{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:50:35Z","timestamp":1775076635901,"version":"3.50.1"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2009\/SGR00853"],"award-info":[{"award-number":["2009\/SGR00853"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["SAF2011-23631"],"award-info":[{"award-number":["SAF2011-23631"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["0177594"],"award-info":[{"award-number":["0177594"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004299","name":"SENESCYT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.lfs.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T22:15:08Z","timestamp":1432073708000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin"],"prefix":"10.1016","volume":"140","author":[{"given":"Jaume","family":"Folch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Patraca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohora","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Pedr\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miren","family":"Ettcheto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Abad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Beas-Zarate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Camins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2015.05.002_bb0005","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.pneurobio.2011.11.008","article-title":"German Task Force on Alzheimer\u2019s Disease. The future of Alzheimer's disease: the next 10years","volume":"95","author":"Hampel","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2012.11.006","article-title":"The worldwide economic impact of dementia 2010","volume":"9","author":"Wimo","year":"2013","journal-title":"Alzheimer's Dement, J. Alzheimer's Assoc"},{"key":"10.1016\/j.lfs.2015.05.002_bb0015","series-title":"Dementia Treatments and Developments","first-page":"1","article-title":"Epidemiology of dementia","author":"Qiu","year":"2011"},{"key":"10.1016\/j.lfs.2015.05.002_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneurol.2011.2","article-title":"Epidemiology of Alzheimer disease","volume":"7","author":"Reitz","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-2008-13302","article-title":"An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease","volume":"13","author":"Erol","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0030","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.biocel.2008.12.015","article-title":"Reassessing the amyloid cascade hypothesis of Alzheimer's disease","volume":"41","author":"Pimplikar","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0035","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2015.05.002_bb0040","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.disamonth.2010.06.001","article-title":"Alzheimer disease","volume":"56","author":"Castellani","year":"2010","journal-title":"Dis. Mon."},{"key":"10.1016\/j.lfs.2015.05.002_bb0045","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.lfs.2015.05.002_bb0050","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.lfs.2015.05.002_bb0055","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2337\/db12-1549","article-title":"Plasma \u03b2-amyloid: a possible missing link between Alzheimer disease and diabetes","volume":"62","author":"Sato","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2015.05.002_bb0060","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/j.neurobiolaging.2011.12.023","article-title":"Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe\/PS1dE9 mice","volume":"33","author":"Zhang","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.lfs.2015.05.002_bb0065","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0070","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1096\/fj.13-231456","article-title":"Suppression of amyloid-\u03b2 production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking","volume":"27","author":"Urano","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2015.05.002_bb0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamaneurol.2013.5390","article-title":"Associations between serum cholesterol levels and cerebral amyloidosis","volume":"71","author":"Reed","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.lfs.2015.05.002_bb0080","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1093\/hmg\/ddt201","article-title":"APP\/PS1 mice overexpressing SREBP-2 exhibit combined A\u03b2 accumulation and tau pathology underlying Alzheimer's disease","volume":"22","author":"Barbero-Camps","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.lfs.2015.05.002_bb0085","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1212\/01.wnl.0000176061.33817.90","article-title":"Change in body mass index and risk of incident Alzheimer disease","volume":"65","author":"Buchman","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis","volume":"29","author":"Haataja","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2015.05.002_bb0095","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1582-4934.2011.01384.x","article-title":"Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP\/PS1 transgenic mice","volume":"16","author":"Hiltunen","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2015.05.002_bb0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2014.04.028","article-title":"Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus","volume":"571","author":"Koga","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2015.05.002_bb0105","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.euroneuro.2014.03.002","article-title":"Obesity and dementia: adipokines interact with the brain","volume":"24","author":"Arnoldussen","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbi.2014.06.017","article-title":"High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1\u03b2, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism","volume":"42","author":"Sobesky","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"Suppl. 2","key":"10.1016\/j.lfs.2015.05.002_bb0115","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.3233\/JAD-2011-111073","article-title":"Cognitive function and decline in obesity","volume":"30","author":"Sellbom","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.physbeh.2010.12.003","article-title":"Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity","volume":"103","author":"Kanoski","year":"2011","journal-title":"Physiol. Behav."