{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:41:46Z","timestamp":1773351706608,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science, Education and Sports, Republic of Croatia","award":["108-1083570-3635"],"award-info":[{"award-number":["108-1083570-3635"]}]},{"name":"Ministry of Science, Education and Sports, Republic of Croatia","award":["108-1080321-0389"],"award-info":[{"award-number":["108-1080321-0389"]}]},{"name":"Ministry of Science, Education and Sports, Republic of Croatia","award":["108-1083570-3636"],"award-info":[{"award-number":["108-1083570-3636"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.lfs.2016.02.029","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T18:16:41Z","timestamp":1455041801000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats"],"prefix":"10.1016","volume":"148","author":[{"given":"Marko","family":"Baric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Zenko","family":"Sever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lovorka Batelja","family":"Vuletic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarko","family":"Rasic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Sever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domagoj","family":"Drmic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pavelic-Turudic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Sucic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrvoje","family":"Vrcic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Seiwerth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Sikiric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2016.02.029_bb0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/2277-9175.131033","article-title":"A new method to repair recto-vaginal fistula: use of human amniotic membrane in an animal model","volume":"3","author":"Roshanravan","year":"2014","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0010","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2174\/13816128113199990421","article-title":"BPC 157 and blood vessels","volume":"20","author":"Seiwerth","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2016.02.029_bb0015","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2174\/13816128113190990411","article-title":"Stable gastric pentadecapeptide BPC 157-NO-system relation","volume":"20","author":"Sikiric","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2016.02.029_bb0020","first-page":"76","article-title":"Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157","volume":"19","author":"Sikiric","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2016.02.029_bb0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/092986712803414015","article-title":"Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157","volume":"19","author":"Sikiric","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2016.02.029_bb0030","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.2174\/138161211796196954","article-title":"Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract","volume":"17","author":"Sikiric","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2016.02.029_bb0035","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2174\/138161210790945977","article-title":"Revised Robert's cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator","volume":"16","author":"Sikiric","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2016.02.029_bb0040","first-page":"597","article-title":"Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability","volume":"64","author":"Klicek","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejphar.2012.11.055","article-title":"Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy","volume":"701","author":"Cesarec","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2016.02.029_bb0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10620-008-0332-9","article-title":"Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole","volume":"54","author":"Skorjanec","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2016.02.029_bb0055","first-page":"581","article-title":"Duodenocutaneous fistula in rats as a model for \u201cwound healing-therapy: in ulcer healing: the effect of pentadecapeptide BPC 157, l-nitro-arginine methyl ester and l-arginine","volume":"66","author":"Skorjanec","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1254\/jphs.FP0072161","article-title":"Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system","volume":"108","author":"Klicek","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2016.02.029_bb0065","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1007\/s10620-008-0598-y","article-title":"Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats","volume":"54","author":"Sever","year":"2009","journal-title":"Dig. Dis. Sci."},{"issue":"9","key":"10.1016\/j.lfs.2016.02.029_bb0070","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00595-006-3498-9","article-title":"Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat","volume":"37","author":"Vuksic","year":"2007","journal-title":"Surg. Today"},{"issue":"3","key":"10.1016\/j.lfs.2016.02.029_bb0075","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.burns.2004.10.013","article-title":"The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice","volume":"31","author":"Bilic","year":"2005","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.lfs.2016.02.029_bb0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0305-4179(03)00004-4","article-title":"Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice","volume":"29","author":"Sikiric","year":"2003","journal-title":"Burns"},{"issue":"8","key":"10.1016\/j.lfs.2016.02.029_bb0085","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0305-4179(01)00055-9","article-title":"Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice","volume":"27","author":"Mikus","year":"2001","journal-title":"Burns"},{"key":"10.1016\/j.lfs.2016.02.029_bb0090","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/DCR.0b013e3181e536cb","article-title":"Are there predictors of outcome following rectovaginal fistula repair?","volume":"53","author":"Pinto","year":"2010","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.lfs.2016.02.029_bb0095","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s003840000253","article-title":"Simple rectovaginal fistulas","volume":"15","author":"Baik","year":"2000","journal-title":"Int. J. Color. Dis."},{"key":"10.1016\/j.lfs.2016.02.029_bb0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-0030-1254296","article-title":"Rectovaginal fistulas","volume":"23","author":"Debeche-Adams","year":"2010","journal-title":"Clin. Colon Rectal Surg."