{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:00:49Z","timestamp":1771012849308,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.lfs.2015.11.009","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T22:30:29Z","timestamp":1447194629000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Involvement of the monoamine system in antidepressant-like properties of 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester"],"prefix":"10.1016","volume":"143","author":[{"given":"Pablinny Moreira","family":"Galdino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danillo Ramos","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iziara Ferreira","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Oluwagbamigbe","family":"Fajemiroye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marize Campos","family":"Valadares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraia Santana","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Fagundes","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thereza Christina Monteiro","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2015.11.009_bb0005","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Life time prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.lfs.2015.11.009_bb0010","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2015.11.009_bb0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2015.11.009_bb0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/dneu.20758","article-title":"The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity","volume":"70","author":"Castr\u00e9n","year":"2010","journal-title":"Dev. Neurobiol."},{"issue":"7","key":"10.1016\/j.lfs.2015.11.009_bb0025","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.bmcl.2012.02.023","article-title":"Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents","volume":"22","author":"Chae","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2015.11.009_bb0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1734-1140(11)70400-5","article-title":"Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice","volume":"63","author":"Sapa","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.lfs.2015.11.009_bb0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pbb.2013.05.006","article-title":"Antidepressant-like activity of 2-(4-phenylpiperazin-1-yl)-1, 8-naphthyridine-3-carboxylic acid (7a), a 5-HT\u2083 receptor antagonist in behaviour based rodent models: evidence for the involvement of serotonergic system","volume":"109","author":"Gautam","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"7","key":"10.1016\/j.lfs.2015.11.009_bb0040","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s12272-013-0119-1","article-title":"Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects","volume":"36","author":"\u00d6zkay","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.lfs.2015.11.009_bb0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ejmech.2013.04.054","article-title":"Synthesis of novel 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl] piperazine derivatives and evaluation of their in vivo anticonvulsant activity","volume":"65","author":"Harish","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2015.11.009_bb0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejmech.2013.05.027","article-title":"Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579","volume":"66","author":"Pompeu","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.lfs.2015.11.009_bb0055","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.bmc.2012.02.009","article-title":"Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with \u03b11-adrenoceptor affinities","volume":"20","author":"Handzlik","year":"2012","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.lfs.2015.11.009_bb0060","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.3390\/molecules17089451","article-title":"Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives","volume":"17","author":"Barea","year":"2012","journal-title":"Molecules"},{"issue":"23\u201324","key":"10.1016\/j.lfs.2015.11.009_bb0065","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.lfs.2012.04.037","article-title":"Central pharmacological activity of a new piperazine derivative: 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester","volume":"90","author":"Brito","year":"2012","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.lfs.2015.11.009_bb0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","article-title":"Tests for emotionality in rats and mice: a review","volume":"21","author":"Archer","year":"1973","journal-title":"Anim. Behav."},{"key":"10.1016\/j.lfs.2015.11.009_bb0075","first-page":"291","article-title":"Behavioural despair in rats and mice: strain differences and the effects of imipramine Eur","volume":"51","author":"Porsolt","year":"1978","journal-title":"J. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2015.11.009_bb0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.lfs.2015.11.009_bb0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2015.11.009_bb0090","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1006\/abio.1996.9911","article-title":"A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates","volume":"244","author":"Holt","year":"1997","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2015.11.009_bb0095","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.sajb.2007.03.001","article-title":"Monoamine oxidase inhibition by southern African traditional medicinal plants","volume":"73","author":"Stafford","year":"2007","journal-title":"S. Afr. J. Bot."},{"issue":"2","key":"10.1016\/j.lfs.2015.11.009_bb0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","article-title":"In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride","volume":"160","author":"Fotakis","year":"2006","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.lfs.2015.11.009_bb0105","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.etp.2010.03.012","article-title":"In vitro basal cytotoxicity assay applied to estimate acute oral systemic toxicity of grandisin and its major metabolite","volume":"63","author":"Vieira","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2015.11.009_bb0110","author":"ICCVAM"},{"key":"10.1016\/j.lfs.2015.11.009_bb0115","first-page":"320","article-title":"A Hippocratic screen for pure or crude drug materials","volume":"25","author":"Malone","year":"1962","journal-title":"Lloydia"},{"key":"10.1016\/j.lfs.2015.11.009_bb0120","series-title":"New Natural Products and Plant Drugs With Pharmacological, Biological or Therapeutical activity","first-page":"23","article-title":"Pharmacological approaches