{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:11Z","timestamp":1792786991543,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Nature Science Foundation of China (NSFC)","award":["81202843"],"award-info":[{"award-number":["81202843"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Scientific Research Innovation Team Foundation","award":["WHTD201304"],"award-info":[{"award-number":["WHTD201304"]}]},{"name":"Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury","award":["TJC1402"],"award-info":[{"award-number":["TJC1402"]}]},{"name":"Programs of Science Foundation of Tianjin","award":["14JCZDJC36700"],"award-info":[{"award-number":["14JCZDJC36700"]}]},{"name":"Programs of Science Foundation of Tianjin","award":["11JCYBJC14600"],"award-info":[{"award-number":["11JCYBJC14600"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.lfs.2014.11.020","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T19:48:17Z","timestamp":1418068097000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Pseudolaric acid B inhibits T-cell mediated immune response in vivo via p38MAPK signal cascades and PPAR\u03b3 activation"],"prefix":"10.1016","volume":"121","author":[{"given":"Tan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2014.11.020_bb0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10875-010-9507-1","article-title":"Leptin activates human B cells to secrete TNF-alpha, IL-6, and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 signaling pathway","volume":"31","author":"Agrawal","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0010","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1074\/jbc.M610987200","article-title":"Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling","volume":"282","author":"Alford","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2014.11.020_bb0015","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1016\/j.bbagen.2013.06.021","article-title":"Honokiol: a non-adipogenic PPARgamma agonist from nature","volume":"1830","author":"Atanasov","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2014.11.020_bb0020","doi-asserted-by":"crossref","first-page":"e2325","DOI":"10.1371\/journal.pntd.0002325","article-title":"TNF-alpha and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis","volume":"7","author":"Bernardino","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.lfs.2014.11.020_bb0025","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.0022-202X.2004.23229.x","article-title":"Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK","volume":"123","author":"Boisleve","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0030","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.4049\/jimmunol.173.11.6928","article-title":"A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis","volume":"173","author":"Campbell","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0035","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1039\/b906520m","article-title":"Pseudolaric acids: isolation, bioactivity and synthetic studies","volume":"27","author":"Chiu","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.lfs.2014.11.020_bb0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10059-012-2297-y","article-title":"The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases","volume":"33","author":"Choi","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2014.11.020_bb0045","first-page":"506","article-title":"Type IV of hypersensitivity and its subtypes","volume":"64","author":"Czarnobilska","year":"2007","journal-title":"Przegl. Lek."},{"key":"10.1016\/j.lfs.2014.11.020_bb0050","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1016\/j.bmcl.2013.09.010","article-title":"Structure-based identification of novel PPAR gamma ligands","volume":"23","author":"da Silva","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.lfs.2014.11.020_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0060","doi-asserted-by":"crossref","first-page":"541871","DOI":"10.1155\/2013\/541871","article-title":"Effects of PPAR gamma agonist pioglitazone on redox-sensitive cellular signaling in young spontaneously hypertensive rats","volume":"2013","author":"Dovinova","year":"2013","journal-title":"PPAR Res."},{"key":"10.1016\/j.lfs.2014.11.020_bb0065","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.intimp.2009.07.003","article-title":"Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: role for p38 kinase","volume":"9","author":"Engstrom","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0070","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.pain.2013.04.039","article-title":"Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates inflammatory pain through the induction of heme oxygenase-1 in macrophages","volume":"154","author":"Hasegawa-Moriyama","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2014.11.020_bb0075","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.cellsig.2013.05.024","article-title":"A feedback loop in PPARgamma-adenosine A2A receptor signaling inhibits inflammation and attenuates lung damages in a mouse model of LPS-induced acute lung injury","volume":"25","author":"He","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2014.11.020_bb0080","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1128\/IAI.70.6.2959-2964.2002","article-title":"Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection","volume":"70","author":"Herring","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.lfs.2014.11.020_bb0085","first-page":"867","article-title":"What's new in contact dermatitis: allergy to topical steroids in Israeli patients with contact dermatitis","volume":"4","author":"Ingber","year":"2002","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.lfs.2014.11.020_bb0090","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1055\/s-2002-33785","article-title":"Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists","volume":"68","author":"Jaradat","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2014.11.020_bb0095","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.micinf.2013.03.009","article-title":"A MAP kinase pathway in Caenorhabditis elegans is required for defense against infection by opportunistic Proteus species","volume":"15","author":"JebaMercy","year":"2013","journal-title":"Microbes Infect."