{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:36:51Z","timestamp":1791387411921,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.lfs.2017.05.010","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T23:31:20Z","timestamp":1494372680000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Matrine promotes oligodendrocyte development in CNS autoimmunity through the PI3K\/Akt signaling pathway"],"prefix":"10.1016","volume":"180","author":[{"given":"Shu-Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HUi-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Zhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao-Juan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.05.010_bb0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.nbd.2015.10.002","article-title":"Prospects for mTOR-mediated functional repair after central nervous system trauma","volume":"85","author":"Berry","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2017.05.010_bb0010","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1471-4159.2009.06071.x","article-title":"IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K\/mTOR\/Akt and MEK\/ERK pathways","volume":"109","author":"Bibollet-Bahena","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2017.05.010_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ana.22627","article-title":"Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants","volume":"71","author":"Buser","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0020","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuropharm.2015.10.010","article-title":"Oligodendrocyte regeneration: its significance in myelin replacement and neuroprotection in multiple sclerosis","volume":"110","author":"Chamberlain","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2017.05.010_bb0025","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1523\/JNEUROSCI.3521-15.2016","article-title":"Akt regulates axon wrapping and myelin sheath thickness in the PNS","volume":"36","author":"Domenech-Estevez","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.01.005","article-title":"Adult oligodendrocyte progenitor cells - multifaceted regulators of the CNS in health and disease","volume":"57","author":"Fernandez-Castaneda","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2017.05.010_bb0035","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1523\/JNEUROSCI.0150-08.2008","article-title":"Constitutively active Akt induces enhanced myelination in the CNS","volume":"28","author":"Flores","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0040","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrneurol.2014.37","article-title":"Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis","volume":"10","author":"Friese","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.expneurol.2016.03.008","article-title":"Intracellular signaling pathway regulation of myelination and remyelination in the CNS","volume":"283","author":"Gaesser","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0055","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1007\/s11064-016-2040-8","article-title":"Neuroprotective effect of matrine in mouse model of vincristine-induced neuropathic pain","volume":"41","author":"Gong","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2017.05.010_bb0060","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.22090","article-title":"Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination","volume":"68","author":"Harrington","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0065","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/glia.22737","article-title":"Adapting brain metabolism to myelination and long-range signal transduction","volume":"62","author":"Hirrlinger","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2017.05.010_bb0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2016.06.008","article-title":"Microglia response in retina and optic nerve in chronic experimental autoimmune encephalomyelitis","volume":"298","author":"Horstmann","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yexmp.2015.01.001","article-title":"Matrine protects neuro-axon from CNS inflammation-induced injury","volume":"98","author":"Kan","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12026-013-8393-z","article-title":"Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity","volume":"56","author":"Kan","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.lfs.2017.05.010_bb0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsbmb.2016.01.006","article-title":"Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: estrogen receptor ligand effects","volume":"160","author":"Khalaj","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0090","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.neuroimage.2011.01.007","article-title":"Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords","volume":"55","author":"Klawiter","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.lfs.2017.05.010_bb0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.nbd.2013.04.005","article-title":"Estrogen receptor beta ligand therapy activates PI3K\/Akt\/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis","volume":"56","author":"Kumar","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2017.05.010_bb0100","doi-asserted-by":"crossref","first-page":"34503","DOI":"10.1038\/srep34503","article-title":"MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis","volume":"6","author":"Lecca","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2017.05.010_bb0105","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.yexmp.2014.10.004","article-title":"Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis","volume":"97","author":"Liu","year":"2014","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrd2926","article-title":"Targeting the phosphoinositide 3-kinase pathway in cancer","volume":"8","author":"Liu","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2017.05.010_bb0115","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S1474-4422(16)30165-X","article-title":"Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities","volume":"15","author":"Macrez","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1474-4422(14)70256-X","article-title":"Pathological mechanisms in progressive multiple sclerosis","volume":"14","author":"Mahad","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0125","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1750-3639.2010.00444.x","article-title":"An animal model of cortical and callosal pathology in multiple sclerosis","volume":"21","author":"Mangiardi","year":"2011","journal-title":"Brain Pathol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0130","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1523\/JNEUROSCI.0726-16.2016","article-title":"Cholesterol biosynthesis supports myelin gene expression and axon ensheathment through modulation of P13K\/Akt\/mTor signaling","volume":"36","author":"Mathews","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0135","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/eji.1830250723","article-title":"A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells","volume":"25","author":"Mendel","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0140","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1523\/JNEUROSCI.4380-14.2015","article-title":"Translational control of myelin basic protein expression by ERK2 MAP kinase regulates timely remyelination in the adult brain","volume":"35","author":"Michel","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0145","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0150","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1523\/JNEUROSCI.0232-09.2009","article-title":"Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination","volume":"29","author":"Narayanan","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0155","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1042\/BST20130046","article-title":"Akt\/mTOR signalling in myelination","volume":"41","author":"Norrmen","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.lfs.2017.05.010_bb0160","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2009.03.046","article-title":"DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival","volume":"137","author":"Peterson","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2017.05.010_bb0165","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09611","article-title":"Developmental genetics of vertebrate glial-cell specification","volume":"468","author":"Rowitch","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2017.05.010_bb0170","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1523\/JNEUROSCI.4814-11.2012","article-title":"Arrest of myelination and reduced axon growth when Schwann cells lack mTOR","volume":"32","author":"Sherman","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.05.010_bb0175","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2017.05.010_bb0180","doi-asserted-by":"crossref","first-page":"14235","DOI":"10.1038\/srep14235","article-title":"LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice","volume":"5","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2017.05.010_bb0185","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1158\/0008-5472.CAN-05-0917","article-title":"Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition","volume":"65","author":"Sun","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2017.05.010_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172037","article-title":"Th40 cells (CD4+CD40+ Tcells) drive a more severe form of experimental autoimmune encephalomyelitis than conventional CD4 T cells","volume":"12","author":"Vaitaitis","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.05.010_bb0195","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1142\/S0192415X14500359","article-title":"Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development","volume":"42","author":"Wang","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.lfs.2017.05.010_bb0200","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.3892\/mmr.2014.2642","article-title":"Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking beta3adrenoreceptor\/endothelial nitric oxide synthase pathway","volume":"10","author":"Yu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2017.05.010_bb0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2015.01.006","article-title":"Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis","volume":"76","author":"Zhang","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2017.05.010_bb0210","doi-asserted-by":"crossref","first-page":"736085","DOI":"10.1155\/2013\/736085","article-title":"Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis","volume":"2013","author":"Zhang","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2017.05.010_bb0215","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1142\/S0192415X11009317","article-title":"Matrine suppresses production of IL-23\/IL-17 and ameliorates experimental autoimmune encephalomyelitis","volume":"39","author":"Zhao","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.lfs.2017.05.010_bb0220","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.yexmp.2015.12.006","article-title":"Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling","volume":"100","author":"Zhu","year":"2016","journal-title":"Exp. Mol. Pathol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517302308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517302308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T21:27:34Z","timestamp":1535837254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517302308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":44,"alternative-id":["S0024320517302308"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.05.010","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrine promotes oligodendrocyte development in CNS autoimmunity through the PI3K\/Akt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}