{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:24:29Z","timestamp":1759962269492,"version":"3.40.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81470588","81100527","81100090","81171792"],"award-info":[{"award-number":["81470588","81100527","81100090","81171792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.lfs.2016.01.003","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T07:00:37Z","timestamp":1452236437000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics"],"prefix":"10.1016","volume":"146","author":[{"given":"Rong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-0335","authenticated-orcid":false,"given":"Jun-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.lfs.2016.01.003_bb0005","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Hsu C-y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.lfs.2016.01.003_bb0010","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.lfs.2016.01.003_bb0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.lfs.2016.01.003_bb0020","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2215\/CJN.07810910","article-title":"Chronic kidney disease progression and outcome according to serum phosphorus in mild-to-moderate kidney dysfunction","volume":"6","author":"Bellasi","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2016.01.003_bb0025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"issue":"6","key":"10.1016\/j.lfs.2016.01.003_bb0030","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/01.CIR.0000028581.07992.56","article-title":"Endothelial function a barometer for cardiovascular risk?","volume":"106","author":"Vita","year":"2002","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.lfs.2016.01.003_bb0035","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1681\/ASN.2008101106","article-title":"Dietary phosphorus acutely impairs endothelial function","volume":"20","author":"Shuto","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.lfs.2016.01.003_bb0040","doi-asserted-by":"crossref","first-page":"F1381","DOI":"10.1152\/ajprenal.00003.2008","article-title":"Increased inorganic phosphate induces human endothelial cell apoptosis in vitro","volume":"294","author":"Di Marco","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2016.01.003_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ki.2012.300","article-title":"High phosphate directly affects endothelial function by downregulating annexin II","volume":"83","author":"Di Marco","year":"2013","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.lfs.2016.01.003_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023268","article-title":"Adverse effects of simulated hyper-and hypo-phosphatemia on endothelial cell function and viability","volume":"6","author":"Peng","year":"2011","journal-title":"PLoS One"},{"issue":"7216","key":"10.1016\/j.lfs.2016.01.003_bb0055","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","article-title":"Systems biology: metabonomics","volume":"455","author":"Nicholson","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.lfs.2016.01.003_bb0060","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s10157-011-0467-4","article-title":"Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model","volume":"15","author":"Toyohara","year":"2011","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.lfs.2016.01.003_bb0065","article-title":"Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats","author":"Uehara","year":"2013","journal-title":"J. Appl. Toxicol."},{"issue":"5","key":"10.1016\/j.lfs.2016.01.003_bb0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1752-8062.2012.00437.x","article-title":"A pilot metabolic profiling study in serum of patients with chronic kidney disease based on 1H-NMR-spectroscopy","volume":"5","author":"Qi","year":"2012","journal-title":"Clin. Transl. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2016.01.003_bb0075","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1681\/ASN.2009111132","article-title":"Metabolite profiling identifies markers of uremia","volume":"21","author":"Rhee","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.lfs.2016.01.003_bb0080","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2215\/CJN.05540512","article-title":"Plasma metabolomic profiles in different stages of CKD","volume":"8","author":"Shah","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.lfs.2016.01.003_bb0085","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1681\/ASN.2013020126","article-title":"Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease","volume":"24","author":"Sharma","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.lfs.2016.01.003_bb0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1582-4934.2009.00939.x","article-title":"Metabolic profiling reveals key metabolic features of renal cell carcinoma","volume":"15","author":"Catchpole","year":"2011","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.lfs.2016.01.003_bb0095","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jpba.2011.04.001","article-title":"Metabolite profiling of hemodialysate using gas chromatography time-of-flight mass spectrometry","volume":"55","author":"Qi","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.lfs.2016.01.003_bb0100","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/tx8003246","article-title":"Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells","volume":"22","author":"Vulimiri","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"16","key":"10.1016\/j.lfs.2016.01.003_bb0105","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/ac901536h","article-title":"Integrated, nontargeted ultrahigh performance liquid chromatography\/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems","volume":"81","author":"Evans","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.lfs.2016.01.003_bb0110","first-page":"25","article-title":"The Bradford method for protein quantitation","volume":"3","author":"Hammond","year":"1988","journal-title":"Methods Mol. Biol."