},{"key":"10.1016\/j.lfs.2014.11.020_bb0100","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.lfs.2014.11.020_bb0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35012097","article-title":"ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation","volume":"405","author":"Kawasaki","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2014.11.020_bb0110","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.0022-202X.2005.23747.x","article-title":"Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice","volume":"124","author":"Kim","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0115","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jaci.2007.01.016","article-title":"Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence","volume":"119","author":"Kim","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0120","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.intimp.2010.06.024","article-title":"Preventive and therapeutic potential of placental extract in contact hypersensitivity","volume":"10","author":"Kim","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0125","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1021\/jm300411k","article-title":"Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach","volume":"55","author":"Kosugi","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.lfs.2014.11.020_bb0130","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.110.172395","article-title":"Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss","volume":"336","author":"Li","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2014.11.020_bb0135","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ejps.2012.01.005","article-title":"Topical application of pseudolaric acid B improve DNFB-induced contact hypersensitivity via regulating the balance of Th1\/Th17\/Treg cell subsets","volume":"45","author":"Li","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2014.11.020_bb0140","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.intimp.2013.03.011","article-title":"Evaluation of the immunosuppressive activity of artesunate in vitro and in vivo","volume":"16","author":"Li","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0145","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.intimp.2007.05.008","article-title":"Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo","volume":"7","author":"Li","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jcb.22230","article-title":"Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-kappaB signaling pathway and p38 phosphorylation","volume":"108","author":"Li","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2014.11.020_bb0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejmech.2009.09.030","article-title":"Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies","volume":"45","author":"Miglani","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2014.11.020_bb0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrd2070","article-title":"Targeting signal transduction as a strategy to treat inflammatory diseases","volume":"5","author":"O'Neill","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2014.11.020_bb0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1055\/s-2006-960989","article-title":"The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives","volume":"56","author":"Pan","year":"1990","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2014.11.020_bb0170","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2014.11.020_bb0175","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/toxsci\/kfj062","article-title":"The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR)","volume":"90","author":"Peraza","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2014.11.020_bb0180","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbr.2011.06.011","article-title":"Antidepressant-like effect of pioglitazone in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway","volume":"224","author":"Sadaghiani","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2014.11.020_bb0185","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1111\/j.1742-4658.2009.07023.x","article-title":"The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo","volume":"276","author":"Schuchardt","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.lfs.2014.11.020_bb0190","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1476-5381.2011.01411.x","article-title":"Modulation of diabetic retinopathy pathophysiology by natural medicines through PPAR-gamma-related pharmacology","volume":"165","author":"Song","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2012.01.009","article-title":"Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro","volume":"210","author":"Tang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2014.11.020_bb0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3109\/09513590.2010.507287","article-title":"Inhibitory effect of curcumin on uterine leiomyoma cell proliferation","volume":"27","author":"Tsuiji","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.lfs.2014.11.020_bb0205","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2014.11.020_bb0210","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/ptr.4824","article-title":"The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro","volume":"27","author":"Wei","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2014.11.020_bb0215","first-page":"1240","article-title":"Advance in the research of pharmacology of pseudolaric acid B","volume":"7","author":"Zhou","year":"2007","journal-title":"China Trop. Med."},{"key":"10.1016\/j.lfs.2014.11.020_bb0220","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jaci.2006.12.654","article-title":"Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference","volume":"119","author":"Meller","year":"2007","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514009412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514009412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:23:02Z","timestamp":1538007782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320514009412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":44,"alternative-id":["S0024320514009412"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2014.11.020","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pseudolaric acid B inhibits T-cell mediated immune response in vivo via p38MAPK signal cascades and PPAR\u03b3 activation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2014.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}