{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:52:31Z","timestamp":1768531951871,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.lfs.2015.09.004","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T21:04:31Z","timestamp":1442264671000},"page":"128-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Antifungal antibiotics modulate the pro-inflammatory cytokine production and phagocytic activity of human monocytes in an in vitro sepsis model"],"prefix":"10.1016","volume":"141","author":[{"given":"Stefan","family":"Muenster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Jahnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Weisheit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert","family":"Steinhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stilla","family":"Frede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hoeft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Knuefermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Baumgarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2015.09.004_bb0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/CCM.0b013e3181d8cc1d","article-title":"Long-term mortality and quality of life in sepsis: a systematic review","volume":"38","author":"Winters","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2015.09.004_bb0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1473-3099(12)70239-6","article-title":"Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study","volume":"12","author":"Levy","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.lfs.2015.09.004_bb0015","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1378\/chest.11-0352","article-title":"Nationwide trends of severe sepsis in the 21st century (2000\u20132007)","volume":"140","author":"Kumar","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2015.09.004_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccc.2010.11.001","article-title":"Fungal sepsis: optimizing antifungal therapy in the critical care setting","volume":"27","author":"Lepak","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.lfs.2015.09.004_bb0025","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2015.09.004_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nri1255","article-title":"Immunity to fungal infections","volume":"4","author":"Romani","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.lfs.2015.09.004_bb0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.lfs.2015.09.004_bb0040","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2015.09.004_bb0045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1369-5274(02)00342-9","article-title":"Interactions of fungi with phagocytes","volume":"5","author":"Mansour","year":"2002","journal-title":"Curr. Opin. Microbiol."},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2015.09.004_bb0050","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/590061","article-title":"Broad-spectrum antimicrobials and the treatment of serious bacterial infections: getting it right up front","volume":"47","author":"Kollef","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.lfs.2015.09.004_bb0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/2047-783X-16-4-159","article-title":"Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis: review of the literature","volume":"16","author":"Kofla","year":"2011","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.lfs.2015.09.004_bb0060","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.2165\/11596540-000000000-00000","article-title":"Triazole antifungal agents in invasive fungal infections: a comparative review","volume":"71","author":"Lass-Florl","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.lfs.2015.09.004_bb0065","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fmicb.2012.00286","article-title":"It only takes one to do many jobs: amphotericin B as antifungal and immunomodulatory drug","volume":"3","author":"Mesa-Arango","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2015.09.004_bb0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1086\/589290","article-title":"Immunocompromised hosts: immunopharmacology of modern antifungals","volume":"47","author":"Ben-Ami","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2015.09.004_bb0075","doi-asserted-by":"crossref","first-page":"e19588","DOI":"10.1371\/journal.pone.0019588","article-title":"Polyene macrolide antifungal drugs trigger interleukin-1beta secretion by activating the NLRP3 inflammasome","volume":"6","author":"Darisipudi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2015.09.004_bb0080","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1097\/CCM.0b013e31816fc4cd","article-title":"Risk factors for albicans and non-albicans candidemia in the intensive care unit","volume":"36","author":"Chow","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2015.09.004_bb0085","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/00003246-199906000-00019","article-title":"Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients","volume":"27","author":"Eggimann","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2015.09.004_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.intimp.2013.10.025","article-title":"Antibiotics regulate the immune response in both presence and absence of lipopolysaccharide through modulation of Toll-like receptors, cytokine production and phagocytosis in vitro","volume":"18","author":"Bode","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2015.09.004_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-1759(93)90400-2","article-title":"A rapid and simple microfluorometric phagocytosis assay","volume":"162","author":"Wan","year":"1993","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.lfs.2015.09.004_bb0100","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1128\/AAC.49.4.1397-1403.2005","article-title":"Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B","volume":"49","author":"Simitsopoulou","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.lfs.2015.09.004_bb0105","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: complexity in action","volume":"20","author":"Underhill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2015.09.004_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0b013e318181a343","article-title":"Experimental models of sepsis and their clinical relevance","volume":"30","author":"Poli-de-Figueiredo","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2015.09.004_bb0115","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/00003246-199612000-00021","article-title":"Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis","volume":"24","author":"Piper","year":"1996","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2015.09.