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2015.05.002_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neurobiolaging.2005.09.003","article-title":"Studies of the effects of high fat diets on cognitive function in a rat model","volume":"26","author":"Winocur","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.lfs.2015.05.002_bb0130","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nlm.2010.11.007","article-title":"High-fat diets impair spatial learning in the radial-arm maze in mice","volume":"95","author":"Valladolid-Acebes","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbr.2012.07.017","article-title":"Effect of western and high fat diets on memory and cholinergic measures in the rat","volume":"235","author":"Kosari","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2015.05.002_bb0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.physbeh.2012.01.008","article-title":"Nonalcoholic fatty liver disease impairs hippocampal-dependent memory in male rats","volume":"106","author":"Ross","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2015.05.002_bb0145","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1365-2826.2012.02327.x","article-title":"Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice","volume":"24","author":"Yamada-Goto","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2004.02.049","article-title":"Glucose metabolism and insulin receptor signal transduction in Alzheimer disease","volume":"490","author":"Hoyer","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0155","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tem.2010.05.005","article-title":"Alzheimer's disease: brain expression of a metabolic disorder?","volume":"21","author":"Merlo","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2015.05.002_bb0160","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.arr.2010.04.007","article-title":"Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease","volume":"9","author":"Frisardi","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.lfs.2015.05.002_bb0165","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/cercor\/bht101","article-title":"Altered expression of diabetes-related genes in Alzheimer\u2019s disease brains: the Hisayama Study","volume":"24","author":"Hokama","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.lfs.2015.05.002_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archneurol.2010.225","article-title":"Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes","volume":"68","author":"Baker","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0175","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nm1295-1311","article-title":"Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action","volume":"1","author":"Frederich","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2015.05.002_bb0180","doi-asserted-by":"crossref","unstructured":"K.C. de Git, R.A. Adan, Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation, Obes. Rev., 2015, http:\/\/dx.doi.org\/10.1111\/obr.12243","DOI":"10.1111\/obr.12243"},{"key":"10.1016\/j.lfs.2015.05.002_bb0185","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1159\/000354191","article-title":"Circulating leptin concentrations in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"86","author":"Zhou","year":"2013","journal-title":"Respiration"},{"key":"10.1016\/j.lfs.2015.05.002_bb0190","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1381\/0960892053923789","article-title":"Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin","volume":"15","author":"Ballantyne","year":"2005","journal-title":"Obes. Surg."},{"key":"10.1016\/j.lfs.2015.05.002_bb0195","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.2000.278.1.E1","article-title":"The adipoinsular axis: effects of leptin on pancreatic beta-cells","volume":"278","author":"Kieffer","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2015.05.002_bb0200","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/0006-2952(82)90036-3","article-title":"Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells","volume":"31","author":"Henquin","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0205","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1210\/en.2003-1523","article-title":"Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide","volume":"145","author":"Alemzadeh","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0210","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2015.05.002_bb0215","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1172\/JCI45888","article-title":"Sixteen years and counting: an update on leptin in energy balance","volume":"121","author":"Gautron","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2015.05.002_bb0220","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nbd.2014.08.015","article-title":"Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression","volume":"71","author":"Koga","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0225","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1210\/en.2003-0241","article-title":"Minireview: from anorexia to obesity\u2014the yin and yang of body weight control","volume":"144","author":"Zigman","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0230","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature01388","article-title":"STAT3 signalling is required for leptin regulation of energy balance but not reproduction","volume":"421","author":"Bates","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2015.05.002_bb0235","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cmet.2010.05.010","article-title":"SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity","volume":"12","author":"Ramadori","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2015.05.002_bb0240","doi-asserted-by":"crossref","first-page":"9989","DOI":"10.1523\/JNEUROSCI.3257-08.2008","article-title":"Brain SIRT1: anatomical distribution and regulation by energy availability","volume":"28","author":"Ramadori","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0245","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.1523\/JNEUROSCI.0872-14.2014","article-title":"Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons","volume":"34","author":"Ishii","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0250","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yfrne.2009.10.002","article-title":"Hypothalamic inflammation and energy homeostasis: resolving the paradox","volume":"31","author":"Thaler","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0255","doi-asserted-by":"crossref","first-page":"18820","DOI":"10.1074\/jbc.M111.331181","article-title":"Amyloid \u03b2 (A\u03b2) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways","volume":"287","author":"Fu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0260","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.1365-2796.2002.01018.x","article-title":"T. Olsson T. The association between leptin and proinsulin is lost with central