{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:04:00Z","timestamp":1770915840337,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Scientific Research Foundation of Shandong Province of China","award":["2006BS03012"],"award-info":[{"award-number":["2006BS03012"]}]},{"name":"Scientific Research Foundation of Shandong Province of China","award":["2012GSF11823"],"award-info":[{"award-number":["2012GSF11823"]}]},{"name":"Scientific Research Foundation of Shandong Province of China","award":["2013GSF11814"],"award-info":[{"award-number":["2013GSF11814"]}]},{"name":"Science and Technology Development Program of Shandong Province","award":["2009HW058"],"award-info":[{"award-number":["2009HW058"]}]},{"name":"National Center for Clinical Medicine for Metabolic Diseases","award":["2013BAI09B13"],"award-info":[{"award-number":["2013BAI09B13"]}]},{"DOI":"10.13039\/501100002855","name":"Chinese Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2012ZX09303006-001"],"award-info":[{"award-number":["2012ZX09303006-001"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.lfs.2019.01.036","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T23:39:47Z","timestamp":1548373187000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Viscus fat area contributes to the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"220","author":[{"given":"Lan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbo","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2019.01.036_bb0005","doi-asserted-by":"crossref","first-page":"S302","DOI":"10.1007\/s00592-003-0093-z","article-title":"Ethnic differences in abdominal visceral fat accumulation between Japanese, African-Americans, and Caucasians: a meta-analysis","volume":"40","author":"Tanaka","year":"2003","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham heart study","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.01.036_bb0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2298\/SARH1308460M","article-title":"Relationship between abdominal obesity and other cardiovascular risk factors: cross sectional study of patients with symptomatic carotid disease","volume":"141","author":"Maksimovic","year":"2013","journal-title":"Srp. Arh. Celok. Lek."},{"key":"10.1016\/j.lfs.2019.01.036_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2017.11.008","article-title":"Visceral fat index\/percentage body fat ratio is independently associated with proximal aortic dilatation in a middle-aged and aged Chinese population in Liujiang of Guangxi","volume":"268","author":"Jiang","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2019.01.036_bb0025","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1161\/CIRCULATIONAHA.114.015000","article-title":"Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors","volume":"132","author":"Abraham","year":"2015","journal-title":"Circulation"},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2019.01.036_bb0030","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1080\/02701367.2015.1042998","article-title":"Agreement between Omron 306 and biospace InBody 720 bioelectrical impedance analyzers (BIA) in children and adolescents","volume":"86","author":"Finn","year":"2015","journal-title":"Res. Q. Exerc. Sport"},{"key":"10.1016\/j.lfs.2019.01.036_bb0035","first-page":"42","article-title":"InBody 720 as a new method of evaluating visceral obesity","volume":"58","author":"Ogawa","year":"2011","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.lfs.2019.01.036_bb0040","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/0301446031000095211","article-title":"Cross-calibration of eight-polar bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for the assessment of total and appendicular body composition in healthy subjects aged 21\u201382\u202fyears","volume":"30","author":"Malavolti","year":"2003","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0045","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/sj.ejcn.1602165","article-title":"Accuracy of eight-polar bioelectrical impedance analysis for the assessment of total and appendicular body composition in peritoneal dialysis patients","volume":"59","author":"Medici","year":"2005","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2019.01.036_bb0050","doi-asserted-by":"crossref","first-page":"568","DOI":"10.12965\/jer.1735132.566","article-title":"Changes in physical fitness and body composition according to the physical activities of Korean adolescents","volume":"13","author":"Cho","year":"2017","journal-title":"J. Exerc. Rehabil."},{"key":"10.1016\/j.lfs.2019.01.036_bb0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/1753-0407.12558","article-title":"Interactions between general and central obesity in predicting gestational diabetes mellitus in Chinese pregnant women: a prospective population-based study in Tianjin, China","volume":"10","author":"Han","year":"2018","journal-title":"J. Diabetes"},{"key":"10.1016\/j.lfs.2019.01.036_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2337\/dc11-1333","article-title":"Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes","volume":"35","author":"Yoshida","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2019.01.036_bb0065","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.01.036_bb0070","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1001\/archinte.165.22.2644","article-title":"Metabolic syndrome vs Framingham risk score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus","volume":"165","author":"Wannamethee","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.lfs.2019.01.036_bb0075","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.2337\/diacare.27.11.2676","article-title":"Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and\/or cardiovascular disease?","volume":"27","author":"Stern","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2019.01.036_bb0080","doi-asserted-by":"crossref","first-page":"e007324","DOI":"10.1136\/bmjopen-2014-007324","article-title":"Validation of the Framingham general cardiovascular risk score in a multiethnic Asian population: a retrospective cohort study","volume":"5","author":"Chia","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.lfs.2019.01.036_bb0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.01.004","article-title":"Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines","volume":"17","author":"Hishinuma","year":"2008","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.lfs.2019.01.036_bb0090","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.00033.2011","article-title":"Pathophysiology of human visceral obesity: an update","volume":"93","author":"Tchernof","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2019.01.036_bb0095","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.ijo.0800929","article-title":"The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis","volume":"23","author":"Rankinen","year":"1999","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.lfs.2019.01.036_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/1753-0407.12108","article-title":"Cohort profile: risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study","volume":"6","author":"Bi","year":"2014","journal-title":"J. Diabetes"},{"key":"10.1016\/j.lfs.2019.01.036_bb0105","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijcard.2014.01.073","article-title":"The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population: results of the REACTION study","volume":"172","author":"Lu","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1753-0407.2012.00182.x","article-title":"Risk evaluation of cAncers in Chinese diabeTic individuals: a lONgitudinal (REACTION) study","volume":"4","author":"Ning","year":"2012","journal-title":"J. Diabetes"},{"key":"10.1016\/j.lfs.2019.01.036_bb0115","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/infdis\/jiv035","article-title":"Gynecological