{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:05:27Z","timestamp":1773533127128,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006109","name":"VEGA","doi-asserted-by":"publisher","award":["2\/0082\/16"],"award-info":[{"award-number":["2\/0082\/16"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"VEGA","doi-asserted-by":"publisher","award":["2\/0073\/16"],"award-info":[{"award-number":["2\/0073\/16"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"APVV","doi-asserted-by":"publisher","award":["16-0246"],"award-info":[{"award-number":["16-0246"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant Agency of Czech Republic","award":["P102\/12\/2034"],"award-info":[{"award-number":["P102\/12\/2034"]}]},{"name":"National Program of Sustainability II","award":["LQ1605"],"award-info":[{"award-number":["LQ1605"]}]},{"name":"European Regional Development Fund ITMS","award":["26240220044"],"award-info":[{"award-number":["26240220044"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.lfs.2017.10.026","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T20:30:44Z","timestamp":1508358644000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Disruption of dopamine D1\/D2 receptor complex is involved in the function of haloperidol in cardiac H9c2 cells"],"prefix":"10.1016","volume":"191","author":[{"given":"L.","family":"Lencesova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Szadvari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Babula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kubickova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Chovancova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lopusna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rezuchova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Novakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Krizanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Novakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2017.10.026_bb0005","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMra1407298","article-title":"Recognition and management of withdrawal delirium (delirium tremens)","volume":"371","author":"Schuckit","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2017.10.026_bb0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S1461145713000801","article-title":"Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor","volume":"17","author":"Sahlholm","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0015","first-page":"110","article-title":"Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions","volume":"26","author":"Novakova","year":"2007","journal-title":"Physiol. Biophys."},{"key":"10.1016\/j.lfs.2017.10.026_bb0020","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4149\/gpb_2010_04_381","article-title":"Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in ventricles","volume":"29","author":"Novakova","year":"2010","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.lfs.2017.10.026_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1620\/tjem.236.199","article-title":"Long-term haloperidol treatment prolongs QT interval and increases expression of sigma 1 and IP3 receptors in guinea pig hearts","volume":"236","author":"Stracina","year":"2015","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.lfs.2017.10.026_bb0030","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.euroneuro.2013.06.005","article-title":"Schizophrenia and dopamine receptors","volume":"23","author":"Seeman","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0035","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.euroneuro.2016.01.001","article-title":"The fast-off hypothesis revisited: a functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor","volume":"26","author":"Sahlholm","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0040","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1073\/pnas.0604049104","article-title":"D1\u2013D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq\/11 in the striatum","volume":"104","author":"Rashid","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2017.10.026_bb0045","article-title":"Haloperidol affects plasticity of differentiated NG-108 cells through \u03c31R\/IP3R1 complex","author":"Kubickova","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0050","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.euroneuro.2008.05.001","article-title":"The role of D1\u2013D2 receptor hetero-dimerization in the mechanism of action of clozapine","volume":"18","author":"Faron-Gorecka","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011038","article-title":"Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine","volume":"5","author":"Thompson","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.10.026_bb0060","doi-asserted-by":"crossref","first-page":"e33348","DOI":"10.1371\/journal.pone.0033348","article-title":"Dopamine D1\u2013D2 receptor heteromer in dual phenotype GABA\/glutamate-coexepressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1\/2","volume":"7","author":"Perreault","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2017.10.026_bb0065","series-title":"Evidence Against Dopamine D1\/D2 Receptor Heteromers","first-page":"1373","volume":"20","author":"Frederick","year":"2015"},{"key":"10.1016\/j.lfs.2017.10.026_bb0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/00004714-199304000-00007","article-title":"Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill","volume":"13","author":"Metzger","year":"1993","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0075","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/bmj.325.7372.1070","article-title":"Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data","volume":"325","author":"Hennessy","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2017.10.026_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psym.2012.11.001","article-title":"QTc prolongation, torsades de pointes, and psychotropic medications","volume":"54","author":"Beach","year":"2013","journal-title":"Psychosomatics"},{"key":"10.1016\/j.lfs.2017.10.026_bb0085","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuroscience.2016.03.057","article-title":"Slow