{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:56:54Z","timestamp":1770278214981,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.lfs.2014.03.009","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:31:54Z","timestamp":1395275514000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: An endothelin receptor antagonist improves the peak PETCO2"],"prefix":"10.1016","volume":"118","author":[{"given":"Akihiro","family":"Hirashiki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Shimazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2014.03.009_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.healun.2009.09.003","article-title":"Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: an evidence-based review","volume":"29","author":"Arena","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.lfs.2014.03.009_bb0010","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.thromres.2010.01.007","article-title":"Bosentan for chronic thromboembolic pulmonary hypertension: findings from a systematic review and meta-analysis","volume":"126","author":"Becattini","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.lfs.2014.03.009_bb0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(01)06250-X","article-title":"Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study","volume":"358","author":"Channick","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2014.03.009_bb0020","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/ajrccm.158.5.9710086","article-title":"Reference equations for the six-minute walk in healthy adults","volume":"158","author":"Enright","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lfs.2014.03.009_bb0025","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1056\/NEJMra010902","article-title":"Chronic thromboembolic pulmonary hypertension","volume":"345","author":"Fedullo","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lfs.2014.03.009_bb0030","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","article-title":"Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial","volume":"371","author":"Galie","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2014.03.009_bb0035","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Galie","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lfs.2014.03.009_bb0040","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jjcc.2009.01.002","article-title":"Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension","volume":"53","author":"Hiramoto","year":"2009","journal-title":"J Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0045","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1378\/chest.128.4.2363","article-title":"Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension","volume":"128","author":"Hoeper","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2014.03.009_bb0050","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1183\/09031936.05.00075305","article-title":"Goal-oriented treatment and combination therapy for pulmonary arterial hypertension","volume":"26","author":"Hoeper","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lfs.2014.03.009_bb0055","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/thx.2005.046961","article-title":"Bosentan in inoperable chronic thromboembolic pulmonary hypertension","volume":"60","author":"Hughes","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.lfs.2014.03.009_bb0060","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.jacc.2008.08.059","article-title":"Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial","volume":"52","author":"Jais","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1183\/09059180.00009211","article-title":"State-of-the-art chronic thromboembolic pulmonary hypertension diagnosis and management","volume":"21","author":"Jenkins","year":"2012","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.lfs.2014.03.009_bb0075","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1183\/09031936.00046906","article-title":"Recommendations on the use of exercise testing in clinical practice","volume":"29","author":"Palange","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lfs.2014.03.009_bb0085","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2281.1998.00109.x","article-title":"Ventilatory inefficiency for carbon dioxide during exercise in patients with pulmonary hypertension","volume":"18","author":"Reybrouck","year":"1998","journal-title":"Clin Physiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0090","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1164\/ajrccm.167.10.950","article-title":"ATS\/ACCP statement on cardiopulmonary exercise testing","volume":"167","author":"Ross","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lfs.2014.03.009_bb0095","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa012212","article-title":"Bosentan therapy for pulmonary arterial hypertension","volume":"346","author":"Rubin","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lfs.2014.03.009_bb0100","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jacc.2012.01.083","article-title":"Do changes of 6-minute walk distance predict clinical events in patients with pulmonary arterial hypertension? A meta-analysis of 22 randomized trials","volume":"60","author":"Savarese","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0105","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/CIRCHEARTFAILURE.108.807826","article-title":"Value of exercise treadmill testing in the risk stratification of patients with pulmonary hypertension","volume":"2","author":"Shah","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.lfs.2014.03.009_bb0110","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2009.04.012","article-title":"Updated clinical classification of pulmonary hypertension","volume":"54","author":"Simonneau","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0120","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1183\/09031936.00072709","article-title":"Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation","volume":"35","author":"Thenappan","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lfs.2014.03.009_bb0125","first-page":"245","article-title":"The importance of cardiopulmonary exercise testing in the diagnosis, prognosis and monitoring of patients with pulmonary arterial hypertension","volume":"51","author":"Triantafyllidi","year":"2010","journal-title":"Hellenic J Cardiol"},{"key":"10.1016\/j.lfs.2014.03.009_bb0130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0009-9236(96)90127-7","article-title":"Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects","volume":"60","author":"Weber","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.lfs.2014.03.009_bb0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.CIR.0000022687.18568.2A","article-title":"Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing","volume":"106","author":"Wensel","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2014.03.009_bb0140","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1378\/chest.127.5.1637","article-title":"End-tidal PCO2 abnormality and exercise limitation in patients with primary pulmonary hypertension","volume":"127","author":"Yasunobu","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2014.03.009_bb0145","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1378\/chest.10-3357","article-title":"Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension","volume":"140","author":"Zhai","year":"2011","journal-title":"Chest"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514003336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514003336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:13:47Z","timestamp":1758399227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320514003336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0024320514003336"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2014.03.009","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: An endothelin receptor antagonist improves the peak PETCO2","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2014.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}