given":"Xueping","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sagave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkady","family":"Rutkovskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Baysa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e5le","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Czibik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen Peder","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarle","family":"Vaage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guro","family":"Valen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2013.12.030_bb0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","article-title":"Genetic analysis of the mammalian transforming growth factor-beta superfamily","volume":"23","author":"Chang","year":"2002","journal-title":"Endocr Rev"},{"issue":"7","key":"10.1016\/j.lfs.2013.12.030_bb0010","first-page":"903","article-title":"Re-analysis of expression profiles for revealing new potential candidate genes of heart failure","volume":"17","author":"Chen","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.lfs.2013.12.030_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290146","article-title":"Hypertrophic cardiomyopathy: from gene defect to clinical disease","volume":"13","author":"Chung","year":"2003","journal-title":"Cell Res"},{"issue":"6","key":"10.1016\/j.lfs.2013.12.030_bb0020","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.lfs.2013.12.030_bb0025","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1378\/chest.08-1341","article-title":"Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor","volume":"134","author":"Davies","year":"2008","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.lfs.2013.12.030_bb0030","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of fetal gene expression in heart failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"10.1016\/j.lfs.2013.12.030_bb0035","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.cellsig.2011.04.004","article-title":"Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling","volume":"23","author":"Ehrlich","year":"2011","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.lfs.2013.12.030_bb0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cardiores.2005.07.007","article-title":"The complex pattern of SMAD signaling in the cardiovascular system","volume":"69","author":"Euler-Taimor","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"Suppl. 2","key":"10.1016\/j.lfs.2013.12.030_bb0045","first-page":"S14","article-title":"Pathophysiology of congestive heart failure","volume":"4","author":"Francis","year":"2003","journal-title":"Rev Cardiovasc Med"},{"issue":"19","key":"10.1016\/j.lfs.2013.12.030_bb0050","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1101\/gad.1124803","article-title":"An essential role of Bmp4 in the atrioventricular septation of the mouse heart","volume":"17","author":"Jiao","year":"2003","journal-title":"Genes Dev"},{"issue":"8","key":"10.1016\/j.lfs.2013.12.030_bb0055","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1161\/01.CIR.103.8.1089","article-title":"Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression","volume":"103","author":"Kinugawa","year":"2001","journal-title":"Circulation"},{"issue":"47","key":"10.1016\/j.lfs.2013.12.030_bb0060","doi-asserted-by":"crossref","first-page":"18531","DOI":"10.1073\/pnas.0703113104","article-title":"Distinct roles of Wnt\/beta-catenin and Bmp signaling during early cardiogenesis","volume":"104","author":"Klaus","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.lfs.2013.12.030_bb0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00395-012-0323-z","article-title":"Activation of liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia\u2013reperfusion injury","volume":"108","author":"Lei","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"10.1016\/j.lfs.2013.12.030_bb0070","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s11033-009-9743-8","article-title":"Characterization and expression of bone morphogenetic protein 4 gene in postnatal pigs","volume":"37","author":"Li","year":"2010","journal-title":"Mol Biol Rep"},{"issue":"6","key":"10.1016\/j.lfs.2013.12.030_bb0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1513\/pats.201002-024AW","article-title":"Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension","volume":"7","author":"Li","year":"2010","journal-title":"Proc Am Thorac Soc"},{"issue":"24","key":"10.1016\/j.lfs.2013.12.030_bb0080","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1242\/dev.02156","article-title":"Bmp2 is essential for cardiac cushion epithelial\u2013mesenchymal transition and myocardial patterning","volume":"132","author":"Ma","year":"2005","journal-title":"Development"},{"issue":"21","key":"10.1016\/j.lfs.2013.12.030_bb0085","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1161\/CIRCULATIONAHA.104.490946","article-title":"Smad1 protects cardiomyocytes from ischemia\u2013reperfusion injury","volume":"111","author":"Masaki","year":"2005","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.lfs.2013.12.030_bb0090","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1002\/dvdy.21743","article-title":"BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development","volume":"237","author":"McCulley","year":"2008","journal-title":"Dev Dyn"},{"issue":"6 Pt 2","key":"10.1016\/j.lfs.2013.12.030_bb0095","first-page":"H2147","article-title":"Myocardial ischemia and reperfusion: a murine model","volume":"269","author":"Michael","year":"1995","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.lfs.2013.12.030_bb0100","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cytogfr.2005.01.009","article-title":"BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk","volume":"16","author":"Miyazono","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"issue":"14","key":"10.1016\/j.lfs.2013.12.030_bb0105","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.112.115089","article-title":"Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models","volume":"126","author":"Ogura","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.lfs.2013.12.030_bb0110","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.yjmcc.2010.01.010","article-title":"Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway","volume":"48","author":"Pachori","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.lfs.2013.12.030_bb9000","series-title":"R: A Language and Environment for Statistical Computing","author":"R.D.C. Team","year":"2009"},{"issue":"2","key":"10.1016\/j.lfs.2013.12.030_bb0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1101\/gad.327005","article-title":"Distinct functions of junD in cardiac hypertrophy and heart failure","volume":"19","author":"Ricci","year":"2005","journal-title":"Genes Dev"},{"issue":"1","key":"10.1016\/j.lfs.2013.12.030_bb0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2012.07.052","article-title":"Transient hyperosmolality modulates expression of cardiac aquaporins","volume":"425","author":"Rutkovskiy","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.lfs.2013.12.030_bb0125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00395-007-0644-5","article-title":"Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases","volume":"102","author":"Ruusalepp","year":"2007","journal-title":"Basic Res Cardiol"},{"issue":"20","key":"10.1016\/j.lfs.2013.12.030_bb0130","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1093\/hmg\/ddn214","article-title":"Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue","volume":"17","author":"Sobolewski","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"8","key":"10.1016\/j.lfs.2013.12.030_bb0135","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.RES.0000145728.22878.45","article-title":"Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase","volume":"95","author":"Sorescu","year":"2004","journal-title":"Circ Res"},{"issue":"22","key":"10.1016\/j.lfs.2013.12.030_bb0140","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1161\/CIRCULATIONAHA.107.696583","article-title":"Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3\/Bmpr1a receptor","volume":"116","author":"Stroud","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.lfs.2013.12.030_bb0145","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/HYPERTENSIONAHA.111.00562","article-title":"Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy","volume":"61","author":"Sun","year":"2013","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.lfs.2013.12.030_bb0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.yjmcc.2011.10.013","article-title":"Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway","volume":"52","author":"Tian","year":"2012","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"10.1016\/j.lfs.2013.12.030_bb0155","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.cardiores.2006.11.022","article-title":"Role of bone morphogenetic proteins in cardiac differentiation","volume":"74","author":"van Wijk","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.lfs.2013.12.030_bb0160","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/CIRCRESAHA.110.222794","article-title":"Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension","volume":"107","author":"Wong","year":"2010","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.lfs.2013.12.030_bb0165","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbrc.2007.08.045","article-title":"Bone morphogenetic protein","volume":"362","author":"Xiao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.lfs.2013.12.030_bb0170","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP2 are nonviable and have defects in amnion\/chorion and cardiac development","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513008011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320513008011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T15:03:23Z","timestamp":1647875003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320513008011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0024320513008011"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2013.12.030","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2013.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}