{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:11:41Z","timestamp":1774537901021,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.lfs.2017.08.019","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T15:31:06Z","timestamp":1503156666000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K\/Akt pathway"],"prefix":"10.1016","volume":"187","author":[{"given":"Kholoud Alaa","family":"El-Mihi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany Ibrahim","family":"Kenawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amro","family":"El-Karef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal Mohsen","family":"Elsherbiny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Ahmed","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.08.019_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2017.08.019_bb0010","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2017.08.019_bb0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0020","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"Sanchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2017.08.019_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1756283X11413002","article-title":"Current status of novel antifibrotic therapies in patients with chronic liver disease","volume":"4","author":"Cohen-Naftaly","year":"2011","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0030","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jhep.2010.12.013","article-title":"PI(3)K\/PTEN\/AKT pathway","volume":"54","author":"Piguet","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0035","first-page":"81","article-title":"Antifibrotic effects of tanshinol in experimental hepatic fibrosis by targeting PI3K\/AKT\/mTOR\/p70S6K1 signaling pathways","volume":"23","author":"Peng","year":"2017","journal-title":"Discov. Med."},{"key":"10.1016\/j.lfs.2017.08.019_bb0040","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/srep03470","article-title":"HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis","volume":"3","author":"Son","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.lfs.2017.08.019_bb0045","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jhep.2010.10.040","article-title":"Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells","volume":"55","author":"Wang","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/15569543.2013.805144","article-title":"An overview of thioacetamide-induced hepatotoxicity","volume":"32","author":"Akhtar","year":"2013","journal-title":"Toxin Rev."},{"key":"10.1016\/j.lfs.2017.08.019_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2013\/157456","article-title":"Mechanism of hepatoprotective effect of Boesenbergia rotunda in thioacetamide-induced liver damage in rats","volume":"2013","author":"Salama","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2017.08.019_bb0060","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.foodchem.2006.11.054","article-title":"Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review","volume":"104","author":"Tripoli","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.lfs.2017.08.019_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF03216747","article-title":"Intestinal bacterial metabolism of flavonoids and its relation to some biological activities","volume":"21","author":"Kim","year":"1998","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.lfs.2017.08.019_bb0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2014.02.022","article-title":"Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection","volume":"277","author":"Sahu","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0075","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tox.2008.11.012","article-title":"Naringenin protects against cadmium-induced oxidative renal dysfunction in rats","volume":"256","author":"Renugadevi","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2017.08.019_bb0080","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s10753-014-9994-y","article-title":"Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-\u03baB, STAT3 and pro-inflammatory mediators and enhancement of I\u03baB\u03b1 and anti-inflammatory cytokines","volume":"38","author":"Ahmad","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.lfs.2017.08.019_bb0085","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S1734-1140(13)71492-0","article-title":"Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: involvement of hemeoxygenase-1","volume":"65","author":"Chandramohan","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.lfs.2017.08.019_bb0090","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.neuint.2011.08.022","article-title":"Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis","volume":"59","author":"Gopinath","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2017.08.019_bb0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/molecules21020195","article-title":"The anti-atherosclerotic effect of naringin is associated with reduced expressions of cell adhesion molecules and chemokines through NF-\u03baB pathway","volume":"21","author":"Hsueh","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2017.08.019_bb0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jdiacomp.2012.06.001","article-title":"Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed\/streptozotocin-induced type 2 diabetic rats","volume":"26","author":"Mahmoud","year":"2012","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.lfs.2017.08.019_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082577","article-title":"Regulation of heat shock proteins 27 and 70, p-Akt\/p-eNOS and MAPKs by naringin dampens myocardial injury and dysfunction in vivo after ischemia\/reperfusion","volume":"8","author":"Rani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.08.019_bb0110","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biomag.2013.01.006","article-title":"Antiproliferative and apoptotic effects of naringin on diethylnitrosamine induced hepatocellular carcinoma in rats","volume":"3","author":"Thangavel","year":"2013","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0115","doi-asserted-by":"crossref","first-page":"PJ51","DOI":"10.1055\/s-0029-1234856","article-title":"Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats","volume":"75","author":"Tsai","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2017.08.019_bb0120","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","author":"Aebi","year":"1984"},{"key":"10.1016\/j.lfs.2017.08.019_bb0125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2017.08.019_bb0130","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.lfs.2017.08.019_bb0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"Satoh","year":"1978","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2017.08.019_bb0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2017.08.019_bb0145","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0676.1990.tb00428.x","article-title":"Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liver","volume":"10","author":"James","year":"1990","journal-title":"Liver"},{"key":"10.1016\/j.lfs.2017.08.019_bb0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.0959-9673.2005.00411.x","article-title":"Apoptosis