{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:58:41Z","timestamp":1783108721074,"version":"3.54.6"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007298","name":"Urmia University","doi-asserted-by":"publisher","award":["008-D-93"],"award-info":[{"award-number":["008-D-93"]}],"id":[{"id":"10.13039\/501100007298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.lfs.2018.10.043","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T19:29:30Z","timestamp":1541100570000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats"],"prefix":"10.1016","volume":"215","author":[{"given":"Navideh","family":"Mirzakhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Abbas","family":"Farshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmaeal","family":"Tamaddonfard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Imani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Erfanparast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Noroozinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2018.10.043_bb0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.hcl.2013.04.002","article-title":"Nerve physiology: mechanisms of injury and recovery","volume":"29","author":"Menorca","year":"2013","journal-title":"Hand Clin."},{"key":"10.1016\/j.lfs.2018.10.043_bb0010","first-page":"243","article-title":"Biologic strategies to improve nerve regeneration after peripheral nerve repair","volume":"31","author":"Folwer","year":"2015","journal-title":"J. Reconstr. Microsurg."},{"key":"10.1016\/j.lfs.2018.10.043_bb0015","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.3928\/01477447-20161019-01","article-title":"The present and future of peripheral nerve regeneration","volume":"40","author":"Panagopoulos","year":"2017","journal-title":"Orthopedics"},{"key":"10.1016\/j.lfs.2018.10.043_bb0020","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1007\/s00018-017-2565-2","article-title":"Wallerian demyelination: chronicle of a cellular cataclysm","volume":"74","author":"Tricaud","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2018.10.043_bb0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pneurobio.2012.05.005","article-title":"Specificity of peripheral nerve regeneration: interactions at the axon leve","volume":"98","author":"Allodi","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-12-420045-6.00008-0","article-title":"Future perspectives in nerve repair and regeneration","volume":"109","author":"Tos","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3240261","article-title":"On the anticataractogenic effects of L-carnosine: is it best described as an antioxidant, metal chelating agent or glycation inhibitor?","author":"Abdelkader","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2018.10.043_bb0040","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1152\/physrev.00039.2012","article-title":"Physiology and pathophysiology of carnosine","volume":"93","author":"Boldyrev","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2018.10.043_bb0045","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3892\/etm.2017.4571","article-title":"Neuroprotective effects of carnosine against salsolinal-induced Parkinson's disease","volume":"14","author":"Zhao","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.lfs.2018.10.043_bb0050","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1755-5949.2012.00362.x","article-title":"Protective effect of carnosine on subcortical ischemic vascular dementia in mice","volume":"18","author":"Ma","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.lfs.2018.10.043_bb0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.peptides.2016.10.008","article-title":"Carnosine ameliorates cognitive deficits in stereptozotocin (STZ)-induced diabetic rats: possible involved mechanisms","volume":"86","author":"Ahshin-Majd","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2018.10.043_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/B978-0-12-410499-0.00007-1","article-title":"Role of inflammation and cytokines in peripheral nerve regeneration","volume":"108","author":"Dubov\u00fd","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2015.01.048","article-title":"Mechanisms of distal axonal degeneration in peripheral neuropathies","volume":"596","author":"Cashman","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2018.10.043_bb0070","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/mus.26033","article-title":"Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury","volume":"57","author":"Lin","year":"2018","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.lfs.2018.10.043_bb0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuropharm.2017.10.020","article-title":"Monoamine oxidase-B inhibitor protects degenerating spinal neurons, enhances nerve regeneration and functional recovery in sciatic nerve crush injury model","volume":"128","author":"Hussain","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2018.10.043_bb0080","first-page":"83","article-title":"Crocin enhanced functional recovery after sciatic nerve crush injury in rats","volume":"16","author":"Tamaddonfard","year":"2013","journal-title":"Iran J. Basic Med. Sci."