{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:50:42Z","timestamp":1787313042525,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81270280"],"award-info":[{"award-number":["No. 81270280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.lfs.2017.08.036","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T23:17:40Z","timestamp":1504307860000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["SOCS2 exacerbates myocardial injury induced by ischemia\/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway"],"prefix":"10.1016","volume":"188","author":[{"given":"Mengting","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.08.036_bb0005","doi-asserted-by":"crossref","first-page":"653789","DOI":"10.1155\/2013\/653789","article-title":"Impact of diabetes on cardiovascular disease: an update","volume":"2013","author":"Matheus","year":"2013","journal-title":"Int. J. Hypertens."},{"issue":"13","key":"10.1016\/j.lfs.2017.08.036_bb0010","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.4239\/wjd.v6.i13.1246","article-title":"Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research","volume":"6","author":"Leon","year":"2015","journal-title":"World J. Diabetes"},{"issue":"3","key":"10.1016\/j.lfs.2017.08.036_bb0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijcard.2013.11.007","article-title":"Progression in attenuating myocardial reperfusion injury: an overview","volume":"170","author":"Bernink","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002424","article-title":"Chronic co-Administration of Sepiapterin and L-Citrulline ameliorates diabetic cardiomyopathy and myocardial ischemia\/reperfusion injury in obese type 2 diabetic mice","volume":"9","author":"Baumgardt","year":"2016","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.lfs.2017.08.036_bb0025","doi-asserted-by":"crossref","first-page":"9213034","DOI":"10.1155\/2016\/9213034","article-title":"N-Acetylcysteine restores Sevoflurane Postconditioning Cardioprotection against myocardial ischemia-reperfusion injury in diabetic rats","volume":"2016","author":"Lin","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.lfs.2017.08.036_bb0030","doi-asserted-by":"crossref","DOI":"10.3402\/ljm.v10.29269","article-title":"The effect of levosimendan on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats","volume":"10","author":"Kiraz","year":"2015","journal-title":"Libyan J. Med."},{"issue":"2","key":"10.1016\/j.lfs.2017.08.036_bb0035","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/1440-1681.12516","article-title":"Mechanism of sphingosine-1-phosphate induced cardioprotection against I\/R injury in diabetic rat heart: possible involvement of glycogen synthase kinase 3beta and mitochondrial permeability transition pore","volume":"43","author":"Rana","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.lfs.2017.08.036_bb0040","first-page":"189","article-title":"SOCS2: physiological and pathological functions","volume":"8","author":"Letellier","year":"2016","journal-title":"Front. Biosci. (Elite Ed.)"},{"issue":"9","key":"10.1016\/j.lfs.2017.08.036_bb0045","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1007\/s11033-012-1783-9","article-title":"Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte","volume":"39","author":"Yang","year":"2012","journal-title":"Mol. Biol. Rep."},{"issue":"11","key":"10.1016\/j.lfs.2017.08.036_bb0050","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1006\/jmcc.1999.1036","article-title":"Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease","volume":"31","author":"Ren","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.lfs.2017.08.036_bb0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00395-004-0506-3","article-title":"Administration of insulin-like growth factor-1 (IGF-1) improves both structure and function of delta-sarcoglycan deficient cardiac muscle in the hamster","volume":"100","author":"Serose","year":"2005","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.036_bb0060","doi-asserted-by":"crossref","first-page":"245412","DOI":"10.1155\/2015\/245412","article-title":"After myocardial ischemia-reperfusion, miR-29a, and let 7 could affect apoptosis through regulating IGF-1","volume":"2015","author":"Wang","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"21","key":"10.1016\/j.lfs.2017.08.036_bb0065","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1073\/pnas.0602877103","article-title":"Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction","volume":"103","author":"Davis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.lfs.2017.08.036_bb0070","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.freeradbiomed.2010.07.020","article-title":"Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: roles of Akt, mTOR, GSK3beta, and PTEN","volume":"49","author":"Zhang","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0075","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/en.2015-1709","article-title":"Deletion of IGF-1 receptors in Cardiomyocytes attenuates cardiac aging in male mice","volume":"157","author":"Ock","year":"2016","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.lfs.2017.08.036_bb0080","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2165\/00003495-200060040-00002","article-title":"Role of growth hormone in chronic heart failure. Therapeutic implications","volume":"60","author":"Volterrani","year":"2000","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijdevneu.2009.09.002","article-title":"Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia","volume":"28","author":"Beresewicz","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"issue":"4\u20135","key":"10.1016\/j.lfs.2017.08.036_bb0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000014599","article-title":"Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain","volume":"8","author":"Clawson","year":"1999","journal-title":"Biol. Signals Recept."