{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:04:52Z","timestamp":1768590292157,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Firat University Scientific Research Projects Unit (FUBAP)","award":["FF.13.19"],"award-info":[{"award-number":["FF.13.19"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.lfs.2014.09.005","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T15:05:49Z","timestamp":1412867149000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway"],"prefix":"10.1016","volume":"117","author":[{"given":"Abdullah","family":"Aslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed \u0130smail","family":"Can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2014.09.005_bb0005","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.etp.2010.04.009","article-title":"Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis","volume":"63","author":"Aghazadeh","year":"2011","journal-title":"Exp Toxicol Pathol"},{"issue":"3","key":"10.1016\/j.lfs.2014.09.005_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.sjbs.2013.09.006","article-title":"Potential impact of silymarin in combination with chlorogenic acid and\/or melatonin in combating cardiomyopathy induced by carbon tetrachloride","volume":"21","author":"Al-Rasheed","year":"2014","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.lfs.2014.09.005_bb0015","series-title":"The effect of lycopene on the cyclooxygenase (Cox-2), caspase-3, caspase-9, bax, bcl-2, P53 protein expression and DNA damage in rats with azoxymethane-induced colorectal cancer","author":"Aslan","year":"2011"},{"key":"10.1016\/j.lfs.2014.09.005_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.lfs.2010.06.014","article-title":"Epigallocatechin-3-gallate activates Nrf2\/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats","volume":"87","author":"Sahin","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.lfs.2014.09.005_bb0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10753-008-9067-1","article-title":"Hepatoprotective effect of infliximab, an anti-TNF-\u03b1 agent, on carbon tetrachloride-induced hepatic fibrosis","volume":"31","author":"Bah\u00e7ecioglu","year":"2008","journal-title":"Inflammation"},{"key":"10.1016\/j.lfs.2014.09.005_bb0025","first-page":"657","article-title":"Lipid peroxidation, antioxidant enzymes and levels of nitric oxide in sheep infected with Fasciola hepatica","volume":"27","author":"Benzer","year":"2003","journal-title":"Turk J Vet Anim Sci"},{"key":"10.1016\/j.lfs.2014.09.005_bb0030","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jep.2011.09.032","article-title":"Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats","volume":"138","author":"Feng","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0035","first-page":"39","article-title":"Determination of apoptosis in liver and kidney tissues in experimental copper toxicity in rats","volume":"60","author":"Kabak","year":"2013","journal-title":"Ank \u00dcniv Vet Fak Derg"},{"key":"10.1016\/j.lfs.2014.09.005_bb0040","first-page":"1693","article-title":"BCL-2 gene family and the regulation of programmed cell death","volume":"59","author":"Korsmeyer","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.lfs.2014.09.005_bb0045","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.nutres.2012.06.007","article-title":"Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease","volume":"32","author":"Kuwahata","year":"2012","journal-title":"Nutr Res"},{"key":"10.1016\/j.lfs.2014.09.005_bb0050","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2014.09.005_bb0055","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fct.2013.11.006","article-title":"The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats","volume":"63","author":"Lee","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.etap.2012.03.010","article-title":"Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice","volume":"34","author":"Lu","year":"2012","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0065","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0006-2952(03)00444-1","article-title":"Protective role of oxygenase-1 induction in carbon tetrachloride-induced hepatoxicity","volume":"66","author":"Nakahira","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"issue":"5","key":"10.1016\/j.lfs.2014.09.005_bb0080","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1179\/1476830512Y.0000000018","article-title":"A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2\/HO-1 and protects the brain against oxidative stress in high-fat\u2013fed rats","volume":"15","author":"Sahin","year":"2012","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.lfs.2014.09.005_bb0100","first-page":"59","article-title":"The effect of silymarin on oxidative stress during renal ischemia\u2013reperfusion injury in rat kidney crashed","volume":"1","author":"\u015eent\u00fcrk","year":"2010","journal-title":"\u00c7ankaya Univ J Sci Eng"},{"key":"10.1016\/j.lfs.2014.09.005_bb0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.fct.2009.12.011","article-title":"Silymarin, the antioxidant component, and Silybum marianum extracts prevent liver damage","volume":"48","author":"Shaker","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(01)00473-5","article-title":"Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants","volume":"169","author":"Sheweita","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2014.09.005_bb0095","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0022-3565(24)35045-1","article-title":"Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells","volume":"290","author":"Sonnenbichler","year":"1999","journal-title":"JPET"},{"issue":"9","key":"10.1016\/j.lfs.2014.09.005_bb0105","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/mnfr.201200130","article-title":"Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-\u03baB and regulating Nrf2\/HO-1 pathway","volume":"56","author":"Tuzcu","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.lfs.2014.09.005_bb0110","first-page":"263","article-title":"Effects of Soy isoflavones on carbon tetrachloride (CCL4)-induced liver damage and on the level of plasma paraoxonase with arylesterase activities","volume":"19","author":"\u00dcst\u00fcndag","year":"2005","journal-title":"Firat Univ Med J Health"},{"key":"10.1016\/j.lfs.2014.09.005_bb0115","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.etp.2011.03.006","article-title":"Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats","volume":"64","author":"Vuda","year":"2012","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0120","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.intimp.2014.01.019","article-title":"Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation","volume":"19","author":"Yu","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.lfs.2014.09.005_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2012.08.005","article-title":"Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo","volume":"214","author":"Zhao","year":"2012","journal-title":"Toxicol Lett"},{"issue":"9","key":"10.1016\/j.lfs.2014.09.005_bb0130","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1248\/bpb.29.1900","article-title":"Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle","volume":"29","author":"Zhou","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.lfs.2014.09.005_bb0135","first-page":"1055","article-title":"Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468","volume":"4","author":"Zi","year":"1998","journal-title":"Clin Cancer Res"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514007541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514007541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:12:56Z","timestamp":1758399176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320514007541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0024320514007541"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2014.09.005","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of bcl-2 and regulating caspase pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2014.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}