},{"key":"10.1016\/j.lfs.2018.10.043_bb0085","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.phymed.2013.10.031","article-title":"Effects of safranal, a constituent of saffron, and vitamin E on nerve functions and histopathology following crush injury of sciatic nerve in rats","volume":"21","author":"Tamaddonfard","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2018.10.043_bb0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jneumeth.2013.11.012","article-title":"The functional and morphological characteristics of sciatic nerve degeneration and regeneration after crush injury in rats","volume":"222","author":"Sta","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.lfs.2018.10.043_bb0095","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.etap.2017.08.021","article-title":"Therapeutic effect of carnosine in rat model of experimental liver carcinogenesis","volume":"56","author":"Fouad","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0100","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000479879","article-title":"Mechanistic evaluation of the protective effect of carnosine on acute lung injury in sepsis rats","volume":"100","author":"Sun","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.lfs.2018.10.043_bb0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.12659\/MSM.890528","article-title":"L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats","volume":"20","author":"Yapislar","year":"2014","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.lfs.2018.10.043_bb0110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s12011-010-8875-y","article-title":"Protection against adriamycin-induced cardiomyopathy by carnosine: role of endogenous antioxidants","volume":"143","author":"Dursun","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2017.07.018","article-title":"Neuroprotective effect of Lovastatin on motor deficit induced by sciatic nerve crush in the rat","volume":"812","author":"Ghayour","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0120","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1590\/s0102-865020160110000005","article-title":"Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury","volume":"31","author":"Ozturk","year":"2016","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.lfs.2018.10.043_bb0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.5152\/balkanmedj.2016.14701","article-title":"The effect of sildenafil on recuperation from sciatic nerve injury in rats","volume":"33","author":"Korkmaz","year":"2016","journal-title":"Balkan Med. J."},{"key":"10.1016\/j.lfs.2018.10.043_bb0130","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00006534-198901000-00024","article-title":"Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat","volume":"83","author":"Bain","year":"1989","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.lfs.2018.10.043_bb0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxidase in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2018.10.043_bb0140","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2018.10.043_bb0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2018.10.043_bb0150","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jemt.20577","article-title":"A simple protocol for paraffin-embedded myelin sheath staining with osmium tetroxide for light microscope observation","volume":"71","author":"Di Scipio","year":"2008","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.lfs.2018.10.043_bb0155","first-page":"377","article-title":"Effects of ascorbic acid and alpha-tocopherol on collagen fibril stereological parameters in rabbits","volume":"54","author":"Sarrafzadeh-Rezaei","year":"2010","journal-title":"Bull. Vet. Inst. Pulawy"},{"key":"10.1016\/j.lfs.2018.10.043_bb0160","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/mus.23662","article-title":"Regenerative cell injection in denervated muscle reduces muscle atrophy and enhances recovery following nerve repair","volume":"47","author":"Schaakxs","year":"2013","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.lfs.2018.10.043_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0270(01)00378-8","article-title":"Functional evaluation of peripheral nerve regeneration in rats: walking track analysis","volume":"108","author":"Varej\u00e3o","year":"2001","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.lfs.2018.10.043_bb0170","first-page":"1","article-title":"Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat","volume":"68","author":"Sarikciouglu","year":"2009","journal-title":"Folia Morphol. (Warsz)"},{"key":"10.1016\/j.lfs.2018.10.043_bb0175","first-page":"4360","article-title":"Chitosan conduit combined with hyaluronic acid prevent sciatic nerve scar in a rat model of peripheral nerve crush injury","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2018.10.043_bb0180","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bcp.2011.07.074","article-title":"Administration of carnosine in the treatment of acute spinal cord injury","volume":"82","author":"Di Paola","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.1999.19410001.x","article-title":"Peripheral nerve regeneration and neurotrophic factors","volume":"194","author":"Terenghi","year":"1999","journal-title":"J. Anat."},{"key":"10.1016\/j.lfs.2018.10.043_bb0190","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.mad.2004.08.012","article-title":"Superoxide dismutase evolution and life span regulation","volume":"126","author":"Landis","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.lfs.2018.10.043_bb0195","first-page":"22","article-title":"Intraperitoneal alpha-lipoic acid to prevent neural damage after crush injury to the rat sciatic nerve","volume":"4","author":"Senoglu","year":"2009","journal-title":"J. Brachial Plex Peripher. Nerve Inj."