in chronic viral hepatitis parallels histological activity: an immunohistochemical investigation using anti-activated caspase-3 and M30 cytodeath antibody","volume":"86","author":"McPartland","year":"2005","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0160","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2105-6-62","article-title":"A standard curve based method for relative real time PCR data processing","volume":"6","author":"Larionov","year":"2005","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.lfs.2017.08.019_bb0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejbas.2014.12.005","article-title":"Hepatoprotective effects of glycyrrhizin and omega-3 fatty acids on nuclear factor-kappa B pathway in thioacetamide-induced fibrosis in rats","volume":"2","author":"El-Magd","year":"2015","journal-title":"Egypt. J. Basic Appl. Sci."},{"key":"10.1016\/j.lfs.2017.08.019_bb0170","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0192623311418680","article-title":"Role of quercetin in preventing thioacetamide-induced liver injury in rats","volume":"39","author":"de David","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jff.2014.11.020","article-title":"Naringin prevents carbon tetrachloride-induced acute liver injury in mice","volume":"12","author":"Dong","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.lfs.2017.08.019_bb0180","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into transforming growth factor \u03b2 Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2017.08.019_bb0185","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.3892\/mmr.2016.5673","article-title":"Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro","volume":"14","author":"Liu","year":"2016","journal-title":"Mol. Med. Report."},{"key":"10.1016\/j.lfs.2017.08.019_bb0190","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1258\/ebm.2011.011127","article-title":"Melittin attenuates liver injury in thioacetamide-treated mice through modulating inflammation and fibrogenesis","volume":"236","author":"Park","year":"2011","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2017.08.019_bb0195","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1021\/jf203259h","article-title":"Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice","volume":"60","author":"Tsai","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2017.08.019_bb0200","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/liv.12638","article-title":"Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT\/mTOR\/p70S6K and TGF beta\/Smad signalling pathways","volume":"35","author":"Li","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2017.08.019_bb0205","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/mnfr.200800210","article-title":"Naringin inhibits matrix metalloproteinase-9 expression and Akt phosphorylation in tumor necrosis factor-\u03b1-induced vascular smooth muscle cells","volume":"53","author":"Lee","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.lfs.2017.08.019_bb0210","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2174\/1389201015666141111114442","article-title":"Naringin inhibits TNF-\u03b1 induced oxidative stress and inflammatory response in HUVECs via NOX4\/NF-\u03baB and PI3K\/Akt pathways","volume":"15","author":"Wenshuang","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0215","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/iub.1478","article-title":"Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K\/Akt pathway","volume":"68","author":"Chen","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.lfs.2017.08.019_bb0220","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/jhep.2002.30362","article-title":"Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species","volume":"35","author":"Nieto","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2017.08.019_bb0225","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2016-000079","article-title":"Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets","volume":"3","author":"Li","year":"2016","journal-title":"BMJ Open Gastroenterol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0230","doi-asserted-by":"crossref","first-page":"G1324","DOI":"10.1152\/ajpgi.90564.2008","article-title":"Interleukin-1 participates in the progression from liver injury to fibrosis","volume":"296","author":"Gieling","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0235","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.immuni.2013.10.022","article-title":"Interleukin-6 signaling drives fibrosis in unresolved inflammation","volume":"40","author":"Fielding","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2017.08.019_bb0240","first-page":"2092","article-title":"Antifibrotic effects of interleukin-10 on experimental hepatic fibrosis","volume":"54","author":"Zhang","year":"2007","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.lfs.2017.08.019_bb0245","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0250","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2017.05.130","article-title":"ERK1\/2 signaling mediated naringin-induced osteogenic differentiation of immortalized human periodontal ligament stem cells","volume":"489","author":"Wei","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2017.08.019_bb0255","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2893.2005.00689.x","article-title":"Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection","volume":"13","author":"Muir","year":"2006","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.lfs.2017.08.019_bb0260","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1542-3565(05)00404-0","article-title":"Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study","volume":"3","author":"Weng","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2017.08.019_bb0265","doi-asserted-by":"crossref","first-page":"40404","DOI":"10.1038\/srep40404","article-title":"Predictive value of serum IFN-\u03b3 inducible protein-10 and IFN-\u03b3\/IL-4 ratio for liver fibrosis progression in CHB patients","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T13:51:06Z","timestamp":1659361866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517304125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":53,"alternative-id":["S0024320517304125"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.019","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K\/Akt pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}