{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:29Z","timestamp":1786993709042,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005071","name":"Shiraz University","doi-asserted-by":"crossref","award":["89GCU1M1741"],"award-info":[{"award-number":["89GCU1M1741"]}],"id":[{"id":"10.13039\/501100005071","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.lfs.2016.02.078","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T01:23:58Z","timestamp":1456363438000},"page":"39-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone"],"prefix":"10.1016","volume":"150","author":[{"given":"Khyber","family":"Saify","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Saadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2016.02.078_bb0005","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nn1804","article-title":"Dynorphin A activates bradykinin receptors to maintain neuropathic pain","volume":"9","author":"Lai","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0010","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00439-012-1172-4","article-title":"The genetics of the opioid system and specific drug addictions","volume":"131","author":"Levran","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.lfs.2016.02.078_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.57.1.1","article-title":"Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments","volume":"57","author":"Kreek","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2016.02.078_bb0020","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/306611a0","article-title":"Isolation and structural organization of the human preproenkephalin B gene","volume":"306","author":"Horikawa","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2016.02.078_bb0025","doi-asserted-by":"crossref","first-page":"13879","DOI":"10.1523\/JNEUROSCI.2711-15.2015","article-title":"Pain and poppies: the good, the bad, and the ugly of opioid analgesics","volume":"35","author":"Trang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0030","first-page":"1036","article-title":"Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis","volume":"2010","author":"Perez-Alvarez","year":"1802","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2016.02.078_bb0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.clpt.2006.09.012","article-title":"ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment","volume":"80","author":"Crettol","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2016.02.078_bb0040","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.lfs.2015.01.003","article-title":"The role of reactive oxygen species in morphine addiction of SH-SY5Y cells","volume":"124","author":"Ma","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0045","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12031-013-0019-3","article-title":"Morphine and fentanyl differently affect MOP and NOP gene expression in human neuroblastoma SH-SY5Y cells","volume":"51","author":"Caputi","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0050","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1096\/fj.07-8346com","article-title":"The role of acetaldehyde in mediating effects of alcohol on expression of endogenous opioid system genes in a neuroblastoma cell line","volume":"3","author":"D'Addario","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2016.02.078_bb0055","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1096\/fj.10-168534","article-title":"Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line","volume":"25","author":"D'Addario","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2016.02.078_bb0060","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psychres.2015.08.027","article-title":"Expression patterns of antioxidant genes in human SH-SY5Y cells after treatment with methadone","volume":"230","author":"Saify","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.lfs.2016.02.078_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2015.11.014","article-title":"Down-regulation of antioxidant genes in human SH-SY5Y cells after treatment with morphine","volume":"144","author":"Saify","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0070","doi-asserted-by":"crossref","first-page":"e1641","DOI":"10.1371\/journal.pone.0001641","article-title":"Endogenous morphine in SH-SY5Y cells and the mouse cerebellum","volume":"3","author":"Muller","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2016.02.078_bb0075","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1460-9568.2010.07142.x","article-title":"Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells","volume":"31","author":"Mann","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.lfs.2016.02.078_bb0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainresbull.2006.05.005","article-title":"Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxymetopon and oxycodone-6-oxime","volume":"70","author":"Kir\u00e1ly","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.lfs.2016.02.078_bb0085","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.psychres.2014.06.048","article-title":"Association between VNTR polymorphism in promoter region of prodynorphin (PDYN) gene and heroin dependence","volume":"219","author":"Saify","year":"2014","journal-title":"Psychiatry Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516301278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516301278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T19:53:24Z","timestamp":1567626804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516301278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":17,"alternative-id":["S0024320516301278"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.078","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.02.078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}