},{"issue":"12","key":"10.1016\/j.lfs.2016.01.003_bb0115","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1002\/ijc.26274","article-title":"Urinary acylcarnitines are altered in human kidney cancer","volume":"130","author":"Ganti","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2016.01.003_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-2-9","article-title":"Organization of GC\/MS and LC\/MS metabolomics data into chemical libraries","volume":"2","author":"DeHaven","year":"2010","journal-title":"J. Cheminf."},{"issue":"5","key":"10.1016\/j.lfs.2016.01.003_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010883","article-title":"Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population","volume":"5","author":"Gall","year":"2010","journal-title":"Plos One"},{"issue":"19","key":"10.1016\/j.lfs.2016.01.003_bb0130","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.1021\/ac800954c","article-title":"Analysis of metabolomic data using support vector machines","volume":"80","author":"Mahadevan","year":"2008","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.lfs.2016.01.003_bb0135","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/pr901081y","article-title":"Urinary metabonomic study on colorectal cancer","volume":"9","author":"Qiu","year":"2010","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.lfs.2016.01.003_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037210","article-title":"Metabolic disturbances associated with systemic lupus erythematosus","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2016.01.003_bb0145","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/bj3120649","article-title":"Transcriptional regulation of genes for ornithine cycle enzymes","volume":"312","author":"Takiguchi","year":"1995","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.lfs.2016.01.003_bb0150","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/cbf.2849","article-title":"N-acetylcysteine normalizes the urea cycle and DNA repair in cells from patients with Batten disease","volume":"30","author":"Kim","year":"2012","journal-title":"Cell Biochem. Funct."},{"issue":"10","key":"10.1016\/j.lfs.2016.01.003_bb0155","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.109.908988","article-title":"Homoarginine, cardiovascular risk, and mortality","volume":"122","author":"Marz","year":"2010","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.lfs.2016.01.003_bb0160","doi-asserted-by":"crossref","first-page":"21819","DOI":"10.3390\/ijms141121819","article-title":"Opposite associations of plasma homoarginine and ornithine with arginine in healthy children and adolescents","volume":"14","author":"Jazwinska-Kozuba","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2016.01.003_bb0165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.CIR.88.1.77","article-title":"Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans","volume":"88","author":"Egashira","year":"1993","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.lfs.2016.01.003_bb0170","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000153339.27064.14","article-title":"Endothelial function \u2014 cardiac events","volume":"111","author":"Lerman","year":"2005","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.lfs.2016.01.003_bb0175","doi-asserted-by":"crossref","first-page":"H651","DOI":"10.1152\/ajpheart.00755.2012","article-title":"Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS","volume":"305","author":"Elms","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2016.01.003_bb0180","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2014.11.002","article-title":"Asymmetric dimethylarginine (ADMA) in cardiovascular and renal disease","volume":"440","author":"Alpoim","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.lfs.2016.01.003_bb0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2460\/ajvr.1999.60.01.109","article-title":"Plasma amino acid profiles in cats with naturally acquired chronic renal failure","volume":"60","author":"Goldstein","year":"1999","journal-title":"Am. J. Vet. Res."},{"issue":"6","key":"10.1016\/j.lfs.2016.01.003_bb0190","first-page":"240","article-title":"Amino acid metabolism in the chronically uremic rat","volume":"3","author":"Swendseid","year":"1975","journal-title":"Clin. Nephrol."},{"issue":"4","key":"10.1016\/j.lfs.2016.01.003_bb0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ki.1978.131","article-title":"Effect of essential amino acid supplementation on muscle and plasma free amino acids in chronic uremia","volume":"14","author":"Alvestrand","year":"1978","journal-title":"Kidney Int."},{"issue":"2 Pt 2","key":"10.1016\/j.lfs.2016.01.003_bb0200","first-page":"F197","article-title":"Cytokines and L-arginine in renal injury and repair","volume":"267","author":"Ketteler","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"21","key":"10.1016\/j.lfs.2016.01.003_bb0205","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1021\/es034281x","article-title":"NMR-based metabolomics: a powerful approach for characterizing the effects of environmental stressors on organism health","volume":"37","author":"Viant","year":"2003","journal-title":"Environ. Sci. Technol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T17:59:43Z","timestamp":1718301583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516300030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":41,"alternative-id":["S0024320516300030"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.01.003","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}