{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:29:56Z","timestamp":1781249396107,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.lfs.2015.05.008","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T08:39:43Z","timestamp":1432975183000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease"],"prefix":"10.1016","volume":"134","author":[{"given":"Artem A.","family":"Tykhomyrov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S.","family":"Nedzvetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia I.","family":"Bardachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana V.","family":"Grinenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olexandr V.","family":"Kuryata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2015.05.008_bb0005","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1089\/ars.2013.5526","article-title":"Rac1-mediated effects of HMG-CoA reductase inhibitors (statins) in cardiovascular disease","volume":"20","author":"Adam","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2015.05.008_bb0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/138161212799504803","article-title":"Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials","volume":"18","author":"Antonopoulos","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2015.05.008_bb0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/2048872612441582","article-title":"Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease","volume":"1","author":"Badimon","year":"2012","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.lfs.2015.05.008_bb0020","doi-asserted-by":"crossref","first-page":"F893","DOI":"10.1152\/ajprenal.00328.2003","article-title":"Angiostatin and matrix metalloprotease expression following ischemic acute renal failure","volume":"286","author":"Basile","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4 Suppl S","key":"10.1016\/j.lfs.2015.05.008_bb0025","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/S0735-1097(02)02953-4","article-title":"C-reactive protein and other inflammatory risk markers in acute coronary syndromes","volume":"41","author":"Blake","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lfs.2007.04.027","article-title":"Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine","volume":"81","author":"Bolayirli","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2015.05.008_bb0035","doi-asserted-by":"crossref","first-page":"29461","DOI":"10.1074\/jbc.271.46.29461","article-title":"Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells","volume":"271","author":"Cao","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2015.05.008_bb0040","first-page":"179","article-title":"Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?","volume":"9","author":"Cao","year":"2010","journal-title":"Discov. Med."},{"key":"10.1016\/j.lfs.2015.05.008_bb0045","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1538-7836.2009.03671.x","article-title":"Human plasminogen kringle 1\u20135 reduces atherosclerosis and neointima formation in mice by suppressing the inflammatory signaling pathway","volume":"8","author":"Chang","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.lfs.2015.05.008_bb0050","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2174\/1570161112999141127161508","article-title":"Pleiotropic effects of statin in therapy in heart failure: a review","volume":"12","author":"Correale","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0055","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/ATVBAHA.113.301533","article-title":"Impaired coronary collateral growth in the metabolic syndrome is in part mediated by matrix metalloproteinase 12-dependent production of endostatin and angiostatin","volume":"33","author":"Dodd","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0021-9150(03)00299-5","article-title":"Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells","volume":"170","author":"Frick","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2015.05.008_bb0065","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"issue":"8A","key":"10.1016\/j.lfs.2015.05.008_bb0070","doi-asserted-by":"crossref","first-page":"44C","DOI":"10.1016\/j.amjcard.2005.12.009","article-title":"Statin safety: lessons from new drug applications for marketed statins","volume":"97","author":"Jacobson","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0075","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/01.ATV.17.6.1114","article-title":"Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease. An 8-year follow-up in the Copenhagen Male Study","volume":"17","author":"Jeppersen","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.lfs.2015.05.008_bb0080","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ahj.2004.06.027","article-title":"Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients","volume":"149","author":"John","year":"2005","journal-title":"Am. Heart J."},{"key":"10.1016\/j.lfs.2015.05.008_bb0085","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1538-7836.2006.01878.x","article-title":"Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects on angiogenesis","volume":"4","author":"Jurasz","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.lfs.2015.05.008_bb0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0025-6196(11)60544-2","article-title":"Intensive lowering of low-density lipoprotein cholesterol levels for primary prevention of coronary artery disease","volume":"84","author":"Karalis","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.lfs.2015.05.008_bb0095","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1179\/2295333714Y.0000000030","article-title":"Serum angiostatin levels in patients with Beh\u00e7et's disease: does angiogenesis play a role in the pathogenesis of Beh\u00e7et's disease?","volume":"69","author":"Keskin","year":"2014","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.lfs.2015.05.008_bb0100","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/CIRCULATIONAHA.105.535294","article-title":"Role of angiogenesis in cardiovascular disease: a critical appraisal","volume":"112","author":"Khurana","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2015.05.008_bb0105","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/clc.4960261008","article-title":"Rapid effects of simvastatin on lipid profile and C-reactive protein in patients with hypercholesterolemia","volume":"26","author":"Li","year":"2003","journal-title":"Clin. Cardiol."