{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:33:02Z","timestamp":1783110782370,"version":"3.54.6"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Scientific Research Fund of Hunan Provincial Education Department","award":["13k113"],"award-info":[{"award-number":["13k113"]}]},{"name":"Scientific Research Fund of Xiangnan University","award":["2015XB18"],"award-info":[{"award-number":["2015XB18"]}]},{"DOI":"10.13039\/501100010451","name":"Health and Family Planning Commission of Hunan Province","doi-asserted-by":"crossref","award":["B2017043"],"award-info":[{"award-number":["B2017043"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005225","name":"Construct Program of the Key Discipline in Hunan Province","doi-asserted-by":"publisher","award":["2011-76"],"award-info":[{"award-number":["2011-76"]}],"id":[{"id":"10.13039\/501100005225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Construction Disciplines of Xiangnan University","award":["XNU-125-KD-019"],"award-info":[{"award-number":["XNU-125-KD-019"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.lfs.2017.10.018","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T17:00:35Z","timestamp":1508000435000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K\/Akt\/eNOS pathway and inhibiting activation of ERK1\/2 and NF-\u03baB"],"prefix":"10.1016","volume":"191","author":[{"given":"Hua-Fei","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Zhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1253\/circj.CJ-09-0818","article-title":"Tissue factor and cardiovascular disease: quo vadis?","volume":"74","author":"Breitenstein","year":"2010","journal-title":"Circ. J."},{"issue":"14","key":"10.1016\/j.lfs.2017.10.018_bb0010","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/eurheartj\/ehp598","article-title":"Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4","volume":"31","author":"Gebhard","year":"2010","journal-title":"Eur. Heart J."},{"issue":"17","key":"10.1016\/j.lfs.2017.10.018_bb0015","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2009.07.037","article-title":"CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1\/2 MAPK pathway","volume":"583","author":"Chen","year":"2009","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.lfs.2017.10.018_bb0020","first-page":"601","article-title":"Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells","volume":"138","author":"Drake","year":"1991","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.lfs.2017.10.018_bb0025","first-page":"979","article-title":"Exogenous hydrogen sulfide inhibits expression of tissue factor induced by ox-LDL through reducing generation of ROS and inhibiting NF-\u03baB activation in endothelial cells","volume":"30","author":"Deng","year":"2014","journal-title":"Chin. Pharmacol. Bull."},{"issue":"2","key":"10.1016\/j.lfs.2017.10.018_bb0030","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2016.05.068","article-title":"Ox-LDL induces endothelial dysfunction by promoting Arp2\/3 complex expression","volume":"475","author":"Tang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2017.10.018_bb0035","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1172\/JCI58969","article-title":"Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin","volume":"122","author":"Owens","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 2","key":"10.1016\/j.lfs.2017.10.018_bb0040","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.thromres.2012.02.026","article-title":"Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque","volume":"129","author":"Owens","year":"2012","journal-title":"Thromb. Res."},{"issue":"6824","key":"10.1016\/j.lfs.2017.10.018_bb0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.lfs.2017.10.018_bb0050","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1159\/000438526","article-title":"Exogenous bradykinin inhibits tissue factor induction and deep vein thrombosis via activating the eNOS\/phosphoinositide 3-kinase\/Akt signaling pathway","volume":"37","author":"Dong","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.lfs.2017.10.018_bb0055","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1160\/TH11-09-0624","article-title":"Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition","volume":"107","author":"Gebhard","year":"2012","journal-title":"Thromb. Haemost."},{"issue":"18","key":"10.1016\/j.lfs.2017.10.018_bb0060","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1161\/01.CIR.101.18.2144","article-title":"Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide","volume":"101","author":"Yang","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0065","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1124\/jpet.107.125567","article-title":"Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation","volume":"323","author":"Sun","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000264938","article-title":"Puerarin inhibits adhesion molecule expression in TNF-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway","volume":"85","author":"Hu","year":"2010","journal-title":"Pharmacology"},{"issue":"4","key":"10.1016\/j.lfs.2017.10.018_bb0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1139\/cjpp-2013-0322","article-title":"Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS","volume":"92","author":"Bao","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"7","key":"10.1016\/j.lfs.2017.10.018_bb0080","first-page":"559","article-title":"Protection of puerarin on impaired vascular endothelial function induced by glycosylated protein","volume":"49","author":"Deng","year":"2014","journal-title":"Chin. Pharm. J."},{"issue":"2","key":"10.1016\/j.lfs.2017.10.018_bb0085","first-page":"89","article-title":"Inhibitory effect of puerarin on vascular smooth muscle cells proliferation induced by oxidised low-density lipoprotein via suppressing ERK 1\/2 phosphorylation and PCNA expression","volume":"71","author":"Hu","year":"2016","journal-title":"Pharmazie"},{"issue":"8","key":"10.1016\/j.lfs.2017.10.018_bb0090","first-page":"1077","article-title":"The anti-apoptotic effect of puerarin on myocardial ischemia-reperfusion injury mediated by PI3K\/Akt signaling pathway in rats","volume":"30","author":"May","year":"2010","journal-title":"Chin. J. Gerontol."