{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:23:11Z","timestamp":1790432591096,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Ministry of Education, Culture, Sport, Science and Technology of the Japanese Government","award":["40159588"],"award-info":[{"award-number":["40159588"]}]},{"name":"Ministry of Education, Culture, Sport, Science and Technology of the Japanese Government","award":["80595257"],"award-info":[{"award-number":["80595257"]}]},{"name":"RaQualia Pharma Inc."}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.lfs.2018.12.031","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T03:33:35Z","timestamp":1545276815000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary bladder afferent nerves in rats"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-9293","authenticated-orcid":false,"given":"Naoki","family":"Aizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ohshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Igawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2018.12.031_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2018.12.031_bb0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2018.12.031_bb0015","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cne.20794","article-title":"Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta\/c-fibers and colocalization with trk receptors","volume":"493","author":"Kobayashi","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0020","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2018.12.031_bb0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2018.12.031_bb0030","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/nau.23532","article-title":"KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats","volume":"37","author":"Aizawa","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2018.12.031_bb0035","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/bju.13225","article-title":"Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry and ex vivo measurements of single-unit mechanosensitive bladder afferent activities in the rat","volume":"117","author":"Ito","year":"2016","journal-title":"BJU Int."},{"key":"10.1016\/j.lfs.2018.12.031_bb0040","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1113\/jphysiol.1990.sp018117","article-title":"Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat","volume":"425","author":"Habler","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.1993.sp019604","article-title":"Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder","volume":"463","author":"Habler","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0050","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1152\/jn.2000.84.4.1924","article-title":"Sensory fibers of the pelvic nerve innervating the Rat's urinary bladder","volume":"84","author":"Shea","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.autneu.2011.05.006","article-title":"Function and expression pattern of TRPM8 in bladder afferent neurons associated with bladder outlet obstruction in rats","volume":"164","author":"Hayashi","year":"2011","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.lfs.2018.12.031_bb0060","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1124\/jpet.115.228684","article-title":"DFL23448, a novel transient receptor potential Melastin 8-selective ion channel antagonist, modifies bladder function and reduces bladder overactivity in awake rats","volume":"356","author":"Mistretta","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2018.12.031_bb0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2490-6-31","article-title":"Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders","volume":"6","author":"Mukerji","year":"2006","journal-title":"BMC Urol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0070","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2490-6-6","article-title":"Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations","volume":"6","author":"Mukerji","year":"2006","journal-title":"BMC Urol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0075","series-title":"In Vitro and in Vivo Characterization of RQ-00434739: a Novel Orally Active and Selective TRPM8 Antagonist for the Treatment of Oxaliplatin-induced Peripheral Neuropathic Pain","author":"Ohshiro","year":"2016"},{"key":"10.1016\/j.lfs.2018.12.031_bb0080","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/S0022-5347(01)67397-X","article-title":"Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins?","volume":"153","author":"Ishizuka","year":"1995","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0085","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00300786","article-title":"Comparison of the mode of action of prostaglandin E2 (PGE2) and sulprostone, a PGE2-derivative, on the lower urinary tract in healthy women. A urodynamic study","volume":"18","author":"Schussler","year":"1990","journal-title":"Urol. Res."},{"key":"10.1016\/j.lfs.2018.12.031_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2220\/biomedres.29.105","article-title":"Urothelium EP1 receptor facilitates the micturition reflex in mice","volume":"29","author":"Wang","year":"2008","journal-title":"Biomed. Res."},{"key":"10.1016\/j.lfs.2018.12.031_bb0095","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/bju.13223","article-title":"URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats","volume":"117","author":"Aizawa","year":"2016","journal-title":"BJU Int."},{"key":"10.1016\/j.lfs.2018.12.031_bb0100","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/nau.20826","article-title":"Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat","volume":"y","author":"Aizawa","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2018.12.031_bb0105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/nau.20940","article-title":"Effects of intravesical instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity","volume":"30","author":"Aizawa","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2018.12.031_bb0110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/nau.21212","article-title":"Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat","volume":"31","author":"Aizawa","year":"2012","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.lfs.2018.12.031_bb0115","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2018.12.031_bb0120","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2006.05.005","article-title":"More than cool: promiscuous relationships of menthol and other sensory compounds","volume":"32","author":"Macpherson","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2018.12.031_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5213\/inj.2012.16.2.69","article-title":"Function of the Cold Receptor (TRPM8) associated with voiding dysfunction in bladder outlet obstruction in rats","volume":"16","author":"Jun","year":"2012","journal-title":"Int Neurourol J."},{"key":"10.1016\/j.lfs.2018.12.031_bb0130","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.urology.2007.11.137","article-title":"Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats","volume":"72","author":"Nomoto","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.lfs.2018.12.031_bb0135","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.theriogenology.2010.06.017","article-title":"Expression of prostaglandin E(2) receptor subtypes in the canine lower urinary tract varies according to the gonadal status and gender","volume":"74","author":"Ponglowhapan","year":"2010","journal-title":"Theriogenology"},{"issue":"240","key":"10.1016\/j.lfs.2018.12.031_bb0140","first-page":"e17","article-title":"Interactions between cholinergic and prostaglandin signaling elements in the urothelium: role for muscarinic type 2 receptors","volume":"79","author":"Nile","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.lfs.2018.12.031_bb0145","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/01.ju.0000134880.55119.cf","article-title":"Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract","volume":"172","author":"Stein","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2018.12.031_bb0150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/WNR.0b013e3283424c9c","article-title":"TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats","volume":"22","author":"Shibata","year":"2011","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2018.12.031_bb0155","article-title":"Estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract of female rats upon colon-bladder cross-sensitization","volume":"9","author":"Pan","year":"2014","journal-title":"PLoS One"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518308245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320518308245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:20:02Z","timestamp":1758399602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320518308245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":31,"alternative-id":["S0024320518308245"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2018.12.031","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary bladder afferent nerves in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2018.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}