manifestations, histopathological findings, and schistosoma-specific polymerase chain reaction results among women with Schistosoma haematobium infection: a cross-sectional study in Madagascar","volume":"212","author":"Randrianasolo","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.lfs.2019.01.036_bb0120","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1161\/01.CIR.0000161956.75255.7B","article-title":"Interaction of body mass index and Framingham risk score in predicting incident coronary disease in families","volume":"111","author":"Mora","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.01.036_bb0125","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jama.2013.168118","article-title":"Prevalence and control of diabetes in Chinese adults","volume":"310","author":"Xu","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2019.01.036_bb0130","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1210\/jc.2006-0814","article-title":"Influence of body fat content and distribution on variation in metabolic risk","volume":"91","author":"Vega","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2019.01.036_bb0135","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.01.036_bb0140","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2337\/diacare.27.6.1375","article-title":"Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults","volume":"27","author":"Kanaya","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2019.01.036_bb0145","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.3390\/ijms15046184","article-title":"Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2019.01.036_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0155","first-page":"320","article-title":"Epicardial adipose tissue: more than a simple fat deposit?","volume":"60","author":"Lima-Martinez","year":"2013","journal-title":"Endocrinol. Nutr."},{"key":"10.1016\/j.lfs.2019.01.036_bb0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0895-7061(02)02257-4","article-title":"Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects","volume":"15","author":"Giacchetti","year":"2002","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.lfs.2019.01.036_bb0165","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1462-8902.2003.0342.x","article-title":"Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects","volume":"6","author":"Saijo","year":"2004","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.lfs.2019.01.036_bb0170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2147\/DMSO.S150914","article-title":"Visceral-to-subcutaneous fat ratio as a predictor of the multiple metabolic risk factors for subjects with normal waist circumference in Korea","volume":"10","author":"Oh","year":"2017","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.lfs.2019.01.036_bb0175","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/jdi.12713","article-title":"Ratio of visceral-to-subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes","volume":"9","author":"Fukuda","year":"2018","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.lfs.2019.01.036_bb0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.atherosclerosis.2017.03.001","article-title":"Visceral-to-subcutaneous fat ratio is independently related to small and large cerebrovascular lesions even in healthy subjects","volume":"259","author":"Higuchi","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.lfs.2019.01.036_bb0185","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.jacc.2015.01.061","article-title":"Body fat distribution and incident cardiovascular disease in obese adults","volume":"65","author":"Neeland","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0190","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jacc.2013.06.027","article-title":"Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality","volume":"62","author":"Britton","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2019.01.036_bb0195","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.jcmg.2014.07.017","article-title":"Visceral adiposity and the risk of metabolic syndrome across body mass index: the MESA Study","volume":"7","author":"Shah","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.lfs.2019.01.036_bb0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ijo.2008.222","article-title":"Visceral fat amount is associated with carotid atherosclerosis even in type 2 diabetic men with a normal waist circumference","volume":"33","author":"Kim","year":"2009","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2019.01.036_bb0205","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001357","article-title":"Abdominal obesity and association with atherosclerosis risk factors: the Uberlandia heart Study","volume":"95","author":"Roever","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lfs.2019.01.036_bb0210","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/hrt.2008.155804","article-title":"The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction","volume":"95","author":"Champney","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.lfs.2019.01.036_bb0215","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s13679-014-0119-6","article-title":"Androgens, body fat distribution and adipogenesis","volume":"3","author":"Zerradi","year":"2014","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.lfs.2019.01.036_bb0220","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1161\/HYPERTENSIONAHA.109.146720","article-title":"Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents","volume":"55","author":"Pausova","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2019.01.036_bb0225","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1089\/jwh.2012.4035","article-title":"Body fat distribution after menopause and cardiovascular disease risk factors: Korean National Health and Nutrition Examination Survey 2010","volume":"22","author":"Park","year":"2013","journal-title":"J. Women's Health (Larchmt)"},{"key":"10.1016\/j.lfs.2019.01.036_bb0230","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.111.067264","article-title":"Body fat distribution and risk of cardiovascular disease: an update","volume":"126","author":"Despres","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.01.036_bb0235","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4068\/cmj.2013.49.1.31","article-title":"Rosuvastatin does not affect fasting glucose, insulin resistance, or adiponectin in patients with mild to moderate hypertension","volume":"49","author":"Kim","year":"2013","journal-title":"Chonnam Med. J."},{"key":"10.1016\/j.lfs.2019.01.036_bb0240","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1758-5996-4-3","article-title":"The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus","volume":"4","author":"Kim","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.lfs.2019.01.036_bb0245","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00041552-200303000-00011","article-title":"Obesity-associated hypertension and kidney disease","volume":"12","author":"Hall","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519300505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519300505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T19:45:22Z","timestamp":1565207122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519300505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":49,"alternative-id":["S0024320519300505"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.01.036","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viscus fat area contributes to the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.01.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}