},{"key":"10.1016\/j.lfs.2016.02.029_bb0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/s-2007-977487","article-title":"Rectovaginal fistulas: current surgical management","volume":"20","author":"Rivadeneira","year":"2007","journal-title":"Clin. Colon Rectal Surg."},{"key":"10.1016\/j.lfs.2016.02.029_bb0110","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0039-6109(02)00055-5","article-title":"Rectovaginal fistula","volume":"82","author":"Saclarides","year":"2002","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.lfs.2016.02.029_bb0115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4240\/wjgs.v7.i8.133","article-title":"Operative considerations for rectovaginal fistulas","volume":"7","author":"Kniery","year":"2015","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.lfs.2016.02.029_bb0120","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00192-010-1118-0","article-title":"Rectovaginal fistula model in the New Zealand white rabbit","volume":"21","author":"Aungst","year":"2010","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.lfs.2016.02.029_bb0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00192-010-1096-2","article-title":"Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit","volume":"21","author":"Aungst","year":"2010","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.lfs.2016.02.029_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0167-8140(88)90265-4","article-title":"Radiation tolerance of the rat rectum to fractionated X-rays and pi-mesons","volume":"12","author":"van der Kogel","year":"1988","journal-title":"Radiother. Oncol."},{"issue":"Suppl. 7","key":"10.1016\/j.lfs.2016.02.029_bb0135","first-page":"161","article-title":"Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy","volume":"60","author":"Hrelec","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0140","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.thromres.2011.07.035","article-title":"Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin","volume":"129","author":"Stupnisek","year":"2012","journal-title":"Thromb. Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0145","article-title":"Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin","volume":"10","author":"Stupnisek","year":"2015","journal-title":"L-NAME and L-arginine. PLoS One."},{"issue":"2011","key":"10.1016\/j.lfs.2016.02.029_bb0150","first-page":"774","article-title":"The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration","volume":"110","author":"Chang","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0155","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.3390\/molecules191119066","article-title":"Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts","volume":"19","author":"Chang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2016.02.029_bb0160","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/DDDT.S82030","article-title":"Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro","volume":"9","author":"Huang","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2016.02.029_bb0165","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2007.05.072","article-title":"Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression","volume":"570","author":"Tkalcevi\u0107","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0170","doi-asserted-by":"crossref","first-page":"10542","DOI":"10.3748\/wjg.v21.i37.10542","article-title":"Endoscopic management of gastrointestinal perforations, leaks and fistulas","volume":"21","author":"Rogalski","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.12659\/MSMBR.883828","article-title":"Salutary effect of gastric pentadecapeptide BPC 157 in two different stress urinary incontinence models in female rats","volume":"19","author":"Jandric","year":"2013","journal-title":"Med. Sci. Monit. Basic Res."},{"issue":"Suppl. 7","key":"10.1016\/j.lfs.2016.02.029_bb0180","first-page":"191","article-title":"Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing","volume":"60","author":"Brcic","year":"2009","journal-title":"J Physiol Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.029_bb0185","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jor.21107","article-title":"Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat","volume":"28","author":"Cerovecki","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0190","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jor.20089","article-title":"Effective therapy of transected quadriceps muscle in rat: gastric pentadecapeptide BPC 157","volume":"24","author":"Staresinic","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0195","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0736-0266(03)00110-4","article-title":"Gastric pentadecapeptide BPC 157 accelerates healing of transected rat achilles tendon and in vitro stimulates tendocytes growth","volume":"21","author":"Staresinic","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1254\/jphs.95.19","article-title":"Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse","volume":"95","author":"Lovric-Bencic","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2016.02.029_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2015.04.016","article-title":"Perforating corneal injury in rat and pentadecapeptide BPC 157","volume":"136","author":"Masnec","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.lfs.2016.02.029_bb0210","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/physiol.00034.2004","article-title":"The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904","volume":"19","author":"Wood","year":"2004","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.lfs.2016.02.029_bb0215","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/0016-5085(95)28049-9","article-title":"Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action","volume":"108","author":"Veljaca","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2016.02.029_bb0220","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3565(25)24349-X","article-title":"BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats","volume":"272","author":"Veljaca","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Suppl. 2","key":"10.1016\/j.lfs.2016.02.029_bb0225","first-page":"69","article-title":"BPC 157 enhances function of immunological effector cells in mice","volume":"60","author":"Orsolic","year":"2009","journal-title":"J. Physiol. Pharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T10:20:03Z","timestamp":1748773203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516300807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":45,"alternative-id":["S0024320516300807"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.029","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}