{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:13:10Z","timestamp":1788930790319,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.lfs.2018.09.037","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T07:39:55Z","timestamp":1537429195000},"page":"245-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-\u03b21, IL-10 and c-Myc"],"prefix":"10.1016","volume":"211","author":[{"given":"Maha H.","family":"Sharawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-3697","authenticated-orcid":false,"given":"Noha","family":"Abdel-Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmeen","family":"Megahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"El-Awady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2018.09.037_bb0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s40139-014-0050-2","article-title":"Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies","volume":"2","author":"Martinez","year":"2014","journal-title":"Curr Pathobiol Rep."},{"key":"10.1016\/j.lfs.2018.09.037_bb0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.dld.2004.11.009","article-title":"Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation","volume":"37","author":"Carpino","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.lfs.2018.09.037_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jss.2006.12.558","article-title":"Paclitaxel interrupts TGF-beta1 signaling between gallbladder epithelial cells and myofibroblasts","volume":"141","author":"Choi","year":"2007","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.lfs.2018.09.037_bb0025","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.3748\/wjg.v21.i23.7155","article-title":"Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats","volume":"21","author":"Zhen","year":"2015","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.lfs.2018.09.037_bb0030","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.fct.2015.10.010","article-title":"Protective effect of gastrodin on bile duct ligation-induced hepatic fibrosis in rats","volume":"86","author":"Zhao","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bpg.2011.02.011","article-title":"Anti-fibrogenic strategies and the regression of fibrosis","volume":"25","author":"Kisseleva","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010263","article-title":"Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application","volume":"19","author":"Seca","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2018.09.037_bb0045","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/path.2961","article-title":"Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192","volume":"225","author":"Sun","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s005200050135","article-title":"Lung fibrosis induced by paclitaxel","volume":"6","author":"Sotiriou","year":"1998","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.lfs.2018.09.037_bb0055","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/nep.12747","article-title":"Low-dose paclitaxel ameliorates renal fibrosis by suppressing transforming growth factor-beta1-induced plasminogen activator inhibitor-1 signaling","volume":"21","author":"Jung","year":"2016","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.lfs.2018.09.037_bb0060","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/labinvest.2009.149","article-title":"Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-beta\/Smad activity","volume":"90","author":"Zhang","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2018.09.037_bb0065","article-title":"Low-dose paclitaxel ameliorates pulmonary fibrosis by suppressing TGF-beta1\/Smad3 pathway via miR-140 upregulation","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2018.09.037_bb0070","article-title":"Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis","volume":"96","author":"Tag","year":"2015","journal-title":"J. Visualized Exp.: JoVE"},{"key":"10.1016\/j.lfs.2018.09.037_bb0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/laban0608-271","article-title":"Refinement of the dosage and dosing schedule of ketoprofen for postoperative analgesia in Sprague-Dawley rats","volume":"37","author":"Cooper","year":"2008","journal-title":"Lab Anim."},{"key":"10.1016\/j.lfs.2018.09.037_bb0080","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.lfs.2018.09.037_bb0085","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras","year":"1984","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"4","key":"10.1016\/j.lfs.2018.09.037_bb0095","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbadis.2017.06.027","article-title":"Animal models of biliary injury and altered bile acid metabolism","volume":"1864","author":"Mariotti","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.lfs.2018.09.037_bb0100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2018.09.037_bb0105","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2353\/ajpath.2006.050747","article-title":"Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation","volume":"168","author":"Xia","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0110","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.2147\/DDDT.S81390","article-title":"Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling","volume":"9","author":"Zhang","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2018.09.037_bb0115","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.3748\/wjg.v16.i26.3330","article-title":"Paclitaxel ameliorates fibrosis in hepatic stellate cells via inhibition of TGF-beta\/Smad activity","volume":"16","author":"Zhou","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00534-002-0804-9","article-title":"Suppression of proliferative cholangitis in a rat model by local delivery of paclitaxel","volume":"10","author":"Park","year":"2003","journal-title":"J. Hepato-Biliary-Pancreat. Surg."},{"key":"10.1016\/j.lfs.2018.09.037_bb0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10856-016-5737-y","article-title":"Coating of intravascular balloon with paclitaxel prevents constrictive remodeling of the dilated porcine femoral artery due to inhibition of intimal and media fibrosis","volume":"27","author":"Pavo","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.lfs.2018.09.037_bb0130","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3892\/ijo.2013.1801","article-title":"Low-dose paclitaxel modulates tumour fibrosis in gastric cancer","volume":"42","author":"Tsukada","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0135","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/art.1780370611","article-title":"Regression of collagen-induced arthritis with taxol, a microtubule stabilizer","volume":"37","author":"Brahn","year":"1994","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2018.09.037_bb0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4137\/BMI.S10009","article-title":"Molecular serum markers of liver fibrosis","volume":"7","author":"Liu","year":"2012","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.lfs.2018.09.037_bb0145","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7629724","article-title":"Clinical advancements in the targeted therapies against liver fibrosis","volume":"2016","author":"Bansal","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2018.09.037_bb0150","first-page":"297","article-title":"Interleukins in chronic liver disease: lessons learned from experimental mouse models","volume":"7","author":"Hammerich","year":"2014","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3072745","article-title":"Exemestane attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells and promoting the secretion of interleukin 10","volume":"2017","author":"Wang","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.lfs.2018.09.037_bb0160","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2005.08.085","article-title":"Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice","volume":"336","author":"Hung","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2018.09.037_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/276850","article-title":"Interactions between Myc and mediators of inflammation in chronic liver diseases","volume":"2015","author":"Liu","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2018.09.037_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/genes8040123","article-title":"c-MYC-making liver sick: role of c-MYC in hepatic cell function, homeostasis and disease","volume":"8","author":"Zheng","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.lfs.2018.09.037_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphys.2012.00053","article-title":"Differential regulation of TGF-beta\/Smad signaling in hepatic stellate cells between acute and chronic liver injuries","volume":"3","author":"Yoshida","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0180","doi-asserted-by":"crossref","first-page":"476","DOI":"10.5152\/tjg.2017.16742","article-title":"Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: role of the hepatic stem cells","volume":"28","author":"Alaca","year":"2017","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.lfs.2018.09.037_bb0185","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3748\/wjg.v12.i13.2065","article-title":"Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis","volume":"12","author":"Farinati","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2018.09.037_bb0190","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbadis.2013.06.001","article-title":"Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis","volume":"1832","author":"Nevzorova","year":"2013","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518305897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518305897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T08:20:52Z","timestamp":1538468452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320518305897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":38,"alternative-id":["S0024320518305897"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2018.09.037","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-\u03b21, IL-10 and c-Myc","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2018.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}