{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:24:33Z","timestamp":1790418273022,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2013M542421"],"award-info":[{"award-number":["2013M542421"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014T70877"],"award-info":[{"award-number":["2014T70877"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Support Project from Sichuan Province","award":["2012SZ0018"],"award-info":[{"award-number":["2012SZ0018"]}]},{"name":"Applied and Fundamental Research Project from Sichuan Province","award":["2012JY0006"],"award-info":[{"award-number":["2012JY0006"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.lfs.2016.02.045","type":"journal-article","created":{"date-parts":[[2016,2,14]],"date-time":"2016-02-14T08:15:03Z","timestamp":1455437703000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Gastroprotective effects of several H2RAs on ibuprofen-induced gastric ulcer in rats"],"prefix":"10.1016","volume":"149","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-ping","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-385X","authenticated-orcid":false,"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2016.02.045_bb0005","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0304-4165(90)90050-7","article-title":"Non-steroidal anti-inflammatory drugs inhibit gastric peroxidase activity","volume":"1034","author":"Banarjee","year":"1990","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.lfs.2016.02.045_bb0010","first-page":"693","article-title":"Involvement of reactive oxygen species in gastric ulceration: protection by melatonin","volume":"40","author":"Bandyopadhyay","year":"2002","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.lfs.2016.02.045_bb0015","first-page":"658","article-title":"Reactive oxygen species: oxidative damage and pathogenesis","volume":"77","author":"Bandyopadhyay","year":"1999","journal-title":"Curr. Sci."},{"key":"10.1016\/j.lfs.2016.02.045_bb0020","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0891-5849(02)00757-8","article-title":"Critical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and nonmediated gastric ulcer","volume":"32","author":"Bhattacharjee","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2016.02.045_bb0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2016.02.045_bb0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.lfs.2016.02.045_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2008.09.004","article-title":"Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and\/or pathological conditions","volume":"157","author":"Catal\u00e1","year":"2009","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.lfs.2016.02.045_bb0040","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1023\/A:1016221923679","article-title":"Sucrose urinary excretion in the rat measured using a simple assay: a model of gastroduodenal permeability","volume":"12","author":"Davies","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.lfs.2016.02.045_bb0045","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2016.02.045_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/974185","article-title":"Acute toxicity and gastroprotective role of M. pruriens in ethanol-induced gastric mucosal injuries in rats","author":"Golbabapour","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2016.02.045_bb0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s002040000167","article-title":"The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro)","volume":"74","author":"Gultekin","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2016.02.045_bb0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0016-5085(79)80133-X","article-title":"Topical aspirin plus HCl gastric lesions in the rat","volume":"76","author":"Guth","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2016.02.045_bb0065","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/jn\/104.5.580","article-title":"Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat","volume":"104","author":"Hafeman","year":"1974","journal-title":"J. Nutr."},{"key":"10.1016\/j.lfs.2016.02.045_bb0070","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(94)92211-X","article-title":"Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?","volume":"344","author":"Halliwell","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2016.02.045_bb0075","first-page":"4255","article-title":"Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils","volume":"58","author":"Honda","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2016.02.045_bb0080","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.3748\/wjg.v11.i42.6662","article-title":"Gastroprotective activity of Nigella sativa L. oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats","volume":"11","author":"Kanter","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2016.02.045_bb0085","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.carbpol.2008.09.008","article-title":"Antioxidant acitivity in vitro and in vivo of the capsule polysaccharides from Streptococcus equi subsp. zooepidemicus","volume":"75","author":"Ke","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.lfs.2016.02.045_bb0090","article-title":"A method of determining catalase activity","volume":"16","author":"Koroliuk","year":"1988","journal-title":"Lab. Delo"},{"issue":"1","key":"10.1016\/j.lfs.2016.02.045_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2009.08.016","article-title":"Effect of acute and chronic administration of progesterone, estrogen, FSH and LH on oxidant and antioxidant parameters in rat gastric tissue","volume":"182","author":"Kumtepe","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2016.02.045_bb0100","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1365-2362.1994.tb02378.x","article-title":"H2-receptor antagonists are scavengers of oxygen radicals","volume":"24","author":"Lapenna","year":"1994","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.lfs.2016.02.045_bb0105","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bbrc.2003.08.105","article-title":"Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses","volume":"309","author":"Leonard","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2016.02.045_bb0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/art.1780380103","article-title":"Nonsteroidal antiinflammatory drugs and the gastrointestinal tract the double-edged sword","volume":"38","author":"Lichtenstein","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2016.02.045_bb0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0041-0101(03)00104-1","article-title":"Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR","volume":"42","author":"Li","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2016.02.045_bb0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3164\/jcbn.10-79","article-title":"The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine","volume":"48","author":"Matsui","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.lfs.2016.02.045_bb0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2036.1992.tb00546.x","article-title":"A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats","volume":"6","author":"Melarange","year":"1992","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2016.02.045_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0928-4680(95)00010-X","article-title":"Role of lipid peroxidation and neutrophil accumulation in the gastric mucosal injury induced by aspirin-HCl in rats effect of roxatidine, a histamine H2 receptor antagonist with antioxidative properties","volume":"2","author":"Naito","year":"1995","journal-title":"Pathophysiology"},{"key":"10.1016\/j.lfs.2016.02.045_bb0135","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ptr.1764","article-title":"Pterocarpus santalinus: a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers","volume":"19","author":"Narayan","year":"2005","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2016.02.045_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2016.02.045_bb0145","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.arcmed.2005.03.021","article-title":"Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin","volume":"36","author":"Oktem","year":"2005","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.lfs.2016.02.045_bb0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-8981(99)00246-6","article-title":"A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)","volume":"293","author":"Peskin","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2016.02.045_bb0155","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1073\/pnas.95.9.5061","article-title":"Activation of apurinic\/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals","volume":"95","author":"Ramana","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2016.02.045_bb0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cbi.2010.07.020","article-title":"Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice","volume":"188","author":"Rios","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2016.02.045_bb0165","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1023\/A:1005652815921","article-title":"Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats","volume":"46","author":"\u015eener-Murato\u011flu","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2016.02.045_bb0170","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1503\/cmaj.071330","article-title":"Use of proton pump inhibitors and risk of osteoporosis-related fractures","volume":"179","author":"Targownik","year":"2008","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.lfs.2016.02.045_bb0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jpba.2005.12.011","article-title":"Optimization and validation of a dissolution test for famotidine tablets using flow injection analysis","volume":"41","author":"Tzanavaras","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.lfs.2016.02.045_bb0180","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/0006-2952(93)90218-L","article-title":"Anti-oxidant properties of H2 receptor antagonists: effects on myeloperoxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system","volume":"45","author":"van Zyl","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2016.02.045_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.74.1.1","article-title":"Free radicals and myocardial injury: pharmacologic implications","volume":"74","author":"Werns","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2016.02.045_bb0190","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/gut.34.6.732","article-title":"Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats","volume":"34","author":"Yoshikawa","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2016.02.045_bb0195","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF02915141","article-title":"Effect of reactive oxygen species on lysosomal membrane integrity","volume":"64","author":"Zdolsek","year":"1993","journal-title":"Virchows Arch."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516300947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T11:38:08Z","timestamp":1600169888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516300947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":39,"alternative-id":["S0024320516300947"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.045","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastroprotective effects of several H2RAs on ibuprofen-induced gastric ulcer in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}