sulfide donor GYY4137 differentiates NG108-15 neuronal cells through different intracellular transporters than dbcAMP","volume":"325","author":"Kubickova","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2017.10.026_bb0090","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00424-013-1366-1","article-title":"Sodium\/calcium exchanger is upregulated by sulfide signaling, forms complex with the \u03b21 and \u03b23 but not \u03b22 adrenergic receptors, and induces apoptosis","volume":"466","author":"Markova","year":"2014","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2017.10.026_bb0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2017.10.026_bb0100","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/apha.12105","article-title":"Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2","volume":"208","author":"Lencesova","year":"2013","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.lfs.2017.10.026_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/bph.12906","article-title":"Dopamine receptors - IUPHAR review 13","volume":"172","author":"Beaulieu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0110","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.bmc.2005.09.008","article-title":"Synthesis and characterization of selective dopamine D2 receptor antagonists","volume":"14","author":"Vangveravong","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.lfs.2017.10.026_bb0115","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2017.10.026_bb0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0952-3278(92)90059-R","article-title":"Effect of haloperidol on cyclic AMP and inositol trisphosphate in rat striatum in vivo","volume":"46","author":"Kaneko","year":"1992","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.lfs.2017.10.026_bb0125","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.euroneuro.2016.07.008","article-title":"Disruption of a dopamine receptor complex amplifies the actions of cocaine","volume":"26","author":"Perreault","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0130","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1093\/cercor\/bhv222","article-title":"Age-dependent D1\u2013D2 receptor coactivation in the lateral orbitofrontal cortex potentiates NMDA receptors and facilitates cognitive flexibility","volume":"26","author":"Thompson","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.lfs.2017.10.026_bb0135","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/0748233713518601","article-title":"Evaluation of intravenous lipid emulsion on haloperidol-induced hypotension in rabbits","volume":"32","author":"Moshiri","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.lfs.2017.10.026_bb0140","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/01.jcp.0000104913.75206.62","article-title":"A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition","volume":"24","author":"Harrigan","year":"2004","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0145","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1253\/jcj.64.445","article-title":"Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed in the canine in vivo model under the monitoring of monophasic action potential","volume":"64","author":"Satoh","year":"2000","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.lfs.2017.10.026_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000026512","article-title":"Cardiovascular autonomic reactivity in schizophrenics under neuroleptic treatment: a potential predictor of short-term outcome?","volume":"38","author":"Agelink","year":"1998","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.lfs.2017.10.026_bb0155","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1651-2227.1993.tb12584.x","article-title":"Acute accidental overdosage of haloperidol in children","volume":"82","author":"Yoshida","year":"1993","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.lfs.2017.10.026_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0773.1991.tb01305.x","article-title":"The effect of haloperidol on ventricular fibrillation threshold in pigs","volume":"69","author":"Tisdale","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0165","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/taap.2001.9168","article-title":"In vivo canine model comparison of cardiohemodynamic and electrophysiological effects of a new antipsychotic drug aripiprazole (OPC-14597) to haloperidol","volume":"173","author":"Sugiyama","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0170","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/00005344-199612000-00009","article-title":"Effect of ethanol, haloperidol, and lorazepam on cardiac conduction and contraction","volume":"28","author":"Medlin Jr","year":"1996","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2017.10.026_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpsychires.2015.07.025","article-title":"Heart rate variability and vagal tone in schizophrenia: a review","volume":"69","author":"Montaquila","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.lfs.2017.10.026_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fneur.2015.00139","article-title":"Cardiac autonomic dysfunction in patients with schizophrenia and their healthy relatives - a small review","volume":"6","author":"B\u00e4r","year":"2015","journal-title":"Front. Neurol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517305404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320517305404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T05:38:05Z","timestamp":1656049085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320517305404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":36,"alternative-id":["S0024320517305404"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2017.10.026","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of dopamine D1\/D2 receptor complex is involved in the function of haloperidol in cardiac H9c2 cells","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2017.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}