obesity","volume":"252","author":"S\u00f6derberg","year":"2002","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.lfs.2015.05.002_bb0265","doi-asserted-by":"crossref","unstructured":"E. Hartter, T. Svoboda, B. Ludvik, M. Schuller, B. Lell, E. Kuenburg, M. Brunnbauer, W. Woloszczuk, R. Prager. Basal and stimulated plasma levelsof pancreatic amylin indicate itsco-secretion with insulin in humans, Diabetologia, 34 (1991) 52\u201354. http:\/\/dx.doi.org\/10.1007\/BF00404025","DOI":"10.1007\/BF00404025"},{"key":"10.1016\/j.lfs.2015.05.002_bb0270","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0140-6736(92)90785-2","article-title":"Amylin concentrations and glucose control","volume":"339","author":"Koda","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2015.05.002_bb0275","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF00401833","article-title":"Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin","volume":"38","author":"Young","year":"1995","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2015.05.002_bb0280","first-page":"R514","article-title":"Actions of amylin on subfornical organ neurons and on drinking behaviour in rats","volume":"276","author":"Riediger","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0285","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/j.1471-4159.1993.tb07480.x","article-title":"Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity","volume":"61","author":"May","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0290","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1139\/y95-147","article-title":"Effects of amylin on appetite regulation and memory","volume":"73","author":"Morley","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0295","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/MCO.0b013e32829fb37c","article-title":"Influence of ghrelin on food intake and energy homeostasis","volume":"10","author":"De Vriese","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.lfs.2015.05.002_bb0300","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3233\/JAD-2010-100873","article-title":"Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients","volume":"22","author":"Gahete","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0305","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0169-328X(97)00071-5","article-title":"Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues","volume":"48","author":"Guan","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.lfs.2015.05.002_bb0310","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2015.05.002_bb0315","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0006-291X(02)02740-7","article-title":"Ghrelin increases anxiety-like behavior and memory retention in rats","volume":"299","author":"Carlini","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.lfs.2015.05.002_bb0320","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders","volume":"9","author":"Cai","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.lfs.2015.05.002_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-012-8173-2","article-title":"Roles of AMP-activated protein kinase in Alzheimer's disease","volume":"14","author":"Cai","year":"2012","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.lfs.2015.05.002_bb0330","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2010-101263","article-title":"Ghrelin ameliorates cognitive dysfunction and neurodegeneration in intrahippocampal amyloid-b1-42 oligomer-injected mice","volume":"23","author":"Moon","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0335","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1248\/bpb.33.1165","article-title":"Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons","volume":"33","author":"Chen","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.lfs.2015.05.002_bb0340","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11064-006-9125-8","article-title":"Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia","volume":"32","author":"Giordano","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2015.05.002_bb0345","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/187152710793361513","article-title":"Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction","volume":"9","author":"Cong","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.lfs.2015.05.002_bb0350","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/jne.12138","article-title":"Protective effect of leptin and ghrelin against toxicity induced by amyloid-\u03b2 oligomers in a hypothalamic cell line","volume":"26","author":"Gomes","year":"2014","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0355","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.nlm.2011.08.005","article-title":"Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes","volume":"96","author":"McNay","year":"2011","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0360","first-page":"245","article-title":"Leptin signaling and Alzheimer's disease","volume":"1","author":"Marwarha","year":"2012","journal-title":"Am J Neurodegener Dis"},{"key":"10.1016\/j.lfs.2015.05.002_bb0365","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3233\/JAD-2010-1308","article-title":"Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease","volume":"19","author":"Greco","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0370","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2011.09.050","article-title":"Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and \u03b2-amyloid in neurons","volume":"14","author":"Greco","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2015.05.002_bb0375","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/me.2014-1328","article-title":"Minireview: food for thought: regulation of synaptic function by metabolic hormones","volume":"29","author":"McGregor","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0380","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bbadis.2014.05.015","article-title":"Leptin attenuates BACE1 expression and amyloid-\u03b2 genesis via the activation of SIRT1 signaling pathway","volume":"1842","author":"Marwarha","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2015.05.002_bb0385","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1098\/rstb.2013.0155","article-title":"Leptin regulation of hippocampal synaptic function in health and disease","volume":"369","author":"Irving","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2015.05.002_bb0390","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/1567205010666131212114156","article-title":"Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential","volume":"1","author":"Johnston","year":"2014","journal-title":"Curr. Alzheimer Res."