{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:38:26Z","timestamp":1792521506727,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502553"],"award-info":[{"award-number":["81502553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M610947"],"award-info":[{"award-number":["2017M610947"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017T100091"],"award-info":[{"award-number":["2017T100091"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.lfs.2017.09.037","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T03:45:23Z","timestamp":1506570323000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K\/AKT pathway"],"prefix":"10.1016","volume":"190","author":[{"given":"Hongyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-8634","authenticated-orcid":false,"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2017.09.037_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.lfs.2017.09.037_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/254954","article-title":"Genetics of Alzheimer's Disease","volume":"2013","author":"Ridge","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2017.09.037_bb0015","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1111\/jgs.12553","article-title":"Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer's disease: a scoping review of the evidence","volume":"61","author":"Affoo","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.lfs.2017.09.037_bb0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3233\/JAD-130831","article-title":"Mediterranean diet and cognitive decline. A lesson from the whole-diet approach: what challenges lie ahead?","volume":"39","author":"Solfrizzi","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.lfs.2017.09.037_bb0025","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00023.2009","article-title":"Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process","volume":"90","author":"De Strooper","year":"2010","journal-title":"Physiol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2017.09.037_bb0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbadis.2004.06.017","article-title":"Tau phosphorylation: physiological and pathological consequences","volume":"1739","author":"Stoothoff","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.lfs.2017.09.037_bb0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/pin.12520","article-title":"Plaque formation and the intraneuronal accumulation of beta-amyloid in Alzheimer's disease","volume":"67","author":"Takahashi","year":"2017","journal-title":"Pathol. Int."},{"issue":"3","key":"10.1016\/j.lfs.2017.09.037_bb0040","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3233\/JAD-131733","article-title":"The temporospatial evolution of NP-related and independent tangleopathies: implications for dementia staging","volume":"40","author":"Royall","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.lfs.2017.09.037_bb0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.lfs.2017.09.037_bb0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000464422","article-title":"Molecular pathogenesis of Alzheimer's disease: an update","volume":"24","author":"Sanabria-Castro","year":"2017","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.lfs.2017.09.037_bb0055","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fneur.2013.00122","article-title":"Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease","volume":"4","author":"Chesser","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.lfs.2017.09.037_bb0060","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neuroscience.2004.05.036","article-title":"Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT","volume":"127","author":"Kyoung Pyo","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2017.09.037_bb0065","first-page":"159","article-title":"AKT\/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro","volume":"2003","author":"Ksiezak-Reding","year":"1639","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2017.09.037_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2014.10.045","article-title":"SnapShot: Mammalian sirtuins","volume":"159","author":"Anderson","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2017.09.037_bb0075","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2011.09.050","article-title":"Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and \u03b2-amyloid in neurons","volume":"414","author":"Greco","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2017.09.037_bb0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.lfs.2017.09.037_bb0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exger.2014.07.008","article-title":"Mitochondrial quality control and age-associated arterial stiffening","volume":"58","author":"LaRocca","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.lfs.2017.09.037_bb0090","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tibs.2012.12.004","article-title":"The ways and means that fine tune Sirt1 activity","volume":"38","author":"Revollo","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.lfs.2017.09.037_bb0095","doi-asserted-by":"crossref","first-page":"21745","DOI":"10.1074\/jbc.M602909200","article-title":"Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2017.09.037_bb0100","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","article-title":"Acetylation of tau inhibits its degradation and contributes to tauopathy","volume":"67","author":"Min","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2017.09.037_bb0105","article-title":"Cilostazol modulates autophagic degradation of \u03b2-amyloid peptide via SIRT1-coupled LKB1\/AMPK\u03b1 signaling in neuronal cells","volume":"11","author":"Park","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.09.037_bb0110","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1523\/JNEUROSCI.2939-14.2015","article-title":"SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1 