},{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.taap.2011.08.017","article-title":"Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase","volume":"257","author":"Hwang","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2017.10.018_bb0100","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.pharep.2016.06.007","article-title":"Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF-\u03baB pathway in a rabbit model","volume":"68","author":"Ji","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"7","key":"10.1016\/j.lfs.2017.10.018_bb0105","first-page":"611","article-title":"Effects of puerarin on lipidemia, blood coagulation and platelet aggregation in hyperlipidemia rats","volume":"28","author":"Deng","year":"2011","journal-title":"Chin JMAP"},{"issue":"11","key":"10.1016\/j.lfs.2017.10.018_bb0110","first-page":"2269","article-title":"The effect of puerarin on peripheral tissue factor and tissue factor pathway inhibitor in patients with acute coronary syndromes","volume":"4","author":"Niu","year":"2010","journal-title":"Chin J. Clinicians (Electronic Edition)."},{"issue":"8","key":"10.1016\/j.lfs.2017.10.018_bb0115","first-page":"692","article-title":"Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarinon them","volume":"27","author":"Li","year":"2007","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"12","key":"10.1016\/j.lfs.2017.10.018_bb0120","first-page":"13","article-title":"Influence of puerarin on the expression of tissue factor induced by angiotensin II and its mechanism in vascular endothelial cells","volume":"22","author":"Ran","year":"2012","journal-title":"Chin J. Modern Med."},{"key":"10.1016\/j.lfs.2017.10.018_bb0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"15","key":"10.1016\/j.lfs.2017.10.018_bb0130","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1161\/01.CIR.0000015465.73933.3B","article-title":"Statin prevents tissue factor expression in human endothelial cells: role of Rho\/Rho-kinase and Akt pathways","volume":"105","author":"Eto","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2017.10.018_bb0135","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1096\/fj.00-0247com","article-title":"Specificity, diversity, and convergence in VEGF and TNF-\u03baB signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells","volume":"15","author":"Mechtcheriakova","year":"2001","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.lfs.2017.10.018_bb0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1097-2765(02)00477-X","article-title":"The phosphorylation status of nuclear NF-kappa B determines its association with CBP\/p300 or HDAC-1","volume":"9","author":"Zhong","year":"2002","journal-title":"Mol. Cell"},{"issue":"20","key":"10.1016\/j.lfs.2017.10.018_bb0145","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1128\/MCB.21.20.7065-7077.2001","article-title":"The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression","volume":"21","author":"Ashburner","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.lfs.2017.10.018_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1101\/gad.183434.111","article-title":"NF-\u03baB, the first quarter-century: remarkable progress and outstanding questions","volume":"26","author":"Hayden","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2017.10.018_bb0155","doi-asserted-by":"crossref","first-page":"860301","DOI":"10.1155\/2012\/860301","article-title":"The interface between inflammation and coagulation in cardiovascular disease","volume":"2012","author":"Demetz","year":"2012","journal-title":"Int. J. Inflamm."},{"issue":"3","key":"10.1016\/j.lfs.2017.10.018_bb0160","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.thromres.2011.12.026","article-title":"Thrombosis and acute coronary syndrome","volume":"129","author":"Abbate","year":"2012","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.lfs.2017.10.018_bb0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCULATIONAHA.105.553735","article-title":"Histamine induces tissue factor expression: implications for acute coronary syndromes","volume":"112","author":"Steffel","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.thromres.2006.07.007","article-title":"The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC","volume":"120","author":"Holzer","year":"2007","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.lfs.2017.10.018_bb0175","first-page":"1610","article-title":"Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-\u03baB translocation","volume":"40","author":"Zheng","year":"2012","journal-title":"Int. J. Oncol."},{"issue":"10","key":"10.1016\/j.lfs.2017.10.018_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025921","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1\/2 and p38MAPK signaling pathways in PC12 cells","volume":"6","author":"Lan","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.lfs.2017.10.018_bb0185","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2010.05.020","article-title":"Angiotensin II induces C-reactive protein expression through ERK1\/2 and JNK signaling in human aortic endothelial cells","volume":"212","author":"Han","year":"2010","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.lfs.2017.10.018_bb0190","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00018-015-2091-z","article-title":"Advanced glycation end products upregulate lysyl oxidase and endothelin-1 in human aortic endothelial cells via parallel activation of ERK1\/2-NF-\u03baB and JNK-AP-1 signaling pathways","volume":"73","author":"Adamopoulos","year":"2016","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517305325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517305325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T14:06:43Z","timestamp":1570198003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517305325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":38,"alternative-id":["S0024320517305325"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.10.018","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K\/Akt\/eNOS pathway and inhibiting activation of ERK1\/2 and NF-\u03baB","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}