{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:07:53Z","timestamp":1786993673474,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.lfs.2014.12.010","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T01:21:27Z","timestamp":1419038487000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Molecular and functional characterization of TRPV4 channels in pregnant and nonpregnant mouse uterus"],"prefix":"10.1016","volume":"122","author":[{"given":"Vishakha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Kandasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Thangamalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumen","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevan Ranjan","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashree","family":"Parida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur Uttam","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2014.12.010_bb0005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-2999(02)02487-1","article-title":"Effects of mibefradil on uterine contractility","volume":"455","author":"Asokan","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1095\/biolreprod.103.023325","article-title":"Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy","volume":"70","author":"Babich","year":"2004","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.lfs.2014.12.010_bb0015","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/1933719112438971","article-title":"Contractile efficacy of various prostaglandins in pregnant rat myometrium pretreated with oxytocin","volume":"19","author":"Balki","year":"2012","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2014.12.010_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1124\/jpet.107.125435","article-title":"Activation of urothelial transient receptor potential vanilloid 4 by 4\u03b1-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat","volume":"323","author":"Birder","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2014.12.010_bb0025","doi-asserted-by":"crossref","first-page":"L824","DOI":"10.1152\/ajplung.00244.2011","article-title":"Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats","volume":"303","author":"Dahan","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0030","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/molehr\/8.10.946","article-title":"Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus","volume":"8","author":"Dalrymple","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.lfs.2014.12.010_bb0035","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.RES.0000194321.60300.d6","article-title":"TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels","volume":"97","author":"Earley","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2014.12.010_bb0040","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/j.1600-0412.2000.079003174.x","article-title":"Oxytocin-induced oscillations of cytoplasmic Ca2+ in human myometrial cells","volume":"79","author":"Fu","year":"2000","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.lfs.2014.12.010_bb0045","doi-asserted-by":"crossref","first-page":"L272","DOI":"10.1152\/ajplung.00393.2003","article-title":"Functional TRPV4 channels are expressed in human airway smooth muscle cells","volume":"287","author":"Jia","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2014.12.010_bb0050","doi-asserted-by":"crossref","first-page":"e16713","DOI":"10.1371\/journal.pone.0016713","article-title":"Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A","volume":"6","author":"Jin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2014.12.010_bb0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0002-9378(99)70580-6","article-title":"Intracellular calcium stores and agonist-induced contractions in isolated human myometrium","volume":"181","author":"Luckas","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0060","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1210\/jc.2003-031037","article-title":"Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal","volume":"89","author":"Madsen","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"28","key":"10.1016\/j.lfs.2014.12.010_bb0065","doi-asserted-by":"crossref","first-page":"20306","DOI":"10.1074\/jbc.M113.466797","article-title":"Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C","volume":"288","author":"Mamenko","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2014.12.010_bb0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ncb1218","article-title":"TrpC1 forms the stretch-activated cation channel in vertebrate cells","volume":"7","author":"Maroto","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0075","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4067\/S0716-97602004000400017","article-title":"Ca2+ entry, efflux and release in smooth muscle","volume":"37","author":"Matthew","year":"2004","journal-title":"Biol. Res."},{"key":"10.1016\/j.lfs.2014.12.010_bb0080","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00008.2014","article-title":"Intravesical TRPV4 blockade reduces repeated variate stress (RVS)-inducedbladderdysfunction by increasing bladdercapacity and decreasing voiding frequency","author":"Merrill","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0085","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1530\/eje.0.1330467","article-title":"Signal transduction in rat myometrial cells: comparison of the actions of endothelin-1, oxytocin and prostaglandin F2 alpha","volume":"133","author":"Molnar","year":"1995","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0090","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00424-003-1028-9","article-title":"The TRPV4 channel: structure\u2013function relationship and promiscuous gating behaviour","volume":"446","author":"Nilius","year":"2003","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2014.12.010_bb0095","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2012.11.048","article-title":"Molecular and functional characteristics of \u03b23-adrenoceptors in late pregnant mouse uterus: a comparison with \u03b22-adrenoceptors","volume":"700","author":"Parida","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2014.12.010_bb0100","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.bbrc.2009.12.140","article-title":"Identification of a protein kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel","volume":"391","author":"Peng","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2014.12.010_bb0105","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0002-9378(03)00949-9","article-title":"Mechanisms of lipopolysaccharide-induced changes in effects of contractile agonists on pregnant rat myometrium","volume":"190","author":"Ross","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jsgi.2005.07.002","article-title":"Molecular signaling through G-protein-coupled receptors and the control of intracellular calcium in myometrium","volume":"12","author":"Sanborn","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"10.1016\/j.lfs.2014.12.010_bb0115","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/joa.12127","article-title":"Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions","volume":"223","author":"Senadheera","year":"2013","journal-title":"J. Anat."},{"key":"10.1016\/j.lfs.2014.12.010_bb0120","doi-asserted-by":"crossref","first-page":"29897","DOI":"10.1074\/jbc.M605394200","article-title":"Bisandrographolide from Andrographis paniculata activates TRPV4 channels","volume":"281","author":"Smith","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2014.12.010_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2013.09.005","article-title":"TRPV4 channel activation leads to endothelium-dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery","volume":"78C","author":"Sukumaran","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2014.12.010_bb0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/mrd.20312","article-title":"Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs","volume":"71","author":"Teilmann","year":"2005","journal-title":"Mol. Reprod. Dev."},{"issue":"5","key":"10.1016\/j.lfs.2014.12.010_bb0135","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/SHK.0000000000000138","article-title":"Atorvastatin prevents sepsis-induced downregulation of myocardial \u03b21-adrenoceptors and decreased cAMP response in mice","volume":"41","author":"Thangamalai","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2014.12.010_bb0140","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1124\/jpet.108.139295","article-title":"GSK1016790A, a novel and potent TRPV4 channel agonist induces urinary bladder contraction and hyperactivity: part I","volume":"326","author":"Thorneloe","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2014.12.010_bb0145","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/eph8602180","article-title":"Regulation of human myometrial contractility during pregnancy and labour: are calcium homeostatic pathways important?","volume":"86","author":"Tribe","year":"2001","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0150","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1074\/jbc.M200062200","article-title":"Activation of TRPV4 channels (hVRL-2\/mTRP12) by phorbol derivatives","volume":"277","author":"Watanabe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2014.12.010_bb0155","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nature01807","article-title":"Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels","volume":"424","author":"Watanabe","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2014.12.010_bb0160","doi-asserted-by":"crossref","first-page":"C704","DOI":"10.1152\/ajpcell.00099.2013","article-title":"TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension","volume":"305","author":"Xia","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0165","doi-asserted-by":"crossref","first-page":"F1103","DOI":"10.1152\/ajprenal.00245.2005","article-title":"Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking","volume":"290","author":"Xu","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.lfs.2014.12.010_bb0170","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1369\/jhc.2008.951962","article-title":"Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder","volume":"57","author":"Yamada","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.lfs.2014.12.010_bb0175","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00515.2005","article-title":"Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2014.12.010_bb0180","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1152\/ajprenal.00349.2010","article-title":"Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium","volume":"300","author":"Yu","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514009734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320514009734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T16:58:49Z","timestamp":1537981129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320514009734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":36,"alternative-id":["S0024320514009734"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2014.12.010","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and functional characterization of TRPV4 channels in pregnant and nonpregnant mouse uterus","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2014.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}