{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:52:50Z","timestamp":1778817170609,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11372204"],"award-info":[{"award-number":["11372204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11672197"],"award-info":[{"award-number":["11672197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.lfs.2017.03.006","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T05:15:25Z","timestamp":1489122925000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor"],"prefix":"10.1016","volume":"175","author":[{"given":"Qinxue","family":"Bao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.03.006_bb0005","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1177\/1753944716642677","article-title":"Cardiac remodelling and RAS inhibition","volume":"10","author":"Ferrario","year":"2016","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.lfs.2017.03.006_bb0010","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0015","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1093\/eurheartj\/ehs041","article-title":"The human sympathetic nervous system: its relevance in hypertension and heart failure","volume":"33","author":"Parati","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2017.03.006_bb0020","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.03.019","article-title":"Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease","volume":"164","author":"Michel","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2017.03.006_bb0025","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1161\/CIRCRESAHA.116.308688","article-title":"Deletion of interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction","volume":"118","author":"Zhao","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2017.03.006_bb0030","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fphar.2016.00037","article-title":"Scaffold proteins regulating extracellular regulated kinase function in cardiac hypertrophy and disease","volume":"7","author":"Liang","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0035","doi-asserted-by":"publisher","first-page":"945076","DOI":"10.1155\/2015\/945076","article-title":"The protective effect of lacidipine on myocardial remodeling is mediated by the suppression in expression of GPR78 and CHOP in rats","volume":"2015","author":"Ge","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2017.03.006_bb0040","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020193","article-title":"The role of endoplasmic reticulum stress and unfolded protein response in atherosclerosis","volume":"17","author":"Ivanova","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0045","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/aps.2015.136","article-title":"Berberine protects rat heart from ischemia\/reperfusion injury via activating JAK2\/STAT3 signaling and attenuating endoplasmic reticulum stress","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2017.03.006_bb0050","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091558","article-title":"ER stress-mediated signaling: action potential and Ca(2+) as key players","volume":"17","author":"Bahar","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0055","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/aps.2015.145","article-title":"Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases","volume":"37","author":"Liu","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2017.03.006_bb0060","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.301","article-title":"Fluvoxamine alleviates ER stress via induction of sigma-1 receptor","volume":"5","author":"Omi","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2017.03.006_bb0065","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jphs.2016.05.012","article-title":"Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction","volume":"131","author":"Shinoda","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0070","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tips.2016.01.003","article-title":"The sigma-1 receptor as a pluripotent modulator in living systems","volume":"37","author":"Su","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0075","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2012.01.030","article-title":"The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements","volume":"682","author":"Pal","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0080","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bbrc.2011.10.113","article-title":"Sigma-1Rs are upregulated via PERK\/eIF2alpha\/ATF4 pathway and execute protective function in ER stress","volume":"415","author":"Mitsuda","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2017.03.006_bb0085","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1517\/14728220903264064","article-title":"Stimulation of sigma-1 receptor signaling by dehydroepiandrosterone ameliorates pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats","volume":"13","author":"Bhuiyan","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.lfs.2017.03.006_bb0090","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.lfs.2013.12.019","article-title":"Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through sigma(1)-receptor in hypertrophic cardiomyocytes","volume":"95","author":"Tagashira","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0095","article-title":"Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0100","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000078","article-title":"Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling","volume":"2","author":"Karakikes","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2017.03.006_bb0105","article-title":"miR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathways","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.03.006_bb0110","article-title":"Cardiomyocyte overexpression of FABP4 aggravates pressure overload-induced heart hypertrophy","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.03.006_bb0115","first-page":"778","article-title":"Exendin-4 therapy still offered an additional benefit on reducing transverse aortic constriction-induced cardiac hypertrophy-caused myocardial damage in DPP-4 deficient rats","volume":"8","author":"Lu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.lfs.2017.03.006_bb0120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168078","article-title":"MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4","volume":"11","author":"Xiao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.03.006_bb0125","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1097\/HJH.0000000000000597","article-title":"Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase","volume":"33","author":"Lu","year":"2015","journal-title":"J. Hypertens."},{"key":"10.1016\/j.lfs.2017.03.006_bb0130","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00229.2016","article-title":"Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes","author":"Fan","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0135","doi-asserted-by":"publisher","first-page":"1451676","DOI":"10.1155\/2016\/1451676","article-title":"Inhibition of receptor interacting protein kinases attenuates cardiomyocyte hypertrophy induced by palmitic acid","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2017.03.006_bb0140","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00011-014-0747-z","article-title":"Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88\/TAK1\/IKKbeta\/IkappaB-alpha\/NF-kappaB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock","volume":"63","author":"Sari","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.lfs.2017.03.006_bb0145","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jphs.2014.07.001","article-title":"Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs","volume":"127","author":"Hayashi","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0150","doi-asserted-by":"publisher","first-page":"H1201","DOI":"10.1152\/ajpheart.00300.2013","article-title":"Diverse regulation of IP3 and ryanodine receptors by pentazocine through sigma1-receptor in cardiomyocytes","volume":"305","author":"Tagashira","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0155","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/FJC.0b013e3182970b15","article-title":"Brain sigma-1 receptor stimulation improves mental disorder and cardiac function in mice with myocardial infarction","volume":"62","author":"Ito","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0160","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1053\/j.tcam.2013.03.003","article-title":"Selective serotonin reuptake inhibitor exposure","volume":"28","author":"Fitzgerald","year":"2013","journal-title":"Top. Companion Anim. Med."},{"key":"10.1016\/j.lfs.2017.03.006_bb0165","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1517\/14728222.2010.509348","article-title":"Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions","volume":"14","author":"Bhuiyan","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.lfs.2017.03.006_bb0170","doi-asserted-by":"publisher","first-page":"H459","DOI":"10.1152\/ajpheart.00056.2015","article-title":"Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy","volume":"309","author":"Castillero","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0175","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1161\/CIRCEP.113.000274","article-title":"Unfolded protein response regulates cardiac sodium current in systolic human heart failure","volume":"6","author":"Gao","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.lfs.2017.03.006_bb0180","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12031-015-0577-7","article-title":"IRE1alpha-XBP1 pathway is activated upon induction of single-prolonged stress in rat neurons of the medial prefrontal cortex","volume":"57","author":"Li","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2017.03.006_bb0185","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/acel.12460","article-title":"Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-a expression and angiogenesis during cardiac hypertrophy in vivo","volume":"15","author":"Duan","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.lfs.2017.03.006_bb0190","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/s12967-015-0725-4","article-title":"MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo","volume":"13","author":"Duan","year":"2015","journal-title":"J. Transl. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517300899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517300899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T13:26:50Z","timestamp":1535981210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517300899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":38,"alternative-id":["S0024320517300899"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.03.006","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}