{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:47:13Z","timestamp":1787503633929,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["P303\/12\/G163"],"award-info":[{"award-number":["P303\/12\/G163"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Palacky University","award":["LF_2015_004"],"award-info":[{"award-number":["LF_2015_004"]}]},{"name":"Palacky University","award":["007"],"award-info":[{"award-number":["007"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.lfs.2015.04.014","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T12:43:43Z","timestamp":1431953023000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity"],"prefix":"10.1016","volume":"133","author":[{"given":"Veronika","family":"Tomankova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Liskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Skalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Bartikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-717X","authenticated-orcid":false,"given":"Iva","family":"Bousova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Jourova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Anzenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Ulrichova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Anzenbacherova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2015.04.014_bb0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/138920013804545223","article-title":"Function and regulation of the Cyp2a5\/CYP2A6 genes in response to toxic insults in the liver","volume":"14","author":"Abu-Bakar","year":"2013","journal-title":"Curr. Drug Metab."},{"issue":"5\u20136","key":"10.1016\/j.lfs.2015.04.014_bb0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/PL00000897","article-title":"Cytochromes P450 and metabolism of xenobiotics","volume":"58","author":"Anzenbacher","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.lfs.2015.04.014_bb0015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2165\/11599410-000000000-00000","article-title":"Impact of obesity on drug metabolism and elimination in adult and children","volume":"51","author":"Brill","year":"2012","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.lfs.2015.04.014_bb0020","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0092-8674(05)80067-4","article-title":"Molecular characterization of the mouse agouti locus","volume":"71","author":"Bultman","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2015.04.014_bb0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/DMSO.S51325","article-title":"Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review","volume":"6","author":"Colosia","year":"2013","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.lfs.2015.04.014_bb0030","doi-asserted-by":"crossref","first-page":"291546","DOI":"10.1155\/2013\/291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"De Pergola","year":"2013","journal-title":"J. Obes."},{"key":"10.1016\/j.lfs.2015.04.014_bb0035","series-title":"Cytochromes P450, Structure, Mechanism and Biochemistr","first-page":"377","article-title":"Human cytochrome P450 enzymes","author":"Guengerich","year":"2005"},{"key":"10.1016\/j.lfs.2015.04.014_bb0040","series-title":"Cytochrome P450. Structure, Mechanism and Biochemistry","first-page":"377","article-title":"Human cytochromes P450","author":"Guengerich","year":"2005"},{"issue":"7121","key":"10.1016\/j.lfs.2015.04.014_bb0045","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2015.04.014_bb0050","first-page":"78","article-title":"Catalytic assays for human cytochrome P450","volume":"vol. 320","author":"Chang","year":"2006"},{"issue":"1","key":"10.1016\/j.lfs.2015.04.014_bb0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2125.2012.04309.x","article-title":"Birthweight and cytochrome P4503A4\/5 activity in obese women","volume":"75","author":"Cheral","year":"2012","journal-title":"Br. J. Clin. Pharma2col."},{"issue":"4","key":"10.1016\/j.lfs.2015.04.014_bb0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0926-6917(95)90059-4","article-title":"Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat","volume":"293","author":"Irizar","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2015.04.014_bb0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.taap.2013.04.013","article-title":"Cytochrome P450 2A5 and bilirubin: mechanisms of gene regulation and cytoprotection","volume":"270","author":"Kim","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2015.04.014_bb0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/138920011795016845","article-title":"CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis","volume":"12","author":"Kirby","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.lfs.2015.04.014_bb0075","series-title":"Biochemical Toxicology, A Practical Approach","first-page":"183","article-title":"Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism","author":"Lake","year":"1987"},{"key":"10.1016\/j.lfs.2015.04.014_bb0080","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1530\/EJE-11-0596","article-title":"Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways","volume":"165","author":"Liu","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.lfs.2015.04.014_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0561s58","article-title":"Overview of animal models of obesity","author":"Lutz","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2015.04.014_bb0090","doi-asserted-by":"crossref","first-page":"727","DOI":"10.33549\/physiolres.931274","article-title":"Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and\/or the high fat diet feeding in C57BL\/6 and NMRI mice","volume":"57","author":"Matyskov\u00e1","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.lfs.2015.04.014_bb0095","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/1471-2474-14-219","article-title":"Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort","volume":"14","author":"Martin","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"issue":"6","key":"10.1016\/j.lfs.2015.04.014_bb0100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1517\/17425255.2.6.875","article-title":"Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction","volume":"2","author":"Martignoni","year":"2006","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.lfs.2015.04.014_bb0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/138920006774832569","article-title":"Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis","volume":"7","author":"Murray","year":"2006","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.lfs.2015.04.014_bb0110","series-title":"Cytochrome P450 Protocols","article-title":"Spectral analyses of cytochromes P450","volume":"vol. 320","author":"Schenkman","year":"1998"},{"key":"10.1016\/j.lfs.2015.04.014_bb0115","doi-asserted-by":"crossref","DOI":"10.1513\/pats.200708-137MG","article-title":"Obesity and obstructive sleep apnea, pathogenic mechanisms and therapeutic approaches","volume":"5","author":"Schwartz","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"1","key":"10.1016\/j.lfs.2015.04.014_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"issue":"9","key":"10.1016\/j.lfs.2015.04.014_bb0125","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2015.04.014_bb0130","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0090-9556(24)15307-X","article-title":"Effect of leptin on cytochrome P-450, conjugation, and antioxidant enzymes in the ob\/ob mouse","volume":"27","author":"Watson","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.lfs.2015.04.014_bb0135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1467-789X.2006.00251.x","article-title":"Musculoskeletal disorders associated with obesity: a biomechanical perspective","volume":"7","author":"Wearing","year":"2006","journal-title":"Obes. Rev."},{"key":"10.1016\/j.lfs.2015.04.014_bb0140","series-title":"Obesity and overweight, fact sheet no. 311","author":"World Health Organization","year":"2012"},{"issue":"1","key":"10.1016\/j.lfs.2015.04.014_bb0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/bbrc.1997.6054","article-title":"Posttranscriptional elevation of cytochrome P450 3A expression","volume":"231","author":"Zangar","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2015.04.014_bb0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1582-4934.2002.tb00186.x","article-title":"Cytochromes P450 and experimental models of drug metabolism","volume":"6","author":"Zuber","year":"2002","journal-title":"J. Cell. Mol. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:57:44Z","timestamp":1748379464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":30,"alternative-id":["S0024320515002556"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.04.014","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}