to natural product screening and evaluation","author":"Malone","year":"1977"},{"key":"10.1016\/j.lfs.2015.11.009_bb0125","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbr.2005.06.015","article-title":"A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests","volume":"164","author":"Bourin","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.lfs.2015.11.009_bb0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.lfs.2015.11.009_bb0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"issue":"4\u20135","key":"10.1016\/j.lfs.2015.11.009_bb0140","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2015.11.009_bb0145","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/10408440802014238","article-title":"An assessment of anxiolytic drug screening tests: hormetic dose responses predominate","volume":"38","author":"Calabrese","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"issue":"3","key":"10.1016\/j.lfs.2015.11.009_bb0150","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.pbb.2012.11.004","article-title":"Participation of estrogen receptors in the antidepressant-like effect of prolame on the forced swimming test","volume":"103","author":"Lemini","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3","key":"10.1016\/j.lfs.2015.11.009_bb0155","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.euroneuro.2006.03.002","article-title":"Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests","volume":"17","author":"Belozertseva","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"8","key":"10.1016\/j.lfs.2015.11.009_bb0160","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1248\/yakushi.125.653","article-title":"Biphasic effects of losartan potassium on immobility in mice","volume":"125","author":"Vijayapandi","year":"2005","journal-title":"Yakugaku Zasshi"},{"issue":"4","key":"10.1016\/j.lfs.2015.11.009_bb0165","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF02247141","article-title":"Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice","volume":"102","author":"Reis de Oliveria","year":"1990","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.lfs.2015.11.009_bb0170","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0165-6147(00)01719-3","article-title":"Hormesis: U-shaped dose responses and their centrality in toxicology","volume":"22","author":"Calabrese","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"issue":"13","key":"10.1016\/j.lfs.2015.11.009_bb0175","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1016\/j.bmcl.2010.05.008","article-title":"2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression","volume":"20","author":"Carter","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.lfs.2015.11.009_bb0180","article-title":"Antidepressive-like property of dichloromethane fraction of Pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes","volume":"659391","author":"Fajemiroye","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2015.11.009_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuropharm.2012.09.002","article-title":"Cannabinoid CB\u2081 receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations","volume":"65","author":"H\u00e4ring","year":"2013","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.lfs.2015.11.009_bb0190","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbr.2011.09.031","article-title":"Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test","volume":"226","author":"Kawaura","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2015.11.009_bb0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0022-3565(25)27497-3","article-title":"p-Chlorophenylalanine: a specific depletor of brain serotonin","volume":"154","author":"Koe","year":"1966","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.lfs.2015.11.009_bb0200","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0091-3057(75)90010-6","article-title":"Alpha-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas","volume":"3","author":"Kostrzewa","year":"1975","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"14","key":"10.1016\/j.lfs.2015.11.009_bb0205","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2174\/138161209788168001","article-title":"Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today","volume":"15","author":"L\u00f3pez-Mu\u00f1oz","year":"2009","journal-title":"Curr. Pharm. Des."},{"issue":"13\u201314","key":"10.1016\/j.lfs.2015.11.009_bb0210","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: from pathophysiology to therapeutics","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2015.11.009_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2015.11.009_bb0220","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pnpbp.2007.07.027","article-title":"Acute administration of ketamine induces antidepressant like effects in the forced swimming test and increases BDNF levels in the rat hippocampus","volume":"32","author":"Garcia","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.lfs.2015.11.009_bb0225","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","article-title":"Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments","volume":"15","author":"Nibuya","year":"1995","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2015.11.009_bb0230","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.yrtph.2008.02.002","article-title":"Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: opportunities, limits and regulatory status","volume":"51","author":"Ukelis","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2015.11.009_bb0235","article-title":"Globally harmonised system of classification and labelling of chemicals, fourth revised edition","author":"United Nations","year":"2011"},{"issue":"4","key":"10.1016\/j.lfs.2015.11.009_bb0240","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.1996.03540040037030","article-title":"Cross-national epidemiology of major depression and bipolar disorder","volume":"276","author":"Weissman","year":"1996","journal-title":"J. Am. Med. Assoc."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515300722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320515300722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T11:00:33Z","timestamp":1748689233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320515300722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":48,"alternative-id":["S0024320515300722"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2015.11.009","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of the monoamine system in antidepressant-like properties of 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2015.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}