{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:27:40Z","timestamp":1778243260331,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"PAUSA Initiative for Urological Training in Africa"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.lfs.2018.08.069","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T11:46:26Z","timestamp":1536061586000},"page":"192-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dietary macronutrient content affects inflammatory and fibrotic factors in normal and obstructed bladders"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-2708","authenticated-orcid":false,"given":"Temitope Gabriel","family":"Adedeji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiola Oluwabunmi","family":"Olapade-Olaopa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2018.08.069_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.afju.2015.11.002","article-title":"An association between diet, metabolic syndrome and lower urinary tract symptoms","volume":"22","author":"Adedeji","year":"2016","journal-title":"Afr. J. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0010","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5410\/wjcu.v3.i3.330","article-title":"Metabolic syndrome and lower urinary tract symptoms","volume":"3","author":"Ito","year":"2014","journal-title":"World J. Clin. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/pros.2990040305","article-title":"High-risk group for benign prostatic hypertrophy","volume":"4","author":"Araki","year":"1983","journal-title":"Prostate"},{"key":"10.1016\/j.lfs.2018.08.069_bb0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0090-4295(99)00096-5","article-title":"Diet and benign prostatic hyperplasia: a study in Greece","volume":"54","author":"Lagiou","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.lfs.2018.08.069_bb0025","series-title":"Nutrition Epidemiology","author":"Willett","year":"1998"},{"key":"10.1016\/j.lfs.2018.08.069_bb0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1097-0045(19980901)36:4<235::AID-PROS4>3.0.CO;2-E","article-title":"Fatty acid composition of phospholipids in epithelium and stroma of human benign prostatic hyperplasia","volume":"36","author":"Weisser","year":"1998","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.lfs.2018.08.069_bb0035","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/0970-1591.127856","article-title":"Management of the complications of BPH\/BOO","volume":"30","author":"Speakman","year":"2014","journal-title":"Indian J. Urol."},{"issue":"2","key":"10.1016\/j.lfs.2018.08.069_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/tcmj.tcmj_20_17","article-title":"Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: current concepts","volume":"29","author":"Lee","year":"2017","journal-title":"Tzu-Chi Med. J."},{"issue":"11","key":"10.1016\/j.lfs.2018.08.069_bb0045","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1111\/j.1464-410X.2010.09445.x","article-title":"Bladder outlet obstruction: progression from inflammation to fibrosis","volume":"106","author":"Metcalfe","year":"2010","journal-title":"BJU Int."},{"key":"10.1016\/j.lfs.2018.08.069_bb0050","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2018.08.069_bb0055","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2018.08.069_bb0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1056\/NEJMp038190","article-title":"From asthma to atherosclerosis\u20145-lipoxygenase, leukotrienes, and inflammation","volume":"350","author":"De Caterina","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2018.08.069_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003898","article-title":"Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association","volume":"3","author":"Vera","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2018.08.069_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6793-7-9","article-title":"Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cord","volume":"7","author":"Zvara","year":"2007","journal-title":"BMC Physiol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1879-5226(10)60028-0","article-title":"Urine and serum C-reactive protein levels as potential biomarkers of lower urinary tract symptoms","volume":"21","author":"Chuang","year":"2010","journal-title":"Urol. Sci."},{"key":"10.1016\/j.lfs.2018.08.069_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neures.2004.01.004","article-title":"Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain","volume":"48","author":"Tanaka","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.lfs.2018.08.069_bb0085","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","article-title":"Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons","volume":"21","author":"Oh","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2018.08.069_bb0090","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1464-410X.1997.00097.x","article-title":"Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis","volume":"79","author":"Lowe","year":"1997","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0095","first-page":"S7","article-title":"Pathophysiology of overactive bladder and urge urinary incontinence","volume":"4","author":"Steers","year":"2002","journal-title":"Rev. Urol."},{"issue":"6 Pt 2","key":"10.1016\/j.lfs.2018.08.069_bb0100","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0022-5347(05)66173-3","article-title":"Extracellular matrix gene responses in a novel ex vivo model of bladder stretch injury","volume":"165","author":"Capolicchio","year":"2001","journal-title":"J. Urol."},{"issue":"6 Pt 2","key":"10.1016\/j.lfs.2018.08.069_bb0105","first-page":"R1960","article-title":"Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease","volume":"272","author":"Peters","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2018.08.069_bb0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2007.01.031","article-title":"Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats","volume":"561","author":"Mittra","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2018.08.069_bb0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1756287216675778","article-title":"The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction","volume":"9","author":"Andersson","year":"2017","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12894-018-0329-4","article-title":"Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans","volume":"18","author":"Fusco","year":"2018","journal-title":"BMC Urol."},{"issue":"3","key":"10.1016\/j.lfs.2018.08.069_bb0125","doi-asserted-by":"crossref","first-page":"F603","DOI":"10.1152\/ajprenal.00128.2017","article-title":"Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1\u03b2","volume":"313","author":"Hughes","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0130","article-title":"Increased serum C-reactive protein level is associated with increased storage lower urinary tract symptoms in men with benign prostatic hyperplasia","volume":"9","author":"Hung","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2018.08.069_bb0135","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/ajcn\/79.6.969","article-title":"Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized cross-over study","volume":"79","author":"Baer","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2018.08.069_bb0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ajcn\/73.1.61","article-title":"Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk","volume":"73","author":"Fung","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2018.08.069_bb0145","series-title":"Nerve Growth Factors","first-page":"213","article-title":"Nerve growth factor","author":"Johnson","year":"1989"},{"key":"10.1016\/j.lfs.2018.08.069_bb0150","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1046\/j.1464-410x.2000.00562.x","article-title":"The production of nerve growth factor by human bladder smooth muscle cells in vivo and in vitro","volume":"85","author":"Tanner","year":"2000","journal-title":"BJU Int."