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2017.08.036_bb0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11010-007-9410-0","article-title":"Mitochondrial involvement in IGF-1 induced protection of cardiomyocytes against hypoxia\/reoxygenation injury","volume":"301","author":"Pi","year":"2007","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2017.08.036_bb0100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/hep.26368","article-title":"Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice","volume":"58","author":"Wang","year":"2013","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1172\/JCI75838","article-title":"Targeting development of incretin-producing cells increases insulin secretion","volume":"125","author":"Petersen","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.lfs.2017.08.036_bb0110","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00395-014-0434-9","article-title":"Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia\/reperfusion injury","volume":"109","author":"Zhang","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"4","key":"10.1016\/j.lfs.2017.08.036_bb0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00125-007-0596-1","article-title":"Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue","volume":"50","author":"Konrad","year":"2007","journal-title":"Diabetologia"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2017.08.036_bb0130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mce.2012.06.002","article-title":"Baicalein, a natural product, selectively activating AMPKalpha(2) and ameliorates metabolic disorder in diet-induced mice","volume":"362","author":"Pu","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.lfs.2017.08.036_bb0135","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.lfs.2017.08.036_bb0140","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00109-014-1146-1","article-title":"The pathobiology of diabetic vascular complications--cardiovascular and kidney disease","volume":"92","author":"Gray","year":"2014","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"3","key":"10.1016\/j.lfs.2017.08.036_bb0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12576-015-0365-8","article-title":"Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus","volume":"65","author":"Badalzadeh","year":"2015","journal-title":"J. Physiol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2017.08.036_bb0150","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00395-011-0216-6","article-title":"The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury","volume":"106","author":"Ye","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2017.08.036_bb0155","doi-asserted-by":"crossref","first-page":"8237264","DOI":"10.1155\/2016\/8237264","article-title":"Fenofibrate plus metformin produces Cardioprotection in a type 2 diabetes and acute myocardial infarction model","volume":"2016","author":"Oidor-Chan","year":"2016","journal-title":"PPAR Res."},{"key":"10.1016\/j.lfs.2017.08.036_bb0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fimmu.2012.00020","article-title":"Inflammation, and autoimmunity","volume":"3","author":"Yoshimura","year":"2012","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2017.08.036_bb0165","article-title":"SOCS, inflammation, and cancer","volume":"2","author":"Inagaki-Ohara","year":"2013","journal-title":"JAKSTAT"},{"issue":"2","key":"10.1016\/j.lfs.2017.08.036_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00024382-200202000-00001","article-title":"Suppressors of cytokine signaling (SOCS): inhibitors of the JAK\/STAT pathway","volume":"17","author":"Cooney","year":"2002","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.lfs.2017.08.036_bb0175","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00467-012-2271-0","article-title":"Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH\/IGF-1 signaling","volume":"28","author":"Farquharson","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.lfs.2017.08.036_bb0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnmol.2014.00039","article-title":"Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player","volume":"7","author":"Uren","year":"2014","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2017.08.036_bb0185","doi-asserted-by":"crossref","first-page":"274","DOI":"10.7150\/ijbs.10684","article-title":"Protracted upregulation of leptin and IGF1 is associated with activation of PI3K\/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure","volume":"11","author":"Suman","year":"2015","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2017.08.036_bb0190","first-page":"686","article-title":"Diagnostic utility of serum GH, IGF-1 and IGFBP3 in patients of acromegaly with uncontrolled diabetes: a pilot study","volume":"62","author":"Dutta","year":"2014","journal-title":"J. Assoc. Physicians India"},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2174\/1871530311313010010","article-title":"The GH\/IGF-1 axis in chronic heart failure","volume":"13","author":"Arcopinto","year":"2013","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"3","key":"10.1016\/j.lfs.2017.08.036_bb0200","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.CIR.104.3.325","article-title":"JAK\/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion","volume":"104","author":"Mascareno","year":"2001","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.lfs.2017.08.036_bb0205","doi-asserted-by":"crossref","first-page":"F762","DOI":"10.1152\/ajprenal.00181.2005","article-title":"Role of the JAK\/STAT signaling pathway in diabetic nephropathy","volume":"290","author":"Marrero","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0210","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0168-8227(94)90121-X","article-title":"Role of the insulin-like growth factors in the endocrine control of glucose homeostasis","volume":"23","author":"Lewitt","year":"1994","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9319","key":"10.1016\/j.lfs.2017.08.036_bb0215","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/S0140-6736(02)08655-5","article-title":"Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study","volume":"359","author":"Sandhu","year":"2002","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.lfs.2017.08.036_bb0220","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1007\/s00125-006-0386-1","article-title":"Insulin-like growth factor I: a predictor of long-term glucose abnormalities in patients with acute myocardial infarction","volume":"49","author":"Wallander","year":"2006","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.lfs.2017.08.036_bb0225","doi-asserted-by":"crossref","first-page":"642","DOI":"10.7326\/0003-4819-139-8-200310210-00007","article-title":"Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham heart study","volume":"139","author":"Vasan","year":"2003","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.lfs.2017.08.036_bb0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2337\/diabetes.54.1.175","article-title":"Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium","volume":"54","author":"Chen","year":"2005","journal-title":"Diabetes"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:15:38Z","timestamp":1758399338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517304290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":44,"alternative-id":["S0024320517304290"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.036","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SOCS2 exacerbates myocardial injury induced by ischemia\/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}