},{"issue":"5","key":"10.1016\/j.lfs.2015.05.002_bb0395","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2217\/thy.11.57","article-title":"Repositioning leptin as a therapy for Alzheimer's disease","volume":"8","author":"Johnston","year":"2011","journal-title":"Therapy"},{"key":"10.1016\/j.lfs.2015.05.002_bb0400","doi-asserted-by":"crossref","first-page":"R149","DOI":"10.1530\/JME-12-0151","article-title":"Neuroprotective and anti-ageing role of leptin","volume":"49","author":"Folch","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0405","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.bbadis.2014.05.025","article-title":"Early alterations in energy metabolism in the hippocampus of APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"1842","author":"Pedr\u00f3s","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2015.05.002_bb0410","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.neurobiolaging.2013.12.006","article-title":"Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology","volume":"35","author":"Orr","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.lfs.2015.05.002_bb0415","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cellbi.2003.12.003","article-title":"Leptin-induced signal transduction pathways","volume":"28","author":"Hegyi","year":"2004","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.lfs.2015.05.002_bb0420","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00109-013-1057-6","article-title":"mTOR and regulation of energy homeostasis in humans","volume":"91","author":"Mannaa","year":"2013","journal-title":"J. Mol. Med."},{"issue":"288","key":"10.1016\/j.lfs.2015.05.002_bb0425","doi-asserted-by":"crossref","first-page":"15556","DOI":"10.1074\/jbc.M112.435123","article-title":"Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease","volume":"31","author":"Tang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0430","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2015.05.002_bb0435","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4161\/cc.10.20.17886","article-title":"Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?","volume":"10","author":"Saha","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2015.05.002_bb0440","doi-asserted-by":"crossref","unstructured":"N.A. Shirwany, M.H. Zou, AMPK: a cellular metabolic and redox sensor. A minireview, Front Biosci (Landmark Ed), 19 (2014) 447\u2013474. 10.2741\/4218","DOI":"10.2741\/4218"},{"key":"10.1016\/j.lfs.2015.05.002_bb0445","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2011-101356","article-title":"PPAR\u03b3 co-activator-1\u03b1 (PGC-1\u03b1) reduces amyloid-\u03b2 generation through a PPAR\u03b3-dependent mechanism","volume":"25","author":"Katsouri","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0450","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/gerona\/glq018","article-title":"Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice","volume":"65","author":"Louis","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0455","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.00-0339com","article-title":"Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components","volume":"15","author":"Laflamme","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2015.05.002_bb0460","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jacc.2008.05.060","article-title":"Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease","volume":"52","author":"Martin","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0465","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/acel.12281","article-title":"The Alzheimer's disease neuroimaging initiative. Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease","volume":"14","author":"Maioli","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.lfs.2015.05.002_bb0470","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.peptides.2009.08.023","article-title":"Leptin receptor mRNA in rat brain astrocytes","volume":"30","author":"Hsuchou","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2015.05.002_bb0475","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.1471-4159.2003.01837.x","article-title":"Advanced glycation endproducts and pro-inflammatory cytokines in transg\u00e8nic Tg2576 mice with amyloid plaque pathology","volume":"86","author":"Munch","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2015.05.002_bb0480","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/glia.22289","article-title":"APOE genotype alters glial activation and loss of synaptic markers in mice","volume":"60","author":"Zhu","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2015.05.002_bb0485","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1172\/JCI64102","article-title":"Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes","volume":"122","author":"Fuente-Mart\u00edn","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2015.05.002_bb0490","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.2337\/db11-1498","article-title":"Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet","volume":"61","author":"Jeon","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2015.05.002_bb0495","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's Disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2015.05.002_bb0500","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1582-4934.2008.00314.x","article-title":"Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease","volume":"12","author":"Farfara","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2015.05.002_bb0505","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3109\/08923973.2012.705292","article-title":"The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis","volume":"34","author":"Azizi","year":"2012","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"10","key":"10.1016\/j.lfs.2015.05.002_bb0510","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0515","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0520","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1677\/JOE-10-0040","article-title":"Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus","volume":"205","author":"Lee","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0525","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1046\/j.1460-9568.2000.00140.x","article-title":"Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus","volume":"12","author":"De Simoni","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0530","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1528-1167.2005.01006.x","article-title":"Inflammatory response and glia activation in developing rat hippocampus after status epilepticus","volume":"46","author":"Ravizza","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2015.05.002_bb0535","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.0013-9580.2005.08204.x","article-title":"Correlation of severity of FDG-PET hypometabolism and interictal regional delta