{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:36:23Z","timestamp":1792784183421,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"China National Natural Science Funds","doi-asserted-by":"crossref","award":["81330003"],"award-info":[{"award-number":["81330003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"China National Natural Science Funds","doi-asserted-by":"crossref","award":["81000343"],"award-info":[{"award-number":["81000343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"China National Natural Science Funds","doi-asserted-by":"crossref","award":["81500320"],"award-info":[{"award-number":["81500320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010026","name":"Beijing Higher Education Young Elite Teacher Project","doi-asserted-by":"crossref","award":["YETP1668"],"award-info":[{"award-number":["YETP1668"]}],"id":[{"id":"10.13039\/501100010026","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Importation and Development of High Caliber Talents Project of Beijing Municipal Institutions","award":["CIT&TCD201404180"],"award-info":[{"award-number":["CIT&TCD201404180"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.lfs.2016.02.039","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T06:06:13Z","timestamp":1455170773000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["NOD2 contributes to myocardial ischemia\/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation"],"prefix":"10.1016","volume":"149","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2016.02.039_bb0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cardiores.2006.08.009","article-title":"Innate immunity and inflammation\u2014new frontiers in comparative cardiovascular pathology","volume":"73","author":"Linde","year":"2007","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nri3800","article-title":"Role of innate and adaptive immune mechanisms in cardiac injury and repair","volume":"15","author":"Epelman","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.lfs.2016.02.039_bb0015","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncpcardio0938","article-title":"Mechanisms of disease: toll-like receptors in cardiovascular disease","volume":"4","author":"Frantz","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.lfs.2016.02.039_bb0020","doi-asserted-by":"crossref","first-page":"181394","DOI":"10.1155\/2012\/181394","article-title":"The emerging role of TLR and innate immunity in cardiovascular disease","volume":"2012","author":"Spirig","year":"2012","journal-title":"Cardiol. Res. Pract."},{"issue":"5","key":"10.1016\/j.lfs.2016.02.039_bb0025","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.athoracsur.2008.01.043","article-title":"Cytokines link toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia","volume":"85","author":"Cha","year":"2008","journal-title":"Ann. Thorac. Surg."},{"issue":"6","key":"10.1016\/j.lfs.2016.02.039_bb0030","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/01.CIR.0000112575.66565.84","article-title":"Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice","volume":"109","author":"Oyama","year":"2004","journal-title":"Circulation"},{"issue":"8A","key":"10.1016\/j.lfs.2016.02.039_bb0035","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1582-4934.2009.00798.x","article-title":"Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia","volume":"13","author":"Zhao","year":"2009","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2016.02.039_bb0040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.lfs.2016.02.039_bb0045","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.lfs.2016.02.039_bb0050","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/gut.2010.216259","article-title":"Nod2 is essential for temporal development of intestinal microbial communities","volume":"60","author":"Rehman","year":"2011","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.lfs.2016.02.039_bb0055","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/BSR20120055","article-title":"Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases","volume":"32","author":"Correa","year":"2012","journal-title":"Biosci. Rep."},{"issue":"11","key":"10.1016\/j.lfs.2016.02.039_bb0060","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.ajpath.2014.07.014","article-title":"The microbiota protects against ischemia\/reperfusion-induced intestinal injury through nucleotide-binding oligomerization domain-containing protein 2 (NOD2) signaling","volume":"184","author":"Perez-Chanona","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0065","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ki.2013.113","article-title":"NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy","volume":"84","author":"Du","year":"2013","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.lfs.2016.02.039_bb0070","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/HYPERTENSIONAHA.113.01638","article-title":"Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia","volume":"62","author":"Han","year":"2013","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.lfs.2016.02.039_bb0075","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1161\/ATVBAHA.111.235135","article-title":"Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury","volume":"31","author":"Kwon","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2016.02.039_bb0080","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1159\/000356618","article-title":"NOD2 deficiency protects against cardiac remodeling after myocardial infarction in mice","volume":"32","author":"Li","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2016.02.039_bb0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000343361","article-title":"CHIP enhances angiogenesis and restores cardiac function after infarction in transgenic mice","volume":"31","author":"Xu","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.lfs.2016.02.039_bb0090","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00395-011-0157-0","article-title":"Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury","volume":"106","author":"Zhang","year":"2011","journal-title":"Basic Res. Cardiol."