{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:17:02Z","timestamp":1791314222653,"version":"4.3.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["13\/04744-4"],"award-info":[{"award-number":["13\/04744-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/03016-8"],"award-info":[{"award-number":["14\/03016-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.lfs.2016.08.025","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T03:27:35Z","timestamp":1472786855000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Loss of strength capacity is associated with mortality, but resistance exercise training promotes only modest effects during cachexia progression"],"prefix":"10.1016","volume":"163","author":[{"given":"Willian","family":"das Neves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiano Robles Rodrigues","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ney Robson","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima L\u00facia Rodrigues","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Rizzo","family":"Ramires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Chakur","family":"Brum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Herbert","family":"Lancha Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2016.08.025_bb0005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccr.2005.10.004","article-title":"Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia","volume":"8","author":"Acharyya","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lfs.2016.08.025_bb0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/109980040100200301","article-title":"Resistance exercise training attenuates wasting of the extensor digitorum longus muscle in mice bearing the colon-26 adenocarcinoma","volume":"2","author":"al-Majid","year":"2001","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.lfs.2016.08.025_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2014.11.029","article-title":"Aerobic exercise training as therapy for cardiac and cancer cachexia","volume":"125","author":"Alves","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2016.08.025_bb0020","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/02640414.2011.638086","article-title":"Anthropometric, physiological, performance, and nutritional profile of the Brazil National Canoe Polo Team","volume":"30","author":"Alves","year":"2012","journal-title":"J. Sports Sci."},{"key":"10.1016\/j.lfs.2016.08.025_bb0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/bse0420061","article-title":"Resistance exercise, muscle loading\/unloading and the control of muscle mass","volume":"42","author":"Baar","year":"2006","journal-title":"Essays Biochem."},{"key":"10.1016\/j.lfs.2016.08.025_bb0030","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3181\/0704-RM-93","article-title":"Effect of a high-intensity exercise training on the metabolism and function of macrophages and lymphocytes of walker 256 tumor bearing rats","volume":"232","author":"Bacurau","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.lfs.2016.08.025_bb0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijcard.2016.03.071","article-title":"Akt\/mTOR pathway contributes to skeletal muscle anti-atrophic effect of aerobic exercise training in heart failure mice","volume":"214","author":"Bacurau","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1681.2005.04180.x","article-title":"Cardiovascular adaptations in rats submitted to a resistance-training model","volume":"32","author":"Barauna","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0045","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijcard.2014.06.046","article-title":"NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats","volume":"175","author":"Bechara","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0050","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0055","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1113\/jphysiol.2009.185306","article-title":"Growing collagen, not muscle, with weightlifting and \u201cgrowth\u201d hormone","volume":"588","author":"Burd","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0812s15","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.lfs.2016.08.025_bb0065","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/jcp.24542","article-title":"Basic models modeling resistance training: an update for basic scientists interested in study skeletal muscle hypertrophy","volume":"229","author":"Cholewa","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041701","article-title":"Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure","volume":"7","author":"Cunha","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2016.08.025_bb0075","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s40279-015-0320-0","article-title":"A review of resistance training-induced changes in skeletal muscle protein synthesis and their contribution to hypertrophy","volume":"45","author":"Damas","year":"2015","journal-title":"Sports Med."},{"key":"10.1016\/j.lfs.2016.08.025_bb0080","first-page":"1","article-title":"Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage","author":"Damas","year":"2016","journal-title":"[Epub ahead of print] J. Physiol. 000.0"},{"issue":"80","key":"10.1016\/j.lfs.2016.08.025_bb0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","article-title":"Adipose triglyceride lipase contributes to cancer-associated cachexia","volume":"333","author":"Das","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.lfs.2016.08.025_bb0090","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s004210050347","article-title":"Adaptations in rat skeletal muscle following long-term resistance exercise training","volume":"77","author":"Duncan","year":"1998","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cmet.2012.12.012","article-title":"Exercise metabolism and the molecular regulation of skeletal muscle adaptation","volume":"17","author":"Egan","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2016.08.025_bb0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2016.08.025_bb0115","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1056\/NEJMcibr1106880","article-title":"Cancer cachexia and fat \u2013 muscle physiology","volume":"365","author":"Fearon","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2016.08.025_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/nm.4093","article-title":"Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia","author":"Fukawa","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2016.08.025_bb0125","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/ije\/dyl224","article-title":"Grip strength, body composition, and mortality","volume":"36","author":"Gale","year":"2007","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MCO.0b013e32833862df","article-title":"Signaling pathways perturbing muscle mass","volume":"13","author":"Glass","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.lfs.2016.08.025_bb0135","first-page":"267","article-title":"PI3 kinase regulation of skeletal muscle hypertrophy and