},{"key":"10.1016\/j.lfs.2018.10.043_bb0200","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.4103\/1673-5374.141808","article-title":"Edaravone promotes functional recovery after mechanical peripheral nerve injury","volume":"9","author":"Zhang","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0205","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10571-014-0106-1","article-title":"Carnosine attenuates early brain injury through its antioxidant and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model","volume":"35","author":"Zhang","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0210","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejphar.2011.06.003","article-title":"Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat model","volume":"667","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0215","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.expneurol.2014.04.006","article-title":"Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury","volume":"258","author":"Bastien","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0220","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1742-2094-2-26","article-title":"Cytokine responses during chronic denervation","volume":"2","author":"Ruohonen","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2018.10.043_bb0225","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.pain.2013.06.042","article-title":"P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice","volume":"154","author":"Liou","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2018.10.043_bb0230","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1139\/cjpp-2016-0647","article-title":"Chelating effects of carnosine in ameliorating nickel-induced nephrotoxicity in rats","volume":"95","author":"Hasanein","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2018.10.043_bb0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1684\/ecn.2016.0372","article-title":"Protective effects of L-carnosine on CCl-4-induced hepatic injury in rats","volume":"27","author":"Alsheblak","year":"2016","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.lfs.2018.10.043_bb0240","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1055\/s-0033-1363219","article-title":"Effect of vitamin B12 on functional recovery and histopathological changes of tibial nerve-crushed rats","volume":"64","author":"Tamaddonfard","year":"2014","journal-title":"J. Drug Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0245","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11064-017-2432-4","article-title":"Therapeutic effect of vinorine on sciatic nerve injured rat","volume":"43","author":"Guo","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0250","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3109\/02713683.2013.855235","article-title":"The neuroprotective effect of carnosine (\u03b2-alanyl-L-histidine) on retinal ganglion cell following ischemia-reperfusion injury","volume":"39","author":"Ji","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0255","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4103\/1673-5374.133163","article-title":"L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessment","volume":"9","author":"Avsar","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0260","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00381-012-1936-0","article-title":"Comparison of the beneficial effect of melatonin on recovery after cut and crush sciatic nerve injury: a combined study using functional, electrophysiological, biochemical, and electron microscopic analyses","volume":"29","author":"Kaya","year":"2013","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.lfs.2018.10.043_bb0265","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.4103\/1673-5374.191217","article-title":"Protective effects of carnosine on white matter damage induced by chronic cerebral hypoperfusion","volume":"11","author":"Ma","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0270","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0896-6273(00)80299-8","article-title":"The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelination","volume":"18","author":"Pedraza","year":"1977","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2018.10.043_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054041","article-title":"A new approach to assess the gastrocnemius muscle volume in rodents using ultrasound; comparison with the gastrocnemius muscle index","volume":"8","author":"Nijhuis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2018.10.043_bb0280","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/mus.24622","article-title":"Butyrate prevents muscle atrophy after sciatic nerve crush","volume":"52","author":"Walsh","year":"2015","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.lfs.2018.10.043_bb0285","first-page":"291","article-title":"Carnosine and other imidazole-containing compounds enhance the post-denervation depolarization of the rat diaphragm fibers","volume":"47","author":"Urazaev","year":"1988","journal-title":"Physiol. Res."},{"key":"10.1016\/j.lfs.2018.10.043_bb0290","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3340\/jkns.2014.55.3.125","article-title":"The neuroprotective effects of carnosine in early stage of focal ischemia rodent model","volume":"55","author":"Park","year":"2014","journal-title":"J. Korean Neurosurg. Soc."},{"key":"10.1016\/j.lfs.2018.10.043_bb0295","doi-asserted-by":"crossref","first-page":"344","DOI":"10.18097\/pbmc20186404344","article-title":"Study of the neuroprotective effects of carnosine in an experimental model of focal cerebral ischemia\/reperfusion","volume":"64","author":"Devyatov","year":"2018","journal-title":"Biomed. Khim."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518306684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518306684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T01:54:22Z","timestamp":1662342862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320518306684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":59,"alternative-id":["S0024320518306684"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2018.10.043","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2018.10.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}