},{"issue":"8","key":"10.1016\/j.lfs.2016.02.039_bb0095","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI200422220","article-title":"Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex","volume":"114","author":"Li","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.lfs.2016.02.039_bb0100","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ajh.2012.74","article-title":"Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling","volume":"25","author":"Yang","year":"2012","journal-title":"Am. J. Hypertens."},{"issue":"10","key":"10.1016\/j.lfs.2016.02.039_bb0105","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.peptides.2011.09.015","article-title":"Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor","volume":"32","author":"Yang","year":"2011","journal-title":"Peptides"},{"issue":"10","key":"10.1016\/j.lfs.2016.02.039_bb0110","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ajh\/hpt095","article-title":"Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice","volume":"26","author":"Jiang","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.lfs.2016.02.039_bb0115","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.freeradbiomed.2013.08.179","article-title":"NADPH oxidases mediate a cellular \"memory\" of angiotensin II stress in hypertensive cardiac hypertrophy","volume":"65","author":"Wang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2016.02.039_bb0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbadis.2013.10.006","article-title":"Toll-like receptor 3 plays a role in myocardial infarction and ischemia\/reperfusion injury","volume":"1842","author":"Lu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.lfs.2016.02.039_bb0125","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.4049\/jimmunol.0903065","article-title":"Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury","volume":"184","author":"Shigeoka","year":"2010","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.crohns.2007.08.008","article-title":"The effects of NOD2\/CARD15 mutations on the function of the intestinal barrier","volume":"1","author":"Rogler","year":"2007","journal-title":"J. Crohns Colitis"},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0135","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.atherosclerosis.2013.10.003","article-title":"Coptisine protects rat heart against myocardial ischemia\/reperfusion injury by suppressing myocardial apoptosis and inflammation","volume":"231","author":"Guo","year":"2013","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.lfs.2016.02.039_bb0140","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10495-013-0946-z","article-title":"Inhibition of 12\/15 lipoxygenase by baicalein reduces myocardial ischemia\/reperfusion injury via modulation of multiple signaling pathways","volume":"19","author":"Song","year":"2014","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.lfs.2016.02.039_bb0145","doi-asserted-by":"crossref","first-page":"e92242","DOI":"10.1371\/journal.pone.0092242","article-title":"Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia\/reperfusion injury","volume":"9","author":"Kitano","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.lfs.2016.02.039_bb0150","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/S0003-4975(01)02400-6","article-title":"Are macrophages involved in early myocardial reperfusion injury?","volume":"71","author":"Formigli","year":"2001","journal-title":"Ann. Thorac. Surg."},{"issue":"7","key":"10.1016\/j.lfs.2016.02.039_bb0155","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/labinvest.3780119","article-title":"Roles and relationship of macrophages and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart","volume":"80","author":"Kakio","year":"2000","journal-title":"Lab. Invest."},{"issue":"5","key":"10.1016\/j.lfs.2016.02.039_bb0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tcm.2005.06.005","article-title":"Chemokines in myocardial ischemia","volume":"15","author":"Frangogiannis","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.lfs.2016.02.039_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"44","key":"10.1016\/j.lfs.2016.02.039_bb0170","doi-asserted-by":"crossref","first-page":"41701","DOI":"10.1074\/jbc.M206473200","article-title":"Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation","volume":"277","author":"Gutierrez","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.lfs.2016.02.039_bb0175","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.bbamcr.2012.03.017","article-title":"Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease","volume":"1823","author":"Tigno-Aranjuez","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.lfs.2016.02.039_bb0180","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/ibd.20907","article-title":"Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease","volume":"15","author":"Negroni","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0185","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0014-4886(02)00059-6","article-title":"H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK","volume":"180","author":"Tamagno","year":"2003","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.lfs.2016.02.039_bb0190","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/imm.12307","article-title":"Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils","volume":"143","author":"Jeong","year":"2014","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.lfs.2016.02.039_bb0195","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.bcp.2007.12.014","article-title":"The phosphatidylinositol 3-kinase\/Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway","volume":"75","author":"Zhao","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"5710","key":"10.1016\/j.lfs.2016.02.039_bb0200","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1103685","article-title":"Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing","volume":"307","author":"Maeda","year":"2005","journal-title":"Science"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T05:31:03Z","timestamp":1572499863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516300893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":40,"alternative-id":["S0024320516300893"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.039","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOD2 contributes to myocardial ischemia\/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}