{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:01:33Z","timestamp":1780938093173,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000072"],"award-info":[{"award-number":["81000072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fund for Emphasis on Cultivating Young Teachers"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.lfs.2015.01.015","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T07:33:22Z","timestamp":1422430402000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Effects of ERK1\/2\/PPAR\u03b1\/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine"],"prefix":"10.1016","volume":"124","author":[{"given":"Qiuju","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaorui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuediao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linquan","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2015.01.015_bb0005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5604\/20831862.1077547","article-title":"A 24-hour ambulatory ECG monitoring in assessment of QT interval duration and dispersion in rowers with physiological myocardial hypertrophy","volume":"30","author":"Lutfullin","year":"2013","journal-title":"Biol Sport"},{"key":"10.1016\/j.lfs.2015.01.015_bb0010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling","volume":"367","author":"Opie","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2015.01.015_bb0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiol.00043.2010","article-title":"The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes?","volume":"26","author":"Weeks","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.lfs.2015.01.015_bb0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jjcc.2009.02.014","article-title":"Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis","volume":"53","author":"Kono","year":"2009","journal-title":"J. Cardiol."},{"key":"10.1016\/j.lfs.2015.01.015_bb0025","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1253\/circj.CJ-11-1369","article-title":"Left ventricular dysfunction assessed by cardiac time interval analysis among different geometric patterns in untreated hypertension","volume":"76","author":"Takasaki","year":"2012","journal-title":"Circ. J."},{"key":"10.1016\/j.lfs.2015.01.015_bb0030","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-014-1220-8","article-title":"Resveratrol prevents pathological but not physiological cardiac hypertrophy","author":"Dolinsky","year":"2015","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.lfs.2015.01.015_bb0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/cvr\/cvr071","article-title":"Glucose metabolism and cardiac hypertrophy","volume":"90","author":"Kolwicz","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/cvr\/cvp414","article-title":"Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload","volume":"86","author":"Doenst","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00023.2004","article-title":"Skeletal muscle lipid metabolism in exercise and insulin resistance","volume":"86","author":"Kiens","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2015.01.015_bb0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/ajpheart.01222.2010","article-title":"Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability","volume":"301","author":"Ludwig","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.lfs.2015.01.015_bb0055","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1074\/jbc.M113.523654","article-title":"A role for peroxisome proliferator-activated receptor \u03b3 coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis","volume":"289","author":"Lai","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2015.01.015_bb0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2008.09.007","article-title":"Short-chain acyl-coenzyme A dehydrogenase deficiency","volume":"95","author":"Jethva","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.lfs.2015.01.015_bb0065","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/gim.2011.9","article-title":"Follow-up of patients with short-chain acyl-CoA dehydrogenase and isobutyryl-CoA dehydrogenase deficiencies identified through newborn screening: one center's experience","volume":"14","author":"Pena","year":"2012","journal-title":"Genet. Med."},{"key":"10.1016\/j.lfs.2015.01.015_bb0070","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1021\/pr050456l","article-title":"Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats","volume":"5","author":"Zhou","year":"2006","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbd.2007.11.001","article-title":"Proteomic adaptation to chronic high intensity swimming training in the rat heart","volume":"3","author":"Sun","year":"2008","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.lfs.2015.01.015_bb0080","first-page":"489","article-title":"Effect of berberine on PPAR\u03b1\/NO activation in high glucose- and insulin-induced cardiomyocyte hypertrophy","volume":"285","author":"Wang","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2015.01.015_bb0085","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1152\/ajpendo.00603.2012","article-title":"Expression of lipogenic genes is upregulated in the heart with exercise","volume":"304","author":"Dobrzyn","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2015.01.015_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2011.04.010","article-title":"AMPK activation enhances PPARalpha activity to inhibit cardiac hypertrophy via ERK1\/2 MAPK signaling pathway","volume":"511","author":"Meng","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2015.01.015_bb0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1249\/01.mss.0000205138.02440.79","article-title":"Disparate regulation of signaling proteins after exercise and myocardial infarction","volume":"38","author":"Gosselin","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.lfs.2015.01.015_bb0100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.yjmcc.2012.06.017","article-title":"Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy","volume":"53","author":"Arantes","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2015.01.015_bb0105","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s12265-010-9199-1","article-title":"Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1","volume":"3","author":"Bhavsar","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1152\/physiolgenomics.00226.2004","article-title":"Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats","volume":"21","author":"Kong","year":"2005","journal-title":"Physiol. Genomics"},{"issue":"1","key":"10.1016\/j.lfs.2015.01.015_bb0115","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/cvr\/cvt228","article-title":"A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease","volume":"101","author":"Sergeeva","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0120","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.ph.36.030174.002213","article-title":"Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle","volume":"36","author":"Neely","year":"1974","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.lfs.2015.01.015_bb0125","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0002-8703(69)90135-5","article-title":"Metabolism of the heart in health and disease","volume":"77","author":"Opie","year":"1969","journal-title":"II, Am. Heart J."},{"key":"10.1016\/j.lfs.2015.01.015_bb0130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0005-2760(94)00082-4","article-title":"Regulation of fatty acid oxidation in the mammalian heart in health and disease","volume":"1213","author":"Lopaschuk","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.lfs.2015.01.015_bb0135","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCHEARTFAILURE.114.001469","article-title":"Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach","volume":"7","author":"Lai","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.lfs.2015.01.015_bb0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvn001","article-title":"Cardiac hypertrophy is enhanced in PPAR alpha\u2212\/\u2212 mice in response to chronic pressure overload","volume":"78","author":"Smeets","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0145","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.cardiores.2005.11.016","article-title":"Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease","volume":"69","author":"Goikoetxea","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.01.015_bb0150","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.yjmcc.2009.01.013","article-title":"Stimulus specific changes of energy metabolism in hypertrophied heart","volume":"46","author":"Rimbaud","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2015.01.015_bb0155","first-page":"22293","article-title":"Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity","volume":"275","author":"Watanabe","year":"2000","journal-title":"J. Biophys. Chem."},{"key":"10.1016\/j.lfs.2015.01.015_bb0160","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/j.1530-0277.2008.00781.x","article-title":"Expression of renin\u2013angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy","volume":"32","author":"Jing","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515000557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515000557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T21:30:06Z","timestamp":1717709406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515000557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":32,"alternative-id":["S0024320515000557"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.01.015","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ERK1\/2\/PPAR\u03b1\/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}