beta","volume":"35","author":"Cho","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2017.09.037_bb0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.pneurobio.2011.09.001","article-title":"Protective effects and mechanisms of sirtuins in the nervous system","volume":"95","author":"Zhang","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.lfs.2017.09.037_bb0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuint.2012.10.014","article-title":"Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway","volume":"62","author":"Cheng","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2017.09.037_bb0125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1503\/jpn.110190","article-title":"Glutamate system, amyloid \u03b2 peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology","volume":"38","author":"Revett","year":"2013","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.lfs.2017.09.037_bb0130","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1089\/ars.2011.4400","article-title":"Insights into mitochondrial dysfunction: aging, amyloid-\u03b2, and tau-a deleterious trio","volume":"16","author":"Schmitt","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.lfs.2017.09.037_bb0135","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s10072-014-1717-5","article-title":"Caloric restriction can improve learning ability in C57\/BL mice via regulation of the insulin-PI3K\/Akt signaling pathway","volume":"35","author":"Ma","year":"2014","journal-title":"Neurol. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2017.09.037_bb0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10072-014-1997-9","article-title":"The \u03b2-amyloid precursor protein analog P165 improves impaired insulin signal transduction in type 2 diabetic rats","volume":"36","author":"Ma","year":"2015","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.lfs.2017.09.037_bb0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainresbull.2015.06.004","article-title":"Effect of caloric restriction on the SIRT1\/mTOR signaling pathways in senile mice","volume":"116","author":"Ma","year":"2015","journal-title":"Brain Res. Bull."},{"issue":"7","key":"10.1016\/j.lfs.2017.09.037_bb0150","first-page":"11843","article-title":"Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice","volume":"8","author":"Dong","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.lfs.2017.09.037_bb0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/07853890701408194","article-title":"Sirtuins: the \u2018magnificent seven\u2019, function, metabolism and longevity","volume":"39","author":"Dali-Youcef","year":"2007","journal-title":"Ann. Med."},{"key":"10.1016\/j.lfs.2017.09.037_bb0160","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.lfs.2017.09.037_bb0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRT1 in neurodevelopment and brain senescence","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"issue":"31","key":"10.1016\/j.lfs.2017.09.037_bb0170","doi-asserted-by":"crossref","first-page":"21745","DOI":"10.1074\/jbc.M602909200","article-title":"Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction","volume":"281","author":"Qin","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"48","key":"10.1016\/j.lfs.2017.09.037_bb0175","doi-asserted-by":"crossref","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.lfs.2017.09.037_bb0180","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.lfs.2017.09.037_bb0185","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/emboj\/21.10.2383","article-title":"Human SIR2 deacetylates p53 and antagonizes PML\/p53-induced cellular senescence","volume":"21","author":"Langley","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2017.09.037_bb0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuana","year":"2016","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"10.1016\/j.lfs.2017.09.037_bb0195","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00001756-200302100-00020","article-title":"Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines","volume":"14","author":"Lee","year":"2003","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.lfs.2017.09.037_bb0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbadis.2003.09.001","article-title":"Akt\/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro","volume":"1639","author":"Ksiezak-Reding","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.lfs.2017.09.037_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005917","article-title":"Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262\/356 by Par-1\/MARK Contributes to Augmentation of AD-Related Phosphorylation and A\u03b242-Induced Tau Toxicity","volume":"12","author":"Ando","year":"2016","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.lfs.2017.09.037_bb0210","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.1007\/s11357-014-9705-5","article-title":"Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K\/Akt signaling to improve the effects of exercise in elderly rat hearts","volume":"36","author":"Lin","year":"2014","journal-title":"Age (Dordr.)"},{"issue":"8","key":"10.1016\/j.lfs.2017.09.037_bb0215","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s11064-008-9714-9","article-title":"Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation","volume":"33","author":"Mercado-Gomez","year":"2008","journal-title":"Neurochem. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517304812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T21:39:40Z","timestamp":1570138780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517304812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":43,"alternative-id":["S0024320517304812"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.09.037","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}