slowing in temporal lobe epilepsy","volume":"46","author":"Erbayat-Altay","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2015.05.002_bb0540","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejphar.2011.08.020","article-title":"Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus","volume":"670","author":"Biagini","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0545","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2012-111385","article-title":"Lipids and adipokines as risk factors for Alzheimer's disease","volume":"29","author":"Warren","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2015.05.002_bb0550","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","article-title":"Prolactin: structure, function, and regulation of secretion","volume":"80","author":"Freeman","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2015.05.002_bb0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10284150400027107","article-title":"Brain somatic cross-talk: ghrelin, leptin and ultimate challengers of obesity","volume":"8","author":"Popovic","year":"2005","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0560","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.neuroscience.2010.05.074","article-title":"Prolactin reduces the damaging effects of excitotoxicity in the dorsal hippocampus of the female rat independently of ovarian hormones","volume":"169","author":"Tejadilla","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2015.05.002_bb0565","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/ENDO:20:1-2:139","article-title":"Prolactin replacement must be continuous and initiated prior to 21 d of age to maintain hypothalamic dopaminergic neurons in hypopituitary mice","volume":"20","author":"Phelps","year":"2003","journal-title":"Endocrine"},{"key":"10.1016\/j.lfs.2015.05.002_bb0570","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.devbrainres.2005.01.008","article-title":"Gestation-induced cell proliferation in the rat brain","volume":"156","author":"Furuta","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.lfs.2015.05.002_bb0575","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0736-5748(00)00031-9","article-title":"Prolactin concurrently activates src-PLD and JAK\/Stat signaling pathways to induce proliferation while promoting differentiation in embryonic astrocytes","volume":"18","author":"Mangoura","year":"2000","journal-title":"Int. J. Dev. Neurosci."},{"issue":"2009","key":"10.1016\/j.lfs.2015.05.002_bb0580","article-title":"Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate","volume":"29","author":"Torner","year":"1826","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2015.05.002_bb0585","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.physiol.64.081501.131049","article-title":"Prolactin: the new biology of an old hormone","volume":"64","author":"Goffin","year":"2002","journal-title":"Annu Ver Physiol"},{"key":"10.1016\/j.lfs.2015.05.002_bb0590","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1365-2826.2011.02141.x","article-title":"Recent findings on neuroprotection against excitotoxicity in the hippocampus of female rats","volume":"23","author":"Morales","year":"2011","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0595","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1677\/JOE-07-0540","article-title":"Leptin stimulates pituitary prolactin release through an extracellular signal-regulated kinase-dependent pathway","volume":"196","author":"Tipsmark","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0600","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2013.11.050","article-title":"Possible crosstalk between leptin and prolactin during pregnancy","volume":"259","author":"Nagaishi","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2015.05.002_bb0605","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/en.2007-1018","article-title":"Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion","volume":"149","author":"Augustine","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0610","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1365-2826.2010.02017.x","article-title":"Hormone interactions regulating energy balance during pregnancy","volume":"22","author":"Ladyman","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0615","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/JOE-14-0258","article-title":"20years of leptin: leptin in common obesity and associated disorders of metabolism","volume":"223","author":"De Paoli","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0620","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2015.05.002_bb0625","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1210\/en.2010-0590","article-title":"Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats","volume":"151","author":"Trevaskis","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0630","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/en.2009-0546","article-title":"Mechanisms of amylin\/leptin synergy in rodent models","volume":"151","author":"Turek","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0635","article-title":"Amylin-induced central IL-6 production enhances ventromedial hypothalamicleptin signalling","author":"Le Foll","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2015.05.002_bb0640","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha","volume":"104","author":"Jager","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2015.05.002_bb0645","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1210\/en.2005-0770","article-title":"Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons","volume":"146","author":"Ma","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2015.05.002_bb0650","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pneurobio.2014.07.004","article-title":"Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum","volume":"121","author":"R\u00edos","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0655","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/jnen\/63.5.418","article-title":"Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory","volume":"63","author":"Sadowski","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.lfs.2015.05.002_bb0660","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/418595a","article-title":"Obesity: keeping hunger at bay","volume":"418","author":"Schwartz","year":"2002","journal-title":"Nature"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T03:24:28Z","timestamp":1717903468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515002581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":132,"alternative-id":["S0024320515002581"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.05.002","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}