},{"issue":"96(5A)","key":"10.1016\/j.lfs.2015.05.008_bb0110","doi-asserted-by":"crossref","first-page":"24F","DOI":"10.1016\/j.amjcard.2005.06.009","article-title":"Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition beyond low-density lipoprotein cholesterol","volume":"5","author":"Liao","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2015.05.008_bb0120","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.ATV.0000068646.76823.AE","article-title":"Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages","volume":"23","author":"Luan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2015.05.008_bb0125","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1089\/ars.2013.5430","article-title":"Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering","volume":"20","author":"Margaritis","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2015.05.008_bb0130","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1161\/01.CIR.0000015856.84385.E9","article-title":"Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide","volume":"105","author":"Matsunaga","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2015.05.008_bb0135","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2174\/1567205011666141001114858","article-title":"The complex actions of statins in brain and their relevance for Alzheimer's disease treatment: an analytical review","volume":"11","author":"Mendoza-Oliva","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.lfs.2015.05.008_bb0140","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.2174\/138161210794455120","article-title":"The antiplatelet and antithrombotic actions of statins","volume":"16","author":"Mitsios","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2015.05.008_bb0145","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1073\/pnas.0730843100","article-title":"Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis","volume":"100","author":"Moulton","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.lfs.2015.05.008_bb0150","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1002\/art.22861","article-title":"Antiangiogenic plasma activity in patients with systemic sclerosis","volume":"56","author":"Mulligan-Kehoe","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2015.05.008_bb0155","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.CIR.95.5.1126","article-title":"Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1month","volume":"95","author":"O'Driscoll","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2015.05.008_bb0160","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1101\/SQB.1994.059.01.052","article-title":"Angiostatin: a circulating endothelial cell inhibitor that suppresses angiogenesis and tumor growth","volume":"59","author":"O'Reilly","year":"1994","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cardiores.2006.03.004","article-title":"C-reactive protein in atherosclerosis: a causal factor?","volume":"71","author":"Paffen","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2015.05.008_bb0170","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2015.05.008_bb0175","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1517\/14656566.5.12.2583","article-title":"Simvastatin: a review","volume":"5","author":"Pedersen","year":"2004","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.lfs.2015.05.008_bb0180","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.surg.2004.06.004","article-title":"Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases","volume":"137","author":"Peeters","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.lfs.2015.05.008_bb0185","first-page":"109","article-title":"Endothelial dysfunction in the pathogenesis of atherosclerosis","volume":"21","author":"Poredos","year":"2002","journal-title":"Int. Angiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0190","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2174\/15701611113119990134","article-title":"Statin treatment and carotid plaque composition: a review of clinical studies","volume":"12","author":"Puato","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0195","first-page":"927","article-title":"Atherosclerosis: process, indicators, risk factors and new hopes","volume":"5","author":"Rafieian-Kopaei","year":"2014","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.lfs.2015.05.008_bb0200","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/eurheartj\/ehr158","article-title":"ESC\/EAS Guidelines for the management of dyslipidaemias. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)","volume":"32","author":"Reiner","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2015.05.008_bb0205","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa021993","article-title":"Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events","volume":"347","author":"Ridker","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2015.05.008_bb0210","doi-asserted-by":"crossref","first-page":"H428","DOI":"10.1152\/ajpheart.00283.2008","article-title":"Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation","volume":"296","author":"Sodha","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0215","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1026525121027","article-title":"Angiostatin and angiostatin-related proteins","volume":"19","author":"Soff","year":"2000","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.lfs.2015.05.008_bb0220","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/S0735-1097(99)00023-6","article-title":"Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia","volume":"33","author":"Szczeklik","year":"1999","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2015.05.008_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009217.pub2","article-title":"Statins for the primary prevention of cardiovascular disease","volume":"1","author":"Taylor","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.lfs.2015.05.008_bb0230","doi-asserted-by":"crossref","first-page":"86","DOI":"10.15407\/biotech6.01.086","article-title":"Production and characteristics of antibodies against K1\u20133 fragment of human plasminogen","volume":"6","author":"Tykhomyrov","year":"2013","journal-title":"Biotechnologia Acta"},{"key":"10.1016\/j.lfs.2015.05.008_bb0235","series-title":"World health statistics 2009","author":"WHO","year":"2009"},{"key":"10.1016\/j.lfs.2015.05.008_bb0240","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/hc0602.103393","article-title":"Statins have biphasic effects on angiogenesis","volume":"105","author":"Weis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2015.05.008_bb0245","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biopha.2009.08.005","article-title":"The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor","volume":"64","author":"Zhu","year":"2010","journal-title":"Biomed. Pharmacother."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515002842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T04:39:10Z","timestamp":1652157550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515002842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":49,"alternative-id":["S0024320515002842"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.05.008","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}