},{"key":"10.1016\/j.lfs.2018.08.069_bb0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1097-4652(200006)183:3<289::AID-JCP1>3.0.CO;2-6","article-title":"Stretch-activated signalling of nerve growth factor secretion in bladder and vascular smooth muscle cells from hypertensive and hyperactive rats","volume":"183","author":"Clemow","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0160","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0022-5347(05)65931-9","article-title":"Histological and neurotrophic changes triggered by varying models of bladder inflammation","volume":"166","author":"Dupont","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/exnr.1999.7254","article-title":"Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction","volume":"161","author":"Vizzard","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0165-1838(90)90105-R","article-title":"Mechanisms underlying the recovery of urinary bladder function following spinal cord injury","volume":"30","author":"de Groat","year":"1990","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.lfs.2018.08.069_bb0175","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1172\/JCI115488","article-title":"Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function","volume":"88","author":"Steers","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2018.08.069_bb0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/BJ20100285","article-title":"The obese healthy paradox: is inflammation the answer?","volume":"430","author":"Barbarroja","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2018.08.069_bb0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0190","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1182\/blood-2008-12-196618","article-title":"CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling","volume":"113","author":"Levoye","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2018.08.069_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104860","article-title":"Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2018.08.069_bb0200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5966\/sctm.2012-0170","article-title":"Intra-articular injection of human meniscus stem\/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1\/CXCR4-mediated homing","volume":"3","author":"Shen","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.lfs.2018.08.069_bb0205","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuroscience.2011.03.035","article-title":"Sciatic nerve injury induces functional pro-nociceptive chemokine receptors in bladder-associated primary afferent neurons in the rat","volume":"183","author":"Foster","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2018.08.069_bb0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnbeh.2016.00051","article-title":"Relationship of the chemokine, CXCL12, to effects of dietary fat on feeding-related behaviors and hypothalamic neuropeptide systems","volume":"10","author":"Poon","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.lfs.2018.08.069_bb0215","first-page":"157","article-title":"Growth factors and receptors in bladder development and obstruction","volume":"75","author":"Baskin","year":"1996","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2018.08.069_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI115821","article-title":"Transforming growth factor-\u03b2 in disease: the dark side of tissue repair","volume":"90","author":"Border","year":"1992","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.lfs.2018.08.069_bb0225","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-\u03b2 signaling in fibrosis","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"key":"10.1016\/j.lfs.2018.08.069_bb0230","series-title":"Peptide Growth Factors and their Receptors. Vol. 95 of Handbook of Experimental Pharmacology","first-page":"419","article-title":"The transforming growth factors-\u03b2","author":"Roberts","year":"1990"},{"key":"10.1016\/j.lfs.2018.08.069_bb0235","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00191215","article-title":"Peptide growth factors in normal and hypertrophied bladder","volume":"13","author":"Chen","year":"1995","journal-title":"World J. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.90291.2008","article-title":"Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis","volume":"36","author":"Yang","year":"2008","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.lfs.2018.08.069_bb0245","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1111\/j.1432-1033.2004.04382.x","article-title":"Regulation of connective tissue growth factor (CTGF\/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics","volume":"271","author":"Chowdhury","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.lfs.2018.08.069_bb0250","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12079-008-0018-2","article-title":"Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF\/CCN2","volume":"1","author":"Mezzano","year":"2007","journal-title":"J. Cell Commun. Signal"},{"key":"10.1016\/j.lfs.2018.08.069_bb0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/nau.10076","article-title":"Focal hypoxia of the obstructed rabbit bladder wall correlates with intermediate decompensation","volume":"22","author":"Levin","year":"2003","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2018.08.069_bb0260","first-page":"340","article-title":"Defining the role of HIF-1\u03b1 and CTGF in fibrosis \u2013 biomed 2009","volume":"45","author":"Haung","year":"2009","journal-title":"Biomed. Sci. Instrum."},{"key":"10.1016\/j.lfs.2018.08.069_bb0265","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/physiolgenomics.00181.2004","article-title":"Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells","volume":"20","author":"Adam","year":"2004","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.lfs.2018.08.069_bb0270","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1097\/01.ju.0000063980.99368.35","article-title":"Signaling through PI3K\/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells","volume":"169","author":"Adam","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2018.08.069_bb0275","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/532519","article-title":"Platelet-rich plasma peptides: key for regeneration","volume":"2012","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2012","journal-title":"Int. J. Pept."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518305319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518305319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:17:08Z","timestamp":1758399428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320518305319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":55,"alternative-id":["S0024320518305319"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2018.08.069","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary macronutrient content affects inflammatory and fibrotic factors in normal and obstructed bladders","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2018.08.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}