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/ja.2015.18","article-title":"Linezolid, vancomycin and daptomycin modulate cytokine production, Toll-like receptors and phagocytosis in a human in vitro model of sepsis","author":"Bode","year":"2015","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.lfs.2015.09.004_bb0125","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1469-0691.2002.00374.x","article-title":"Effect of moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide","volume":"8","author":"Araujo","year":"2002","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.lfs.2015.09.004_bb0130","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1439-0507.1995.tb00020.x","article-title":"Infusion-related toxicity of three different amphotericin B formulations and its relation to cytokine plasma levels","volume":"38","author":"Arning","year":"1995","journal-title":"Mycoses"},{"key":"10.1016\/j.lfs.2015.09.004_bb0135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/AAC.00607-11","article-title":"Differences in efficacy and cytokine profiles following echinocandin or liposomal amphotericin B monotherapy or combination therapy for murine pulmonary or systemic Aspergillus flavus infections","volume":"56","author":"Olson","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.lfs.2015.09.004_bb0140","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jac\/dkh542","article-title":"Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4","volume":"55","author":"Bellocchio","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.lfs.2015.09.004_bb0145","doi-asserted-by":"crossref","first-page":"37561","DOI":"10.1074\/jbc.M306137200","article-title":"The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism","volume":"278","author":"Sau","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.lfs.2015.09.004_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2015.09.004_bb0155","first-page":"2013","article-title":"Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide","volume":"697972","author":"Schildberger","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2015.09.004_bb0160","first-page":"2010","article-title":"Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents","volume":"201","author":"Katragkou","year":"1941","journal-title":"The Journal of infectious diseases"},{"key":"10.1016\/j.lfs.2015.09.004_bb0165","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.diagmicrobio.2011.11.004","article-title":"Effects of echinocandins on cytokine\/chemokine production by human monocytes activated by infection with Candida glabrata or by lipopolysaccharide","volume":"72","author":"Baltch","year":"2012","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.lfs.2015.09.004_bb0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tim.2003.09.001","article-title":"Glucose-regulated stress proteins and antibacterial immunity","volume":"11","author":"Rapp","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.lfs.2015.09.004_bb0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.lfs.2015.09.004_bb0180","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/bit.23282","article-title":"A review of the mammalian unfolded protein response","volume":"108","author":"Chakrabarti","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.lfs.2015.09.004_bb0185","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2015.09.004_bb0190","first-page":"709","article-title":"Effect of itraconazoles on the production of pro-inflammatory substances in mouse macrophage-like cells","volume":"24","author":"Kato","year":"2010","journal-title":"In vivo"},{"key":"10.1016\/j.lfs.2015.09.004_bb0195","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1128\/AAC.01018-07","article-title":"Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors","volume":"52","author":"Simitsopoulou","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.lfs.2015.09.004_bb0200","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jac\/dkn036","article-title":"Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus","volume":"61","author":"Dotis","year":"2008","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.lfs.2015.09.004_bb0205","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10096-004-1171-z","article-title":"Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing of Candida albicans by human phagocytes","volume":"23","author":"Frank","year":"2004","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.lfs.2015.09.004_bb0210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/SHK.0000000000000169","article-title":"Itraconazole, a commonly used antifungal, inhibits Fcgamma receptor-mediated phagocytosis: alteration of Fcgamma receptor glycosylation and gene expression","volume":"42","author":"Nino","year":"2014","journal-title":"Shock"},{"issue":"Suppl 1","key":"10.1016\/j.lfs.2015.09.004_bb0215","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.ijantimicag.2008.06.004","article-title":"Immunomodulatory therapies for sepsis: unexpected effects with macrolides","volume":"32","author":"Giamarellos-Bourboulis","year":"2008","journal-title":"Int J Antimicrob Agents"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515300084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515300084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T07:51:23Z","timestamp":1537343483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515300084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":43,"alternative-id":["S0024320515300084"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.09.004","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifungal antibiotics modulate the pro-inflammatory cytokine production and phagocytic activity of human monocytes in an in vitro sepsis model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}