atrophy","volume":"346","author":"Glass","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0140","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"Gomes","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2016.08.025_bb0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exger.2014.02.003","article-title":"Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial","volume":"53","author":"Gualano","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0150","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.3988","article-title":"A TGF-\u03b2 pathway associated with cancer cachexia","volume":"21","author":"Guttridge","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2016.08.025_bb0155","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1073\/pnas.1402714111","article-title":"Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7","volume":"111","author":"He","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2016.08.025_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0085820","article-title":"Autophagy signaling in skeletal muscle of infarcted rats","volume":"9","author":"Jannig","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2016.08.025_bb0165","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.biocel.2013.05.032","article-title":"Muscle wasting in cancer","volume":"45","author":"Johns","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2016.01.014","article-title":"Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia","author":"Khamoui","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2016.08.025_bb0175","first-page":"1699","article-title":"Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer","author":"Kimura","year":"2014","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.lfs.2016.08.025_bb0180","first-page":"1","article-title":"Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia","volume":"1","author":"Kir","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2016.08.025_bb0185","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1158\/0008-5472.CAN-13-1052","article-title":"Cancer usurps skeletal muscle as an energy repository","volume":"74","author":"Luo","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2016.08.025_bb0190","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2016.08.025_bb0195","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signalling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2016.08.025_bb0200","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3181\/0808-RM-251","article-title":"Serum IGF-I-deficiency does not prevent compensatory skeletal muscle hypertrophy in resistance exercise","volume":"234","author":"Matheny","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2016.08.025_bb0205","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1634\/theoncologist.2011-0133","article-title":"Physical exercise for cancer patients with advanced disease: a randomized controlled trial","volume":"16","author":"Oldervoll","year":"2011","journal-title":"Oncologist"},{"key":"10.1016\/j.lfs.2016.08.025_bb0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2012\/175408","article-title":"Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma","volume":"2012","author":"Onuchic","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2016.08.025_bb0215","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/371762a0","article-title":"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5\u2032-cap function","volume":"371","author":"Pause","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2016.08.025_bb0220","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.yebeh.2012.08.011","article-title":"A strength exercise program in rats with epilepsy is protective against seizures","volume":"25","author":"Peixinho-Pena","year":"2012","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.lfs.2016.08.025_bb0225","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ajpath.2012.12.023","article-title":"Autophagic degradation contributes to muscle wasting in cancer cachexia","volume":"182","author":"Penna","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0230","doi-asserted-by":"crossref","first-page":"M168","DOI":"10.1093\/gerona\/55.3.M168","article-title":"Muscle strength and body mass index as long-term predictors of mortality in initially healthy men","volume":"55","author":"Rantanen","year":"2000","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.lfs.2016.08.025_bb0235","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1139\/h10-111","article-title":"Effect of eccentric exercise velocity on akt\/mtor\/p70(s6k) signaling in human skeletal muscle","volume":"36","author":"Roschel","year":"2011","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.lfs.2016.08.025_bb0240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ncb0310-207","article-title":"P62, an autophagy hero or culprit?","volume":"12","author":"Rusten","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2016.08.025_bb0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molmet.2015.11.004","article-title":"Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia","volume":"5","author":"Sch\u00e4fer","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.lfs.2016.08.025_bb0250","series-title":"Resistance Training With Instability for Patients With Parkinson's Disease","author":"Silva-Batista","year":"2016"},{"key":"10.1016\/j.lfs.2016.08.025_bb0255","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis. - PubMed - NCBI","volume":"14","author":"S\u00edlvia Busquets","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2016.08.025_bb0260","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/bjc.1993.126","article-title":"Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia","volume":"67","author":"Smith","year":"1993","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lfs.2016.08.025_bb0265","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1590\/1414-431X20132557","article-title":"The acute effects of strength, endurance and concurrent exercises on the Akt\/mTOR\/p70S6k1 and AMPK signaling pathway responses in rat skeletal muscle","volume":"46","author":"de Souza","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.lfs.2016.08.025_bb0270","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1249\/00005768-199208000-00009","article-title":"A weight-lifting exercise model for inducing hypertrophy in the hindlimb muscles of rats","volume":"24","author":"Tamaki","year":"1992","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.lfs.2016.08.025_bb0275","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cell.2010.08.004","article-title":"Reversing cachexia","volume":"142","author":"Tisdale","year":"2010","journal-title":"Cell"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516304969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320516304969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T17:59:57Z","timestamp":1536429597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320516304969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":55,"alternative-id":["S0024320516304969"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2016.08.025","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of strength capacity is associated with mortality, but resistance exercise training promotes only modest effects during cachexia progression","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2016.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}