{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:29:13Z","timestamp":1781659753601,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.lfs.2017.08.002","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T07:01:01Z","timestamp":1501916461000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Neuropathic pain attenuates ischemia reperfusion injury through \u03b22-adrenergic pathway"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-7352","authenticated-orcid":false,"given":"Shigeaki","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokuhiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Funao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonobu","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.08.002_bb0005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1037\/a0035794","article-title":"Overview of persistent pain in older adults","volume":"69","author":"Molton","year":"2014","journal-title":"Am. Psychol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0010","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0304-3959(00)00297-9","article-title":"Sympathetic-sensory coupling after L5 spinal nerve lesion in the rat and its relation to changes in dorsal root ganglion blood flow","volume":"87","author":"Habler","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pain.2009.07.040","article-title":"Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury","volume":"146","author":"Gemes","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0020","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.pain.2013.12.023","article-title":"The role of cardiovascular activity in fibromyalgia and conditioned pain modulation","volume":"155","author":"Chalaye","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0025","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejpain.2008.07.007","article-title":"Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry","volume":"13","author":"Ziegler","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0030","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d4551","article-title":"Antidepressant use and risk of adverse outcomes in older people: population based cohort study","author":"Coupland","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2017.08.002_bb0035","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM200011233432103","article-title":"Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group","volume":"343","author":"Bombardier","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2017.08.002_bb0040","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ejpain.2007.08.004","article-title":"Modulation of sensitized C-fibers by adrenergic stimulation in human neuropathic pain","volume":"12","author":"Schattschneider","year":"2008","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0045","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0306-4522(94)00435-8","article-title":"Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat","volume":"64","author":"Kinnman","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2017.08.002_bb0050","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/j.1476-5381.2009.00510.x","article-title":"Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment","volume":"158","author":"Choucair-Jaafar","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuint.2016.11.004","article-title":"Stimulation of spinal dorsal horn beta2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase","volume":"101","author":"Zhang","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2017.08.002_bb0060","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2017.08.002_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005344-200501000-00001","article-title":"Adenylyl cyclase-dependent inhibition of myocardial norepinephrine release by presynaptic adenosine A1-receptors","volume":"45","author":"Burgdorf","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0070","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1006\/jmcc.1997.0456","article-title":"Infarct size measurement by triphenyltetrazolium chloride staining versus in vivo injection of propidium iodide","volume":"29","author":"Ito","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0075","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/bph.13013","article-title":"Role of the MPTP in conditioning the heart-translatability and mechanism","volume":"172","author":"Ong","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0080","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00395-007-0675-y","article-title":"Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes","volume":"102","author":"Ruiz-Meana","year":"2007","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10557-010-6275-3","article-title":"The role of beta-adrenergic receptors in the cardioprotective effects of beta-preconditioning (betaPC)","volume":"25","author":"Salie","year":"2011","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.lfs.2017.08.002_bb0090","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/cvr\/cvq058","article-title":"Esmolol cardioplegia: the cellular mechanism of diastolic arrest","volume":"87","author":"Fallouh","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2017.08.002_bb0095","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02191898","article-title":"Myocardial segment shrinkage during coronary reperfusion in situ. Relation to hypercontracture and myocardial necrosis","volume":"431","author":"Barrabes","year":"1996","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2017.08.002_bb0100","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1006\/jmcc.1998.0805","article-title":"Metabolic recovery of isolated adult rat cardiomyocytes after energy depletion: existence of an ATP threshold?","volume":"30","author":"Bonz","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0105","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/j.1476-5381.2010.00986.x","article-title":"Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes","volume":"161","author":"Kojima","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0110","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2017.08.002_bb0115","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/01.CIR.100.9.958","article-title":"Ischemic preconditioning and the beta-adrenergic signal transduction pathway","volume":"100","author":"Lochner","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2017.08.002_bb0120","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/01.RES.87.12.1172","article-title":"The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3\u2032-kinase","volume":"87","author":"Chesley","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2017.08.002_bb0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cvr\/cvq113","article-title":"Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning","volume":"88","author":"Hausenloy","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2017.08.002_bb0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cyto.a.10072","article-title":"Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events","volume":"55","author":"Krutzik","year":"2003","journal-title":"Cytometry A"},{"key":"10.1016\/j.lfs.2017.08.002_bb0135","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.98.4.1607","article-title":"Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes","volume":"98","author":"Zhu","year":"2001","journal-title":"Proc. Natl, Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2017.08.002_bb0140","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1074\/jbc.M114.558882","article-title":"Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of beta2-adrenoceptor","volume":"289","author":"Woo","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2017.08.002_bb0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/CCM.0b013e318206b7e7","article-title":"New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model","volume":"39","author":"Hagiwara","year":"2011","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2017.08.002_bb0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00395-012-0281-5","article-title":"The mechanism of beta-adrenergic preconditioning: roles for adenosine and ROS during triggering and mediation","volume":"107","author":"Salie","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0155","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/01.CIR.98.13.1329","article-title":"Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway","volume":"98","author":"Communal","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2017.08.002_bb0160","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI200316326","article-title":"Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+\/calmodulin kinase II","volume":"111","author":"Zhu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2017.08.002_bb0165","doi-asserted-by":"crossref","first-page":"31249","DOI":"10.1074\/jbc.M202753200","article-title":"Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system","volume":"277","author":"Zamah","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2017.08.002_bb0170","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0022-2828(95)90590-1","article-title":"Ischaemic preconditioning in a model of global ischaemia: infarct size limitation, but no reduction of stunning","volume":"27","author":"Jenkins","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0175","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00395-003-0427-6","article-title":"Ischemic preconditioning: infarct size is a more reliable endpoint than functional recovery","volume":"98","author":"Lochner","year":"2003","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/sj.bjp.0704225","article-title":"Angiotensin II reduces infarct size and has no effect on post-ischaemic contractile dysfunction in isolated rat hearts","volume":"134","author":"Ford","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.002_bb0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/bj3070093","article-title":"Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion","volume":"307","author":"Griffiths","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2017.08.002_bb0190","article-title":"Characteristic interactivity of landiolol, an ultra-short-acting highly selective \u03b21-blocker, with biomimetic membranes: comparisons with \u03b21-selective esmolol and non-selective propranolol and alprenolol","volume":"150","author":"Tsuchiya","year":"2013","journal-title":"Front. Phamacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517303752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517303752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T14:51:35Z","timestamp":1535554295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517303752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":38,"alternative-id":["S0024320517303752"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.002","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropathic pain attenuates ischemia reperfusion injury through \u03b22-adrenergic pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}